{"entity": "label", "iuid": "616e7d03c7864c799b2d5f9b9675400f", "timestamp": "2026-09-10T17:03:16.970Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/label/Erika%20Comasco.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/label/Erika%20Comasco"}}, "value": "Erika Comasco", "created": "2020-09-28T11:42:00.985Z", "modified": "2021-10-04T16:11:41.384Z", "accounts": [{"entity": "account", "iuid": "43d414f3d1d04ea19ac969a8df4ed4a6", "timestamp": "2026-09-10T17:03:16.970Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/account/sune.joubert%40scilifelab.uu.se.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/account/sune.joubert%40scilifelab.uu.se"}}, "email": "sune.joubert@scilifelab.uu.se", "name": "Sun\u00e9 Joubert", "orcid": "", "role": "curator", "status": "enabled", "login": "2025-10-31T11:15:30.148Z", "created": "2024-08-16T10:03:01.443Z", "modified": "2025-10-31T11:15:30.148Z"}, {"entity": "account", "iuid": "59d7e928268c4c5c9d866673716a8f2d", "timestamp": "2026-09-10T17:03:16.970Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/account/christopher.erdmann%40scilifelab.uu.se.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/account/christopher.erdmann%40scilifelab.uu.se"}}, "email": "christopher.erdmann@scilifelab.uu.se", "name": "Christopher Erdmann", "orcid": "", "role": "curator", "status": "enabled", "login": "2024-08-16T11:57:32.037Z", "created": "2024-08-16T10:02:45.342Z", "modified": "2024-10-17T11:21:28.034Z"}, {"entity": "account", "iuid": "ecf4af0e62be4121a0b206b4a33004e5", "timestamp": "2026-09-10T17:03:16.970Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/account/erika.comasco%40neuro.uu.se.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/account/erika.comasco%40neuro.uu.se"}}, "email": "erika.comasco@neuro.uu.se", "name": "Erika Comasco", "orcid": "0000-0002-2174-2068", "role": "curator", "status": "enabled", "login": "2026-08-23T09:38:55.807Z", "created": "2020-09-28T11:42:41.863Z", "modified": "2026-08-23T09:40:01.709Z"}], "publications_count": 124, "publications": [{"entity": "publication", "iuid": "476c4e48974c4067b5c037ef4adfc858", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/476c4e48974c4067b5c037ef4adfc858.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/476c4e48974c4067b5c037ef4adfc858"}}, "title": "Grey matter structural asymmetry and premenstrual dysphoric disorder", "authors": [{"family": "B\u00fccklein-Ehlers", "given": "Elise", "initials": "E"}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Henes", "given": "Melanies", "initials": "M"}, {"family": "Ehlis", "given": "Ann Christine", "initials": "AC"}, {"family": "Dresler", "given": "Thomas", "initials": "T"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Fallgatter", "given": "Andreas", "initials": "A"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal-article", "published": "2026-08-06", "journal": {"title": "Neuropsychobiology", "issn": "0302-282X", "pages": "1-22", "issn-l": null}, "abstract": "Left-right brain asymmetry is an important feature of human neuroanatomy, with implications for cognition, behaviour, and vulnerability to mental disorders. Despite evidence for lateralized sensitivity to hormonal fluctuations, the cortical and subcortical asymmetry profile of individuals with premenstrual dysphoric disorder (PMDD), a hormone-related mood disorder associated with alterations in brain structure, remains unexplored.\n\nIn this study, a total of 68 females with PMDD and 51 healthy females underwent magnetic resonance imaging (MRI) during the luteal phase of the menstrual cycle. Structural asymmetry was assessed using voxel-wise whole-brain analysis and region of interest (ROI) approaches for grey matter volume (GMV), as well as ROI-based analysis of cortical thickness. Associations between asymmetry and symptom severity were also investigated.\n\nWhole-brain analyses revealed significantly greater leftward GMV asymmetry in PMDD participants in two clusters within the anterior fusiform gyrus and the anterior insula. ROI-based analyses did not show any asymmetry group differences in either GMV or cortical thickness. Within the PMDD group, greater leftward asymmetry in the amygdala GMV was moderately associated with higher irritability.\n\nThese findings provide novel, region-specific evidence for structural asymmetry in PMDD and suggest that lateralized brain architecture may contribute to affective symptom expression in this disorder.", "doi": "10.1159/000553663", "pmid": "42560942", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "000553663"}], "notes": [], "created": "2026-08-23T09:40:45.163Z", "modified": "2026-08-24T07:18:22.501Z"}, {"entity": "publication", "iuid": "56efe6252f9443b7be9bdf59131abb8a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/56efe6252f9443b7be9bdf59131abb8a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/56efe6252f9443b7be9bdf59131abb8a"}}, "title": "Escitalopram and brain reactivity to aggressive stimuli in premenstrual dysphoric disorder.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Gr\u00f6ndal", "given": "Maria", "initials": "M"}, {"family": "Schmidt", "given": "Felix", "initials": "F"}, {"family": "Fisher", "given": "Patrick M", "initials": "PM"}, {"family": "Frokjaer", "given": "Vibe Gedsoe", "initials": "VG"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Eriksson", "given": "Elias", "initials": "E", "orcid": "0000-0002-4128-2046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c6705c68b474be9bc40f367cecbd066.json"}}, {"family": "Sundstr\u00f8m", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2026-07-28", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "pages": "1-9", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a condition linked to the menstrual cycle and characterised by cyclic emotional distress, irritability and anger, which can disrupt social functioning. Intermittent selective serotonin reuptake inhibitor treatment is effective in alleviating symptoms, yet the neural underpinnings of its efficacy in PMDD remain unknown.\n\nThis randomised, placebo-controlled trial aimed to evaluate the impact of intermittent escitalopram treatment on PMDD symptoms and aggressiveness, and on neural responses to social provocation.\n\nWomen with PMDD were randomised to receive either intermittent escitalopram (20 mg/day) or placebo during the luteal phase. Outcomes of interest were changes in mood (assessed by the Daily Record of Severity of Problems), self-rated state aggression (measured by the Aggression Questionnaire) and neural responses to aggression-related stimuli, captured by functional magnetic resonance imaging during the Point Subtraction Aggression Paradigm.\n\nIntermittent escitalopram treatment significantly reduced PMDD symptoms compared with placebo, in particular irritability or anger (Cohen's d = -0.93, 95% CI [-1.48, -0.38]). Aggressiveness, which was positively associated with these symptoms (Pearson's r = 0.33, 95% CI [0.06, 0.55]), diminished following treatment (Cohen's d = -0.42, 95% CI [1.4 \u00d7 10-4, 0.84]), with the reduction in irritability or anger partly mediating this association (standardised indirect effect -0.32, 95% CI [-0.77, -0.03]). Escitalopram treatment was nominally associated with lower reactivity to provocation in the anterior insula (involved in salience and threat detection) (Cohen's d = -0.34, 95% CI [-0.66, -0.02]), the activation of which was positively related to irritability or anger (Spearman's \u03c1 = 0.39, 95% CI [0.07, 0.64]).\n\nThis randomised controlled trial provides timely confirmation of escitalopram as an effective treatment for PMDD within a contemporary clinical context and using prospective daily symptom ratings. Functional neuroimaging suggests that modulation of serotonergic function in PMDD is related to corticolimbic circuits involved in irritability or anger and interpersonal behaviour.", "doi": "10.1192/bjp.2026.10721", "pmid": "42515970", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0007125026107211"}], "notes": [], "created": "2026-08-23T09:41:02.729Z", "modified": "2026-08-24T07:18:48.810Z"}, {"entity": "publication", "iuid": "bd5d44cffcf6442cb40b91d2dc805683", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bd5d44cffcf6442cb40b91d2dc805683.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bd5d44cffcf6442cb40b91d2dc805683"}}, "title": "Impairment of Executive Functions in Premenstrual Syndrome: State or Trait?", "authors": [{"family": "Gnaiger", "given": "Anna Madeleine", "initials": "AM", "orcid": "0009-0008-3794-9830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fae12746d3045519cb64739833b659d.json"}}, {"family": "Werlein", "given": "Patricia", "initials": "P"}, {"family": "Gruschwitz", "given": "Patricia", "initials": "P"}, {"family": "Siebers", "given": "Magdalena", "initials": "M"}, {"family": "Panzik", "given": "Alina", "initials": "A"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E"}, {"family": "Pletzer", "given": "Belinda", "initials": "B"}], "type": "journal-article", "published": "2026-07-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "6", "issue": "4", "pages": "100730", "issn-l": null}, "abstract": "The aim of this study was to explore whether cognitive impairments in women with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are phase-dependent or persist across the menstrual cycle. Furthermore, we investigated whether such deficits are limited to working memory (WM) or also extend to inhibitory control (IC).\n\nA total of 105 regularly cycling women between the ages of 19 and 35 years were tested across 3 menstrual cycle phases (mid-follicular, mid-luteal, and late luteal). Premenstrual symptoms were tracked across 2 cycles. Fifty-one women were allocated to the PMS/PMDD group, and 54 women served as control participants. WM and IC were assessed using the n-back and stop signal task, respectively. Hormone levels were determined using saliva samples.\n\nWM deficits in the PMS/PMDD group emerged under high cognitive load and did not vary by cycle phase. The PMS/PMDD group also had significantly longer stop signal reaction times across all cycle phases, with stop signal reaction times positively correlating with premenstrual symptom severity. There was no significant correlation between performance measures and gonadal hormone levels.\n\nCognitive impairments in PMS/PMDD appear to be trait-like and affect both WM and IC. Additionally, IC was significantly associated with premenstrual symptom severity. Executive deficits may underlie difficulties in emotion regulation and are not solely attributable to gonadal hormone levels.", "doi": "10.1016/j.bpsgos.2026.100730", "pmid": "42254277", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC13235494"}, {"db": "pii", "key": "S2667-1743(26)00043-1"}], "notes": [], "created": "2026-08-23T09:41:15.934Z", "modified": "2026-08-25T08:17:53.507Z"}, {"entity": "publication", "iuid": "4536e639f3df4cabb751c858b2b76abb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4536e639f3df4cabb751c858b2b76abb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4536e639f3df4cabb751c858b2b76abb"}}, "title": "Timing Matters: Leveraging Positron Emission Tomography Imaging and Hormonal Cycles for Precision Psychiatry in Female Mental Health.", "authors": [{"family": "May", "given": "Emily", "initials": "E"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Tiepolt", "given": "Solveig", "initials": "S"}, {"family": "Strau\u00df", "given": "Maria", "initials": "M"}, {"family": "Kundakovic", "given": "Marija", "initials": "M"}, {"family": "Hesse", "given": "Swen", "initials": "S"}, {"family": "Sabri", "given": "Osama", "initials": "O"}, {"family": "Villringer", "given": "Arno", "initials": "A"}, {"family": "Sacher", "given": "Julia", "initials": "J", "orcid": "0000-0003-0944-0558", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb8f8d3839014e83b43723c55ad8d1d2.json"}}], "type": "journal article", "published": "2026-05-01", "journal": {"title": "Biol. Psychiatry", "issn": "1873-2402", "volume": "99", "issue": "9", "pages": "713-727", "issn-l": "0006-3223"}, "abstract": "Fluctuations in behavior across the menstrual cycle have been observed in several psychiatric disorders, particularly those affecting mood. Cycle-specific conditions, such as premenstrual dysphoric disorder (PMDD), and cycle-responsive conditions, in which changes in symptoms are tied to the menstrual cycle, including attention-deficit/hyperactivity disorder (ADHD), exemplify this pattern with an increase in symptoms during the luteal phase. Growing evidence indicates that within-cycle ovarian hormone fluctuations and withdrawal, along with associated neurotransmitter changes, shape symptom trajectories. In PMDD, serotonergic tone is associated with mood changes, providing direct evidence of a link between hormonal fluctuations and psychiatric symptoms. Advanced quantitative neuroimaging techniques, such as positron emission tomography (PET), offer a unique opportunity to investigate how neurotransmitter systems, particularly serotonin, GABA (gamma-aminobutyric acid), dopamine, and norepinephrine, interact with hormonal shifts to influence psychiatric symptoms. In this review, we explore the potential of PET neuroreceptor imaging to elucidate the neurobiological mechanisms underlying hormone-related mood changes. With PMDD as a model, we provide a conceptual framework and highlight directions of mechanistic understanding for ADHD and other psychiatric conditions across the relatively brief, yet consistently cyclical intervals, thereby identifying windows for targeted, menstrual phase-informed interventions. By integrating hormonal and cycle variability into psychiatric research and treatment, we aim to advance precision medicine approaches for mood disorders.", "doi": "10.1016/j.biopsych.2026.01.021", "pmid": "41740642", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0006-3223(26)00065-X"}], "notes": [], "created": "2026-08-23T09:42:23.889Z", "modified": "2026-08-24T07:20:18.481Z"}, {"entity": "publication", "iuid": "0f1d2865d828464694053000946e393a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0f1d2865d828464694053000946e393a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0f1d2865d828464694053000946e393a"}}, "title": "Women at the heart of mental science: commentary, Pinto da Costa et al.", "authors": [{"family": "Pinto da Costa", "given": "Mariana", "initials": "M", "orcid": "0000-0002-5966-5723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29c993dd36ac4ccfbcfc5deb4d827aff.json"}}, {"family": "de Cates", "given": "Angharad N", "initials": "AN", "orcid": "0000-0001-7848-1295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12cbd20164b34403b7f21fbe2c65046a.json"}}, {"family": "Dhamala", "given": "Elvisha", "initials": "E"}, {"family": "McAlonan", "given": "Grainne M", "initials": "GM"}, {"family": "Upthegrove", "given": "Rachel", "initials": "R"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2026-05-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "228", "issue": "5", "pages": "484-486", "issn-l": null}, "abstract": null, "doi": "10.1192/bjp.2025.10516", "pmid": "41668430", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0007125025105163"}], "notes": [], "created": "2026-08-23T09:42:33.866Z", "modified": "2026-08-23T09:42:34.003Z"}, {"entity": "publication", "iuid": "dc324abf69b047449d44b2e3ee93f5be", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dc324abf69b047449d44b2e3ee93f5be.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dc324abf69b047449d44b2e3ee93f5be"}}, "title": "Personality and cortical architecture in premenstrual dysphoric disorder", "authors": [{"family": "B\u00fccklein-Ehlers", "given": "Elise", "initials": "E"}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Fallgatter", "given": "Andreas", "initials": "A"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal-article", "published": "2026-04-00", "journal": {"title": "Arch Womens Ment Health", "issn": "1434-1816", "volume": "29", "issue": "2", "issn-l": null}, "abstract": "PURPOSE: Premenstrual dysphoric disorder (PMDD) has been associated with altered grey matter architecture in a trait-like manner. Personality traits, shaped largely by genetics and linked to depressive disorders, may relate to structural properties of the brain and could represent a potential factor mediating vulnerability for PMDD. However, these possible associations remain largely unexplored. METHODS: The present study assessed personality traits in participants with PMDD and healthy controls, as well as how personality is related to symptom severity and cortical surface measures in PMDD. Healthy controls and patients completed the Swedish Universities Scale of Personality. Following prospective validation of the PMDD diagnosis, patients had their brain scanned with magnetic resonance imaging (MRI) during the symptomatic luteal phase of the menstrual cycle. Personality of controls and patients was compared using Mann-Whitney U tests. Associations of personality with symptom severity and brain surface parameters were tested through correlation analysis. RESULTS: PMDD was associated with higher scores in neuroticism and aggressiveness. Aggressiveness was positively correlated with the severity of irritability/anger, though not significant after correcting for multiple testing. Regarding cortical structural measures, aggressiveness was negatively correlated with cortical complexity of the parahippocampal gyrus. CONCLUSION: Considering neuroticism and aggressiveness during screening for PMDD could contribute to the identification of risk factors and personalized treatment of females suffering from PMDD.", "doi": "10.1007/s00737-026-01677-3", "pmid": "41801468", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12971799"}, {"db": "pii", "key": "10.1007/s00737-026-01677-3"}], "notes": [], "created": "2026-08-23T09:41:30.767Z", "modified": "2026-08-24T07:20:39.085Z"}, {"entity": "publication", "iuid": "aec13b87a5484c79bcdf978f206abe84", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aec13b87a5484c79bcdf978f206abe84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aec13b87a5484c79bcdf978f206abe84"}}, "title": "Low-dose testosterone administration and oestrogen synthase availability in the female brain: A pilot study.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Jonasson", "given": "My", "initials": "M"}, {"family": "Takahashi", "given": "Kayo", "initials": "K"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Watanabe", "given": "Yasuyoshi", "initials": "Y"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Lubberink", "given": "Mark", "initials": "M"}, {"family": "Biegon", "given": "Anat", "initials": "A"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2026-03-00", "journal": {"title": "J Neuroendocrinol", "issn": "1365-2826", "volume": "38", "issue": "3", "pages": "e70154", "issn-l": null}, "abstract": "Testosterone and oestrogens play significant roles in female physiology, extending beyond reproductive functions to influence brain health, mood regulation, and behaviour. Testosterone low-dose therapy is increasingly considered for alleviating sexual dysfunction symptoms in postmenopausal women, and has been recently investigated as therapy for depressive symptoms, though the mechanisms and safety of this approach are not entirely clear. Specifically, the effects of testosterone use on brain oestrogen synthase (aromatase), which maintains the balance between androgens and oestrogens, remain unexplored. This study investigated the effects of short-term, low-dose testosterone administration on brain oestrogen synthase availability and associated mood and behavioural changes in healthy women. Healthy women were exposed to 1 week of low-dose testosterone (10 mg/day). Binding of oestrogen synthase was examined by [11C]cetrozole positron emission tomography before and during testosterone exposure. Psychometric assessment of depression, anxiety, and aggression was performed at the same time. Peripheral testosterone levels were significantly increased (up to 33-fold) upon treatment, which had no significant effect on brain oestrogen synthase binding in the thalamus, as supported by Bayesian analyses, nor in the hypothalamus and amygdala. Psychometric measures of depression, anxiety, and aggression also remained unchanged by testosterone treatment. These findings suggest that short-term, clinically relevant testosterone administration has no major effects on the brain oestrogen synthase availability in healthy women, which may reassure patients with hypoactive sexual desire disorder considering this treatment. Larger, long-term studies are needed to confirm these results and explore effects in patients with clinical need for testosterone treatment.", "doi": "10.1111/jne.70154", "pmid": "41771256", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12952942"}], "notes": [], "created": "2026-08-23T09:42:16.372Z", "modified": "2026-08-23T09:42:16.495Z"}, {"entity": "publication", "iuid": "deb7645d196f4c71af84110a0db8a8b5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/deb7645d196f4c71af84110a0db8a8b5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/deb7645d196f4c71af84110a0db8a8b5"}}, "title": "The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project", "authors": [{"family": "Abualia", "given": "Khawla", "initials": "K"}, {"family": "Cediel-Ulloa", "given": "Andrea", "initials": "A"}, {"family": "Allsopp", "given": "Philip", "initials": "P"}, {"family": "Augustine", "given": "Angelika", "initials": "A"}, {"family": "Bergquist", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4597-041X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a27dc0277ccf4b94960dcbdc0e655e30.json"}}, {"family": "Bornehag", "given": "Carl Gustaf", "initials": "CG"}, {"family": "Broberg", "given": "Karin", "initials": "K"}, {"family": "Caporale", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "di Bernardo", "given": "Diego", "initials": "D", "orcid": "0000-0002-1911-7407", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5aca698b815347848a786f6cd47c25a3.json"}}, {"family": "Domingues", "given": "Ros\u00e1rio", "initials": "R"}, {"family": "Drakvik", "given": "Elina", "initials": "E"}, {"family": "Gennings", "given": "Chris", "initials": "C"}, {"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Globisch", "given": "Daniel", "initials": "D"}, {"family": "Kippler", "given": "Maria", "initials": "M"}, {"family": "McSorley", "given": "Emeir", "initials": "E"}, {"family": "Mulhern", "given": "Maria", "initials": "M", "orcid": "0000-0001-8642-4741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/812a4090062b4ac09cd0810b5ed18422.json"}}, {"family": "Motwani", "given": "Hitesh V", "initials": "HV"}, {"family": "Nalvarte", "given": "Ivan", "initials": "I"}, {"family": "Oudin", "given": "Anna", "initials": "A", "orcid": "0000-0002-9876-0627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea57df87411848ed8927515ee4b03137.json"}}, {"family": "Rahman", "given": "Anisur", "initials": "A"}, {"family": "Reifegerste", "given": "Doreen", "initials": "D"}, {"family": "Rein", "given": "Theo", "initials": "T"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}, {"family": "Strain", "given": "J J", "initials": "JJ"}, {"family": "Testa", "given": "Giuseppe", "initials": "G"}, {"family": "Tsiukalo", "given": "Liudmyla", "initials": "L"}, {"family": "van Wijngaarden", "given": "Edwin", "initials": "E"}, {"family": "Yeates", "given": "Alison", "initials": "A"}, {"family": "R\u00fcegg", "given": "Jo\u00eblle", "initials": "J", "orcid": "0000-0002-6580-9201", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10e7c07b9a4646d9858532dc1f24f889.json"}}, {"family": "Antczak", "given": "Philipp", "initials": "P"}], "type": "journal-article", "published": "2026-02-20", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "17", "pages": "1738584", "issn-l": null}, "abstract": "The number of people seeking help for mental illness is increasing across all ages, creating a major burden for individuals, families, and the society. While personalized medicine is advancing in other fields, diagnosis and treatment of mental disorders remain largely symptom-based and fail to capture individual, sex, and gender differences in risk, manifestation, and treatment response. Early signs of illness often go unnoticed due to the lack of monitoring tools, and stigma continues to hinder prevention and care. In some phases of life, an individual's susceptibility to mental illness is heightened and may be influenced by changes in endocrine signalling. To address these challenges, the research project Building REsilience against MEntal illness during ENDocrine-sensitive life stages (RE-MEND) has implemented an interdisciplinary approach focusing on four critical endocrine-sensitive life stages: prenatal, puberty, peripartum, and older age. The project integrates longitudinal population-based cohorts with experimental and clinical studies to identify genetic, environmental, and endocrine factors shaping susceptibility and resilience to mental illness. Multi-omics data (genomics, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics, and adductomics) will be combined with neurobiological, clinical, and behavioural measures, analysed using advanced biostatistics and machine learning. RE-MEND seeks to i) identify risk and resilience factors affecting mental health; ii) deliver biomarker panels for susceptibility, disease progression, and treatment response across sensitive life stages; iii) discover novel drug targets through repurposing strategies, and iv) promote mental health literacy and reduce stigma. The integration of biological research with communication science is anticipated to result in translatable findings, supporting earlier intervention and more effective care.", "doi": "10.3389/fpsyt.2026.1738584", "pmid": "41799821", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12964206"}], "notes": [], "created": "2026-08-23T09:41:45.654Z", "modified": "2026-08-24T11:45:42.071Z"}, {"entity": "publication", "iuid": "488a7b06f3494eacafa058dd3efa5c3b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/488a7b06f3494eacafa058dd3efa5c3b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/488a7b06f3494eacafa058dd3efa5c3b"}}, "title": "Trait- versus state- grey matter volume alterations in premenstrual dysphoric disorder.", "authors": [{"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-12-02", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "25", "issue": "1", "pages": "1139", "issn-l": "1471-244X"}, "abstract": null, "doi": "10.1186/s12888-025-07533-5", "pmid": "41331448", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-025-07533-5"}], "notes": [], "created": "2025-12-03T10:27:39.151Z", "modified": "2025-12-04T16:46:28.933Z"}, {"entity": "publication", "iuid": "8d56a52571f14612adf2eab2250a8bcb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8d56a52571f14612adf2eab2250a8bcb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8d56a52571f14612adf2eab2250a8bcb"}}, "title": "Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health.", "authors": [{"family": "Matte Bon", "given": "Gloria", "initials": "G", "orcid": "0000-0002-1770-1765", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a859233554d34ade8487ef76591302a4.json"}}, {"family": "Walther", "given": "Jonas", "initials": "J", "orcid": "0009-0009-2227-6378", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/206bdcc1205a4a6ebb7c093b99c74885.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Kaufmann", "given": "Tobias", "initials": "T", "orcid": "0000-0002-4003-1018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/066255c20da945f78248d804d270765e.json"}}], "type": "journal article", "published": "2025-11-05", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "8", "issue": "1", "pages": "1524", "issn-l": "2399-3642"}, "abstract": "Sex differences in mental health become more evident across adolescence, with a two-fold increase of prevalence of mood disorders in females compared to males. The brain underpinnings remain understudied. Here, we investigated the role of age, puberty and mental health in determining the longitudinal development of sex differences in brain structure. We captured sex differences in limbic and non-limbic structures using machine learning models trained in cross-sectional brain imaging data of 1132 youths, yielding limbic and non-limbic estimates of brain sex. Applied to two independent longitudinal samples (total: 8184 youths), our models revealed pronounced sex differences in brain structure with increasing age. For females, brain sex was sensitive to pubertal development (menarche) over time and, for limbic structures, to mood-related mental health. Our findings highlight the limbic system as a key contributor to the development of sex differences in the brain and the potential of machine learning models for brain sex classification to investigate sex-specific processes relevant to mental health.", "doi": "10.1038/s42003-025-08866-3", "pmid": "41193617", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s42003-025-08866-3"}], "notes": [], "created": "2025-11-06T11:44:50.581Z", "modified": "2025-11-06T11:44:50.726Z"}, {"entity": "publication", "iuid": "9287b76dfbed4d9a9f28d0e08cdb6fc8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9287b76dfbed4d9a9f28d0e08cdb6fc8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9287b76dfbed4d9a9f28d0e08cdb6fc8"}}, "title": "White Matter Regional Volumes in Relation to Menstrual Cycle Phase and Premenstrual Dysphoric Disorder.", "authors": [{"family": "Stenhammar", "given": "Elin", "initials": "E"}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-11-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "5", "issue": "6", "pages": "100573", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is an understudied, debilitating, and hormone-related mental disorder. Recent evidence suggests alterations in white matter structure during the symptomatic luteal phase in PMDD. In this study, white matter volumes (WMVs) in the brains of women with PMDD versus control women were compared across the menstrual cycle, to determine whether these differences reflect state- or trait-like characteristics.\n\nAnatomical magnetic resonance imaging was performed during the midfollicular phase and the late luteal phase of the menstrual cycle in 28 women with PMDD and 27 control women. WMVs were assessed using voxel-based morphometry, employing both region-of-interest (ROI) and exploratory whole-brain approaches.\n\nNo group-by-phase interaction effects on WMVs were found. Across menstrual cycle phases, women with PMDD exhibited greater WMVs than control women within ROIs (in the bilateral uncinate fasciculus, right inferior fronto-occipital fasciculus, and left crus and fimbria of the fornix) and across the whole brain (in inferior occipital areas and near the angular gyrus), indicating trait- rather than state-like structural markers of PMDD.\n\nThese findings suggest that women with PMDD exhibit larger WMVs than healthy control women, during both the symptomatic and asymptomatic phases of the menstrual cycle, in white matter tracts involved in emotion processing and regulation, memory, and connecting limbic and prefrontal regions of relevance to mood disorders.", "doi": "10.1016/j.bpsgos.2025.100573", "pmid": "41017818", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12466263"}, {"db": "pii", "key": "S2667-1743(25)00127-2"}], "notes": [], "created": "2025-10-02T18:22:37.524Z", "modified": "2025-10-21T07:34:54.521Z"}, {"entity": "publication", "iuid": "dffda432f1054b6f8ea80e9334d16429", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dffda432f1054b6f8ea80e9334d16429.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dffda432f1054b6f8ea80e9334d16429"}}, "title": "Association of estrogen receptor single nucleotide polymorphisms and perinatal depression.", "authors": [{"family": "Bj\u00f6rvang", "given": "Richelle Duque", "initials": "RD", "orcid": "0000-0002-3619-2257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b75b9d528fc43c8b15873f25b0cdf85.json"}}, {"family": "Gumbo", "given": "Lulu Francis", "initials": "LF"}, {"family": "\u00c5rdahl", "given": "Anders", "initials": "A"}, {"family": "Lager", "given": "Susanne", "initials": "S", "orcid": "0000-0003-3556-065X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d162155439a04158b451bcb3265881e3.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c05290187ec426b8804eefc3d954971.json"}}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}], "type": "journal article", "published": "2025-10-16", "journal": {"title": "PLoS ONE", "issn": "1932-6203", "volume": "20", "issue": "10", "pages": "e0334705", "issn-l": "1932-6203"}, "abstract": "Depression during pregnancy and in the postpartum period have been receiving increasing attention considering the possible complications for the mother and baby if left untreated. Genetic variations in the estrogen receptor genes (ESR) have been implicated in susceptibility to depression. However, only few studies investigated them in perinatal depression (PND) and none on its different trajectories (i.e., patterns of time of onset and persistency of depression). Here, we explored the association of single nucleotide polymorphisms (SNPs) of the ESR1 and ESR2 genes with PND among 2,973 women in Sweden. PND was defined using the Edinburgh Postnatal Depression Scale, the Depression Self-Rating Scale, use of selective serotonin reuptake inhibitor, and/or medical records. PND trajectories were identified as follows: controls (no depression at any point in the perinatal period), antepartum (depression during pregnancy and resolved postpartum), postpartum-onset (no depression during pregnancy with onset after delivery), and persistent (depression throughout the perinatal period). Multivariable logistic regression was performed. Out of 56 SNPs analyzed, one SNP in the ESR1 gene (rs2982712) was nominally significantly associated with PND (OR 0.83, 95% CI 0.71-0.98, p = 0.03) as well as with persistent depression (OR 0.77, 95% CI 0.61-0.98, p = 0.03) in the overdominant model (DD/dd vs. Dd). In addition, we also found two SNPs, namely rs1884051 (OR 0.74, 95% CI 0.56-0.98, p = 0.03) and rs2228480 (OR 0.77, 95% CI 0.60-0.99, p = 0.04) in the ESR1 gene, that were nominally significantly associated with persistent depression only. None of the ESR1 SNPs were associated with antepartum or postpartum-onset depression. None of the ESR2 SNPs, nor any haplotypes, were associated with PND or its trajectories. Our findings suggest a role of ESR1 in PND, especially its persistent trajectory.", "doi": "10.1371/journal.pone.0334705", "pmid": "41100533", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12530586"}, {"db": "pii", "key": "PONE-D-24-49872"}], "notes": [], "created": "2025-10-21T07:34:37.924Z", "modified": "2025-11-04T09:38:42.784Z"}, {"entity": "publication", "iuid": "9ae7531fa9fd4822908954b7714623ed", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9ae7531fa9fd4822908954b7714623ed.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9ae7531fa9fd4822908954b7714623ed"}}, "title": "Genetic variation of the estrogen receptor and its association with depression and anxiety symptoms in young females.", "authors": [{"family": "Musaoglu", "given": "Mirac Nur", "initials": "MN"}, {"family": "Olofsdotter", "given": "Susanne", "initials": "S"}, {"family": "Vadlin", "given": "Sofia", "initials": "S"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Kimmig", "given": "Ann-Christin S", "initials": "AS", "orcid": "0000-0002-8353-6593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3ee0f1b0d0b4ebd9c9e66b4850b6600.json"}}, {"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW", "orcid": "0000-0002-8853-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae97f7e5d3e7452d82e3f13e4c1a0a58.json"}}, {"family": "Nieratschker", "given": "Vanessa", "initials": "V"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-10-02", "journal": {"title": "Prog Neuropsychopharmacol Biol Psychiatry", "issn": "1878-4216", "volume": "142", "pages": "111485", "issn-l": null}, "abstract": "Estrogens are suggested to affect mood by binding to widespread estrogen receptors in the brain and therewith modulating a variety of neurosignaling pathways. Single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptors might influence these actions and thereby play a role in the genetic foundation of mood disorders. Several SNPs in the estrogen receptor 1 (ESR1) gene have been studied in relation to anxiety and depression, while confounders and interaction with psychosocial factors have largely been overlooked. The present study investigated the effect of the functional polymorphisms rs2234693 (PvuII) and rs9340799 (XbaI) in the ESR1 gene on depression and anxiety symptoms as well as their interaction with early life adversities and parenting in two independent female cohorts, considering relevant confounding factors. In adolescent females (n = 1036), the rs9340799 minor allele (G) was found to protect against increasing anxiety symptoms from age 14 to 17, whereas, in young adult females (n = 1314, mean age: 22.2 years), it was associated with a greater risk of experiencing above-threshold anxiety symptoms. No genetic effect was found for rs2234693 and depressive symptoms in either cohort. A significant three-way gene-environment interaction was observed between rs9340799, stressful early life events, and supportive parenting on anxiety symptoms in female adolescents. These findings suggest a potential differential plasticity of the G allele in relation to anxiety symptoms in female youth. By incorporating longitudinal assessments and gene-environment analyses, this study contributes to the literature on internalizing symptoms in females in the context of estrogen-related constitutive vulnerability.", "doi": "10.1016/j.pnpbp.2025.111485", "pmid": "40915344", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0278-5846(25)00239-8"}], "notes": [], "created": "2025-09-19T13:50:23.032Z", "modified": "2025-12-09T10:35:03.039Z"}, {"entity": "publication", "iuid": "19e7ba728b4b48c1867a2ae45e808ac7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/19e7ba728b4b48c1867a2ae45e808ac7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/19e7ba728b4b48c1867a2ae45e808ac7"}}, "title": "Contextualizing Telomere Biology Through Biopsychological Plasticity: Insights From the Differential Susceptibility Hypothesis.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "5", "issue": "5", "pages": "100548", "issn-l": null}, "abstract": null, "doi": "10.1016/j.bpsgos.2025.100548", "pmid": "40687635", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC12272861"}, {"db": "pii", "key": "S2667-1743(25)00102-8"}], "notes": [], "created": "2025-07-24T19:46:56.616Z", "modified": "2025-09-09T09:28:53.228Z"}, {"entity": "publication", "iuid": "b30ee4931e334810b1cadbb587df6307", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b30ee4931e334810b1cadbb587df6307.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b30ee4931e334810b1cadbb587df6307"}}, "title": "Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder.", "authors": [{"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Johansson", "given": "Maja", "initials": "M", "orcid": "0000-0001-8811-2629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5832644dbf7c44bd9bbc788e966b977e.json"}}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}], "type": "journal article", "published": "2025-07-23", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "15", "issue": "1", "pages": "255", "issn-l": "2158-3188"}, "abstract": "Premenstrual dysphoric disorder (PMDD) has been hypothesized to be related to an altered sensitivity of the \u03b3-aminobutyric acid type A (GABAA) receptor to progesterone-derived neurosteroids. GABAA receptor sensitivity to neurosteroid-modulation is dependent on its subunit composition. In the present study, we used quantitative reverse transcription polymerase chain reactions (RT-qPCR) to compare messenger ribonucleic acid (mRNA) expression of GABAA receptor subunits in peripheral mononuclear cells (PBMCs) across the menstrual cycle in 29 women with PMDD and 27 controls. We related mRNA subunit expression to serum levels of neurosteroids and to functional activation of the amygdala, a key brain region involved in emotion generation, measured using functional magnetic resonance imaging (fMRI). Women with PMDD had lower mRNA expression of the delta GABAA receptor subunit during the symptomatic, luteal phase (compared to the asymptomatic, follicular phase) of the menstrual cycle. Lower delta mRNA expression was related to higher amygdala activation in PMDD women. GABAA receptors incorporating the delta subunit are especially sensitive to neurosteroid modulation. It is possible that the mood symptoms of PMDD are mediated by an inability to effectively adjust the expression of this receptor type in response to neurosteroid fluctuations, leading to dysregulation GABAergic tone and increased activity in emotion-generating brain circuits.", "doi": "10.1038/s41398-025-03465-6", "pmid": "40701967", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC12287299"}, {"db": "pii", "key": "10.1038/s41398-025-03465-6"}], "notes": [], "created": "2025-07-24T19:46:54.443Z", "modified": "2025-11-04T09:39:23.221Z"}, {"entity": "publication", "iuid": "cc3996606a574425b86f22d0d0853c37", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cc3996606a574425b86f22d0d0853c37.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cc3996606a574425b86f22d0d0853c37"}}, "title": "The value of mental science: we publish what matters.", "authors": [{"family": 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"https://publications-affiliated.scilifelab.se/researcher/93fbceb7f3554211936b546cd3b84cef.json"}}, {"family": "Baldwin", "given": "David S", "initials": "DS", "orcid": "0000-0003-3343-0907", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63e4e328a99843df8f072ed39b5ebd8e.json"}}, {"family": "Batley", "given": "Prathiba", "initials": "P", "orcid": "0000-0002-5137-792X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d0abd9a4b104697a4f3628a10712f66.json"}}, {"family": "Bell", "given": "Erica", "initials": "E", "orcid": "0000-0002-8483-8497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62fd0e31b6dc421bb8f7aa8731746caa.json"}}, {"family": "Berrios", "given": "German", "initials": "G", "orcid": "0000-0001-5979-7251", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09eb88f3b4a5436ba98ecae115912737.json"}}, {"family": "Beveridge", "given": "Allan", 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"initials": "AJ", "orcid": "0000-0003-2004-2382", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8fd51c95cf6a49b0a424023bf75a056f.json"}}, {"family": "Saunders", "given": "Rob", "initials": "R", "orcid": "0000-0002-7077-8729", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca16024b7ba04492b1b6b6a5c5709408.json"}}, {"family": "Schulze", "given": "Thomas G", "initials": "TG", "orcid": "0000-0001-6624-2975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8db800aed89346dba246af97c00d47e5.json"}}, {"family": "Schultze-Lutter", "given": "Frauke", "initials": "F", "orcid": "0000-0003-1956-9574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f737de53410146ff982821bc8eb47671.json"}}, {"family": "Shergill", "given": "Sukhwinder S", "initials": "SS", "orcid": "0000-0003-4928-9100", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35f2f5ec26ed4a36bff570d9959c455d.json"}}, {"family": "Shivakumar", "given": "Gurubhaskar", "initials": "G", "orcid": "0009-0006-7449-5490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b0a9c0645f1498ab81cbb318e3d05a3.json"}}, {"family": "Siskind", "given": "Dan", "initials": "D", "orcid": "0000-0002-2072-9216", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d2c49be767548ababac70f1f2898be9.json"}}, {"family": "Soomro", "given": "G Mustafa", "initials": "GM", "orcid": "0000-0002-0395-557X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdaae25485fc4e469e3bd5cf29c1f721.json"}}, {"family": "Srinivasan", "given": "Ramya", "initials": "R", "orcid": "0000-0003-1478-2018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddea8f5b34724853893fe19b2054eba2.json"}}, {"family": "Sumathipala", "given": "Athula", "initials": "A", "orcid": "0000-0002-8706-2698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abbfab9aa1b04f95a2a11cb89034b21c.json"}}, {"family": "Szymaniak", "given": "Kinga", "initials": "K", "orcid": "0000-0001-5887-9028", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7799c57f193948529f32169f7a93d16c.json"}}, {"family": "Tan", "given": "Eric", "initials": "E", "orcid": "0000-0003-4812-5630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f873452238074442ab0fb5e0da3903d8.json"}}, {"family": "Tarokh", "given": "Leila", "initials": "L", "orcid": "0000-0003-4014-428X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a2d609239304afdb075f65676ad0f61.json"}}, {"family": "Tracy", "given": "Derek", "initials": "D", "orcid": "0000-0002-3609-9407", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a88eecd69e9e48b18750ad184c375808.json"}}, {"family": "Watson", "given": "Stuart", "initials": "S", "orcid": "0000-0002-2558-3367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fffa3d060fef4b2698f820a4a3e66a43.json"}}, {"family": "Williams", "given": "Richard", "initials": "R", "orcid": "0000-0003-1230-0222", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b5df7b383e74e3eabcbce4df4d2c997.json"}}, {"family": "Wu", "given": "Jingwei", "initials": "J", "orcid": "0000-0003-1003-619X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02edef8d2f93440883a56e47718e2795.json"}}, {"family": "Young", "given": "Allan H", "initials": "AH", "orcid": "0000-0003-2291-6952", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66efc06be6af4abd9a354c328595a2eb.json"}}, {"family": "Zisman-Ilani", "given": "Yaara", "initials": "Y", "orcid": "0000-0001-6852-2583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21f287c537194a879b54ae429d0ddac6.json"}}, {"family": "Fernandez-Egea", "given": "Emilio", "initials": "E", "orcid": "0000-0003-4128-8955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/000844480b014d1d985970a6631a7425.json"}}], "type": "editorial", "published": "2025-07-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "227", "issue": "1", "pages": "429-433", "issn-l": null}, "abstract": "Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.", "doi": "10.1192/bjp.2025.118", "pmid": "40485480", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0007125025001187"}], "notes": [], "created": "2025-07-24T19:47:07.778Z", "modified": "2025-07-24T19:47:45.103Z"}, {"entity": "publication", "iuid": "2677736894a443d2ae083cf14d964b06", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2677736894a443d2ae083cf14d964b06.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2677736894a443d2ae083cf14d964b06"}}, "title": "Emotion generation and regulation in premenstrual dysphoric disorder: dysregulation of large-scale brain networks across the menstrual cycle.", "authors": [{"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Johansson", "given": "Maja", "initials": "M", "orcid": "0000-0001-8811-2629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5832644dbf7c44bd9bbc788e966b977e.json"}}, {"family": "Stiernman", "given": "Lars", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}], "type": "journal article", "published": "2025-06-06", "journal": {"title": "Biol. Psychiatry", "issn": "1873-2402", "issn-l": "0006-3223"}, "abstract": "Emotion regulation deficits have been highlighted as a transdiagnostic feature of multiple psychiatric disorders, including premenstrual dysphoric disorder (PMDD). In this study, we hypothesize that deficient prefrontal \"top-down\" regulation of key nodes of the salience network (SN) is a characteristic of PMDD, driven by increased levels of progesterone-derived neuroactive steroids.\n\nFunctional magnetic resonance imaging (fMRI) was used to investigate menstrual-cycle related variations in brain activity and connectivity during two emotional tasks (emotion generation and regulation) in 29 women with PMDD and 27 controls. We also examined whether differential brain activation between groups is related to serum levels of progesterone-derived neuroactive steroids and premenstrual symptom severity.\n\nWomen with PMDD showed increased reactivity in key nodes of the SN and - at subthreshold level - in the default mode network (DMN) during the luteal phase when passively viewing negative emotional stimuli. Intriguingly, SN hyperactivity in PMDD patients was apparent also during the follicular phase and related to premenstrual symptom severity. PMDD and control women had similar network connectivity patterns and activity in regions associated with the conscious control of emotion in PMDD. No link to progesterone-derived neuroactive steroids was found.\n\nMultiple network aberrations during the luteal phase may explain the development of mood symptoms in the luteal phase. Furthermore, higher baseline (follicular) SN activity may render PMDD women more susceptible to severe mood symptoms in response to hormonal fluctuations. What drives increased SN activity in the follicular phase is unknown, but innate and neuroplastic mechanisms are proposed.", "doi": "10.1016/j.biopsych.2025.05.025", "pmid": "40484362", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0006-3223(25)01242-9"}], "notes": [], "created": "2025-07-24T19:47:16.556Z", "modified": "2025-09-09T09:29:07.444Z"}, {"entity": "publication", "iuid": "34f4eb7220ae4fc88136072da6c6f98a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/34f4eb7220ae4fc88136072da6c6f98a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/34f4eb7220ae4fc88136072da6c6f98a"}}, "title": "Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum.", "authors": [{"family": "Bj\u00f6rvang", "given": "Richelle D", "initials": "RD"}, {"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Bujanda Cundin", "given": "Xabier", "initials": "X", "orcid": "0009-0004-4660-7251", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49431807b7634b1cabf3430ed69d9e40.json"}}, {"family": "Del Prete", "given": "Eugenio", "initials": "E", "orcid": "0000-0003-3214-9021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d30251102dd3473a9643aac5c9721d5d.json"}}, {"family": "R\u00fcegg", "given": "Jo\u00eblle", "initials": "J", "orcid": "0000-0002-6580-9201", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10e7c07b9a4646d9858532dc1f24f889.json"}}, {"family": "Lager", "given": "Susanne", "initials": "S", "orcid": "0000-0003-3556-065X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d162155439a04158b451bcb3265881e3.json"}}, {"family": "di Bernardo", "given": "Diego", "initials": "D", "orcid": "0000-0002-1911-7407", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5aca698b815347848a786f6cd47c25a3.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}], "type": "journal article", "published": "2025-06-05", "journal": {"title": "Mol. Psychiatry", "issn": "1476-5578", "issn-l": "1359-4184"}, "abstract": "Peripartum depression can have severe impact on the mother's and the infant's health. Yet, its biological underpinnings are largely unknown. The present study sought to identify transcriptomic signatures of depressive symptoms during pregnancy and postpartum. Blood samples were collected during late pregnancy or early postpartum for mRNA isolation and sequencing, while depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Based on the timepoint when the samples were collected, differentially expressed genes (DEGs) were identified by (1) comparing mRNA levels between the depression symptom trajectory groups, and (2) correlating with EPDS scores. DEGs for samples collected during late pregnancy, but not postpartum, were associated with depressive symptoms occurring only during pregnancy or persisting postpartum, compared with controls. There were 16 upregulated and 109 downregulated DEGs significantly associated with EPDS score at week 32 among samples collected during late pregnancy. Gene Set Enrichment Analysis identified immune response and cell motility as processes linked to these DEGs. Hypothesis-based analysis on previously identified postpartum depressive symptoms-related DEGs replicated a positive association between expression of immune-related genes ISG15 and RSAD2 with postpartum-onset depressive symptoms, both in samples taken during late pregnancy and postpartum. The present findings point to transcriptomic signatures associated with peripartum depressive symptoms, mostly related to immune system dysregulation.", "doi": "10.1038/s41380-025-03068-z", "pmid": "40473930", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41380-025-03068-z"}], "notes": [], "created": "2025-07-24T19:48:32.487Z", "modified": "2025-07-24T19:48:32.774Z"}, {"entity": "publication", "iuid": "935ae35dd7f14a4f9bf49e709c6682ba", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/935ae35dd7f14a4f9bf49e709c6682ba.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/935ae35dd7f14a4f9bf49e709c6682ba"}}, "title": "Trajectories and dimensional phenotypes of depressive symptoms throughout pregnancy and postpartum in relation to prior premenstrual symptoms.", "authors": [{"family": "Schleimann-Jensen", "given": "Ella", "initials": "E"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Meltzer-Brody", "given": "Samantha", "initials": "S"}, {"family": "Eisenlohr-Moul", "given": "Tory A", "initials": "TA"}, {"family": "Papadopoulos", "given": "Fotis C", "initials": "FC"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "226", "issue": "6", "pages": "401-409", "issn-l": null}, "abstract": "Sensitivity to ovarian hormone fluctuations can lead to mental distress during the luteal phase of the menstrual cycle, such as in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), and also during pregnancy and postpartum, as in perinatal depression (PND).\n\nIn two cohorts, we investigated the relationship between history of PMS/PMDD and PND symptoms. We also examined how premenstrual symptoms are associated with perinatal symptom trajectories and dimensional phenotypes of PND symptoms, which remains unidentified.\n\nFrom early pregnancy until 6 months postpartum, participants of two large longitudinal cohorts were followed using the Edinburgh Postnatal Depression Scale (EPDS). Premenstrual symptoms were self-reported retrospectively.\n\nBoth pre-pregnancy PMS and PMDD were associated with higher EPDS scores across pregnancy and postpartum, even after adjustment for confounders. The odds of developing PND were higher among those reporting PMS and PMDD, ranging up to 1.68 (95% CI 1.25-2.29) (6-13 weeks postpartum) and 3.05 (95% CI 2.26-4.10) (late pregnancy) respectively for PMS and PMDD, throughout the perinatal period. Premenstrual symptomatology was associated more with certain PND trajectories based on the time of occurrence and persistence of symptoms. However, PND symptom severity did not differ depending on premenstrual symptomatology in any trajectory. Prior PMS/PMDD was associated with underlying dimensions of symptom constructs of PND, including severe and moderate symptoms of depressed mood, anxiety and anhedonia.\n\nWomen with a history of PMS/PMDD require coordinated care by psychiatrists, other mental health clinicians, midwives and gynaecologists during pregnancy as well as postpartum.", "doi": "10.1192/bjp.2025.38", "pmid": "40538355", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC12257281"}, {"db": "pii", "key": "S0007125025000388"}], "notes": [], "created": "2025-07-24T19:46:59.658Z", "modified": "2025-09-09T09:29:15.693Z"}, {"entity": "publication", "iuid": "44bf7617d6b5480ab8b48a5f35ffd675", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/44bf7617d6b5480ab8b48a5f35ffd675.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/44bf7617d6b5480ab8b48a5f35ffd675"}}, "title": "Subjective, behavioural and physiological correlates of stress in women using hormonal contraceptives.", "authors": [{"family": "B\u00fcrger", "given": "Zo\u00e9", "initials": "Z", "orcid": "0000-0003-4597-0425", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/907b16865ddc43cb93d67781f7864938.json"}}, {"family": "Kordowich", "given": "Charlotte", "initials": "C"}, {"family": "K\u00fcbbeler", "given": "Julia", "initials": "J"}, {"family": "M\u00fcllersch\u00f6n", "given": "Carolin", "initials": "C"}, {"family": "Kimmig", "given": "Ann-Christin S", "initials": "AS", "orcid": "0000-0002-8353-6593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3ee0f1b0d0b4ebd9c9e66b4850b6600.json"}}, {"family": "Su", "given": "Min", "initials": "M"}, {"family": "L\u00e4mmerhofer", "given": "Michael", "initials": "M"}, {"family": "Sacher", "given": "Julia", "initials": "J", "orcid": "0000-0003-0944-0558", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb8f8d3839014e83b43723c55ad8d1d2.json"}}, {"family": "Henes", "given": "Melanie", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Kogler", "given": "Lydia", "initials": "L", "orcid": "0000-0002-9493-2321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d502b7c4fd64f6294534374793fb03e.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "226", "issue": "6", "pages": "392-400", "issn-l": null}, "abstract": "Stress, a major risk factor for mental health problems, is influenced by hormonal fluctuations from the menstrual cycle and hormonal oral contraceptives (OC). Despite widespread use, the impact of hormonal intrauterine devices (IUDs) on stress is limited to one study.\n\nThis study examines psychoendocrine stress responses in women using IUDs, OCs and women with a natural, regular menstrual cycle (NC) to better understand how endogenous and exogenous hormones influence stress.\n\nUsing a repeated-measures design, we investigated stress responses in IUD and OC users and NC women. The Maastricht Acute Stress Task and its control task were applied twice within 4 months to assess subjective, endocrine and physiological stress correlates. Detailed endogenous and exogenous hormonal profiles were obtained, and women completed a 7-day diary (via ecological momentary assessment) after each appointment.\n\nBased on subjective, physiological and cortisol responses, stress induction was successful in all groups. IUD users reported higher subjective stress, negative affect and anxiety and lower positive affect compared to NC women. OC users exhibited a blunted cortisol response and higher heart rate but reported less acute stress and negative emotions than the other groups in the 7-day diary. Oestradiol and progesterone were suppressed in OC and IUD users compared with NC women. Progesterone, testosterone and oestradiol were differently associated with skin conductance, socio-emotional stress and negative affect.\n\nIUD and OC use distinctly affect stress response, possibly because of their diverging metabolic pathways and hormone levels. IUD users showed higher emotional reactivity to stress in both lab and daily life, while OCs influenced physiological correlates. These findings highlight that exogenous hormone administration, previously thought to have limited systemic effects, affects women's psychological well-being, underscoring the need for further research into stress-related disorders among women using hormonal contraceptives.", "doi": "10.1192/bjp.2025.7", "pmid": "40511505", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC12257283"}, {"db": "pii", "key": "S0007125025000078"}], "notes": [], "created": "2025-07-24T19:47:04.097Z", "modified": "2025-07-24T19:47:42.952Z"}, {"entity": "publication", "iuid": "012de59b9bfa4df6b23aa99608e18c84", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/012de59b9bfa4df6b23aa99608e18c84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/012de59b9bfa4df6b23aa99608e18c84"}}, "title": "Psychiatric symptoms on the ovarian hormone roller-coaster.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Kulkarni", "given": "Jayashri", "initials": "J", "orcid": "0000-0002-3875-5623", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c330461db87549bb929d1fa330628753.json"}}], "type": "editorial", "published": "2025-06-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "226", "issue": "6", "pages": "329-330", "issn-l": null}, "abstract": "This themed issue examines the impact of ovarian hormone fluctuations on women's mental health across the lifespan, including puberty, the menstrual cycle, pregnancy, postpartum and menopause. It highlights critical gaps and calls for sex-specific approaches in reproductive psychiatry and hormone-informed mental care.", "doi": "10.1192/bjp.2025.10298", "pmid": "40528482", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0007125025102985"}], "notes": [], "created": "2025-07-24T19:47:01.856Z", "modified": "2025-07-24T19:47:40.285Z"}, {"entity": "publication", "iuid": "2a54a3741bd94b2599cceeeaade89b7e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2a54a3741bd94b2599cceeeaade89b7e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2a54a3741bd94b2599cceeeaade89b7e"}}, "title": "Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden.", "authors": [{"family": "Hoppe", "given": "Johanna M", "initials": "JM", "orcid": "0000-0003-1214-2586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe1f567f38d4e5d8dda446432dd7969.json"}}, {"family": "Weise", "given": "Cornelia", "initials": "C"}, {"family": "Kleinstaeuber", "given": "Maria", "initials": "M"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}, {"family": "Vegelius", "given": "Johan", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Gr\u00f6ndal", "given": "Maria", "initials": "M"}, {"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Sundstr\u00f6m", "given": "Felicia", "initials": "F"}, {"family": "Sampaio", "given": "Filipa", "initials": "F"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Buhrman", "given": "Monica", "initials": "M"}], "type": "journal article", "published": "2025-01-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "15", "issue": "1", "pages": "e091649", "issn-l": "2044-6055"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a cyclic mood disorder affecting around 2%-5% of women of reproductive age. Pharmacological interventions exist, but many patients with PMDD experience residual symptoms, discontinue medications or refrain from them due to side effects. Thus, non-pharmacological treatments are needed as an alternative or additive treatment strategy. Evidence indicates that cognitive behavioural therapy (CBT) is a promising candidate. However, further research is required to establish its efficacy and identify ways to improve the treatment. Specifically, incorporating components targeting emotional and interpersonal dysregulation could theoretically enhance its effects. Furthermore, increasing the generally low accessibility of CBT for PMDD necessitates scalable and cost-effective ways to deliver treatment. The current study aims to evaluate the effects and cost-effectiveness of an internet-delivered CBT (ICBT) intervention for PMDD incorporating skills training in emotion regulation and interpersonal effectiveness.\n\nThe study is a parallel two-group randomised controlled trial with 1:1 allocation to 8 weeks of therapist-guided ICBT or a waitlist control condition. Following recruitment and inclusion, 164 individuals aged 18-45 years who fulfil the Diagnostic Manual of Mental Disorders-5 criteria for PMDD will be randomly assigned to the two groups. Primary outcomes are pretreatment to post-treatment group differences in premenstrual symptoms and their impact on everyday life, as well as psychological and functional impairment during the premenstrual phase. Secondary outcomes include treatment effects on quality of life and difficulties in emotion regulation. Long-term treatment effects will be assessed 6 and 12 months postintervention. Data will be analysed using latent Gaussian process modelling and linear mixed models. The economic evaluation will analyse individual-level societal costs and outcomes between trial arms. Recruitment is expected to begin in February 2025, with study completion anticipated by February 2028.\n\nThe study has been approved by the Swedish Ethical Review Authority (2023-00655-01). Results will be disseminated via presentations and publications in international journals and national outlets for clinicians and patients with PMDD.\n\nPS2024_v1.\n\nNCT06496139.", "doi": "10.1136/bmjopen-2024-091649", "pmid": "39843366", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC11784203"}, {"db": "pii", "key": "bmjopen-2024-091649"}, {"db": "ClinicalTrials.gov", "key": "NCT06496139"}], "notes": [], "created": "2025-07-24T19:48:34.969Z", "modified": "2025-11-04T14:25:07.879Z"}, {"entity": "publication", "iuid": "2d418da0bf284e2095eeaa51b2eedcce", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2d418da0bf284e2095eeaa51b2eedcce.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2d418da0bf284e2095eeaa51b2eedcce"}}, "title": "White matter integrity upon progesterone antagonism in individuals with premenstrual dysphoric disorder: A randomized placebo-controlled diffusion tensor imaging study.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Gu", "given": "Xuan", "initials": "X"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Hahn", "given": "Andreas", "initials": "A"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R", "orcid": "0000-0003-4641-9539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0798fcfac19c499ca5288a5ac182340e.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-01-10", "journal": {"title": "Prog Neuropsychopharmacol Biol Psychiatry", "issn": "1878-4216", "volume": "136", "pages": "111179", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a depressive disorder triggered by fluctuations of progesterone and estradiol during the luteal phase of the menstrual cycle. Selective progesterone receptor modulation (SPRM), while exerting an antagonistic effect on progesterone and maintaining estradiol on moderate levels, has shown beneficial effects on the mental symptoms of PMDD. Progesterone is also known for its neuroprotective effects, while synthetic progestins have been suggested to promote myelination. However, the impact of SPRM treatment on white matter microstructure is unexplored.\n\nDiffusion tensor imaging was employed to collect data on white matter integrity in patients with PMDD, before and after treatment with ulipristal acetate (an SPRM) or placebo, as part of a double-blind randomized controlled-trial. Tract based spatial statistics were performed to investigate SPRM treatment vs. placebo longitudinal effects on fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), on the whole white matter skeleton.\n\nVoxel-wise analyses indicated no change over time in any white matter microstructure metrics in individuals treated with SPRM versus placebo. Improvement in PMDD symptoms did not correlate with changes in white matter microstructure. In secondary, exploratory, cross-sectional comparisons during treatment, the SPRM group displayed lower FA and higher MD, RD, and AD than the placebo group in several tracts.\n\nThe main findings suggest that SPRM treatment did not impact white matter microstructure compared with placebo. However, secondary exploratory analyses yielded between-group differences after treatment, which call for further investigation on the tracts potentially impacted by progesterone antagonism.\n\nEUDRA-CT 2016-001719-19; \"Selective progesterone receptor modulators for treatment of premenstrual dysphoric disorder. A randomized, double-blind, placebo-controlled study.\"; https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-001719-19/SE.", "doi": "10.1016/j.pnpbp.2024.111179", "pmid": "39454851", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0278-5846(24)00247-1"}], "notes": [], "created": "2024-10-29T09:13:36.610Z", "modified": "2025-07-24T19:48:39.207Z"}, {"entity": "publication", "iuid": "8b37fc4061934164a19806dd144bbec8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8b37fc4061934164a19806dd144bbec8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8b37fc4061934164a19806dd144bbec8"}}, "title": "Progestagens and progesterone receptor modulation: Effects on the brain, mood, stress, and cognition in females.", "authors": [{"family": "Bencker", "given": "Celine", "initials": "C"}, {"family": "Gschwandtner", "given": "Laura", "initials": "L"}, {"family": "Nayman", "given": "Sibel", "initials": "S"}, {"family": "Grik\u0161ien\u0117", "given": "Ramun\u0117", "initials": "R"}, {"family": "Nguyen", "given": "Billie", "initials": "B"}, {"family": "Nater", "given": "Urs M", "initials": "UM"}, {"family": "Guennoun", "given": "Rachida", "initials": "R"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Pletzer", "given": "Belinda", "initials": "B"}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-01-00", "journal": {"title": "Front Neuroendocrinol", "issn": "1095-6808", "pages": "101160", "volume": "76", "issn-l": "0091-3022"}, "abstract": "Progesterone is a highly lipophilic gonadal hormone that can influence behavior and mental health through its receptors in the brain. Fluctuations in progesterone levels across critical periods of a females life are associated with increased susceptibility to mental conditions. This review highlights the effects of progestagens, including progesterone and synthetic progestins, on the brain, mood, stress, and cognition in females. The primary focus is on experimental pharmacological research that teases out the distinct effects of progestagens from those of estrogens. Additionally, the key literature on puberty, the menstrual cycle, pregnancy, perimenopause, hormonal contraceptives, and menopausal hormone therapy is reviewed, although conclusions are limited by the nested effects of progestagens and estrogens. Single study-findings suggest an influence of progesterone on amygdala reactivity related to processing of emotional stimuli and memory. In patients with premenstrual dysphoric disorder, progesterone receptor modulation improves premenstrual mood symptoms and potentially enhances fronto-cingulate control over emotion processing. The interaction between progestagens and the systems involved in the regulation of stress seems to influence subjective experiences of mood and stress. Sparse studies investigating the effects of progestin-only contraceptives suggest effects of progestagens on the brain, mood, and stress. Progesterone and progestins used for contraception can influence neural processes as myelination and neuroprotection, exerting protective effects against stroke. Concerning menopausal hormonal therapy, the effects of progestins are largely unknown. Levels of progesterone as well as type, administration route, timing, dose regimen, metabolism, and intracellular activity of progestins in hormonal contraceptives and menopausal hormonal therapy are factors whose effects remain to be elucidated. Altogether, current knowledge highlights the potential role of progestagens in females health but also calls for well-designed pharmaco-behavioral studies disentangling the effects of progestagens from those of estrogens.", "doi": "10.1016/j.yfrne.2024.101160", "pmid": "39515587", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0091-3022(24)00040-2"}], "notes": [], "created": "2024-11-14T10:39:41.020Z", "modified": "2025-07-24T19:48:37.119Z"}, {"entity": "publication", "iuid": "a33ec693db284d85ad002b6783fa95d2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a33ec693db284d85ad002b6783fa95d2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a33ec693db284d85ad002b6783fa95d2"}}, "title": "Menstrual cycle-related changes in the human brain", "authors": [{"family": "Pletzer", "given": "Belinda", "initials": "B"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E"}, {"family": "Kimmig", "given": "Ann Christin S", "initials": "ACS"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}], "type": "book-chapter", "published": "2025-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": "604-623"}, "abstract": null, "doi": "10.1016/b978-0-12-820480-1.00151-0", "pmid": null, "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2024-11-14T10:51:29.598Z", "modified": "2025-03-26T11:39:46.941Z"}, {"entity": "publication", "iuid": "4b1f09d2fc07476997dfb4aa2d37577f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4b1f09d2fc07476997dfb4aa2d37577f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4b1f09d2fc07476997dfb4aa2d37577f"}}, "title": "Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences.", "authors": [{"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Lager", "given": "Susanne", "initials": "S", "orcid": "0000-0003-3556-065X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d162155439a04158b451bcb3265881e3.json"}}, {"family": "Toffoletto", "given": "Simone", "initials": "S"}, {"family": "Iliadis", "given": "Stavros I", "initials": "SI"}, {"family": "Kallak", "given": "Theodora Kunovac", "initials": "TK", "orcid": "0000-0002-2112-8674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6379c3c4a4d14c31af9a62bc3c41d656.json"}}, {"family": "Agnafors", "given": "Sara", "initials": "S", "orcid": "0000-0002-6760-7902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3f27397a434f21a21922c5d19412b3.json"}}, {"family": "Nieratschker", "given": "Vanessa", "initials": "V"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2024-10-08", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "24", "issue": "1", "pages": "661", "issn-l": "1471-244X"}, "abstract": "As a biological marker for cellular senescence, telomere length (TL) has been linked to a variety of psychiatric disorders and adverse childhood experiences (ACE), though only preliminarily to peripartum depression (PPD). The present study sought to examine the association between TL and PPD, assessing the moderating role of ACE and genetic polymorphic variations related with the telomere machinery.\n\nAdversity was self-reported, likewise were depressive symptoms evaluated at pregnancy week 17 and 32, as well as six-weeks and six-months postpartum. TL was assessed by use of qPCR in blood samples collected during delivery from females with antenatal depression resolving postpartum, females with depression persisting to postpartum, and healthy controls. Twenty haplotype-tagging Single Nucleotide Polymorphisms in the Telomerase Reverse Transcriptase (TERT) and three in the Telomerase RNA Component (TERC) genes were genotyped.\n\nTL was negatively correlated with severity of PPD symptoms at pregnancy week 32 and postpartum week 6. PPD was associated with shorter TL. Lastly, ACE, but not the TERT/TERC genotype, moderated the TL-trajectory association; with increasing ACE, individuals with persistent PPD symptoms had shorter TL, whereas the opposite pattern (longer TL) was observed in the controls.\n\nThe findings contribute to further understanding of PPD underpinnings, suggesting a negative relationship with TL.", "doi": "10.1186/s12888-024-06115-1", "pmid": "39379870", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11462957"}, {"db": "pii", "key": "10.1186/s12888-024-06115-1"}], "notes": [], "created": "2024-10-24T08:50:36.393Z", "modified": "2025-07-24T19:48:41.295Z"}, {"entity": "publication", "iuid": "78b136495c8f42f3884c649ef8929030", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/78b136495c8f42f3884c649ef8929030.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/78b136495c8f42f3884c649ef8929030"}}, "title": "Cortical morphology variations during the menstrual cycle in individuals with and without premenstrual dysphoric disorder.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2024-06-15", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "355", "pages": "470-477", "issn-l": "0165-0327"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is hypothesized to stem from maladaptive neural sensitivity to ovarian steroid hormone fluctuations. Recently, we found thinner cortices in individuals with PMDD, compared to healthy controls, during the symptomatic phase. Here, we aimed at investigating whether such differences illustrate state-like characteristics specific to the symptomatic phase, or trait-like features defining PMDD.\n\nPatients and controls were scanned using structural magnetic resonance imaging during the mid-follicular and late-luteal phase of the menstrual cycle. Group-by-phase interaction effects on cortical architecture metrics (cortical thickness, gyrification index, cortical complexity, and sulcal depth) were assessed using surface-based morphometry.\n\nIndependently of menstrual cycle phase, a main effect of diagnostic group on surface metrics was found, primarily illustrating thinner cortices (0.3 < Cohen's d > 1.1) and lower gyrification indices (0.4 < Cohen's d > 1.0) in patients compared to controls. Furthermore, menstrual cycle-specific effects were detected across all participants, depicting a decrease in cortical thickness (0.4 < Cohen's d > 1.7) and region-dependent changes in cortical folding metrics (0.4 < Cohen's d > 2.2) from the mid-follicular to the late luteal phase.\n\nSmall effects (d = 0.3) require a larger sample size to be accurately characterized.\n\nThese findings provide initial evidence of trait-like cortical characteristics of the brain of individuals with premenstrual dysphoric disorder, together with indications of menstrual cycle-related variations in cortical architecture in patients and controls. Further investigations exploring whether these differences constitute stable vulnerability markers or develop over the years may help understand PMDD etiology.", "doi": "10.1016/j.jad.2024.03.130", "pmid": "38552916", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(24)00554-8"}], "notes": [], "created": "2024-10-24T08:50:44.807Z", "modified": "2025-04-08T06:09:16.411Z"}, {"entity": "publication", "iuid": "cdb97dfe5005436d9f87f7c4e86821cc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cdb97dfe5005436d9f87f7c4e86821cc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cdb97dfe5005436d9f87f7c4e86821cc"}}, "title": "Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms.", "authors": [{"family": "Bj\u00f6rv\u00e4ng", "given": "Richelle D", "initials": "RD"}, {"family": "Walld\u00e9n", "given": "Ylva", "initials": "Y"}, {"family": "Fransson", "given": "Emma", "initials": "E"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2024-06-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "164", "pages": "107009", "issn-l": "0306-4530"}, "abstract": "Perinatal depression is a major cause of disability for individuals giving birth worldwide, with detrimental effects on short- and long-term parental and child outcomes. There is emerging evidence that the neuroactive steroid hormone allopregnanolone is implicated in the pathophysiology and course of perinatal mood symptoms. However, no study thus far has examined allopregnanolone levels whilst making use of longitudinal data on depressive symptom trajectories throughout the perinatal period. The present study investigated levels of allopregnanolone at gestational week 17 of 252 participants in relation to perinatal depressive symptom trajectories, with a secondary aim of exploring the role of history of depression as an effect modifier. Four perinatal depressive symptom trajectories were investigated: controls (no depressive symptoms throughout perinatal period) (N=161), antepartum (depressive symptoms prenatally with postpartum remission) (N=31), postpartum-onset (no depressive symptoms during pregnancy, development of depressive symptoms postpartum) (N=23), and persistent (depressive symptoms throughout the perinatal period) (N=37). Results show that for every one nmol/l increase in allopregnanolone, there was 7% higher odds for persistent depressive symptoms (OR 1.07, 95% CI 1.01-1.14) compared to controls. No association was seen for antepartum and postpartum-onset depressive symptoms. History of depression did not modify the association between allopregnanolone and perinatal depressive symptom trajectories. These results show the role of allopregnanolone for persistent depressive symptoms and strengthen the hypothesis of differences in pathophysiology among the trajectories.", "doi": "10.1016/j.psyneuen.2024.107009", "pmid": "38442504", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(24)00053-2"}], "notes": [], "created": "2024-10-24T08:50:47.284Z", "modified": "2024-10-24T08:53:42.406Z"}, {"entity": "publication", "iuid": "71cb388a0b3d4565810dfad345f35889", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/71cb388a0b3d4565810dfad345f35889.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/71cb388a0b3d4565810dfad345f35889"}}, "title": "Modeling brain sex in the limbic system as phenotype for female-prevalent mental disorders.", "authors": [{"family": "Matte Bon", "given": "Gloria", "initials": "G", "orcid": "0000-0002-1770-1765", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a859233554d34ade8487ef76591302a4.json"}}, {"family": "Kraft", "given": "Dominik", "initials": "D", "orcid": "0000-0002-4964-2237", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78cee0da36b645b6afeafa76087fe06a.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Kaufmann", "given": "Tobias", "initials": "T", "orcid": "0000-0002-4003-1018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/066255c20da945f78248d804d270765e.json"}}], "type": "journal article", "published": "2024-05-15", "journal": {"title": "Biol Sex Differ", "issn": "2042-6410", "volume": "15", "issue": "1", "pages": "42", "issn-l": "2042-6410"}, "abstract": "Sex differences exist in the prevalence and clinical manifestation of several mental disorders, suggesting that sex-specific brain phenotypes may play key roles. Previous research used machine learning models to classify sex from imaging data of the whole brain and studied the association of class probabilities with mental health, potentially overlooking regional specific characteristics.\n\nWe here investigated if a regionally constrained model of brain volumetric imaging data may provide estimates that are more sensitive to mental health than whole brain-based estimates. Given its known role in emotional processing and mood disorders, we focused on the limbic system. Using two different cohorts of healthy subjects, the Human Connectome Project and the Queensland Twin IMaging, we investigated sex differences and heritability of brain volumes of limbic structures compared to non-limbic structures, and subsequently applied regionally constrained machine learning models trained solely on limbic or non-limbic features. To investigate the biological underpinnings of such models, we assessed the heritability of the obtained sex class probability estimates, and we investigated the association with major depression diagnosis in an independent clinical sample. All analyses were performed both with and without controlling for estimated total intracranial volume (eTIV).\n\nLimbic structures show greater sex differences and are more heritable compared to non-limbic structures in both analyses, with and without eTIV control. Consequently, machine learning models performed well at classifying sex based solely on limbic structures and achieved performance as high as those on non-limbic or whole brain data, despite the much smaller number of features in the limbic system. The resulting class probabilities were heritable, suggesting potentially meaningful underlying biological information. Applied to an independent population with major depressive disorder, we found that depression is associated with male-female class probabilities, with largest effects obtained using the limbic model. This association was significant for models not controlling for eTIV whereas in those controlling for eTIV the associations did not pass significance correction.\n\nOverall, our results highlight the potential utility of regionally constrained models of brain sex to better understand the link between sex differences in the brain and mental disorders.", "doi": "10.1186/s13293-024-00615-1", "pmid": "38750598", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11097569"}, {"db": "pii", "key": "10.1186/s13293-024-00615-1"}], "notes": [], "created": "2024-10-24T08:50:39.738Z", "modified": "2024-10-24T08:53:40.301Z"}, {"entity": "publication", "iuid": "ed1787a2823b404bb946a4a37403db26", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed1787a2823b404bb946a4a37403db26.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed1787a2823b404bb946a4a37403db26"}}, "title": "White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "randomized controlled trial", "published": "2024-05-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "163", "pages": "106977", "issn-l": "0306-4530"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial. The neural signatures of this treatment have been so far identified as greater fronto-cingulate reactivity during aggressive response to provocation, but no changes in terms of gray matter structure. White matter has recently been found to differ between patients with PMDD and healthy controls. The present study thus sought to investigate the relationship between white matter volume and SPRM treatment in patients with PMDD. A pharmaco-neuroimaging study was conducted on patients with PMDD participating in a randomized controlled trial. Participants underwent magnetic resonance imaging before and after treatment randomization to ulipristal acetate (an SPRM), or placebo, for three months. The interaction effect of treatment by time on white matter volume (WMV) was assessed. Voxel based morphometry analyses were performed on both a whole brain exploratory level and on regions of interest. No treatment effect was observed on WMV in any region, including the anterior thalamic radiations, cingulum, forceps minor, fornix, inferior fronto-occipital fasciculus, superior cerebellar peduncle, superior longitudinal fasciculus, and uncinate fasciculus. This is the first finding to indicate that no white matter volume alterations follow three-month progesterone antagonism, suggesting that white matter volume does not participate in symptom relief upon SPRM treatment for PMDD.", "doi": "10.1016/j.psyneuen.2024.106977", "pmid": "38295626", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(24)00021-0"}], "notes": [], "created": "2024-10-24T08:50:49.778Z", "modified": "2024-10-24T08:53:43.462Z"}, {"entity": "publication", "iuid": "e5fc18c507824af9bf44c3e06919a17c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e5fc18c507824af9bf44c3e06919a17c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e5fc18c507824af9bf44c3e06919a17c"}}, "title": "Electroencephalography findings in menstrually-related mood disorders: A critical review.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Schmidt", "given": "Felix", "initials": "F"}, {"family": "Zsido", "given": "Rachel G", "initials": "RG"}, {"family": "Eriksson", "given": "Allison", "initials": "A"}, {"family": "Sacher", "given": "Julia", "initials": "J"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Sumner", "given": "Rachael L", "initials": "RL"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2024-01-00", "journal": {"title": "Front Neuroendocrinol", "issn": "1095-6808", "volume": "72", "pages": "101120", "issn-l": "0091-3022"}, "abstract": "The female reproductive years are characterized by fluctuations in ovarian hormones across the menstrual cycle, which have the potential to modulate neurophysiological and behavioral dynamics. Menstrually-related mood disorders (MRMDs) comprise cognitive-affective or somatic symptoms that are thought to be triggered by the rapid fluctuations in ovarian hormones in the luteal phase of the menstrual cycle. MRMDs include premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and premenstrual exacerbation (PME) of other psychiatric disorders. Electroencephalography (EEG) non-invasively records in vivo synchronous activity from populations of neurons with high temporal resolution. The present overview sought to systematically review the current state of task-related and resting-state EEG investigations on MRMDs. Preliminary evidence indicates lower alpha asymmetry at rest being associated with MRMDs, while one study points to the effect being luteal-phase specific. Moreover, higher luteal spontaneous frontal brain activity (slow/fast wave ratio as measured by the delta/beta power ratio) has been observed in persons with MRMDs, while sleep architecture results point to potential circadian rhythm disturbances. In this review, we discuss the quality of study designs as well as future perspectives and challenges of supplementing the diagnostic and scientific toolbox for MRMDs with EEG.", "doi": "10.1016/j.yfrne.2023.101120", "pmid": "38176542", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0091-3022(23)00068-7"}], "notes": [], "created": "2024-10-24T08:50:51.977Z", "modified": "2025-04-08T06:14:46.246Z"}, {"entity": "publication", "iuid": "1f4341226f0348caaf6be19813dc9183", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1f4341226f0348caaf6be19813dc9183.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1f4341226f0348caaf6be19813dc9183"}}, "title": "Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain.", "authors": [{"family": "Immenschuh", "given": "Jana", "initials": "J"}, {"family": "Thalhammer", "given": "Stefan Bernhard", "initials": "SB"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Biegon", "given": "Anat", "initials": "A"}, {"family": "Dumas", "given": "Sylvie", "initials": "S"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Biol Sex Differ", "issn": "2042-6410", "volume": "14", "issue": "1", "pages": "54", "issn-l": "2042-6410"}, "abstract": "Aromatase catalyzes the synthesis of estrogens from androgens. Knowledge on its regional expression in the brain is of relevance to the behavioral implications of these hormones that might be linked to sex differences in mental health. The present study investigated the distribution of cells expressing the aromatase coding gene (Cyp19a1) in limbic regions of young adult rats of both sexes, and characterized the cell types expressing this gene.\n\nCyp19a1 mRNA was mapped using fluorescent in situ hybridization (FISH). Co-expression with specific cell markers was assessed with double FISH; glutamatergic, gamma-aminobutyric acid (GABA)-ergic, glial, monoaminergic, as well as interneuron markers were tested. Automated quantification of the cells expressing the different genes was performed using CellProfiler. Sex differences in the number of cells expressing Cyp19a1 was tested non-parametrically, with the effect size indicated by the rank-biserial correlation. FDR correction for multiple testing was applied.\n\nIn the male brain, the highest percentage of Cyp19a1+ cells was found in the medial amygdaloid nucleus and the bed nucleus of stria terminalis, followed by the medial preoptic area, the CA2/3 fields of the hippocampus, the cortical amygdaloid nucleus and the amygdalo-hippocampal area. A lower percentage was detected in the caudate putamen, the nucleus accumbens, and the ventromedial hypothalamus. In females, the distribution of Cyp19a1+ cells was similar but at a lower percentage. In most regions, the majority of Cyp19a1+ cells were GABAergic, except for in the cortical-like regions of the amygdala where most were glutamatergic. A smaller fraction of cells co-expressed Slc1a3, suggesting expression of Cyp19a1 in astrocytes; monoaminergic markers were not co-expressed. Moreover, sex differences were detected regarding the identity of Cyp19a1+ cells.\n\nFemales show overall a lower number of cells expressing Cyp19a1 in the limbic brain. In both sexes, aromatase is expressed in a region-specific manner in GABAergic and glutamatergic neurons. These findings call for investigations of the relevance of sex-specific and region-dependent expression of Cyp19a1 in the limbic brain to sex differences in behavior and mental health.", "doi": "10.1186/s13293-023-00541-8", "pmid": "37658400", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10474706"}, {"db": "pii", "key": "10.1186/s13293-023-00541-8"}], "notes": [], "created": "2023-12-04T09:24:02.290Z", "modified": "2024-10-24T08:53:45.617Z"}, {"entity": "publication", "iuid": "dfa8acb312794d24a72af9bc19af8e39", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dfa8acb312794d24a72af9bc19af8e39.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dfa8acb312794d24a72af9bc19af8e39"}}, "title": "Vesicular glutamate transporter 2 expression in the ventral tegmental area of outbred male rats following exposure to nicotine and alcohol.", "authors": [{"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Thalhammer", "given": "Stefan Bernhard", "initials": "SB"}, {"family": "Svensson", "given": "Anne-Lie", "initials": "AL"}, {"family": "Dumas", "given": "Sylvie", "initials": "S"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW", "orcid": "0000-0002-8853-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae97f7e5d3e7452d82e3f13e4c1a0a58.json"}}, {"family": "Wall\u00e9n-Mackenzie", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Fredriksson", "given": "Robert", "initials": "R"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Drug Alcohol Depend Rep", "issn": "2772-7246", "volume": "8", "pages": "100180", "issn-l": null}, "abstract": "Initiation of use/co-use of nicotine and alcohol, commonly occurring in an episodic manner during adolescence, can imprint vulnerability to the developing brain and lead to addiction. The ventral tegmental area (VTA) is a key heterogeneous region of the mesocorticolimbic circuit involved in the binge-drinking and intoxication step of the addiction circuit. Higher human post-mortem VTA expression of vesicular glutamate transporter 2 (VGLUT2), a marker of the glutamatergic phenotype also expressed in dopaminergic [Tyrosine Hydroxylase (Th)-positive] neurons, has been associated with chronic nicotine use and co-use with alcohol.\n\nThe present study aimed to map and characterize the Vglut2- and Th-expressing neurons in the VTA of adolescent male rats exposed or not to prolonged (six-weeks) episodic (three consecutive days/week) nicotine and/or alcohol administration. Nicotine (0.35 mg/kg free base) was injected subcutaneously, whereas alcohol (2 g/kg 20%) was administrated via gavage. Vglut2 and Th mRNA was assessed in the anterior and posterior VTA by use of in situ hybridization.\n\nThe profile of neurons varied with substance-exposure among VTA subregions. Th-only expressing neurons were more abundant in the posterior VTA of the group exposed to nicotine-only, compared to controls. The same neurons were, on the contrary, less present in the anterior VTA of animals exposed to alcohol-only, who also displayed a higher number of Vglut2-expressing neurons in the lateral anterior VTA.\n\nVTA Vglut2- and Th-only neurons seem differentially involved in the effects of adolescent episodic nicotine and alcohol exposure in the anterior and posterior VTA.", "doi": "10.1016/j.dadr.2023.100180", "pmid": "37533815", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10391930"}, {"db": "pii", "key": "S2772-7246(23)00050-1"}], "notes": [], "created": "2023-12-04T09:24:21.111Z", "modified": "2025-04-11T07:27:00.096Z"}, {"entity": "publication", "iuid": "281d85e6ffd44d9bbd41db082a0a3f67", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/281d85e6ffd44d9bbd41db082a0a3f67.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/281d85e6ffd44d9bbd41db082a0a3f67"}}, "title": "New Pharmacological Approaches to the Management of Premenstrual Dysphoric Disorder.", "authors": [{"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "randomized controlled trial", "published": "2023-05-00", "journal": {"title": "CNS Drugs", "issn": "1179-1934", "volume": "37", "issue": "5", "pages": "371-379", "issn-l": null}, "abstract": "Premenstrual symptoms are experienced by many female individuals during their fertile age. Premenstrual dysphoric disorder (PMDD), a sex-specific mood disorder, affects about 5% of female individuals during the luteal phase of the menstrual cycle. Treatment with selective serotonin reuptake inhibitors represents a valid solution to manage PMDD for many, but not all, patients. Owing to maladaptive neural reactivity to gonadal hormone fluctuations, that is, the putative mechanism postulated to underlie PMDD, drugs suppressing or stabilizing such variations have been tested. Recently, a clinically significant reduction in the severity of the mental symptoms of PMDD was observed upon treatment with a selective progesterone receptor modulator (SPRM), as demonstrated when comparing ulipristal acetate with placebo in a randomised controlled trial. Stable and low progesterone levels, with maintained low-medium oestradiol levels, define the endocrine profile of this treatment. Importantly, the efficacy of SPRM treatment was accompanied by negligible side effects. These promising results represent a headway to understanding the mechanisms behind PMDD symptomatology and opening up new solutions in the management of PMDD. They also call for studies on the long-term efficacy, safety, and viability of SPRMs in female individuals during their fertile age to further support the development of targeted management of female's mental ill-health in relation to the menstrual cycle. The present overview thus seeks to inform about current and new pharmacological approaches to the management of premenstrual dysphoric disorder.", "doi": "10.1007/s40263-023-01004-9", "pmid": "37171547", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10212816"}, {"db": "pii", "key": "10.1007/s40263-023-01004-9"}], "notes": [], "created": "2023-12-04T09:24:32.945Z", "modified": "2024-10-24T08:53:47.989Z"}, {"entity": "publication", "iuid": "c3093e9a796d43248e229e9fd412519b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c3093e9a796d43248e229e9fd412519b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c3093e9a796d43248e229e9fd412519b"}}, "title": "Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Immenschuh", "given": "Jana", "initials": "J"}, {"family": "Jonasson", "given": "My", "initials": "M"}, {"family": "Takahashi", "given": "Kayo", "initials": "K"}, {"family": "Niwa", "given": "Takashi", "initials": "T"}, {"family": "Hosoya", "given": "Takamitsu", "initials": "T"}, {"family": "Roslin", "given": "Sara", "initials": "S"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Watanabe", "given": "Yasuyoshi", "initials": "Y"}, {"family": "Lubberink", "given": "Mark", "initials": "M"}, {"family": "Biegon", "given": "Anat", "initials": "A"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Compr Psychiatry", "issn": "1532-8384", "volume": "123", "pages": "152381", "issn-l": null}, "abstract": "Of interest to women's mental health, a wealth of studies suggests sex differences in nicotine addiction and treatment response, but their psychoneuroendocrine underpinnings remain largely unknown. A pathway involving sex steroids could indeed be involved in the behavioural effects of nicotine, as it was found to inhibit aromatase in vitro and in vivo in rodents and non-human primates, respectively. Aromatase regulates the synthesis of oestrogens and, of relevance to addiction, is highly expressed in the limbic brain.\n\nThe present study sought to investigate in vivo aromatase availability in relation to exposure to nicotine in healthy women. Structural magnetic resonance imaging and two [11C]cetrozole positron emission tomography (PET) scans were performed to assess the availability of aromatase before and after administration of nicotine. Gonadal hormones and cotinine levels were measured. Given the region-specific expression of aromatase, a ROI-based approach was employed to assess changes in [11C]cetrozole non-displaceable binding potential.\n\nThe highest availability of aromatase was found in the right and left thalamus. Upon nicotine exposure, [11C]cetrozole binding in the thalamus was acutely decreased bilaterally (Cohen's d = -0.99). In line, cotinine levels were negatively associated with aromatase availability in the thalamus, although as non-significant trend.\n\nThese findings indicate acute blocking of aromatase availability by nicotine in the thalamic area. This suggests a new putative mechanism mediating the effects of nicotine on human behaviour, particularly relevant to sex differences in nicotine addiction.", "doi": "10.1016/j.comppsych.2023.152381", "pmid": "36905856", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0010-440X(23)00018-4"}], "notes": [], "created": "2023-05-12T11:45:54.015Z", "modified": "2024-10-24T08:55:02.392Z"}, {"entity": "publication", "iuid": "dfdf0c7715f64ed88f1701de4bbbc312", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dfdf0c7715f64ed88f1701de4bbbc312.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dfdf0c7715f64ed88f1701de4bbbc312"}}, "title": "Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids.", "authors": [{"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}, {"family": "Boraxbekk", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Johansson", "given": "Maja", "initials": "M"}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "13", "issue": "1", "pages": "124", "issn-l": "2158-3188"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a debilitating disorder characterized by severe mood symptoms in the luteal phase of the menstrual cycle. PMDD symptoms are hypothesized to be linked to an altered sensitivity to normal luteal phase levels of allopregnanolone (ALLO), a GABAA-modulating progesterone metabolite. Moreover, the endogenous 3\u03b2-epimer of ALLO, isoallopregnanolone (ISO), has been shown to alleviate PMDD symptoms through its selective and dose-dependent antagonism of the ALLO effect. There is preliminary evidence showing altered recruitment of brain regions during emotion processing in PMDD, but whether this is associated to serum levels of ALLO, ISO or their relative concentration is unknown. In the present study, subjects with PMDD and asymptomatic controls underwent functional magnetic resonance imaging (fMRI) in the mid-follicular and the late-luteal phase of the menstrual cycle. Brain responses to emotional stimuli were investigated and related to serum levels of ovarian steroids, the neurosteroids ALLO, ISO, and their ratio ISO/ALLO. Participants with PMDD exhibited greater activity in brain regions which are part of emotion-processing networks during the late-luteal phase of the menstrual cycle. Furthermore, activity in key regions of emotion processing networks - the parahippocampal gyrus and amygdala - was differentially associated to the ratio of ISO/ALLO levels in PMDD subjects and controls. Specifically, a positive relationship between ISO/ALLO levels and brain activity was found in PMDD subjects, while the opposite was observed in controls. In conclusion, individuals with PMDD show altered emotion-induced brain responses in the late-luteal phase of the menstrual cycle which may be related to an abnormal response to physiological levels of GABAA-active neurosteroids.", "doi": "10.1038/s41398-023-02424-3", "pmid": "37055419", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC10101953"}, {"db": "pii", "key": "10.1038/s41398-023-02424-3"}], "notes": [], "created": "2023-05-12T11:46:22.305Z", "modified": "2024-10-24T08:53:49.155Z"}, {"entity": "publication", "iuid": "1775c38e96604dfba8295c3a15cc1443", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1775c38e96604dfba8295c3a15cc1443.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1775c38e96604dfba8295c3a15cc1443"}}, "title": "Editorial: Effects of hormonal contraceptives on the brain.", "authors": [{"family": "Pletzer", "given": "Belinda", "initials": "B"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E"}, {"family": "Lacreuse", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Derntl", "given": "Birgit", "initials": "B"}], "type": "editorial", "published": "2023-01-31", "journal": {"title": "Front Endocrinol (Lausanne)", "issn": "1664-2392", "volume": "14", "pages": "1129203", "issn-l": "1664-2392"}, "abstract": null, "doi": "10.3389/fendo.2023.1129203", "pmid": "36798667", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC9927394"}], "notes": [], "created": "2023-05-12T11:46:41.774Z", "modified": "2024-10-24T08:55:03.442Z"}, {"entity": "publication", "iuid": "61dac86f06e642528673e106aab4ecc0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/61dac86f06e642528673e106aab4ecc0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/61dac86f06e642528673e106aab4ecc0"}}, "title": "Grey matter morphology in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R", "orcid": "0000-0003-4641-9539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0798fcfac19c499ca5288a5ac182340e.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "65", "pages": "35-43", "issn-l": "0924-977X"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is characterized by severe cyclic mood symptoms emerging in the luteal phase of the menstrual cycle. The variation in progesterone levels and its metabolites during the luteal phase seems critical to the occurrence of PMDD symptoms. Notably, the efficacy of selective progesterone receptor modulator (SPRM) treatment on the mental symptoms of PMDD has been recently demonstrated. In the present study, structural magnetic resonance imaging was used to assess the effects of SPRM treatment, compared with placebo, on grey matter morphology in women with PMDD. In total, 35 women were scanned during the luteal phase, before and after three months of treatment with SPRM or placebo. Symptom severity was assessed using the Daily Record of Severity of Problems (DRSP), while gonadal hormone levels were measured by liquid chromatography-tandem mass spectrometry. Region-of-interest and whole-brain approaches were employed to perform voxel-based morphometry analyses, subcortical volumetric analyses, and surface-based morphometry analyses. No interaction or main effects of treatment and time were observed on grey matter volume and cortical surface measures (cortical thickness, gyrification index, sulcal depth, and fractal dimension). The relationship between change in brain morphology and symptom severity was also explored but no treatment-dependant grey matter structure change was related to symptom severity change. These findings suggest that SPRM treatment does not impart macrostructural changes onto grey matter structure, at least in the short term.", "doi": "10.1016/j.euroneuro.2022.10.002", "pmid": "36343426", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(22)00871-9"}], "notes": [], "created": "2022-11-10T20:56:41.257Z", "modified": "2025-04-29T07:06:13.850Z"}, {"entity": "publication", "iuid": "f396c88612d5442abe04d56876d223d8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f396c88612d5442abe04d56876d223d8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f396c88612d5442abe04d56876d223d8"}}, "title": "Differential grey matter structure in women with premenstrual dysphoric disorder: evidence from brain morphometry and data-driven classification.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R", "orcid": "0000-0003-4641-9539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0798fcfac19c499ca5288a5ac182340e.json"}}, {"family": "Neill Epperson", "given": "C", "initials": "C"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Bixo", "given": "Marie", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "12", "issue": "1", "pages": "250", "issn-l": "2158-3188"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a female-specific condition classified in the Diagnostic and Statical Manual-5th edition under depressive disorders. Alterations in grey matter volume, cortical thickness and folding metrics have been associated with a number of mood disorders, though little is known regarding brain morphological alterations in PMDD. Here, women with PMDD and healthy controls underwent magnetic resonance imaging (MRI) during the luteal phase of the menstrual cycle. Differences in grey matter structure between the groups were investigated by use of voxel- and surface-based morphometry. Machine learning and multivariate pattern analysis were performed to test whether MRI data could distinguish women with PMDD from healthy controls. Compared to controls, women with PMDD had smaller grey matter volume in ventral posterior cortices and the cerebellum (Cohen's d = 0.45-0.76). Region-of-interest analyses further indicated smaller volume in the right amygdala and putamen of women with PMDD (Cohen's d = 0.34-0.55). Likewise, thinner cortex was observed in women with PMDD compared to controls, particularly in the left hemisphere (Cohen's d = 0.20-0.74). Classification analyses showed that women with PMDD can be distinguished from controls based on grey matter morphology, with an accuracy up to 74%. In line with the hypothesis of an impaired top-down inhibitory circuit involving limbic structures in PMDD, the present findings point to PMDD-specific grey matter anatomy in regions of corticolimbic networks. Furthermore, the results include widespread cortical and cerebellar regions, suggesting the involvement of distinct networks in PMDD pathophysiology.", "doi": "10.1038/s41398-022-02017-6", "pmid": "35705554", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC9200862"}, {"db": "pii", "key": "10.1038/s41398-022-02017-6"}], "notes": [], "created": "2022-11-10T20:57:08.113Z", "modified": "2024-10-24T08:55:05.592Z"}, {"entity": "publication", "iuid": "67e4738c4c5e49f3a2faba3e1f50064e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/67e4738c4c5e49f3a2faba3e1f50064e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/67e4738c4c5e49f3a2faba3e1f50064e"}}, "title": "Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study.", "authors": [{"family": "Kallak", "given": "Theodora Kunovac", "initials": "TK", "orcid": "0000-0002-2112-8674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6379c3c4a4d14c31af9a62bc3c41d656.json"}}, {"family": "Fransson", "given": "Emma", "initials": "E"}, {"family": "Br\u00e4nn", "given": "Emma", "initials": "E", "orcid": "0000-0001-9664-7973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7bc9e06cfd148ff8f7d5ca43e3d3d28.json"}}, {"family": "Berglund", "given": "Hanna", "initials": "H"}, {"family": "Lager", "given": "Susanne", "initials": "S", "orcid": "0000-0003-3556-065X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d162155439a04158b451bcb3265881e3.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Lyle", "given": "Robert", "initials": "R"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}], "type": "journal article", "published": "2022-05-05", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "12", "issue": "1", "pages": "186", "issn-l": "2158-3188"}, "abstract": "Children of mothers with prenatal depressive symptoms (PND) have a higher risk of behavioral problems; fetal programming through DNA methylation is a possible underlying mechanism. This study investigated DNA methylation in cord blood to identify possible \"at birth\" signatures that may indicate susceptibility to behavioral problems at 18 months of age. Cord blood was collected from 256 children of mothers who had self-reported on symptoms of depression during pregnancy and the behavior of their child at 18 months of age. Whole genome DNA methylation was assessed using Illumina MethylationEPIC assay. The mother and child pairs were categorized into four groups, based on both self-reported depressive symptoms, PND or Healthy control (HC), and scores from the Child Behavior checklist (high or low for internalizing, externalizing, and total scores). Adjustments were made for batch effects, cell-type, and clinical covariates. Differentially methylated sites were identified using Kruskal-Wallis test, and Benjamini-Hochberg adjusted p values < 0.05 were considered significant. The analysis was also stratified by sex of the child. Among boys, we observed higher and correlated DNA methylation of one CpG-site in the promoter region of TPP1 in the HC group, with high externalizing scores compared to HC with low externalizing scores. Boys in the PND group showed lower DNA methylation in NUDT15 among those with high, compared to low, internalizing scores; the DNA methylation levels of CpGs in this gene were positively correlated with the CBCL scores. Hence, the differentially methylated CpG sites could be of interest for resilience, regardless of maternal mental health during pregnancy. The findings are in a relatively healthy study cohort, thus limiting the possibility of detecting strong effects associated with behavioral difficulties. This is the first investigation of cord blood DNA methylation signs of fetal programming of PND on child behavior at 18 months of age and thus calls for independent replications.", "doi": "10.1038/s41398-022-01954-6", "pmid": "35513368", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC9072531"}, {"db": "pii", "key": "10.1038/s41398-022-01954-6"}], "notes": [], "created": "2022-11-10T20:57:24.332Z", "modified": "2024-10-24T08:55:06.783Z"}, {"entity": "publication", "iuid": "fc20f84c5b1c454cb8f549c2fb036121", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fc20f84c5b1c454cb8f549c2fb036121.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fc20f84c5b1c454cb8f549c2fb036121"}}, "title": "Grey matter correlates of affective and somatic symptoms of premenstrual dysphoric disorder.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2022-04-09", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "5996", "issn-l": "2045-2322"}, "abstract": "Ovarian hormones fluctuations across the menstrual cycle are experienced by about 58% of women in their fertile age. Maladaptive brain sensitivity to these changes likely leads to the severe psychological, cognitive, and physical symptoms repeatedly experienced by women with Premenstrual Dysphoric Disorder (PMDD) during the late luteal phase of the menstrual cycle. However, the neuroanatomical correlates of these symptoms are unknown. The relationship between grey matter structure and PMDD symptom severity was delineated using structural magnetic resonance imaging during the late luteal phase of fifty-one women diagnosed with PMDD, combined with Voxel- and Surface-Based Morphometry, as well as subcortical volumetric analyses. A negative correlation was found between depression-related symptoms and grey matter volume of the bilateral amygdala. Moreover, the severity of affective and somatic PMDD symptoms correlated with cortical thickness, gyrification, sulcal depth, and complexity metrics, particularly in the prefrontal, cingulate, and parahippocampal gyri. The present findings provide the first evidence of grey matter morphological characteristics associated with PMDD symptomatology in brain regions expressing ovarian hormone receptors and of relevance to cognitive-affective functions, thus potentially having important implications for understanding how structural brain characteristics relate to PMDD symptomatology.", "doi": "10.1038/s41598-022-07109-3", "pmid": "35397641", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC8994757"}, {"db": "pii", "key": "10.1038/s41598-022-07109-3"}], "notes": [], "created": "2022-11-10T20:57:40.319Z", "modified": "2024-10-24T08:55:07.910Z"}, {"entity": "publication", "iuid": "166fce7a54f5471bbf45c95f45cd3c46", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/166fce7a54f5471bbf45c95f45cd3c46.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/166fce7a54f5471bbf45c95f45cd3c46"}}, "title": "White matter microstructure and volume correlates of premenstrual dysphoric disorder.", "authors": [{"family": "Gu", "given": "Xuan", "initials": "X"}, {"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Stiernman", "given": "Louise", "initials": "L"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Hahn", "given": "Andreas", "initials": "A"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Bixo", "given": "Marie", "initials": "M"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "J Psychiatry Neurosci", "issn": "1488-2434", "volume": "47", "issue": "1", "pages": "E67-E76", "issn-l": "1180-4882"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized by psychological and physical symptoms. Differences in white matter have been associated with affective and anxiety disorders, which share some symptoms with PMDD. However, whether white matter structure differs between the brains of individuals with PMDD and healthy controls is not known, nor is its relation to symptom severity.\n\nWe performed tract-based spatial statistics and voxel-based morphometry analyses of diffusion tensor imaging metrics and white matter volume, using 2 neuroimaging data sets (n = 67 and n = 131) and a combined whole-brain and region-of-interest approach. We performed correlation analyses to investigate the relationship between regions with different white matter microstructure and volume and PMDD symptom severity.\n\nWe found greater fractional anisotropy in the left uncinate fasciculus (d = 0.69) in individuals with PMDD compared to controls. Moreover, the volume of the right uncinate fasciculus was higher in individuals with PMDD compared to controls (d = 0.40). As well, the severity of premenstrual depression was positively correlated with fractional anisotropy in the right superior longitudinal fasciculus (r = 0.35).\n\nIt is challenging to interpret group differences in diffusion tensor imaging metrics in terms of their underlying biophysical properties. The small size of the control group in the diffusion tensor imaging study may have prevented effects of interest from being detected.\n\nThe findings of the present study provide evidence of differential cerebral white matter structure associated with PMDD and its symptoms.", "doi": "10.1503/jpn.210143", "pmid": "35197364", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC9259386"}, {"db": "pii", "key": "47/1/E67"}], "notes": [], "created": "2022-11-10T20:58:02.281Z", "modified": "2024-10-24T08:55:08.996Z"}, {"entity": "publication", "iuid": "f229ab1f9e90433c9e87fb351153d9bb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f229ab1f9e90433c9e87fb351153d9bb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f229ab1f9e90433c9e87fb351153d9bb"}}, "title": "Prevalence and correlates of current suicidal ideation in women with premenstrual dysphoric disorder.", "authors": [{"family": "Wikman", "given": "Anna", "initials": "A", "orcid": "0000-0003-0937-0887", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9192a08459e49aa83140c6ee678e611.json"}}, {"family": "Sacher", "given": "Julia", "initials": "J"}, {"family": "Bixo", "given": "Marie", "initials": "M"}, {"family": "Hirschberg", "given": "Angelica L", "initials": "AL"}, {"family": "Kopp Kallner", "given": "Helena", "initials": "H"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2022-02-11", "journal": {"title": "BMC Womens Health", "issn": "1472-6874", "volume": "22", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "Although previous studies report an association between Premenstrual Dysphoric Disorder (PMDD) and suicidal ideation, most studies have only established a provisional and retrospective diagnosis of PMDD fundamentally invalidating the diagnosis. Therefore, the aim of this study was to describe the prevalence and to explore correlates of current suicidal ideation in the late luteal phase in women with prospectively assessed and confirmed PMDD.\n\nParticipants were 110 women who attended the pre-randomization baseline visit of two randomized placebo-controlled clinical trials between January 15, 2017 and October 19, 2019. PMDD was diagnosed prospectively in line with DSM-5 criteria. Current suicidal ideation was measured by the MADRS-S in the late luteal phase. Descriptive statistics were presented and logistic regression analyses were carried out to explore the association between psychosocial and health characteristics and current suicidal ideation, presenting unadjusted odds ratios (OR) and 95% confidence intervals (CI).\n\nCurrent suicidal ideation was reported by nearly 40% of women with confirmed PMDD (n = 43, 39.1%). Previous psychological treatment for PMDD and higher depressive symptoms in the late luteal phase were positively associated with current suicidal ideation (OR 5.63, 95% CI 1.07-29.49, and OR 1.17, 95% CI 1.10-1.25, respectively), whereas higher ratings of self-rated health were associated with lower odds ratios for current suicidal ideation (OR 0.98, 95% CI 0.96-0.99).\n\nA substantial proportion of women with confirmed PMDD report current suicidal ideation in the late luteal phase. Results point to a need for better awareness and screening of suicidal ideation in women with PMDD.", "doi": "10.1186/s12905-022-01612-5", "pmid": "35148753", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC8832802"}, {"db": "pii", "key": "10.1186/s12905-022-01612-5"}], "notes": [], "created": "2022-11-10T20:58:21.813Z", "modified": "2024-10-24T08:55:10.106Z"}, {"entity": "publication", "iuid": "32ede76f5af94a5a9b4bdcb265592080", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/32ede76f5af94a5a9b4bdcb265592080.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/32ede76f5af94a5a9b4bdcb265592080"}}, "title": "Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review.", "authors": [{"family": "B\u00fcrger", "given": "Zo\u00e9", "initials": "Z"}, {"family": "Bucher", "given": "Anna Magdalena", "initials": "AM"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Henes", "given": "Melanie", "initials": "M"}, {"family": "H\u00fcbner", "given": "Stephanie", "initials": "S"}, {"family": "Kogler", "given": "Lydia", "initials": "L"}, {"family": "Derntl", "given": "Birgit", "initials": "B"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Front Neuroendocrinol", "issn": "1095-6808", "volume": "63", "pages": "100943", "issn-l": "0091-3022"}, "abstract": "Levonorgestrel-intrauterine-devices (LNG-IUD) are one of the most used contraceptive methods worldwide. While several reviews exist on how LNG-IUDs impact physiology and gynaecological functions, this systematic review focuses on stress, mental health, quality of life, sexual functioning, and effects on brain architecture. While data on stress is scarce, results on mental health are ambiguous. More consistently, LNG-IUD use seems to improve quality of life and sexual functioning. No studies highlighting the consequences of LNG-IUD use on the brain were found. The reviewed studies are characterized by a substantial variation in approaches, participant groups, and study quality. More high-quality research assessing the effects of LNG-IUD on mental health, including response to stressors and brain function and structure, is needed to identify women vulnerable to adverse effects of LNG-IUD, also in comparison to oral contraceptives, and to empower women to make more informed choices concerning hormonal contraception.", "doi": "10.1016/j.yfrne.2021.100943", "pmid": "34425187", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0091-3022(21)00045-5"}], "notes": [], "created": "2021-11-22T08:43:07.221Z", "modified": "2024-10-24T08:55:11.119Z"}, {"entity": "publication", "iuid": "e27293bd5d21413690ee5893c7c03e48", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e27293bd5d21413690ee5893c7c03e48.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e27293bd5d21413690ee5893c7c03e48"}}, "title": "DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.", "authors": [{"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Yan", "given": "Liying", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Wall\u00e9n-Mackenzie", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "15322", "issn-l": "2045-2322"}, "abstract": "DNA methylation and gene expression can be altered by early life stress (ELS) and/or ethanol consumption. The present study aimed to investigate whether DNA methylation of the Vesicular Glutamate Transporters (Vglut)1-3 is related to previously observed Vglut1-3 transcriptional differences in the ventral tegmental area (VTA), nucleus accumbens (Acb), dorsal striatum (dStr) and medial prefrontal cortex (mPFC) of adult rats exposed to ELS, modelled by maternal separation, and voluntary ethanol consumption. Targeted next-generation bisulfite sequencing was performed to identify the methylation levels on 61 5'-cytosine-phosphate-guanosine-3' sites (CpGs) in potential regulatory regions of Vglut1, 53 for Vglut2, and 51 for Vglut3. In the VTA, ELS in ethanol-drinking rats was associated with Vglut1-2 CpG-specific hypomethylation, whereas bidirectional Vglut2 methylation differences at single CpGs were associated with ELS alone. Exposure to both ELS and ethanol, in the Acb, was associated with lower promoter and higher intronic Vglut3 methylation; and in the dStr, with higher and lower methylation in 26% and 43% of the analyzed Vglut1 CpGs, respectively. In the mPFC, lower Vglut2 methylation was observed upon exposure to ELS or ethanol. The present findings suggest Vglut1-3 CpG-specific methylation signatures of ELS and ethanol drinking, underlying previously reported Vglut1-3 transcriptional differences in the mesocorticolimbic brain.", "doi": "10.1038/s41598-021-94739-8", "pmid": "34321562", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8319394"}, {"db": "pii", "key": "10.1038/s41598-021-94739-8"}], "notes": [], "created": "2021-11-22T08:42:58.246Z", "modified": "2024-10-24T08:55:12.288Z"}, {"entity": "publication", "iuid": "f6173f42c0604b4ca0136687f67aad69", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f6173f42c0604b4ca0136687f67aad69.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f6173f42c0604b4ca0136687f67aad69"}}, "title": "Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Fisher", "given": "Patrick M", "initials": "PM"}, {"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Hustad", "given": "Steinar", "initials": "S"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R", "orcid": "0000-0003-4641-9539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0798fcfac19c499ca5288a5ac182340e.json"}}, {"family": "Frokjaer", "given": "Vibe G", "initials": "VG"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Neuropsychopharmacology", "issn": "1740-634X", "volume": "46", "issue": "8", "pages": "1460-1467", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their reproductive age. Altered sensitivity of cognitive-affective brain circuits to progesterone and its downstream metabolite allopregnanolone is suggested to underlie PMDD symptomatology. Core mood symptoms include irritability and anger, with aggression being the behavioral outcome of these symptoms. The present study sought to investigate the neural correlates of reactive aggression during the premenstrual phase in women with PMDD, randomized to a selective progesterone receptor modulator (SPRM) or placebo. Self-reports on the Daily Record of Severity of Problems were used to assess PMDD symptoms and gonadal hormone levels were measured by liquid chromatography tandem mass spectrometry. Functional magnetic resonance imaging was performed in 30 women with PMDD, while performing the point subtraction aggression paradigm. Overall, a high SPRM treatment response rate was attained (93%), in comparison with placebo (53.3%). Women with PMDD randomized to SPRM treatment had enhanced brain reactivity in the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex during the aggressive response condition. The fronto-cingulate reactivity during aggressive responses depended on treatment, with a negative relationship between brain reactivity and task-related aggressiveness found in the placebo but not the SPRM group. The findings contribute to define the role of progesterone in PMDD symptomatology, suggesting a beneficial effect of progesterone receptor antagonism, and consequent anovulation, on top-down emotion regulation, i.e., greater fronto-cingulate activity in response to provocation stimuli.", "doi": "10.1038/s41386-021-01010-9", "pmid": "33927343", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8209206"}, {"db": "pii", "key": "10.1038/s41386-021-01010-9"}], "notes": [], "created": "2021-11-22T08:42:46.625Z", "modified": "2024-10-24T08:55:25.976Z"}, {"entity": "publication", "iuid": "6b821930ab7b4f4caa1179ab52271c14", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6b821930ab7b4f4caa1179ab52271c14.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6b821930ab7b4f4caa1179ab52271c14"}}, "title": "DNA methylation in cord blood in association with prenatal depressive symptoms.", "authors": [{"family": "Kallak", "given": "Theodora Kunovac", "initials": "TK", "orcid": "0000-0002-2112-8674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6379c3c4a4d14c31af9a62bc3c41d656.json"}}, {"family": "Br\u00e4nn", "given": "Emma", "initials": "E"}, {"family": "Fransson", "given": "Emma", "initials": "E"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Lager", "given": "Susanne", "initials": "S"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Lyle", "given": "Robert", "initials": "R"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Clin Epigenetics", "issn": "1868-7083", "volume": "13", "issue": "1", "pages": "78", "issn-l": "1868-7075"}, "abstract": "Prenatal symptoms of depression (PND) and anxiety affect up to every third pregnancy. Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic mechanisms together with other factors such as genetic and environmental. We investigated DNA methylation in cord blood in relation to PND, taking into consideration a history of depression, co-morbidity with anxiety and selective serotonin reuptake inhibitors (SSRI) use, and stratified by sex of the child. Mothers (N = 373) prospectively filled out web-based questionnaires regarding mood symptoms and SSRI use throughout pregnancy. Cord blood was collected at birth and DNA methylation was measured using Illumina MethylationEPIC array at 850 000 CpG sites throughout the genome. Differentially methylated regions were identified using Kruskal-Wallis test, and Benjamini-Hochberg adjusted p-values < 0.05 were considered significant.\n\nNo differential DNA methylation was associated with PND alone; however, differential DNA methylation was observed in children exposed to comorbid PND with anxiety symptoms compared with healthy controls in ABCF1 (log twofold change - 0.2), but not after stratification by sex of the child. DNA methylation in children exposed to PND without SSRI treatment and healthy controls both differed in comparison with SSRI exposed children at several sites and regions, among which hypomethylation was observed in CpGs in the promoter region of CRBN (log2 fold change - 0.57), involved in brain development, and hypermethylation in MDFIC (log2 fold change 0.45), associated with the glucocorticoid stress response.\n\nAlthough it is not possible to assess if these methylation differences are due to SSRI treatment itself or to more severe depression, our findings add on to existing knowledge that there might be different biological consequences for the child depending on whether maternal PND was treated with SSRIs or not.", "doi": "10.1186/s13148-021-01054-0", "pmid": "33845866", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8042709"}, {"db": "pii", "key": "10.1186/s13148-021-01054-0"}], "notes": [], "created": "2021-11-22T08:42:19.873Z", "modified": "2024-10-24T08:55:27.131Z"}, {"entity": "publication", "iuid": "5cf00cc788d94fc5942a701963e67e28", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5cf00cc788d94fc5942a701963e67e28.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5cf00cc788d94fc5942a701963e67e28"}}, "title": "Ulipristal Acetate for Treatment of Premenstrual Dysphoric Disorder: A Proof-of-Concept Randomized Controlled Trial.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Kopp Kallner", "given": "Helena", "initials": "H"}, {"family": "Bixo", "given": "Marie", "initials": "M"}, {"family": "Hirschberg", "given": "Angelica L", "initials": "AL"}, {"family": "Nyback", "given": "Sara", "initials": "S"}, {"family": "de Grauw", "given": "Haro", "initials": "H"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2021-03-01", "journal": {"title": "Am J Psychiatry", "issn": "1535-7228", "issn-l": null, "volume": "178", "issue": "3", "pages": "256-265"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a common mood disorder, characterized by distressing affective, behavioral, and somatic symptoms in the late luteal phase of the menstrual cycle. The authors investigated continuous treatment with a selective progesterone receptor modulator, ulipristal acetate (UPA), as a potential treatment for PMDD.\n\nThe authors conducted an investigator-initiated, multicenter, double-blind, randomized, parallel-group clinical trial in which women with PMDD (N=95) were treated with either 5 mg/day of UPA or placebo during three 28-day treatment cycles. The primary outcome was the change in premenstrual total score on the Daily Record of Severity of Problems (DRSP) from baseline to end of treatment. DRSP scores were captured by daily ratings using a smartphone application and were analyzed with linear mixed models for repeated measures.\n\nThe mean improvement in DRSP score after 3 months was 41% (SD=18) in the UPA group, compared with 22% (SD=27) in the placebo group (mean difference -18%; 95% CI=-29, -8). Treatment effects were also noted for the DRSP depressive symptom subscale (42% [SD=22] compared with 22% [SD=32]) and the DRSP anger/irritability subscale (47% [SD=21] compared with 23% [SD=35]), but not for the DRSP physical symptom subscale. Remission based on DRSP score was attained by 20 women in the UPA group (50.0%) and eight women in the placebo group (21.1%) (a statistically significant difference).\n\nIf these results are replicated, UPA could be a useful treatment for PMDD, particularly for the psychological symptoms associated with the disorder.", "doi": "10.1176/appi.ajp.2020.20030286", "pmid": "33297719", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-12-10T13:03:01.765Z", "modified": "2024-10-24T08:55:28.132Z"}, {"entity": "publication", "iuid": "f25e8dc7c1604e0a93976e3e0bd42469", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f25e8dc7c1604e0a93976e3e0bd42469.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f25e8dc7c1604e0a93976e3e0bd42469"}}, "title": "Neuroimaging the menstrual cycle: A multimodal systematic review.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Sacher", "given": "Julia", "initials": "J"}, {"family": "Pletzer", "given": "Belinda", "initials": "B"}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Front Neuroendocrinol", "issn": "1095-6808", "issn-l": "0091-3022", "volume": "60", "issue": null, "pages": "100878"}, "abstract": "Increasing evidence indicates that ovarian hormones affect brain structure, chemistry and function of women in their reproductive age, potentially shaping their behavior and mental health. Throughout the reproductive years, estrogens and progesterone levels fluctuate across the menstrual cycle and can modulate neural circuits involved in affective and cognitive processes. Here, we review seventy-seven neuroimaging studies and provide a comprehensive and data-driven evaluation of the accumulating evidence on brain plasticity associated with endogenous ovarian hormone fluctuations in naturally cycling women (n = 1304). The results particularly suggest modulatory effects of ovarian hormones fluctuations on the reactivity and structure of cortico-limbic brain regions. These findings highlight the importance of performing multimodal neuroimaging studies on neural correlates of systematic ovarian hormone fluctuations in naturally cycling women based on careful menstrual cycle staging.", "doi": "10.1016/j.yfrne.2020.100878", "pmid": "33098847", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0091-3022(20)30069-8"}], "notes": [], "created": "2020-11-20T09:21:40.958Z", "modified": "2024-10-24T08:55:29.197Z"}, {"entity": "publication", "iuid": "2880f6e723fd451eb14e6f2abec59a80", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2880f6e723fd451eb14e6f2abec59a80.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2880f6e723fd451eb14e6f2abec59a80"}}, "title": "Quantification of aromatase binding in the female human brain using [11 C]cetrozole positron emission tomography.", "authors": [{"family": "Jonasson", "given": "My", "initials": "M"}, {"family": "Nordeman", "given": "Patrik", "initials": "P"}, {"family": "Eriksson", "given": "Jonas", "initials": "J", "orcid": "0000-0003-0241-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71cd42cbc17b4eb092c0ea4d452477e9.json"}}, {"family": "Wilking", "given": "Helena", "initials": "H"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Takahashi", "given": "Kayo", "initials": "K"}, {"family": "Niwa", "given": "Takashi", "initials": "T"}, {"family": "Hosoya", "given": "Takamitsu", "initials": "T"}, {"family": "Watanabe", "given": "Yasuyoshi", "initials": "Y"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}, {"family": "Lubberink", "given": "Mark", "initials": "M", "orcid": "0000-0001-8324-7399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8c1d9a8e08a40d3b7a694fd293c2400.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Neurosci Res", "issn": "1097-4547", "issn-l": "0360-4012", "volume": "98", "issue": "11", "pages": "2208-2218"}, "abstract": "Aromatase, the enzyme that in the brain converts testosterone and androstenedione to estradiol and estrone, respectively, is a putative key factor in psychoneuroendocrinology. In vivo assessment of aromatase was performed to evaluate tracer kinetic models and optimal scan duration, for quantitative analysis of the aromatase positron emission tomography (PET) ligand [11 C]cetrozole. Anatomical magnetic resonance and 90-min dynamic [11 C]cetrozole PET-CT scans were performed on healthy women. Volume of interest (VOI)-based analyses with a plasma-input function were performed using the single-tissue and two-tissue (2TCM) reversible compartment models and plasma-input Logan analysis. Additionally, the simplified reference tissue model (SRTM), Logan reference tissue model (LRTM), and standardized uptake volume ratio model, with cerebellum as reference region, were evaluated. Parametric images were generated and regionally averaged voxel values were compared with VOI-based analyses of the reference tissue models. The optimal reference model was used for evaluation of a decreased scan duration. Differences between the plasma-input- and reference tissue-based methods and comparisons between scan durations were assessed by linear regression. The [11 C]cetrozole time-activity curves were best described by the 2TCM. SRTM nondisplaceable binding potential (BPND ), with cerebellum as reference region, can be used to estimate [11 C]cetrozole binding and generated robust and quantitatively accurate results for a reduced scan duration of 60 min. Receptor parametric mapping, a basis function implementation of SRTM, as well as LRTM, produced quantitatively accurate parametric images, showing BPND at the voxel level. As PET tracer, [11 C]cetrozole can be employed for relatively short brain scans to measure aromatase binding using a reference tissue-based approach.", "doi": "10.1002/jnr.24707", "pmid": "32761874", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:21:42.211Z", "modified": "2024-10-24T08:55:30.257Z"}, {"entity": "publication", "iuid": "8a0efcb0d24d45c19a807fcb95897eb8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8a0efcb0d24d45c19a807fcb95897eb8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8a0efcb0d24d45c19a807fcb95897eb8"}}, "title": "Progesterone - Friend or foe?", "authors": [{"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Sumner", "given": "Rachael", "initials": "R"}, {"family": "Luders", "given": "Eileen", "initials": "E"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Front Neuroendocrinol", "issn": "1095-6808", "issn-l": "0091-3022", "volume": "59", "issue": null, "pages": "100856"}, "abstract": "Estradiol is the \"prototypic\" sex hormone of women. Yet, women have another sex hormone, which is often disregarded: Progesterone. The goal of this article is to provide a comprehensive review on progesterone, and its metabolite allopregnanolone, emphasizing three key areas: biological properties, main functions, and effects on mood in women. Recent years of intensive research on progesterone and allopregnanolone have paved the way for new treatment of postpartum depression. However, treatment for premenstrual syndrome and premenstrual dysphoric disorder as well as contraception that women can use without risking mental health problems are still needed. As far as progesterone is concerned, we might be dealing with a two-edged sword: while its metabolite allopregnanolone has been proven useful for treatment of PPD, it may trigger negative symptoms in women with PMS and PMDD. Overall, our current knowledge on the beneficial and harmful effects of progesterone is limited and further research is imperative.", "doi": "10.1016/j.yfrne.2020.100856", "pmid": "32730861", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0091-3022(20)30047-9"}], "notes": [], "created": "2020-11-20T09:21:43.333Z", "modified": "2024-10-24T08:55:31.342Z"}, {"entity": "publication", "iuid": "b08220876210448a9a770e9edbc1744f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b08220876210448a9a770e9edbc1744f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b08220876210448a9a770e9edbc1744f"}}, "title": "Corrigendum to \"Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour\" [Behav. Brain Res. 382 (2020) 112476].", "authors": [{"family": "Checknita", "given": "David", "initials": "D"}, {"family": "Bendre", "given": "Megha", "initials": "M"}, {"family": "Ekstr\u00f6m", "given": "Tomas J", "initials": "TJ"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "published erratum", "published": "2020-09-01", "journal": {"title": "Behav. Brain Res.", "issn": "1872-7549", "volume": "393", "pages": "112721", "issn-l": "0166-4328"}, "abstract": null, "doi": "10.1016/j.bbr.2020.112721", "pmid": "32590300", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0166-4328(20)30420-4"}], "notes": [], "created": "2024-10-24T08:55:20.780Z", "modified": "2024-10-24T08:55:32.373Z"}, {"entity": "publication", "iuid": "247fe990fbe54c0aabbd2fa192d04a3a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/247fe990fbe54c0aabbd2fa192d04a3a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/247fe990fbe54c0aabbd2fa192d04a3a"}}, "title": "Neuroimaging premenstrual dysphoric disorder: A systematic and critical review.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}], "type": "journal article", "published": "2020-04-00", "journal": {"title": "Front Neuroendocrinol", "issn": "1095-6808", "issn-l": "0091-3022", "volume": "57", "issue": null, "pages": "100838"}, "abstract": "Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented here by means of neuroimaging correlates, identified from eighteen publications (n = 361 subjects). While white matter integrity remains uninvestigated, greater cerebellar grey matter volume and metabolism were observed in patients with PMDD, along with altered serotonergic and GABAergic neurotransmission. Differential corticolimbic activation in response to emotional stimuli distinguishes the PMDD brain, namely enhanced amygdalar and diminished fronto-cortical function. Thus far, the emotional distress and dysregulation linked to PMDD seem to be defined by structural, chemical and functional brain signatures; however, their characterization remains sparsely studied and somewhat inconsistent. Clear and well-replicated neurobiological features of PMDD are needed to promote timely diagnoses and inform development of prevention and treatment strategies.", "doi": "10.1016/j.yfrne.2020.100838", "pmid": "32268180", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0091-3022(20)30029-7"}], "notes": [], "created": "2020-11-20T09:21:45.735Z", "modified": "2024-10-24T08:55:33.422Z"}, {"entity": "publication", "iuid": "1e04279706ee4e13b2006b604cf24e52", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1e04279706ee4e13b2006b604cf24e52.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1e04279706ee4e13b2006b604cf24e52"}}, "title": "Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour.", "authors": [{"family": "Checknita", "given": "David", "initials": "D"}, {"family": "Bendre", "given": "Megha", "initials": "M"}, {"family": "Ekstr\u00f6m", "given": "Tomas J", "initials": "TJ"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2020-03-16", "journal": {"title": "Behav. Brain Res.", "issn": "1872-7549", "issn-l": "0166-4328", "volume": "382", "issue": null, "pages": "112476"}, "abstract": "The association between childhood maltreatment and subsequent aggressive behaviour is modified by monoamine oxidase A (MAOA) functional polymorphism (MAOA-uVNTR) genotype, MAOA-Long (MAOA-L) in females, MAOA-Short (MAOA-S) in males. Childhood maltreatment is associated with differential DNA methylation in several genes. Consistent with recent proposals, we hypothesized that the association of the interaction of MAOA genotype and maltreatment with aggressive behaviour is further moderated by methylation of a region of interest (ROI) spanning the first exon and partial first intron of MAOA.\n\nThe sample included 117 women and 77 men who completed interviews and questionnaires to report maltreatment and aggressive behaviour towards others and provided saliva samples for DNA extraction. The MAOA-uVNTR polymorphism was genotyped, and methylation of the MAOA ROI was assessed.\n\nFollowing adjustment for substance misuse, psychoactive medication use, and in males tobacco use, the highest levels of aggressive behaviour were found among maltreated male carriers of MAOA-S with high levels of exonic methylation.\n\nMethylation levels within the MAOA ROI further contributed to the interaction of MAOA risk genotypes and maltreatment on aggressive behaviours among men.", "doi": "10.1016/j.bbr.2020.112476", "pmid": "31931023", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0166-4328(19)31279-3"}], "notes": [], "created": "2020-11-20T09:21:46.854Z", "modified": "2024-10-24T08:55:34.547Z"}, {"entity": "publication", "iuid": "5893901d53924bcbb671a8a7cb9cc51c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5893901d53924bcbb671a8a7cb9cc51c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5893901d53924bcbb671a8a7cb9cc51c"}}, "title": "Handling ties in continuous outcomes for confounder adjustment with rank-ordered logit and its application to ordinal outcomes.", "authors": [{"family": "Ning", "given": "Yilin", "initials": "Y", "orcid": "0000-0002-6758-4472", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d69bc11ba24241fc87cf475a22721228.json"}}, {"family": "Tan", "given": "Chuen Seng", "initials": "CS", "orcid": "0000-0002-6513-2309", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/674ac8b75e5c4c64a34e3f756a429b74.json"}}, {"family": "Maraki", "given": "Angeliki", "initials": "A"}, {"family": "Ho", "given": "Peh Joo", "initials": "PJ"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Wagner", "given": "Philippe", "initials": "P"}, {"family": "Khoo", "given": "Eric Yh", "initials": "EY"}, {"family": "Tai", "given": "E-Shyong", "initials": "ES"}, {"family": "Kao", "given": "Shih Ling", "initials": "SL"}, {"family": "Hartman", "given": "Mikael", "initials": "M"}, {"family": "Reilly", "given": "Marie", "initials": "M"}, {"family": "St\u00f8er", "given": "Nathalie C", "initials": "NC", "orcid": "0000-0001-8994-9332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/624b17951cbd49009854620bdf28471d.json"}}], "type": "comparative study", "published": "2020-02-00", "journal": {"title": "Stat Methods Med Res", "issn": "1477-0334", "issn-l": "0962-2802", "volume": "29", "issue": "2", "pages": "437-454"}, "abstract": "The rank-ordered logit (rologit) model was recently introduced as a robust approach for analysing continuous outcomes, with the linear exposure effect estimated by scaling the rank-based log-odds estimate. Here we extend the application of the rologit model to continuous outcomes with ties and ordinal outcomes treated as imperfectly-observed continuous outcomes. By identifying the functional relationship between survival times and continuous outcomes, we explicitly establish the equivalence between the rologit and Cox models to justify the use of the Breslow, Efron and perturbation methods in the analysis of continuous outcomes with ties. Using simulation, we found all three methods perform well with few ties. Although an increasing extent of ties increased the bias of the log-odds and linear effect estimates and resulted in reduced power, which was somewhat worse when the model was mis-specified, the perturbation method maintained a type I error around 5%, while the Efron method became conservative with heavy ties but outperformed Breslow. In general, the perturbation method had the highest power, followed by the Efron and then the Breslow method. We applied our approach to three real-life datasets, demonstrating a seamless analytical workflow that uses stratification for confounder adjustment in studies of continuous and ordinal outcomes.", "doi": "10.1177/0962280219837656", "pmid": "30943882", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-09-28T11:48:06.939Z", "modified": "2024-10-24T08:55:48.477Z"}, {"entity": "publication", "iuid": "5506a16114fd49c8b8a1e2477595a374", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5506a16114fd49c8b8a1e2477595a374.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5506a16114fd49c8b8a1e2477595a374"}}, "title": "VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths.", "authors": [{"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Rehn", "given": "Mattias", "initials": "M"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Andershed", "given": "Anna-Karin", "initials": "AK"}, {"family": "Wall\u00e9n-Mackenzie", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Andershed", "given": "Henrik", "initials": "H"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2019-10-00", "journal": {"title": "Eur Child Adolesc Psychiatry", "issn": "1435-165X", "issn-l": "1018-8827", "volume": "28", "issue": "10", "pages": "1329-1340"}, "abstract": "The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6-6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting.", "doi": "10.1007/s00787-019-01293-w", "pmid": "30805764", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC6785645"}, {"db": "pii", "key": "10.1007/s00787-019-01293-w"}], "notes": [], "created": "2020-09-28T11:50:39.556Z", "modified": "2024-10-24T08:55:50.689Z"}, {"entity": "publication", "iuid": "b0109b53d3f6472682e71fe7246641ea", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b0109b53d3f6472682e71fe7246641ea.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b0109b53d3f6472682e71fe7246641ea"}}, "title": "Association between Transcription Factor AP-2B genotype, obesity, insulin resistance and dietary intake in a longitudinal birth cohort study.", "authors": [{"family": "Joost", "given": "Urmeli", "initials": "U"}, {"family": "Villa", "given": "Inga", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Veidebaum", "given": "Toomas", "initials": "T"}, {"family": "Harro", "given": "Jaanus", "initials": "J", "orcid": "0000-0002-4484-2096", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330.json"}}], "type": "journal article", "published": "2019-10-00", "journal": {"title": "Int J Obes (Lond)", "issn": "1476-5497", "issn-l": "0307-0565", "volume": "43", "issue": "10", "pages": "2095-2106"}, "abstract": "The development of obesity has a large genetic component, and the gene encoding the transcription factor 2 beta (TFAP2B) has been identified as one of the responsible factors. We investigated the effect of TFAP2B intron 2 variable number tandem repeat (VNTR) genotype on obesity, insulin resistance and dietary intake from 15 to 33 years of age.\n\nThe sample included both birth cohorts (originally n = 1176) of the longitudinal Estonian Children Personality Behaviour and Health Study. The association between TFAP2B genotype, and anthropometric measurements, glucose metabolism and dietary intake at ages 15, 18 and 25 years was assessed using the linear mixed-effects regression models. Differences in anthropometric measurements, biochemical measures, blood pressure and dietary intake between TFAP2B genotypes at different age, including data of the older cohort at age 33, were assessed by one-way ANOVA.\n\nMale homozygotes for the TFAP2B 5-repeat allele had significantly higher body weight, body mass index, sum of 5 skinfolds, proportion of body fat, waist circumference, hip circumference, waist-to-hip ratio, waist-to-height ratio, fasting insulin and HOMA index. In female subjects, homozygotes for the TFAP2B 5-repeat allele had significantly larger increase in the rate of change per year in body weight, body mass index and hip circumference between years 15 and 25. By age 33, the findings were similar. A decrease in daily energy intake from adolescence to young adulthood was observed. In males, heterozygotes had significantly smaller decrease in the rate of change per year in daily energy intake.\n\nThe association of TFAP2B with the development of obesity and insulin resistance is present throughout adolescence to young adulthood in males. In females the effect of TFAP2B on obesity appears later, in young adulthood. The TFAP2B effect is rather related to differences in metabolism than energy intake.", "doi": "10.1038/s41366-019-0396-y", "pmid": "31209268", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41366-019-0396-y"}], "notes": [], "created": "2020-09-28T11:49:43.996Z", "modified": "2024-10-24T08:55:35.643Z"}, {"entity": "publication", "iuid": "f321d09d68f34127a282adc16ddaaf79", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f321d09d68f34127a282adc16ddaaf79.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f321d09d68f34127a282adc16ddaaf79"}}, "title": "Early life stress and voluntary alcohol consumption in relation to Maoa methylation in male rats.", "authors": [{"family": "Bendre", "given": "Megha", "initials": "M"}, {"family": "Granholm", "given": "Linnea", "initials": "L"}, {"family": "Drennan", "given": "Ryan", "initials": "R"}, {"family": "Meyer", "given": "Ann", "initials": "A"}, {"family": "Yan", "given": "Liying", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2019-09-00", "journal": {"title": "Alcohol", "issn": "1873-6823", "issn-l": "0741-8329", "volume": "79", "issue": null, "pages": "7-16"}, "abstract": "Early life stress (ELS) or alcohol consumption can influence DNA methylation and affect gene expression. Monoamine oxidase A (Maoa) encodes the enzyme that metabolizes monoaminergic neurotransmitters crucial for the stress response, alcohol reward, and reinforcement. Previously, we reported lower Maoa expression in the nucleus accumbens and dorsal striatum of male rats exposed to ELS during the first three postnatal weeks, and to voluntary alcohol consumption in adulthood, compared with controls. The present study continued to investigate the effect of ELS and alcohol consumption on Maoa methylation, and its relation to Maoa expression in these animals. We selected candidate CpGs after performing next-generation bisulfite sequencing of the Maoa promoter, intron 1-5, and exons 5 and 6, together composed of 107 CpGs (5'-cytosine-phosphate-guanosine-3'), in a subgroup of rats. Pyrosequencing was used to analyze the methylation of 10 candidate CpGs in the promoter and intron 1 in the entire sample. ELS and alcohol displayed an interactive effect on CpG-specific methylation in the dorsal striatum. CpG-specific methylation correlated with Maoa expression, corticosterone levels, and alcohol consumption in a brain region-specific manner. CpG-specific methylation in the Maoa promoter was a potential moderator of the interaction of ELS with alcohol consumption on Maoa expression in the NAc. However, the findings were sparse, did not survive correction for multiple testing, and the magnitude of differences in methylation levels was small. In conclusion, CpG-specific Maoa methylation in the promoter and intron 1 may associate with ELS, alcohol consumption, and Maoa expression in reward-related brain regions.", "doi": "10.1016/j.alcohol.2018.11.001", "pmid": "30414913", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0741-8329(18)30238-6"}], "notes": [], "created": "2020-09-28T11:47:34.637Z", "modified": "2024-10-24T08:55:55.051Z"}, {"entity": "publication", "iuid": "e7dc8eace75944eca577dda88d59a52a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e7dc8eace75944eca577dda88d59a52a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e7dc8eace75944eca577dda88d59a52a"}}, "title": "Hypothalamic-pituitary-adrenal axis responsiveness, startle response, and sensorimotor gating in late pregnancy.", "authors": [{"family": "Breedh", "given": "Julia", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Hellgren", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-4329-6721", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ca2583f7cf24960ab99f52f46249644.json"}}, {"family": "Papadopoulos", "given": "Fotios C", "initials": "FC"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Poromaa", "given": "Inger Sundstr\u00f6m", "initials": "IS", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}], "type": "journal article", "published": "2019-08-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "issn-l": "0306-4530", "volume": "106", "issue": null, "pages": "1-8"}, "abstract": "During pregnancy, the hypothalamic-pituitary-adrenal (HPA) axis, the main regulator of the stress response, undergoes dramatic changes. The acoustic startle response (ASR) and the prepulse inhibition (PPI) of the startle response are neurophysiological research tools and objective measures of an individual's response to an emotional context or stressor. The ASR and PPI are influenced by psychiatric diseases characterized by anxiety symptoms and are sensitive to cortisol. Hence, the ASR and the PPI can be used to investigate the effects of pregnancy-induced endocrine changes and their contribution to affective disorders. The present study sought to investigate the association between measures of HPA-axis responsiveness, startle reactivity and sensorimotor gating during pregnancy that to date remains unknown. The eye-blink component of the ASR, and its prepulse inhibition, were measured in 107 late third trimester pregnant women. Saliva samples were collected to assess the cortisol awakening response (CAR), a measure of HPA-axis activity. Blood was sampled to measure serum levels of cortisol, cortisone and the cortisone to cortisol ratio. Ongoing anxiety disorders, sleep duration, smoking, and age were considered as potential confounders in the statistical analyses. CAR reactivity, measured as area under the curve (AUC) increase and above baseline, was positively associated with baseline startle magnitude [Cohen's d = 0.27; F (1, 105) = 4.99; p = 0.028, and Cohen's d = 0.30; F (1, 105) = 6.25; p = 0.014, respectively] as well as PPI at 86 dB [Cohen's d = 0.29; F (1, 105) = 5.93; p = 0.017; and Cohen's d = 0.34; F (1, 105) = 8.38; p = 0.005, respectively]. The observed positive correlation between startle magnitude in pregnant women and greater increase in cortisol during the awakening response may be interpreted as heightened neurophysiological reactivity, likely associated with dysregulation of the stress system.", "doi": "10.1016/j.psyneuen.2019.03.008", "pmid": "30927623", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(18)31160-0"}], "notes": [], "created": "2020-09-28T11:48:54.286Z", "modified": "2024-10-24T08:55:49.523Z"}, {"entity": "publication", "iuid": "d82b9d5bf06246d9bba1a30870ca7b00", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d82b9d5bf06246d9bba1a30870ca7b00.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d82b9d5bf06246d9bba1a30870ca7b00"}}, "title": "Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study.", "authors": [{"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Poromaa", "given": "Inger Sundstr\u00f6m", "initials": "IS", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}, {"family": "Iliadis", "given": "Stavros I", "initials": "SI"}, {"family": "Huizink", "given": "Anja C", "initials": "AC"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-4329-6721", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ca2583f7cf24960ab99f52f46249644.json"}}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2019-05-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "issn-l": "0306-4530", "volume": "103", "issue": null, "pages": "296-305"}, "abstract": "Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected. In sub-studies, salivary cortisol awakening response in gestational week 35-39, salivary evening cortisol levels in gestational week 36 and postpartum week 6, and blood cortisol and cortisone levels in gestational week 35-39 were analyzed. SNP-set kernel association tests were performed at the gene-level, considering psychosocial and demographic factors, followed by post-hoc analyses of SNPs of significant genes. Statistically significant findings at the 0.05 p-level included SNPs in the hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) gene in relation to self-rated depression scores in postpartum week six among all participants, and serpin family A member 6 (SERPINA6) gene at the same time-point among women with de novo onset of postpartum depression. SNPs in these genes also associated with stress hormone levels during pregnancy. The present study adds knowledge to the neurobiological basis of peripartum depression by systematically assessing SNPs in stress-regulatory genes and stress-hormone levels in a population-based sample of women.", "doi": "10.1016/j.psyneuen.2019.02.002", "pmid": "30776573", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(18)31036-9"}], "notes": [], "created": "2020-09-28T11:51:05.734Z", "modified": "2024-10-24T08:55:51.718Z"}, {"entity": "publication", "iuid": "1b57e00b3f7147a4b4fad594623fa821", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1b57e00b3f7147a4b4fad594623fa821.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1b57e00b3f7147a4b4fad594623fa821"}}, "title": "Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age.", "authors": [{"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Bixo", "given": "Marie", "initials": "M"}, {"family": "Jensen", "given": "Peter", "initials": "P"}, {"family": "Frokjaer", "given": "Vibe G", "initials": "VG"}], "type": "journal article", "published": "2019-01-11", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "9", "issue": null, "pages": "2767"}, "abstract": "Allopregnanolone is a metabolite of the sex hormone progesterone, with suggested relevance for female mood disorders. While allopregnanolone and serotonin are known to influence psychological well-being, the molecular and psychological specifics of their relationship are to date poorly understood, especially in women of fertile age who experience regular fluctuations of progesterone across the menstrual cycle. Availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (SERT), which can be imaged in the living human brain by use of positron emission tomography (PET) and the radiotracer [11C]DASB. To evaluate sex-specific allopregnanolone-SERT interactions, the present study investigated the relationship between cerebral SERT availability, serum allopregnanolone levels and psychological well-being in women of fertile age. Brain imaging data, self-reported symptoms of mental distress and emotion regulation, and biobank material from ninety healthy women were available from the Center for Integrated Molecular Brain Imaging (CIMBI) database. Age, BMI, and daylight minutes were included as covariates in the analyses and SERT genotype (5-HTTLPR) was considered a potential confounder. Lower serum allopregnanolone levels were associated with higher SERT binding in the prefrontal cortex. Moreover, allopregnanolone levels were negatively associated with measures of alertness, although this finding was not mediated by prefrontal cortex SERT binding. These findings suggest a link between the typical psychological well-being experienced in the follicular phase when allopregnanolone levels are low and higher SERT in the prefrontal cortex, a region for higher cognitive functions and top-down regulation of emotions.", "doi": "10.3389/fpsyg.2018.02767", "pmid": "30687199", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC6336902"}], "notes": [], "created": "2020-09-28T11:49:17.346Z", "modified": "2024-10-24T08:55:52.868Z"}, {"entity": "publication", "iuid": "203d7d9e40a344ecba3fe69540c125a7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/203d7d9e40a344ecba3fe69540c125a7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/203d7d9e40a344ecba3fe69540c125a7"}}, "title": "Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.", "authors": [{"family": "Nilsson", "given": "Kent W", "initials": "KW", "orcid": "0000-0002-8853-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae97f7e5d3e7452d82e3f13e4c1a0a58.json"}}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Oreland", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2018-11-00", "journal": {"title": "J Neural Transm (Vienna)", "issn": "1435-1463", "issn-l": "0300-9564", "volume": "125", "issue": "11", "pages": "1601-1626"}, "abstract": "Since the pioneering finding of Caspi and co-workers in 2002 that exposure to childhood maltreatment predicted later antisocial behaviour (ASB) in male carriers of the low-activity MAOA-uVNTR allele, frequent replication studies have been published. Two meta-analyses, one in 2006 and the other in 2014, confirmed the original findings by Caspi and co-workers. In the present paper, we review the literature, note some methodological aspects of candidate gene-environment interaction (cG\u00d7E) studies and suggest some future directions. Our conclusions are as follows. (1) The direction of the effect in a cG\u00d7E model may differ according to the positive and negative environmental background of the population. (2) There is a predictor-intersection problem such that when measuring one type of maltreatment in a person, other kinds of maltreatment often co-occur. Other forms of abuse are implicitly considered in statistical models; therefore, it is difficult to draw conclusions about the effects of timing and the severity of different forms of stressful life events in relation to ASB. (3) There is also an outcome-intersection problem because of the major intersection of ASB and other forms of mental health problems. It is likely that the G\u00d7E with MAOA is related to a common unmeasured factor. (4) For the G\u00d7E model, in which the effect of the gene on the outcome variable is dependent on other predictor variables, theoretically, hypothesis-driven statistical modelling is needed.", "doi": "10.1007/s00702-018-1892-2", "pmid": "29881923", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC6224008"}, {"db": "pii", "key": "10.1007/s00702-018-1892-2"}], "notes": [], "created": "2020-09-28T11:47:08.435Z", "modified": "2024-10-24T08:55:56.290Z"}, {"entity": "publication", "iuid": "85343616348e49eda11811df03c1d971", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/85343616348e49eda11811df03c1d971.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/85343616348e49eda11811df03c1d971"}}, "title": "Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women.", "authors": [{"family": "Checknita", "given": "David", "initials": "D", "orcid": "0000-0002-7005-2565", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fe9698b38e6443181505573bcb03e73.json"}}, {"family": "Ekstr\u00f6m", "given": "Tomas J", "initials": "TJ"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}], "type": "journal article", "published": "2018-07-00", "journal": {"title": "J Neural Transm (Vienna)", "issn": "1435-1463", "issn-l": "0300-9564", "volume": "125", "issue": "7", "pages": "1053-1064"}, "abstract": "Childhood physical abuse (PA) and sexual abuse (SA) interact with monoamine oxidase A (MAOA) gene polymorphism to modify risk for mental disorders. In addition, PA and SA may alter gene activity through epigenetic mechanisms such as DNA methylation, thereby further modifying risk for disorders. We investigated whether methylation in a region spanning the MAOA first exon and part of the first intron was associated with PA and/or SA, MAOA genotype, alcohol dependence, drug dependence, depression disorders, anxiety disorders, and conduct disorder. 114 Swedish women completed standardized diagnostic interviews and questionnaires to report PA and SA, and provided saliva samples for DNA extraction. DNA was genotyped for MAOA-uVNTR polymorphisms, and methylation of a MAOA region of interest (chrX: 43,515,544-43,515,991) was measured. SA, not PA, was associated with hypermethylation of the MAOA first exon relative to no-abuse, and the association was robust to adjustment for psychoactive medication, alcohol and drug dependence, and current substance use. SA and MAOA-uVNTR genotype, but not their interaction, was associated with MAOA methylation. SA associated with all measured mental disorders. Hypermethylation of MAOA first exon mediated the association of SA with current depression, and both methylation levels and SA independently predicted lifetime depression. Much remains to be learned about the independent effects of SA and MAOA-uVNTR genotypes on methylation of the MAOA first exon.", "doi": "10.1007/s00702-018-1875-3", "pmid": "29600412", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5999185"}, {"db": "pii", "key": "10.1007/s00702-018-1875-3"}], "notes": [], "created": "2020-09-28T11:44:15.816Z", "modified": "2024-10-24T08:55:58.637Z"}, {"entity": "publication", "iuid": "cfc14dffb1ee46849f09df795fba49a4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cfc14dffb1ee46849f09df795fba49a4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cfc14dffb1ee46849f09df795fba49a4"}}, "title": "Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents.", "authors": [{"family": "Olofsdotter", "given": "Susanne", "initials": "S"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Furmark", "given": "Tomas", "initials": "T"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2018-05-00", "journal": {"title": "Dev Psychopathol", "issn": "1469-2198", "issn-l": "0954-5794", "volume": "30", "issue": "2", "pages": "449-459"}, "abstract": "Social anxiety is one of the most commonly reported mental health problems among adolescents, and it has been suggested that parenting style influences an adolescent's level of anxiety. A context-dependent effect of oxytocin on human social behavior has been proposed; however, research on the oxytocin gene (OXT) has mostly been reported without considering contextual factors. This study investigated the interactions between parenting style and polymorphic variations in the OXT gene in association with social anxiety symptoms in a community sample of adolescents (n = 1,359). Two single nucleotide polymorphisms linked to OXT, rs4813625 and rs2770378, were genotyped. Social anxiety and perceived parenting style were assessed by behavioral questionnaires. In interaction models adjusted for sex, significant interaction effects with parenting style were observed for both variants in relation to social anxiety. The nature of the interactions was in line with the differential susceptibility framework for rs4813625, whereas for rs2770378 the results indicated a diathesis-stress type of interaction. The findings may be interpreted from the perspective of the social salience hypothesis of oxytocin, with rs4813625 affecting social anxiety levels along a perceived unsafe-safe social context dimension.", "doi": "10.1017/S0954579417000967", "pmid": "28606214", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0954579417000967"}], "notes": [], "created": "2018-12-03T14:46:06.282Z", "modified": "2024-10-24T08:56:16.066Z"}, {"entity": "publication", "iuid": "03a627a608694dfe97d8b135c763d163", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/03a627a608694dfe97d8b135c763d163.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/03a627a608694dfe97d8b135c763d163"}}, "title": "Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers.", "authors": [{"family": "Andreou", "given": "Dimitrios", "initials": "D"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}], "type": "journal article", "published": "2018-03-22", "journal": {"title": "Front. Hum. Neurosci.", "issn": "1662-5161", "issn-l": "1662-5161", "volume": "12", "issue": null, "pages": "112"}, "abstract": "The oxytocin receptor gene (OXTR) influences human behavior. The G allele of OXTR rs53576 has been associated with both prosocial and maladaptive behaviors but few studies have taken account of environmental factors. The present study determined whether the association of childhood maltreatment with conduct problems was modified by OXTR rs53576 genotypes. In a general population sample of 1591 teenagers, conduct problems as well as maltreatment were measured by self-report. DNA was extracted from saliva samples. In males, there was a significant positive association between maltreatment and conduct problems independent of the genotype. In females, among G allele carriers, the level of conduct problems was significantly higher among those who had been maltreated as compared to those not maltreated. By contrast, among female AA carriers, conduct problems did not vary between those who were, and who were not, maltreated. The results indicate that OXTR rs53576 plays a role in antisocial behavior in females such that the G allele confers vulnerability for antisocial behavior if they experience maltreatment, whereas the A allele has a protective effect.", "doi": "10.3389/fnhum.2018.00112", "pmid": "29623035", "labels": {"Affiliated researcher": null, "Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5874495"}], "notes": [], "created": "2018-12-03T14:45:41.153Z", "modified": "2024-10-24T08:55:57.453Z"}, {"entity": "publication", "iuid": "83cebeefb6bd4e8da302d5c1104f0bca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/83cebeefb6bd4e8da302d5c1104f0bca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/83cebeefb6bd4e8da302d5c1104f0bca"}}, "title": "Associations Between MAOA-uVNTR Genotype, Maltreatment, MAOA Methylation, and Alcohol Consumption in Young Adult Males.", "authors": [{"family": "Bendre", "given": "Megha", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Checknita", "given": "Dave", "initials": "D"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2018-03-00", "journal": {"title": "Alcohol Clin Exp Res", "issn": "1530-0277", "issn-l": "0145-6008", "volume": "42", "issue": "3", "pages": "508-519"}, "abstract": "Epigenetic mechanisms are candidate moderators of the effect of maltreatment on brain and behavior. Interactions between maltreatment and the monoamine oxidase A upstream variable number tandem repeat genotype (MAOA-uVNTR) are associated with alcohol-related problems. However, presently it is not known whether DNA methylation moderates this association. The study focused on 53 young adult males and aimed to determine whether MAOA methylation moderated the association of alcohol-related problems with the interaction of MAOA-uVNTR and maltreatment, and whether alcohol consumption moderated the association of MAOA methylation with the interaction of MAOA-uVNTR and maltreatment.\n\nMAOA-uVNTR genotypes with \u2264 3 and > 3 repeats were categorized as short (S) and long (L), respectively. Data on maltreatment were obtained retrospectively, using self-reported questionnaires. DNA methylation of 16 candidate CpGs within part of the MAOA first exon and intron was assessed and grouped based on principal component analyses. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test (AUDIT). Alcohol consumption was measured using AUDIT-C. Moderation effects were assessed and probed using the moderated moderation model and Johnson-Neyman's method, respectively.\n\nCarriers of the S allele, who experienced maltreatment and displayed lower Component 1 (mean of CpGs 13-16 in the first intron) MAOA methylation levels, reported higher AUDIT score in contrast to L-allele carriers. Carriers of the S allele, who reported higher AUDIT-C score and experienced maltreatment, displayed lower Component 3 (mean of CpGs 2-6 in the first exon) MAOA methylation levels than L-allele carriers.\n\nIntronic methylation moderated the association of alcohol-related problems with the interaction of MAOA-uVNTR and maltreatment. Alcohol consumption moderated the association of exonic methylation with the interaction of MAOA-uVNTR and maltreatment. These results suggest that epigenetic factors as well as genotype and maltreatment play a role in the development of alcohol misuse among young adult males.", "doi": "10.1111/acer.13578", "pmid": "29222910", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2018-12-03T14:45:16.869Z", "modified": "2024-10-24T08:56:11.567Z"}, {"entity": "publication", "iuid": "d57cd1068a8a4d0bb2f029a0fa136cd9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d57cd1068a8a4d0bb2f029a0fa136cd9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d57cd1068a8a4d0bb2f029a0fa136cd9"}}, "title": "Personality as an intermediate phenotype for genetic dissection of alcohol use disorder.", "authors": [{"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Lagravinese", "given": "Gianvito", "initials": "G"}, {"family": "Toffoletto", "given": "Simone", "initials": "S"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Harro", "given": "Jaanus", "initials": "J"}, {"family": "Robert Cloninger", "given": "C", "initials": "C"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2018-01-00", "journal": {"title": "J Neural Transm (Vienna)", "issn": "1435-1463", "issn-l": "0300-9564", "volume": "125", "issue": "1", "pages": "107-130"}, "abstract": "Genetic and environmental interactive influences on predisposition to develop alcohol use disorder (AUD) account for the high heterogeneity among AUD patients and make research on the risk and resiliency factors complicated. Several attempts have been made to identify the genetic basis of AUD; however, only few genetic polymorphisms have consistently been associated with AUD. Intermediate phenotypes are expected to be in-between proxies of basic neuronal biological processes and nosological symptoms of AUD. Personality is likely to be a top candidate intermediate phenotype for the dissection of the genetic underpinnings of different subtypes of AUD. To date, 38 studies have investigated personality traits, commonly assessed by the Cloninger's Tridimensional Personality Questionnaire (TPQ) or Temperament and Character Inventory (TCI), in relation to polymorphisms of candidate genes of neurotransmitter systems in alcohol-dependent patients. Particular attention has been given to the functional polymorphism of the serotonin transporter gene (5-HTTLPR), however, leading to contradictory results, whereas results with polymorphisms in other candidate monoaminergic genes (e.g., tryptophan hydroxylase, serotonin receptors, monoamine oxidases, dopamine receptors and transporter) are sparse. Only one genome-wide association study has been performed so far and identified the ABLIM1 gene of relevance for novelty seeking, harm avoidance and reward dependence in alcohol-dependent patients. Studies investigating genetic factors together with personality could help to define more homogenous subgroups of AUD patients and facilitate treatment strategies. This review also urges the scientific community to combine genetic data with psychobiological and environmental data to further dissect the link between personality and AUD.", "doi": "10.1007/s00702-016-1672-9", "pmid": "28054193", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5754455"}, {"db": "pii", "key": "10.1007/s00702-016-1672-9"}], "notes": [], "created": "2018-12-03T14:44:11.481Z", "modified": "2024-10-24T08:56:21.507Z"}, {"entity": "publication", "iuid": "112d332444da455cbad00a93443633f9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/112d332444da455cbad00a93443633f9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/112d332444da455cbad00a93443633f9"}}, "title": "Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure.", "authors": [{"family": "Comasco", "given": "E", "initials": "E"}, {"family": "Rangmar", "given": "J", "initials": "J"}, {"family": "Eriksson", "given": "U J", "initials": "UJ"}, {"family": "Oreland", "given": "L", "initials": "L"}], "type": "journal article", "published": "2018-01-00", "journal": {"title": "Acta Physiol", "issn": "1748-1716", "issn-l": "1748-1708", "volume": "222", "issue": "1", "pages": "e12892"}, "abstract": "Several explanations for the diverse results in research on foetal alcohol spectrum disorders or alcohol-related neurodevelopmental disorder might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and post-natal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed. Special focus is put on the serotonergic system within developmental and gene-environment frameworks. The review also suggests guidelines for future studies and also summarizes some of to-be-answered questions of relevance to clinical practice. Contradictory findings and paucity of studies on the effects of exposure to low alcohol levels during foetal life for the offspring's neuropsychological development call for large prospective studies, as well as for studies including neuroimaging and multi-omics analyses to dissect the neurobiological underpinnings of alcohol exposure-related phenotypes and to identify biomarkers. Finally, it remains to be investigated whether any safe threshold of alcohol drinking during pregnancy can be identified.", "doi": "10.1111/apha.12892", "pmid": "28470828", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2018-12-03T14:44:18.512Z", "modified": "2024-10-24T08:56:18.141Z"}, {"entity": "publication", "iuid": "f666b25e32254f2f978fc24f7280ee52", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f666b25e32254f2f978fc24f7280ee52.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f666b25e32254f2f978fc24f7280ee52"}}, "title": "COMT genotype and non-recovery after a whiplash injury in a Northern European population.", "authors": [{"family": "Rydman", "given": "Eric", "initials": "E", "orcid": "0000-0002-3603-4419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef37b910723b474e96bea313a8b67d9a.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Pettersson", "given": "H", "initials": "H"}, {"family": "Oreland", "given": "L", "initials": "L"}, {"family": "Ponzer", "given": "S", "initials": "S"}, {"family": "Ottosson", "given": "C", "initials": "C"}], "type": "journal article", "published": "2017-12-01", "journal": {"title": "BMC Musculoskelet Disord", "issn": "1471-2474", "issn-l": "1471-2474", "volume": "18", "issue": "1", "pages": "507"}, "abstract": "The COMT (Catechol-O-Methyl Transferase) gene may influence a person's vulnerability to develop long-term pain and some COMT single nucleotide polymorphisms (SNPs) may associate with patterns of acute or chronic pain. Many patients with whiplash-associated disorders (WADs) suffer from long-term pain and other related symptoms, but it is less known if genetic factors play a role in the recovery process. The primary aim of this study was to evaluate whether self-reported non-recovery, including pain, was related to COMT genotype in patients with WAD. The secondary aim was to investigate whether or not background factors, including mental health, were related to genotype and non-recovery.\n\nA total of 133 patients with neck pain after a whiplash trauma were included. Background factors were collected and blood samples were taken during the acute phase after the accident. DNA was isolated from blood and used to genotype the SNPs rs6269, rs4633, rs4818 and rs4680 in the COMT gene; additionally haplotypes were estimated and haplogenotypes inferred. The patients were followed up after 12 months and asked to rate their recovery including pain, mental health and quality of life.\n\nThe overall reported non-recovery rate at 12 months was 44% with no significant differences in distribution of the COMT haplotypes. High levels of self-reported pain (OR 7.2) and anxiety (OR 4.4) after the accident were associated with non-recovery, but not related to the haplotypes. None of the other background factors were related to the haplotypes or non-recovery.\n\nNo association between self-reported non-recovery or pain levels and COMT haplotypes in patients with acute whiplash injuries could be detected. Independent replications are necessary to discard the hypothesis that COMT haplotypes do not influence non-recovery or pain levels in patients with acute whiplash injuries. High levels of initial pain and anxiety were associated with non-recovery, thereby confirming previously published reports.", "doi": "10.1186/s12891-017-1810-z", "pmid": "29195501", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5709856"}, {"db": "pii", "key": "10.1186/s12891-017-1810-z"}], "notes": [], "created": "2020-11-20T09:23:58.956Z", "modified": "2024-10-24T08:56:12.833Z"}, {"entity": "publication", "iuid": "5a1d6933b37b496bae8cd2cac7dc5bdb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5a1d6933b37b496bae8cd2cac7dc5bdb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5a1d6933b37b496bae8cd2cac7dc5bdb"}}, "title": "Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain.", "authors": [{"family": "Kallak", "given": "Theodora Kunovac", "initials": "TK"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Sandelin-Francke", "given": "Lotta", "initials": "L"}, {"family": "Ubhayasekhera", "given": "Kumari", "initials": "K"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Axelsson", "given": "Ove", "initials": "O"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Campbell", "given": "Rebecca E", "initials": "RE"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2017-10-00", "journal": {"title": "Eur. J. Endocrinol.", "issn": "1479-683X", "issn-l": "0804-4643", "volume": "177", "issue": "4", "pages": "379-388"}, "abstract": "Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses.\n\nBlood samples from pregnant women (n = 216) obtained in gestational weeks 35-39, and pre-labor amniotic fluid samples from female fetuses (n = 56), taken at planned Caesarean section or in conjunction with amniotomy for induction of labor, were analyzed. Maternal serum testosterone and amniotic fluid testosterone and cortisol were measured by tandem mass spectrometry.\n\nMultiparity (\u03b2 = -0.28, P < 0.001), self-rated depression (\u03b2 = 0.26, P < 0.001) and weight gain (\u03b2 = 0.18, P < 0.05) were independent explanatory factors for the maternal total testosterone levels. Maternal age (\u03b2 = -0.34, P < 0.001), weight gain (\u03b2 = 0.19, P < 0.05) and amniotic fluid cortisol levels (\u03b2 = 0.44, P < 0.001) were independent explanatory factors of amniotic fluid testosterone in female fetuses, explaining 64.3% of the variability in amniotic fluid testosterone.\n\nYoung maternal age and excessive maternal weight gain may increase the prenatal androgen exposure of female fetuses. Further studies are needed to explore this finding.", "doi": "10.1530/EJE-17-0207", "pmid": "28705923", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5597951"}, {"db": "pii", "key": "EJE-17-0207"}], "notes": [], "created": "2020-11-20T09:26:22.072Z", "modified": "2024-10-24T08:56:13.915Z"}, {"entity": "publication", "iuid": "86f30f3b54ac4b5eab3899c9b2c13cb1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/86f30f3b54ac4b5eab3899c9b2c13cb1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/86f30f3b54ac4b5eab3899c9b2c13cb1"}}, "title": "Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans.", "authors": [{"family": "Nylander", "given": "Ingrid", "initials": "I"}, {"family": "Todkar", "given": "Aniruddha", "initials": "A"}, {"family": "Granholm", "given": "Linnea", "initials": "L"}, {"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Bendre", "given": "Megha", "initials": "M"}, {"family": "Boon", "given": "Wout", "initials": "W"}, {"family": "Andershed", "given": "Henrik", "initials": "H"}, {"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2017-10-00", "journal": {"title": "Mol. Neurobiol.", "issn": "1559-1182", "volume": "54", "issue": "8", "pages": "6225-6234", "issn-l": "0893-7648"}, "abstract": "Alcohol misuse has been linked to dysregulation of stress, emotion, and reward brain circuitries. A candidate key mediator of this association is the FK506-binding protein (FKBP5), a negative regulator of the glucocorticoid receptor. The aim of the present study was to further understand the Fkbp5/FKBP5-related genetic underpinnings underlying the relationship between early life social relations and alcohol drinking. The effect of maternal separation and voluntary alcohol drinking on Fkbp5 expression was investigated in the brain of young adult rats, whereas the interaction effect of the functional FKBP5 single nucleotide polymorphism rs1360780 genotype and parent-child relationship on problematic drinking was examined in young adult humans. In rats, Fkbp5 expression in the nucleus accumbens and ventral tegmental area, core regions of the reward system, was affected in a region-dependent manner and in opposite direction by maternal separation and alcohol drinking. Fkbp5 expression in the cingulate cortex was affected by the combined effect of maternal separation and alcohol drinking. In humans, the TT genotype, in the presence of a poor relationship between the child and parents, was associated with problematic drinking behavior. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking. These findings are the first to point to a role of FKBP5 in propensity to alcohol misuse and call for studies of the underlying molecular mechanisms to identify potential drug targets.", "doi": "10.1007/s12035-016-0157-z", "pmid": "27709495", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5583263"}, {"db": "pii", "key": "10.1007/s12035-016-0157-z"}], "notes": [], "created": "2024-10-24T11:30:41.297Z", "modified": "2024-10-24T11:30:53.844Z"}, {"entity": "publication", "iuid": "ea9f1bf14c9f45dfbd59c9df17fb54f9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ea9f1bf14c9f45dfbd59c9df17fb54f9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ea9f1bf14c9f45dfbd59c9df17fb54f9"}}, "title": "The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake.", "authors": [{"family": "Granholm", "given": "Linnea", "initials": "L"}, {"family": "Todkar", "given": "Aniruddah", "initials": "A"}, {"family": "Bergman", "given": "Sofia", "initials": "S"}, {"family": "Nilsson", "given": "Kent", "initials": "K"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}], "type": "journal article", "published": "2017-08-01", "journal": {"title": "Brain Res", "issn": "1872-6240", "issn-l": "0006-8993", "volume": "1668", "issue": null, "pages": "36-45"}, "abstract": "The young brain is highly sensitive to environmental influences that can cause long-term changes in neuronal function, possibly through altered gene expression. The endogenous opioid system continues to mature after birth and because of its involvement in reward, an inadequate maturation of this system could lead to enhanced susceptibility for alcohol use disorder. Recent studies show that the classical reward areas nucleus accumbens and ventral tegmental area are less affected by early life stress whereas endogenous opioids in non-classical areas, e.g. dorsal striatum and amygdala, are highly responsive. The aim was to investigate the interaction between early life conditions and adult voluntary ethanol intake on opioid gene expression. Male Wistar rats were exposed to conventional rearing, 15, or 360min of daily maternal separation (MS) postnatal day 1-21, and randomly assigned to ethanol or water drinking postnatal week 10-16. Rats exposed to early life stress (MS360) had increased opioid receptor gene (Oprm1, Oprd1 and Oprk1) expression in the dorsal striatum. Ethanol drinking was associated with lower striatal Oprd1 and Oprk1 expression solely in rats exposed to early life stress. Furthermore, rats exposed to early life stress had high inherent Pomc expression in the amygdala but low expression after ethanol intake. Thus, adverse events early in life induced changes in opioid gene expression and also influenced the central molecular response to ethanol intake. These long-term consequences of early life stress can contribute to the enhanced risk for excessive ethanol intake and alcohol use disorder seen after exposure to childhood adversity.", "doi": "10.1016/j.brainres.2017.05.006", "pmid": "28511993", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0006-8993(17)30195-6"}], "notes": [], "created": "2020-11-20T09:26:25.652Z", "modified": "2024-10-24T08:56:17.077Z"}, {"entity": "publication", "iuid": "de9ec9afd17147b7a93f579a358d7a33", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/de9ec9afd17147b7a93f579a358d7a33.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/de9ec9afd17147b7a93f579a358d7a33"}}, "title": "Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway.", "authors": [{"family": "Hellgren", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-4329-6721", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ca2583f7cf24960ab99f52f46249644.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2017-08-00", "journal": {"title": "Horm Behav", "issn": "1095-6867", "issn-l": "0018-506X", "volume": "94", "issue": null, "pages": "106-113"}, "abstract": "Allopregnanolone, a neurosteroid whose levels rise throughout gestation, putatively stabilizes antenatal mood. The present study aimed to investigate associations of plasma allopregnanolone to antenatal depressive symptoms, as well as to genetic and obstetric factors. Allopregnanolone plasma levels from 284 pregnant women were measured around gestational week 18. Haplotype tag single nucleotide polymorphisms in the aldo-keto reductase family 1, members C2 and C4 (AKR1C2, AKR1C4), and steroid 5 alpha-reductase 1 and 2 (SRD5A1, and SRD5A2) genes were genotyped in a larger sample of pregnant women (n=1351). The Edinburgh Postnatal Depression Scale (EPDS) was administered via web-questionnaires in gestational weeks 17 and 32. Demographic and obstetric data was retrieved from web-questionnaires and medical records. There was no association between allopregnanolone levels and depressive symptoms. Furthermore, no associations between allopregnanolone level and synthesis pathway genotypes were found after accounting for multiple comparisons. However, exploratory analyses suggested that the women who were homozygous for the minor allele of the AKR1C2 polymorphism rs1937863 had nominally lower allopregnanolone levels and lower depression scores in gestational week 17, but also the highest increase in depression scores between week 17 and 32. Additionally, higher body mass index was associated with lower allopregnanolone levels. The results do not support second trimester plasma allopregnanolone as a mood stabilizing factor. However, we speculate that AKR1C2 variation may alter the susceptibility to depressive symptoms through effects on central allopregnanolone synthesis. Another implication of this study is that the relationship between neuroactive steroids and obesity in pregnancy deserves to be investigated.", "doi": "10.1016/j.yhbeh.2017.06.008", "pmid": "28666923", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0018-506X(17)30026-0"}], "notes": [], "created": "2020-11-20T09:26:23.266Z", "modified": "2024-10-24T08:56:15.004Z"}, {"entity": "publication", "iuid": "d8740c37a90c4224a1f5354e36563d84", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d8740c37a90c4224a1f5354e36563d84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d8740c37a90c4224a1f5354e36563d84"}}, "title": "A Biopsychosocial Approach to Risk and Resilience on Behavior in Children Followed from Birth to Age 12.", "authors": [{"family": "Agnafors", "given": "Sara", "initials": "S", "orcid": "0000-0002-6760-7902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3f27397a434f21a21922c5d19412b3.json"}}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Bladh", "given": "Marie", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sydsj\u00f6", "given": "Gunilla", "initials": "G"}], "type": "journal article", "published": "2017-08-00", "journal": {"title": "Child Psychiatry Hum Dev", "issn": "1573-3327", "issn-l": "0009-398X", "volume": "48", "issue": "4", "pages": "584-596"}, "abstract": "An increasing prevalence of mental health problems calls for more knowledge into factors associated with resilience. The present study used multiple statistical methodologies to examine a biopsychosocial model of risk and resilience on preadolescence behavior. Data from 889 children and mothers from a birth cohort were used. An adversity score was created by combining maternal symptoms of depression, psychosocial risk and children's experiences of life events. The proposed resilience factors investigated were candidate genetic polymorphisms, child temperament, social functioning, and maternal sense of coherence. The l/l genotype of the serotonin transporter linked polymorphic region was associated with lower internalizing scores, but not mainly related to the level of adversity. An easy temperament was associated with resilience for children exposed to high adversity. Social functioning was found to be promotive independent of the risk level. The results support a multiple-level model of resilience indicating effects, though small, of both biological and psychosocial factors.", "doi": "10.1007/s10578-016-0684-x", "pmid": "27628896", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5487709"}, {"db": "pii", "key": "10.1007/s10578-016-0684-x"}], "notes": [], "created": "2020-11-20T09:27:29.195Z", "modified": "2024-10-24T11:30:54.924Z"}, {"entity": "publication", "iuid": "f30ccfb4127c4c47847821ca83333ec3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f30ccfb4127c4c47847821ca83333ec3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f30ccfb4127c4c47847821ca83333ec3"}}, "title": "Emotional anticipation after delivery - a longitudinal neuroimaging study of the postpartum period.", "authors": [{"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Toffoletto", "given": "Simone", "initials": "S"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Engman", "given": "Jonas", "initials": "J"}, {"family": "Bannbers", "given": "Elin", "initials": "E"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2017-03-08", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "7", "issue": "1", "pages": "114"}, "abstract": "Neuroimaging research has begun to unveil the mechanisms behind emotion processing during the postpartum period, which, in turn, may be of relevance for the development of postpartum depression. The present study sought to longitudinally investigate the neural correlates of emotion anticipation during the postpartum period in healthy women. Functional magnetic resonance imaging was employed to measure the blood oxygen level-dependent signal in the brain in response to anticipation of negative emotional stimuli and during processing of images with positive or negative valence. The participating women were scanned twice: the first scan occurred during the first 48 hours after delivery, and the second was performed 4-6 weeks after delivery. The early postpartum period was characterized by higher anterior cingulate cortex reactivity during anticipation of negative emotional stimuli than the late postpartum period. This was accompanied by a negative relationship with insular reactivity during the early postpartum period and a trend towards an increase in insular reactivity in the late postpartum period. Thus, during the first four weeks of the postpartum period, a diminished top-down regulatory feedback on emotion-related areas of the brain was noted. This finding suggests a physiologically important adaptation during the healthy postpartum period.", "doi": "10.1038/s41598-017-00146-3", "pmid": "28273912", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5427895"}, {"db": "pii", "key": "10.1038/s41598-017-00146-3"}], "notes": [], "created": "2020-11-20T09:26:28.021Z", "modified": "2024-10-24T08:56:19.215Z"}, {"entity": "publication", "iuid": "19b03bd3d4744553ae4a2135969f37d7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/19b03bd3d4744553ae4a2135969f37d7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/19b03bd3d4744553ae4a2135969f37d7"}}, "title": "Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress.", "authors": [{"family": "Vrettou", "given": "Maria", "initials": "M"}, {"family": "Granholm", "given": "Linnea", "initials": "L"}, {"family": "Todkar", "given": "Aniruddha", "initials": "A"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Wall\u00e9n-Mackenzie", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2017-03-00", "journal": {"title": "Addict Biol", "issn": "1369-1600", "issn-l": "1355-6215", "volume": "22", "issue": "2", "pages": "369-380"}, "abstract": "Alcohol use disorder is the outcome of both genetic and environmental influences and their interaction via epigenetic mechanisms. The neurotransmitter glutamate is an important regulator of reward circuits and implicated in adaptive changes induced by ethanol intake. The present study aimed at investigating corticolimbic and corticostriatal genetic signatures focusing on the glutamatergic phenotype in relation to early-life stress (ELS) and consequent adult ethanol consumption. A rodent maternal separation model was employed to mimic ELS, and a free-choice paradigm was used to assess ethanol intake in adulthood. Gene expression levels of the Vesicular Glutamate Transporters (Vglut) 1, 2 and 3, as well as two key regulators of DNA methylation, DNA (cytosine-5)-methyltransferase 1 (Dnmt1) and methyl-CpG-binding protein 2 (Mecp2), were analyzed. Brain regions of interest were the ventral tegmental area (VTA), nucleus accumbens (Acb), medial prefrontal cortex (mPFC) and dorsal striatum (dStr), all involved in mediating aspects of ethanol reward. Region-specific Vglut, Dnmt1 and Mecp2 expression patterns were observed. ELS was associated with down-regulated expression of Vglut2 in the VTA and mPFC. Rats exposed to ELS were more sensitive to ethanol-induced changes in Vglut expression in the VTA, Acb, and dStr and in Dnmt1 and Mecp2 expression in the striatal regions. These findings suggest long-term glutamatergic and DNA methylation neuroadaptations as a consequence of ELS, and show an association between voluntary drinking in non-preferring, non-dependent, rodents and different Vglut, Dnmt1 and Mecp2 expression depending on early-life history.", "doi": "10.1111/adb.12331", "pmid": "26610727", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:28:49.445Z", "modified": "2024-10-24T11:30:31.035Z"}, {"entity": "publication", "iuid": "13a11e4f7c994807bebdfe7901f1ecf6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/13a11e4f7c994807bebdfe7901f1ecf6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/13a11e4f7c994807bebdfe7901f1ecf6"}}, "title": "Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Vumma", "given": "Ravi", "initials": "R"}, {"family": "Toffoletto", "given": "Simone", "initials": "S"}, {"family": "Johansson", "given": "Jessica", "initials": "J"}, {"family": "Flyckt", "given": "Lena", "initials": "L"}, {"family": "Lewander", "given": "Tommy", "initials": "T"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Bjerkenstedt", "given": "Lars", "initials": "L"}, {"family": "Andreou", "given": "Dimitrios", "initials": "D"}, {"family": "S\u00f6derman", "given": "Erik", "initials": "E"}, {"family": "Terenius", "given": "Lars", "initials": "L"}, {"family": "Agartz", "given": "Ingrid", "initials": "I"}, {"family": "J\u00f6nsson", "given": "Erik G", "initials": "EG"}, {"family": "Venizelos", "given": "Nikolaos", "initials": "N"}], "type": "journal article", "published": "2017-02-11", "journal": {"title": "Neuropsychobiology", "issn": "1423-0224", "issn-l": "0302-282X", "volume": "74", "issue": "2", "pages": "96-103"}, "abstract": "Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Moreover, the involvement of the different isoforms of the system L in tyrosine uptake and LAT1 tyrosine kinetics were studied in fibroblast cell lines of 10 patients with schizophrenia and 10 healthy controls. The results provide suggestive evidence of individual vulnerability to schizophrenia related to the LAT1 SNP rs9936204 genotype. A number of SNPs were nominally associated with CSF HVA and MHPG concentrations but did not survive correction for multiple testing. The LAT1 isoform was confirmed as the major tyrosine transporter in patients with schizophrenia. However, the kinetic parameters (maximal transport capacity, affinity of the binding sites, and diffusion constant of tyrosine transport through the LAT1 isoform) did not differ between patients with schizophrenia and controls. The present genetic findings call for independent replication in larger samples, while the functional study seems to exclude a role of LAT1 in the aberrant transport of tyrosine in fibroblasts of patients with schizophrenia.", "doi": "10.1159/000455234", "pmid": "28190014", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "000455234"}], "notes": [], "created": "2020-11-20T09:26:29.166Z", "modified": "2024-10-24T08:56:20.347Z"}, {"entity": "publication", "iuid": "a54b89e88d834fc3b886771f7c3966cd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a54b89e88d834fc3b886771f7c3966cd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a54b89e88d834fc3b886771f7c3966cd"}}, "title": "Sex differences in depression during pregnancy and the postpartum period.", "authors": [{"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Georgakis", "given": "Marios K", "initials": "MK"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2017-01-02", "journal": {"title": "J Neurosci Res", "issn": "1097-4547", "issn-l": "0360-4012", "volume": "95", "issue": "1-2", "pages": "719-730"}, "abstract": "Women have a lifetime risk of major depression double that of men but only during their reproductive years. This sex difference has been attributed partially to activational effects of female sex steroids and also to the burdens of pregnancy, childbirth, and parenting. Men, in contrast, have a reproductive period difficult to delineate, and research on the mental health of men has rarely considered the effects of fatherhood. However, the couple goes through a number of potentially stressing events during the reproductive period, and both mothers and fathers are at risk of developing peripartum depression. This Review discusses the literature on maternal and paternal depression and the endocrine changes that may predispose a person to depression at this stage of life, with specific focus on the hypothalamus-pituitary axis, oxytocin, and testosterone levels in men. Important findings on sex differences in the neural correlates of maternal and paternal behavior have emerged, highlighting the relevance of the emotional brain in mothers and the sociocognitive brain in fathers and pointing toward the presence of a common parents' brain. Additionally, sex differences in neurogenesis and brain plasticity are described in relation to peripartum depression. \u00a9 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc.", "doi": "10.1002/jnr.23859", "pmid": "27870443", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5129485"}], "notes": [], "created": "2020-11-20T09:26:31.751Z", "modified": "2024-10-24T11:30:51.539Z"}, {"entity": "publication", "iuid": "2305a44d089748ae918e99d407631fd9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2305a44d089748ae918e99d407631fd9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2305a44d089748ae918e99d407631fd9"}}, "title": "Associations between a polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene, neuroticism and postpartum depression.", "authors": [{"family": "Iliadis", "given": "S I", "initials": "SI"}, {"family": "Comasco", "given": "E", "initials": "E"}, {"family": "Hellgren", "given": "C", "initials": "C"}, {"family": "Kollia", "given": "N", "initials": "N"}, {"family": "Sundstr\u00f6m Poromaa", "given": "I", "initials": "I"}, {"family": "Skalkidou", "given": "A", "initials": "A"}], "type": "journal article", "published": "2017-01-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": "0165-0327", "volume": "207", "issue": null, "pages": "141-147"}, "abstract": "This study examined the association between a single nucleotide polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene and neuroticism, as well as the possible mediatory role of neuroticism in the association between the polymorphism and postpartum depressive symptoms.\n\n769 women received questionnaires containing the Edinburgh Postnatal Depression Scale (EPDS) at six weeks postpartum and demographic data at pregnancy week 17 and 32 and at six weeks postpartum, as well as the Swedish universities Scales of Personality at pregnancy week 32.\n\nLinear regression models showed an association between the GG genotype and depressive symptoms. When neuroticism was introduced in the model, it was associated with EPDS score, whereas the association between the GG genotype and EPDS became borderline significant. A path analysis showed that neuroticism had a mediatory role in the association between the polymorphism and EPDS score.\n\nThe use of the EPDS, which is a self-reporting instrument.\n\nNeuroticism was associated with the polymorphism and had a mediatory role in the association between the polymorphism and postpartum depression. This finding elucidates the genetic background of neuroticism and postpartum depression.", "doi": "10.1016/j.jad.2016.09.030", "pmid": "27721188", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(16)31047-3"}], "notes": [], "created": "2020-11-20T09:26:32.873Z", "modified": "2024-10-24T11:30:52.670Z"}, {"entity": "publication", "iuid": "5c6126b0406e4712bf774abdb195f00c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5c6126b0406e4712bf774abdb195f00c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5c6126b0406e4712bf774abdb195f00c"}}, "title": "MID-PREGNANCY CORTICOTROPIN-RELEASING HORMONE LEVELS IN ASSOCIATION WITH POSTPARTUM DEPRESSIVE SYMPTOMS.", "authors": [{"family": "Iliadis", "given": "Stavros I", "initials": "SI"}, {"family": "Sylv\u00e9n", "given": "Sara", "initials": "S"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Olivier", "given": "Jocelien D", "initials": "JD"}, {"family": "Schijven", "given": "Dick", "initials": "D"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Chrousos", "given": "George P", "initials": "GP"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2016-11-00", "journal": {"title": "Depress Anxiety", "issn": "1520-6394", "volume": "33", "issue": "11", "pages": "1023-1030", "issn-l": "1091-4269"}, "abstract": "Peripartum depression is a common cause of pregnancy- and postpartum-related morbidity. The production of corticotropin-releasing hormone (CRH) from the placenta alters the profile of hypothalamus-pituitary-adrenal axis hormones and may be associated with postpartum depression. The purpose of this study was to assess, in nondepressed pregnant women, the possible association between CRH levels in pregnancy and depressive symptoms postpartum.\n\nA questionnaire containing demographic data and the Edinburgh Postnatal Depression Scale (EPDS) was filled in gestational weeks 17 and 32, and 6 week postpartum. Blood samples were collected in week 17 for assessment of CRH. A logistic regression model was constructed, using postpartum EPDS score as the dependent variable and log-transformed CRH levels as the independent variable. Confounding factors were included in the model. Subanalyses after exclusion of study subjects with preterm birth, newborns small for gestational age (SGA), and women on corticosteroids were performed.\n\nFive hundred thirty-five women without depressive symptoms during pregnancy were included. Logistic regression showed an association between high CRH levels in gestational week 17 and postpartum depressive symptoms, before and after controlling for several confounders (unadjusted OR = 1.11, 95% CI 1.01-1.22; adjusted OR = 1.13, 95% CI 1.02-1.26; per 0.1 unit increase in log CRH). Exclusion of women with preterm birth and newborns SGA as well as women who used inhalation corticosteroids during pregnancy did not alter the results.\n\nThis study suggests an association between high CRH levels in gestational week 17 and the development of postpartum depressive symptoms, among women without depressive symptoms during pregnancy.", "doi": "10.1002/da.22529", "pmid": "27232288", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:27:33.875Z", "modified": "2024-10-24T11:30:59.195Z"}, {"entity": "publication", "iuid": "66264c425bd64946982b70c37da9feaa", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/66264c425bd64946982b70c37da9feaa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/66264c425bd64946982b70c37da9feaa"}}, "title": "Associations between the FKBP5 haplotype, exposure to violence and anxiety in females.", "authors": [{"family": "Isaksson", "given": "Johan", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Rehn", "given": "Mattias", "initials": "M"}, {"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Andershed", "given": "Henrik", "initials": "H"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2016-10-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "72", "issue": null, "pages": "196-204", "issn-l": "0306-4530"}, "abstract": "The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females.", "doi": "10.1016/j.psyneuen.2016.07.206", "pmid": "27448712", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(16)30434-6"}], "notes": [], "created": "2020-11-20T09:27:30.328Z", "modified": "2024-10-24T11:30:55.955Z"}, {"entity": "publication", "iuid": "33b72d504eba4d858865f58808c675a1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/33b72d504eba4d858865f58808c675a1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/33b72d504eba4d858865f58808c675a1"}}, "title": "Gender transition affects neural correlates of empathy: A resting state functional connectivity study with ultra high-field 7T MR imaging.", "authors": [{"family": "Spies", "given": "M", "initials": "M"}, {"family": "Hahn", "given": "A", "initials": "A"}, {"family": "Kranz", "given": "G S", "initials": "GS"}, {"family": "Sladky", "given": "R", "initials": "R"}, {"family": "Kaufmann", "given": "U", "initials": "U"}, {"family": "Hummer", "given": "A", "initials": "A"}, {"family": "Ganger", "given": "S", "initials": "S"}, {"family": "Kraus", "given": "C", "initials": "C"}, {"family": "Winkler", "given": "D", "initials": "D"}, {"family": "Seiger", "given": "R", "initials": "R"}, {"family": "Comasco", "given": "E", "initials": "E"}, {"family": "Windischberger", "given": "C", "initials": "C"}, {"family": "Kasper", "given": "S", "initials": "S"}, {"family": "Lanzenberger", "given": "R", "initials": "R"}], "type": "journal article", "published": "2016-09-00", "journal": {"title": "NeuroImage", "issn": "1095-9572", "volume": "138", "issue": null, "pages": "257-265", "issn-l": "1053-8119"}, "abstract": "Sex-steroid hormones have repeatedly been shown to influence empathy, which is in turn reflected in resting state functional connectivity (rsFC). Cross-sex hormone treatment in transgender individuals provides the opportunity to examine changes to rsFC over gender transition. We aimed to investigate whether sex-steroid hormones influence rsFC patterns related to unique aspects of empathy, namely emotion recognition and description as well as emotional contagion. RsFC data was acquired with 7Tesla magnetic resonance imaging in 24 male-to-female (MtF) and 33 female-to-male (FtM) transgender individuals before treatment, in addition to 33 male- and 44 female controls. Of the transgender participants, 15 MtF and 20 FtM were additionally assessed after 4 weeks and 4 months of treatment. Empathy scores were acquired at the same time-points. MtF differed at baseline from all other groups and assimilated over the course of gender transition in a rsFC network around the supramarginal gyrus, a region central to interpersonal emotion processing. While changes to sex-steroid hormones did not correlate with rsFC in this network, a sex hormone independent association between empathy scores and rsFC was found. Our results underline that 1) MtF transgender persons demonstrate unique rsFC patterns in a network related to empathy and 2) changes within this network over gender transition are likely related to changes in emotion recognition, -description, and -contagion, and are sex-steroid hormone independent.", "doi": "10.1016/j.neuroimage.2016.05.060", "pmid": "27236082", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S1053-8119(16)30179-3"}], "notes": [], "created": "2020-11-20T09:27:32.758Z", "modified": "2024-10-24T11:30:58.161Z"}, {"entity": "publication", "iuid": "88589e1c089e48a88ee841628f6d646f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/88589e1c089e48a88ee841628f6d646f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/88589e1c089e48a88ee841628f6d646f"}}, "title": "Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment.", "authors": [{"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Narusyte", "given": "Jurgita", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Andershed", "given": "Henrik", "initials": "H"}, {"family": "Andershed", "given": "Anna-Karin", "initials": "AK"}, {"family": "Colins", "given": "Olivier F", "initials": "OF"}, {"family": "Fanti", "given": "Kostas A", "initials": "KA"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2016-07-00", "journal": {"title": "Am. J. Med. Genet. B Neuropsychiatr. Genet.", "issn": "1552-485X", "volume": "171", "issue": "5", "pages": "708-718", "issn-l": "1552-4841"}, "abstract": "Catechol-O-methyltransferase (COMT) genotype has been implicated as a vulnerability factor for several psychiatric diseases as well as aggressive behavior, either directly, or in interaction with an adverse environment. The present study aimed at investigating the susceptibility properties of COMT genotype to adverse and favorable environment in relation to physical and verbal aggressive behavior. The COMT Val158Met polymorphism was genotyped in a Swedish population-based cohort including 1,783 individuals, ages 20-24 years (47% males). A significant three-way interaction was found, after correction for multiple testing, between COMT genotype, exposure to violence, and parent-child relationship in association with physical but not verbal aggressive behavior. Homozygous for the Val allele reported lower levels of physical aggressive behavior when they were exposed to violence and at the same time experienced a positive parent-child relationship compared to Met carriers. Thus, susceptibility properties of COMT genotype were observed in relation to physical aggressive behavior supporting the hypothesis that COMT genotypes are modifying the sensitivity to environment that confers either risk or protection for aggressive behavior. As these are novel findings, they warrant further investigation and replication in independent samples. \u00a9 2016 Wiley Periodicals, Inc.", "doi": "10.1002/ajmg.b.32430", "pmid": "26888414", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:27:36.263Z", "modified": "2024-10-24T11:31:01.569Z"}, {"entity": "publication", "iuid": "cfd186f70150413f9aabe34feff0d501", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cfd186f70150413f9aabe34feff0d501.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cfd186f70150413f9aabe34feff0d501"}}, "title": "Corticolimbic anatomical characteristics predetermine risk for chronic pain.", "authors": [{"family": "Vachon-Presseau", "given": "Etienne", "initials": "E"}, {"family": "T\u00e9treault", "given": "Pascal", "initials": "P"}, {"family": "Petre", "given": "Bogdan", "initials": "B"}, {"family": "Huang", "given": "Lejian", "initials": "L"}, {"family": "Berger", "given": "Sara E", "initials": "SE"}, {"family": "Torbey", "given": "Souraya", "initials": "S"}, {"family": "Baria", "given": "Alexis T", "initials": "AT"}, {"family": "Mansour", "given": "Ali R", "initials": "AR"}, {"family": "Hashmi", "given": "Javeria A", "initials": "JA"}, {"family": "Griffith", "given": "James W", "initials": "JW"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Schnitzer", "given": "Thomas J", "initials": "TJ"}, {"family": "Baliki", "given": "Marwan N", "initials": "MN"}, {"family": "Apkarian", "given": "A Vania", "initials": "AV"}], "type": "journal article", "published": "2016-07-00", "journal": {"title": "Brain", "issn": "1460-2156", "volume": "139", "issue": "Pt 7", "pages": "1958-1970", "issn-l": "0006-8950"}, "abstract": "SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors.", "doi": "10.1093/brain/aww100", "pmid": "27190016", "labels": {"Affiliated researcher": null, "Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4939699"}, {"db": "pii", "key": "aww100"}], "notes": [], "created": "2018-12-05T09:09:44.480Z", "modified": "2024-10-24T11:31:00.387Z"}, {"entity": "publication", "iuid": "7c582539660f49529c8cf007067d1174", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7c582539660f49529c8cf007067d1174.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7c582539660f49529c8cf007067d1174"}}, "title": "Early predictors of behavioural problems in pre-schoolers - a longitudinal study of constitutional and environmental main and interaction effects.", "authors": [{"family": "Agnafors", "given": "Sara", "initials": "S"}, {"family": "Sydsj\u00f6", "given": "Gunilla", "initials": "G"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Bladh", "given": "Marie", "initials": "M"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}], "type": "journal article", "published": "2016-06-07", "journal": {"title": "BMC Pediatr", "issn": "1471-2431", "volume": "16", "issue": null, "pages": "76", "issn-l": "1471-2431"}, "abstract": "The early environment is important for child development and wellbeing. Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive. Methodological differences regarding sample sizes, study population, definitions of adversities and measures of mental health problems obstacle their comparability. Furthermore, very few studies included children. The aim of this study was to examine the associations between a broad range of risk factors covering pregnancy and birth, genetic polymorphism, experience of multiple life events and psychosocial environment, and child behaviour at age 3, using a comparably large, representative, population-based sample.\n\nA total of 1,106 children, and their mothers, were followed from pregnancy to age 3. Information on pregnancy and birth-related factors was retrieved from the Medical Birth Register. Questionnaires on depressive symptoms, child behaviour and child experiences of life events were filled in by the mothers. Child saliva samples were used for genotyping the 5-HTTLPR and BDNF Val66Met polymorphisms. Multiple logistic regression was used to investigate the association between psychological scales and genetic polymorphisms.\n\nSymptoms of postpartum depression increased the risk of both internalizing and externalizing problems. Experience of multiple life events was also a predictor of behavioural problems across the scales. No gene-by-environment or gene-by-gene-by-environment interactions were found. Children of immigrants had an increased risk of internalizing problems and parental unemployment was significantly associated with both internalizing and externalizing type of problems.\n\nThis study shows the importance of the psychosocial environment for psychosocial health in preschool children, and adds to the literature of null-findings of gene-by-environment effects of 5-HTTLPR and BDNF in children.", "doi": "10.1186/s12887-016-0614-x", "pmid": "27267363", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4895962"}, {"db": "pii", "key": "10.1186/s12887-016-0614-x"}], "notes": [], "created": "2020-11-20T09:27:31.621Z", "modified": "2024-10-24T11:30:57.068Z"}, {"entity": "publication", "iuid": "e5d76627bda5424c953422e26d5e47cd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e5d76627bda5424c953422e26d5e47cd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e5d76627bda5424c953422e26d5e47cd"}}, "title": "Sleep duration, depression, and oxytocinergic genotype influence prepulse inhibition of the startle reflex in postpartum women.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Gulinello", "given": "Maria", "initials": "M"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Sylven", "given": "Sara", "initials": "S"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2016-04-00", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "26", "issue": "4", "pages": "767-776", "issn-l": "0924-977X"}, "abstract": "The postpartum period is characterized by a post-withdrawal hormonal status, sleep deprivation, and susceptibility to affective disorders. Postpartum mothering involves automatic and attentional processes to screen out new external as well as internal stimuli. The present study investigated sensorimotor gating in relation to sleep duration, depression, as well as catecholaminergic and oxytocinergic genotypes in postpartum women. Prepulse inhibition (PPI) of the startle reflex and startle reactivity were assessed two months postpartum in 141 healthy and 29 depressed women. The catechol-O-methyltransferase (COMT) Val158Met, and oxytocin receptor (OXTR) rs237885 and rs53576 polymorphisms were genotyped, and data on sleep duration were collected. Short sleep duration (less than four hours in the preceding night) and postpartum depression were independently associated with lower PPI. Also, women with postpartum depression had higher startle reactivity in comparison with controls. The OXTR rs237885 genotype was related to PPI in an allele dose-dependent mode, with T/T healthy postpartum women carriers displaying the lowest PPI. Reduced sensorimotor gating was associated with sleep deprivation and depressive symptoms during the postpartum period. Individual neurophysiological vulnerability might be mediated by oxytocinergic genotype which relates to bonding and stress response. These findings implicate the putative relevance of lower PPI of the startle response as an objective physiological correlate of liability to postpartum depression.", "doi": "10.1016/j.euroneuro.2016.01.002", "pmid": "26857197", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(16)00012-2"}], "notes": [], "created": "2020-11-20T09:27:38.758Z", "modified": "2024-10-24T11:30:28.784Z"}, {"entity": "publication", "iuid": "76729052fc4c451ebe082d320ff8c276", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/76729052fc4c451ebe082d320ff8c276.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/76729052fc4c451ebe082d320ff8c276"}}, "title": "HPA Axis Gene Expression and DNA Methylation Profiles in Rats Exposed to Early Life Stress, Adult Voluntary Ethanol Drinking and Single Housing.", "authors": [{"family": "Todkar", "given": "Aniruddha", "initials": "A"}, {"family": "Granholm", "given": "Linnea", "initials": "L"}, {"family": "Aljumah", "given": "Mujtaba", "initials": "M"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}], "type": "journal article", "published": "2016-01-26", "journal": {"title": "Front Mol Neurosci", "issn": "1662-5099", "volume": "8", "issue": null, "pages": "90", "issn-l": "1662-5099"}, "abstract": "The neurobiological basis of early life stress (ELS) impact on vulnerability to alcohol use disorder is not fully understood. The effect of ELS, adult ethanol consumption and single housing, on expression of stress and DNA methylation regulatory genes as well as blood corticosterone levels was investigated in the hypothalamus and pituitary of adult out-bred Wistar rats subjected to different rearing conditions. A prolonged maternal separation (MS) of 360 min (MS360) was used to study the effect of ELS, and a short MS of 15 min (MS15) was used as a control. Voluntary ethanol drinking was assessed using a two-bottle free choice paradigm to simulate human episodic drinking. The effects of single housing and ethanol were assessed in conventional animal facility rearing (AFR) conditions. Single housing in adulthood was associated with lower Crhr1 and higher Pomc expression in the pituitary, whereas ethanol drinking was associated with higher expression of Crh in the hypothalamus and Crhr1 in the pituitary, accompanied by lower corticosterone levels. As compared to controls with similar early life handling, rats exposed to ELS displayed lower expression of Pomc in the hypothalamus, and higher Dnmt1 expression in the pituitary. Voluntary ethanol drinking resulted in lower Fkbp5 expression in the pituitary and higher Crh expression in the hypothalamus, independently of rearing conditions. In rats exposed to ELS, water and ethanol drinking was associated with higher and lower corticosterone levels, respectively. The use of conventionally reared rats as control group yielded more significant results than the use of rats exposed to short MS. Positive correlations, restricted to the hypothalamus and ELS group, were observed between the expression of the hypothalamus-pituitary-adrenal receptor and the methylation-related genes. Promoter DNA methylation and expression of respective genes did not correlate suggesting that other loci are involved in transcriptional regulation. Concluding, single housing is a confounding factor to be considered in voluntary ethanol drinking paradigms. ELS and ethanol drinking in adulthood exert independent effects on hypothalamic and pituitary related genes, however, in a manner dependent on the control group used.", "doi": "10.3389/fnmol.2015.00090", "pmid": "26858597", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4726785"}], "notes": [], "created": "2020-11-20T09:27:37.503Z", "modified": "2024-10-24T11:30:27.698Z"}, {"entity": "publication", "iuid": "1056dc0babd14acbb340332e4e779a69", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1056dc0babd14acbb340332e4e779a69.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1056dc0babd14acbb340332e4e779a69"}}, "title": "Effect of voluntary alcohol consumption on Maoa expression in the mesocorticolimbic brain of adult male rats previously exposed to prolonged maternal separation.", "authors": [{"family": "Bendre", "given": "M", "initials": "M"}, {"family": "Comasco", "given": "E", "initials": "E"}, {"family": "Nylander", "given": "I", "initials": "I"}, {"family": "Nilsson", "given": "K W", "initials": "KW"}], "type": "journal article", "published": "2015-12-08", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "5", "issue": "12", "pages": "e690", "issn-l": "2158-3188"}, "abstract": "Discordant associations between monoamine oxidase A (MAOA) genotype and high alcohol drinking have been reported in human and non-human primates. Environmental influences likely moderate genetic susceptibility. The biological basis for this interplay remains elusive, and inconsistencies call for translational studies in which conditions can be controlled and brain tissue is accessible. The present study investigated whether early life stress and subsequent adult episodic alcohol consumption affect Maoa expression in stress- and reward-related brain regions in the rat. Outbred Wistar rats were exposed to rearing conditions associated with stress (prolonged maternal separation) or no stress during early life, and given free choice between alcohol and/or water in adulthood. Transcript levels of Maoa were assessed in the ventral tegmental area, nucleus accumbens (NAc), medial prefrontal cortex, cingulate cortex, amygdala and dorsal striatum (DS). Blood was collected to assess corticosterone levels. After alcohol consumption, lower blood corticosterone and Maoa expression in the NAc and DS were found in rats exposed to early life stress compared with control rats. An interaction between early life stress and voluntary alcohol intake was found in the NAc. Alcohol intake before death correlated negatively with Maoa expression in DS in high alcohol-drinking rats exposed to early life stress. Maoa expression is sensitive to adulthood voluntary alcohol consumption in the presence of early life stress in outbred rats. These findings add knowledge of the molecular basis of the previously reported associations between early life stress, MAOA and susceptibility to alcohol misuse.", "doi": "10.1038/tp.2015.186", "pmid": "26645625", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5068586"}, {"db": "pii", "key": "tp2015186"}], "notes": [], "created": "2020-11-20T09:27:40.013Z", "modified": "2024-10-24T11:30:29.949Z"}, {"entity": "publication", "iuid": "17a9e0d0825a4f6ab1dec666b866c059", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/17a9e0d0825a4f6ab1dec666b866c059.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/17a9e0d0825a4f6ab1dec666b866c059"}}, "title": "Psychiatric symptoms in adolescents: FKBP5 genotype--early life adversity interaction effects.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Gustafsson", "given": "Per A", "initials": "PA"}, {"family": "Sydsj\u00f6", "given": "Gunilla", "initials": "G"}, {"family": "Agnafors", "given": "Sara", "initials": "S"}, {"family": "Aho", "given": "Nikolas", "initials": "N"}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}], "type": "journal article", "published": "2015-12-00", "journal": {"title": "Eur Child Adolesc Psychiatry", "issn": "1435-165X", "volume": "24", "issue": "12", "pages": "1473-1483", "issn-l": "1018-8827"}, "abstract": "Psychiatric disorders are multi-factorial and their symptoms overlap. Constitutional and environmental factors influence each other, and this contributes to risk and resilience in mental ill-health. We investigated functional genetic variation of stress responsiveness, assessed as FKBP5 genotype, in relation to early life adversity and mental health in two samples of adolescents. One population-based sample of 909 12-year-old adolescents was assessed using the Life Incidence of Traumatic Events scale and the Strengths and Difficulties Questionnaire. One sample of 398 17-year-old adolescents, enriched for poly-victimized individuals (USSS), was assessed using the Juvenile Victimization Questionnaire and the Trauma Symptom Checklist for Children (TSCC). The FKBP5 rs1360780 and rs3800373 polymorphisms were genotyped using a fluorescence-based competitive allele-specific PCR. Most prominently among poly-victimized older male adolescents, the least common alleles of the polymorphisms, in interaction with adverse life events, were associated with psychiatric symptoms, after controlling for ethno-socio-economic factors. The interaction effect between rs3800373 and adverse life events on the TSCC sub-scales-anxiety, depression, anger, and dissociation-and with the rs1360780 on dissociation in the USSS cohort remained significant after Bonferroni correction. This pattern of association is in line with the findings of clinical and neuroimaging studies, and implies interactive effects of FKBP5 polymorphisms and early life environment on several psychiatric symptoms. These correlates add up to provide constructs that are relevant to several psychiatric symptoms, and to identify early predictors of mental ill-health.", "doi": "10.1007/s00787-015-0768-3", "pmid": "26424511", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00787-015-0768-3"}], "notes": [], "created": "2020-11-20T09:28:50.707Z", "modified": "2024-10-24T11:30:32.121Z"}, {"entity": "publication", "iuid": "e294c84351d6427cafb2c22a0076ac13", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e294c84351d6427cafb2c22a0076ac13.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e294c84351d6427cafb2c22a0076ac13"}}, "title": "Supraphysiological hormonal status, anxiety disorders, and COMT Val/Val genotype are associated with reduced sensorimotor gating in women.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Olivier", "given": "Jocelien", "initials": "J"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2015-10-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "60", "issue": null, "pages": "217-223", "issn-l": "0306-4530"}, "abstract": "Pregnancy is a period characterized by a supraphysiological hormonal status, and greater anxiety proneness, which can lead to peripartum affective symptoms with dramatic consequences not only for the woman but also for the child. Clinical psychiatry is heavily hampered by the paucity of objective and biology-based intermediate phenotypes. Prepulse inhibition (PPI) of the startle response, a neurophysiological measure of sensorimotor gating, has been poorly investigated in relation to anxiety and in pregnant women. In the present study, the PPI of healthy non-pregnant women (n = 82) and late pregnant women (n = 217) was investigated. Age, BMI, depression and anxiety symptoms, tobacco use, and antidepressant medication were considered. We investigated and provided evidence of lower PPI: (i) in healthy pregnant women compared to healthy non-pregnant controls, (ii) in pregnant women with anxiety disorders compared to healthy pregnant women, (iii) in pregnant women with anxiety disorders using SSRI compared to un-medicated pregnant women with anxiety disorders, and (iv) in healthy pregnant women carrying the COMT Val158Met Val/Val genotype compared to Met carriers. Altogether, a reduced sensorimotor gating as an effect of supraphysiological hormonal status, anxiety disorders, SSRIs, and catecholaminergic genotype, implicate the putative relevance of lower PPI as an objective biological correlate of anxiety proneness in pregnant women. These findings call for prospective studies to dissect the multifactorial influences on PPI in relation to mental health of pregnant women.", "doi": "10.1016/j.psyneuen.2015.06.019", "pmid": "26189199", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(15)00234-6"}], "notes": [], "created": "2020-11-20T09:28:54.696Z", "modified": "2024-10-24T11:30:35.401Z"}, {"entity": "publication", "iuid": "b75831d41a6f4a3d863d705eb60dbcb5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b75831d41a6f4a3d863d705eb60dbcb5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b75831d41a6f4a3d863d705eb60dbcb5"}}, "title": "Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2015-10-00", "journal": {"title": "Curr Psychiatry Rep", "issn": "1535-1645", "volume": "17", "issue": "10", "pages": "77", "issn-l": "1523-3812"}, "abstract": "Knowledge of gonadal hormone-related influences on human brain anatomy, function, and chemistry is scarce. The present review scrutinized organizational and functional neuroimaging correlates of the menstrual cycle and premenstrual dysphoric disorder (PMDD). Supportive evidence of cyclic short-term structural and functional brain plasticity in response to gonadal hormonal modulation is provided. The paucity of studies, sparsity and discordance of findings, and weaknesses in study design at present hinder the drawing of firm conclusions. Ideal study designs should comprise high-resolution multimodal neuroimaging (e.g., MRI, DTI, rs-fMRI, fMRI, PET), hormones, genetic, and behavioral longitudinal assessments of healthy women and PMDD patients at critical time points of the menstrual cycle phase (i.e., early follicular phase, late follicular phase, mid-luteal phase) in a counter-balanced setup. Studies integrating large-scale brain network structural, functional, and molecular neuroimaging, as well as treatment data, will deepen the understanding of neural state, disorder, and treatment markers.", "doi": "10.1007/s11920-015-0619-4", "pmid": "26272540", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:28:53.328Z", "modified": "2024-10-24T11:30:34.371Z"}, {"entity": "publication", "iuid": "694c9d2864f14376a8cf45a7a93b3acc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/694c9d2864f14376a8cf45a7a93b3acc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/694c9d2864f14376a8cf45a7a93b3acc"}}, "title": "Prenatal and Postpartum Evening Salivary Cortisol Levels in Association with Peripartum Depressive Symptoms.", "authors": [{"family": "Iliadis", "given": "Stavros I", "initials": "SI"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sylv\u00e9n", "given": "Sara", "initials": "S"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2015-08-31", "journal": {"title": "PLoS ONE", "issn": "1932-6203", "volume": "10", "issue": "8", "pages": "e0135471", "issn-l": "1932-6203"}, "abstract": "The biology of peripartum depression remains unclear, with altered stress and the Hypothalamus-Pituitary-Adrenal axis response having been implicated in its pathophysiology.\n\nThe current study was undertaken as a part of the BASIC project (Biology, Affect, Stress, Imaging, Cognition), a population-based longitudinal study of psychological wellbeing during pregnancy and the postpartum period in Uppsala County, Sweden, in order to assess the association between evening salivary cortisol levels and depressive symptoms in the peripartum period. Three hundred and sixty-five pregnant women from the BASIC cohort were recruited at pregnancy week 18 and instructed to complete a Swedish validated version of the Edinburgh Postnatal Depression Scale at the 36th week of pregnancy as well as the sixth week after delivery. At both times, they were also asked to provide evening salivary samples for cortisol analysis. A comprehensive review of the relevant literature is also provided.\n\nWomen with postpartum EPDS score \u2265 10 had higher salivary evening cortisol at six weeks postpartum compared to healthy controls (median cortisol 1.19 vs 0.89 nmol/L). A logistic regression model showed a positive association between cortisol levels and depressive symptoms postpartum (OR = 4.1; 95% CI 1.7-9.7). This association remained significant even after controlling for history of depression, use of tobacco, partner support, breastfeeding, stressful life events, and sleep problems, as possible confounders (aOR = 4.5; 95% CI 1.5-14.1). Additionally, women with postpartum depressive symptoms had higher postpartum cortisol levels compared to both women with depressive symptoms antenatally and controls (p = 0.019 and p = 0.004, respectively).\n\nWomen with depressive symptoms postpartum had higher postpartum cortisol levels, indicating an altered response of the HPA-axis in postpartum depression.", "doi": "10.1371/journal.pone.0135471", "pmid": "26322643", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4556108"}, {"db": "pii", "key": "PONE-D-15-09250"}], "notes": [], "created": "2020-11-20T09:28:52.013Z", "modified": "2024-10-24T11:30:33.282Z"}, {"entity": "publication", "iuid": "e9ae29cd048f46dd9bd6abf630ec8258", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e9ae29cd048f46dd9bd6abf630ec8258.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e9ae29cd048f46dd9bd6abf630ec8258"}}, "title": "Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels.", "authors": [{"family": "Hannerfors", "given": "A-K", "initials": "AK"}, {"family": "Hellgren", "given": "C", "initials": "C"}, {"family": "Schijven", "given": "D", "initials": "D"}, {"family": "Iliadis", "given": "S I", "initials": "SI"}, {"family": "Comasco", "given": "E", "initials": "E"}, {"family": "Skalkidou", "given": "A", "initials": "A"}, {"family": "Olivier", "given": "J D A", "initials": "JD"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "I", "initials": "I"}], "type": "journal article", "published": "2015-08-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "58", "issue": null, "pages": "104-113", "issn-l": "0306-4530"}, "abstract": "Treatment with serotonin reuptake inhibitors (SSRI) has been associated with an increased risk of preterm birth, but causality remains unclear. While placental CRH production is correlated with gestational length and preterm birth, it has been difficult to establish if psychological stress or mental health problems are associated with increased CRH levels. This study compared second trimester CRH serum concentrations in pregnant women on SSRI treatment (n=207) with untreated depressed women (n=56) and controls (n=609). A secondary aim was to investigate the combined effect of SSRI treatment and CRH levels on gestational length and risk for preterm birth. Women on SSRI treatment had significantly higher second trimester CRH levels than controls, and untreated depressed women. CRH levels and SSRI treatment were independently associated with shorter gestational length. The combined effect of SSRI treatment and high CRH levels yielded the highest risk estimate for preterm birth. SSRI treatment during pregnancy is associated with increased CRH levels. However, the elevated risk for preterm birth in SSRI users appear not to be mediated by increased placental CRH production, instead CRH appear as an independent risk factor for shorter gestational length and preterm birth.", "doi": "10.1016/j.psyneuen.2015.04.009", "pmid": "25978816", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(15)00149-3"}], "notes": [], "created": "2020-11-20T09:28:57.085Z", "modified": "2024-10-24T11:30:37.557Z"}, {"entity": "publication", "iuid": "b26e315ee68145e7bb939bc090c4f7ad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b26e315ee68145e7bb939bc090c4f7ad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b26e315ee68145e7bb939bc090c4f7ad"}}, "title": "\u0391lpha 2a-Adrenoceptor Gene Expression and Early Life Stress-Mediated Propensity to Alcohol Drinking in Outbred Rats.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Todkar", "given": "Aniruddha", "initials": "A"}, {"family": "Granholm", "given": "Linnea", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Nylander", "given": "Ingrid", "initials": "I"}], "type": "journal article", "published": "2015-06-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "12", "issue": "7", "pages": "7154-7171", "issn-l": null}, "abstract": "Stressful events early in life, later high alcohol consumption and vulnerability to alcohol use disorder (AUD) are tightly linked. Norepinephrine is highly involved in the stress response and the \u03b12A-adrenoceptor, which is an important regulator of norepinephrine signalling, is a putative target in pharmacotherapy of AUD. The aim of the present study was to investigate the effects of early-life stress and adult voluntary alcohol drinking on the \u03b12A-adrenoceptor. The relative expression and promoter DNA methylation of the Adra2a gene were measured in the hypothalamus, a key brain region in stress regulation. A well-characterized animal model of early-life stress was used in combination with an episodic voluntary drinking in adulthood. Alcohol drinking rats with a history of early-life stress had lower Adra2a expression than drinking rats not exposed to stress. Alcohol intake and Adra2a gene expression were negatively correlated in high-drinking animals, which were predominantly rats subjected to early-life stress. The results provide support for a link between early-life stress, susceptibility for high alcohol consumption, and low Adra2a expression in the hypothalamus. These findings can increase our understanding of the neurobiological basis for vulnerability to initiate risk alcohol consumption and individual differences in the response to \u03b12A-adrenoceptor agonists.", "doi": "10.3390/ijerph120707154", "pmid": "26121187", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4515647"}, {"db": "pii", "key": "ijerph120707154"}], "notes": [], "created": "2020-11-20T09:28:55.948Z", "modified": "2024-10-24T11:30:36.506Z"}, {"entity": "publication", "iuid": "32c0cf97afdd487cb3d5d7fbcba68a9f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/32c0cf97afdd487cb3d5d7fbcba68a9f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/32c0cf97afdd487cb3d5d7fbcba68a9f"}}, "title": "Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene-environmentinteractions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR [corrected].", "authors": [{"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2014-12-10", "journal": {"title": "Int J Neuropsychopharmacol", "issn": "1469-5111", "volume": "18", "issue": "5", "issn-l": "1461-1457"}, "abstract": "Previous evidence of gene-by-environment interactions associated with emotional and behavioral disorders is contradictory. Differences in findings may result from variation in valence and dose of the environmental factor, and/or failure to take account of gene-by-gene interactions. The present study investigated interactions between the brain-derived neurotrophic factor gene (BDNF Val66Met), the serotonin transporter gene-linked polymorphic region (5-HTTLPR), the monoamine oxidase A (MAOA-uVNTR) polymorphisms, family conflict, sexual abuse, the quality of the child-parent relationship, and teenage delinquency.\n\nIn 2006, as part of the Survey of Adolescent Life in V\u00e4stmanland, Sweden, 1 337 high-school students, aged 17-18 years, anonymously completed questionnaires and provided saliva samples for DNA analyses.\n\nTeenage delinquency was associated with two-, three-, and four-way interactions of each of the genotypes and the three environmental factors. Significant four-way interactions were found for BDNF Val66Met \u00d7 5-HTTLPR\u00d7MAOA-uVNTR \u00d7 family conflicts and for BDNF Val66Met \u00d7 5-HTTLPR\u00d7MAOA-uVNTR \u00d7 sexual abuse. Further, the two genotype combinations that differed the most in expression levels (BDNF Val66Met Val, 5-HTTLPR LL, MAOA-uVNTR LL [girls] and L [boys] vs BDNF Val66Met Val/Met, 5-HTTLPR S/LS, MAOA-uVNTR S/SS/LS) in interaction with family conflict and sexual abuse were associated with the highest delinquency scores. The genetic variants previously shown to confer vulnerability for delinquency (BDNF Val66Met Val/Met \u00d7 5-HTTLPR S \u00d7 MAOA-uVNTR S) were associated with the lowest delinquency scores in interaction with a positive child-parent relationship.\n\nFunctional variants of the MAOA-uVNTR, 5-HTTLPR, and BDNF Val66Met, either alone or in interaction with each other, may be best conceptualized as modifying sensitivity to environmental factors that confer either risk or protection for teenage delinquency.", "doi": "10.1093/ijnp/pyu107", "pmid": "25522433", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4376552"}, {"db": "pii", "key": "pyu107"}], "notes": [], "created": "2020-11-20T09:28:59.601Z", "modified": "2024-10-24T11:29:54.272Z"}, {"entity": "publication", "iuid": "e947b3390aa64153b8ddb3b192e1d32c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e947b3390aa64153b8ddb3b192e1d32c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e947b3390aa64153b8ddb3b192e1d32c"}}, "title": "Functional and molecular neuroimaging of menopause and hormone replacement therapy.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Frokjaer", "given": "Vibe G", "initials": "VG"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2014-12-08", "journal": {"title": "Front Neurosci", "issn": "1662-4548", "volume": "8", "issue": null, "pages": "388", "issn-l": "1662-453X"}, "abstract": "The level of gonadal hormones to which the female brain is exposed considerably changes across the menopausal transition, which in turn, is likely to be of great relevance for neurodegenerative diseases and psychiatric disorders. However, the neurobiological consequences of these hormone fluctuations and of hormone replacement therapy in the menopause have only begun to be understood. The present review summarizes the findings of thirty-five studies of human brain function, including functional magnetic resonance imaging, positron and single-photon computed emission tomography studies, in peri- and postmenopausal women treated with estrogen, or estrogen-progestagen replacement therapy. Seven studies using gonadotropin-releasing hormone agonist intervention as a model of hormonal withdrawal are also included. Cognitive paradigms are employed by the majority of studies evaluating the effect of unopposed estrogen or estrogen-progestagen treatment on peri- and postmenopausal women's brain. In randomized-controlled trials, estrogen treatment enhances activation of fronto-cingulate regions during cognitive functioning, though in many cases no difference in cognitive performance was present. Progestagens seems to counteract the effects of estrogens. Findings on cognitive functioning during acute ovarian hormone withdrawal suggest a decrease in activation of the left inferior frontal gyrus, thus essentially corroborating the findings in postmenopausal women. Studies of the cholinergic and serotonergic systems indicate these systems as biological mediators of hormonal influences on the brain. More, hormonal replacement appears to increase cerebral blood flow in several cortical regions. On the other hand, studies on emotion processing in postmenopausal women are lacking. These results call for well-powered randomized-controlled multi-modal prospective neuroimaging studies as well as investigation on the related molecular mechanisms of effects of menopausal hormonal variations on the brain.", "doi": "10.3389/fnins.2014.00388", "pmid": "25538545", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC4259109"}], "notes": [], "created": "2020-11-20T09:28:58.361Z", "modified": "2024-10-24T11:29:53.180Z"}, {"entity": "publication", "iuid": "b5bdfcebd7644374a3041f7978098d47", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b5bdfcebd7644374a3041f7978098d47.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b5bdfcebd7644374a3041f7978098d47"}}, "title": "Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review.", "authors": [{"family": "Toffoletto", "given": "Simone", "initials": "S"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2014-12-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "50", "issue": null, "pages": "28-52", "issn-l": "0306-4530"}, "abstract": "Ovarian hormones are pivotal for the physiological maintenance of the brain function as well as its response to environmental stimuli. There is mounting evidence attesting the relevance of endogenous ovarian hormones as well as exogenous estradiol and progesterone for emotional and cognitive processing. The present review systematically summarized current knowledge on sex steroid hormonal modulation of neural substrates of emotion and cognition revealed by functional magnetic resonance imaging (fMRI). Twenty-four studies of healthy naturally cycling and combined oral contraceptives (COC) user women, or women undergoing experimental manipulations, during their reproductive age, were included. Furthermore, six studies of premenstrual dysphoric disorder (PMDD), a hormonally based mood disorder, and three of gender dysphoria (GD), which provides an intriguing opportunity to examine the effect of high-dose cross-sex hormone therapy (CSHT) on brain functioning, were included. Globally, low (early follicular and the entire follicular phase for estrogen and progesterone, respectively) and high (COC, CSHT, late follicular and luteal phase for estrogen; COC, mid- and late-luteal phase for progesterone) hormonal milieu diversely affected the response of several brain regions including the amygdala, anterior cingulate cortex, and inferior frontal gyrus, but their functional recruitment across groups and domains was scattered. The constellation of findings provides initial evidence of the influence of sex steroid hormones on cortical and subcortical regions implicated in emotional and cognitive processing. Further well-powered and multimodal neuroimaging studies will be needed to identify the neural mechanism of functional brain alterations induced by sex steroid hormones.", "doi": "10.1016/j.psyneuen.2014.07.025", "pmid": "25222701", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0306-4530(14)00301-1"}], "notes": [], "created": "2020-11-20T09:29:00.735Z", "modified": "2024-10-24T11:29:55.358Z"}, {"entity": "publication", "iuid": "69eed8f6d0fa40c597716fc7d0e9a630", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/69eed8f6d0fa40c597716fc7d0e9a630.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/69eed8f6d0fa40c597716fc7d0e9a630"}}, "title": "Haplotype-tag single nucleotide polymorphism analysis of the vesicular glutamate transporter (VGLUT) genes in severely alcoholic women.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hallman", "given": "Jarmila", "initials": "J"}, {"family": "Wall\u00e9n-Mackenzie", "given": "Asa", "initials": "A"}], "type": "letter", "published": "2014-10-30", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "219", "issue": "2", "pages": "403-405", "issn-l": "0165-1781"}, "abstract": null, "doi": "10.1016/j.psychres.2014.05.052", "pmid": "24953423", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(14)00472-7"}], "notes": [], "created": "2020-11-20T09:29:08.816Z", "modified": "2024-10-24T11:29:57.507Z"}, {"entity": "publication", "iuid": "9e69da98b500445494548a88301632b0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9e69da98b500445494548a88301632b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9e69da98b500445494548a88301632b0"}}, "title": "Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hahn", "given": "Andreas", "initials": "A"}, {"family": "Ganger", "given": "Sebastian", "initials": "S"}, {"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Bannbers", "given": "Elin", "initials": "E"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2014-09-00", "journal": {"title": "Hum Brain Mapp", "issn": "1097-0193", "volume": "35", "issue": "9", "pages": "4450-4458", "issn-l": "1065-9471"}, "abstract": "Premenstrual dysphoric disorder (PMDD) is the prototypical sex-specific disorder in which symptom onset and offset require a particular hormonal milieu and for which there is moderate heritability. The present study investigated brain emotion processing in PMDD and healthy controls, as well as functional polymorphisms in two candidate genes for PMDD, the serotonin transporter (5-HTT) and brain derived neurotrophic factor (BDNF). The 5-HTT linked polymorphic region (5-HTTLPR) and BDNF Val66Met polymorphisms were genotyped in 31 patients with PMDD and 31 healthy controls. A subset of 16 patients and 15 controls participated in two functional magnetic resonance imaging-sessions performing an emotion processing task; once in the mid-follicular, and once in the late luteal phase which corresponds with maximum severity of mood symptoms. Genotypes were not directly associated with PMDD. A main effect of group was found in the whole brain analysis, with patients having lower activation of the pre-genual anterior cingulate and ventro-medial prefrontal cortex, independent of menstrual cycle phase. Post-hoc functional ROI analyses in the fronto-cingulate cluster showed no effect of 5-HTTLPR genotype but a genotype-by-group-by-phase interaction effect of BDNF Val66Met. Women with PMDD who were carriers of the Met-allele had lower fronto-cingulate cortex activation in the luteal phase compared to Met-allele carrying controls. The results provide suggestive evidence of impaired emotion-induced fronto-cingulate cortex activation in PMDD patients. Although limited by a small sample, the potential influence of BDNF Val66Met in PMDD is in line with preclinical findings.", "doi": "10.1002/hbm.22486", "pmid": "24615932", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "mid", "key": "NIHMS562685"}, {"db": "pmc", "key": "PMC4107029"}], "notes": [], "created": "2020-11-20T09:29:14.485Z", "modified": "2024-10-24T11:29:58.561Z"}, {"entity": "publication", "iuid": "6bee5a483a6641fd839752bd401a4e58", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6bee5a483a6641fd839752bd401a4e58.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6bee5a483a6641fd839752bd401a4e58"}}, "title": "Transcription Factor Activating Protein-2\u03b2 (TFAP-2\u03b2) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples.", "authors": [{"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Sonnby", "given": "Karin", "initials": "K"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Leppert", "given": "Jerzy", "initials": "J"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Sj\u00f6berg", "given": "Rickard L", "initials": "RL"}], "type": "journal article", "published": "2014-04-00", "journal": {"title": "Eur Child Adolesc Psychiatry", "issn": "1435-165X", "volume": "23", "issue": "4", "pages": "207-217", "issn-l": "1018-8827"}, "abstract": "The Transcription Factor Activating Protein-2\u03b2 (TFAP-2\u03b2) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2\u03b2. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP-2\u03b2 gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8% of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP-2\u03b2 intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP-2\u03b2 intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.", "doi": "10.1007/s00787-013-0450-6", "pmid": "23824473", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00787-013-0450-6"}], "notes": [], "created": "2020-11-20T09:30:17.442Z", "modified": "2024-10-24T11:30:00.789Z"}, {"entity": "publication", "iuid": "54ea25f0de7f4b6fa24b67b79e03c2f9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/54ea25f0de7f4b6fa24b67b79e03c2f9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/54ea25f0de7f4b6fa24b67b79e03c2f9"}}, "title": "Mitigating aggressiveness through education? The monoamine oxidase A genotype and mental health in general population.", "authors": [{"family": "Kiive", "given": "Evelyn", "initials": "E"}, {"family": "Laas", "given": "Kariina", "initials": "K"}, {"family": "Akkermann", "given": "Kirsti", "initials": "K"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Veidebaum", "given": "Toomas", "initials": "T"}, {"family": "Harro", "given": "Jaanus", "initials": "J"}], "type": "journal article", "published": "2014-02-00", "journal": {"title": "Acta Neuropsychiatr", "issn": "1601-5215", "volume": "26", "issue": "1", "pages": "19-28", "issn-l": "0924-2708"}, "abstract": "Monoamine oxidase A (MAOA) gene promoter region includes a variable number of tandem repeat (VNTR) associated with antisocial behaviour in adverse environment. We have examined the effect of the MAOA-uVNTR on mental health and academic success by using a population representative sample and a longitudinal design.\n\nThe data of the older cohort (n = 593, aged 15 years at the original sampling) of the longitudinal Estonian Children Personality, Behaviour and Health Study (ECPBHS) were used. Follow-ups were conducted at ages 18 and 25 years. Aggressiveness, inattention and hyperactivity were reported by class teachers or, at older age, self-reported. Stressful life events, psychological environment in the family and interactions between family members were self-reported. Data of general mental abilities and education were obtained at the age of 25, and lifetime psychiatric disorder assessment was carried out with the Mini-International Neuropsychiatric Interview (MINI) interview.\n\nMAOA-uVNTR genotype had no independent effect on aggressiveness, hyperactive and inattentive symptoms, and neither was there a genotype interaction with adverse life events. Interestingly, the proportion of male subjects with higher education by the age of 25 was significantly larger among those with MAOA low-activity alleles (\u03c7\u00b2 = 7.13; p = 0.008). Logistic regression revealed that MAOA low-activity alleles, higher mental abilities, occurrence of anxiety disorders and absence of substance-use disorder were significant independent predictors for higher education in male subjects.\n\nIn a population representative sample of young subjects, the MAOA-uVNTR 'risk genotype' predicted better life outcomes as expressed in higher level of education.", "doi": "10.1017/neu.2013.34", "pmid": "25142096", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0924270813000343"}], "notes": [], "created": "2020-11-20T09:29:04.843Z", "modified": "2024-10-24T11:29:56.401Z"}, {"entity": "publication", "iuid": "49502479ef20409faf3b6993c27cb369", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/49502479ef20409faf3b6993c27cb369.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/49502479ef20409faf3b6993c27cb369"}}, "title": "Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression.", "authors": [{"family": "Culverhouse", "given": "Robert C", "initials": "RC"}, {"family": "Bowes", "given": "Lucy", "initials": "L"}, {"family": "Breslau", "given": "Naomi", "initials": "N"}, {"family": "Nurnberger", "given": "John I", "initials": "JI"}, {"family": "Burmeister", "given": "Margit", "initials": "M"}, {"family": "Fergusson", "given": "David M", "initials": "DM"}, {"family": "Munaf\u00f2", "given": "Marcus", "initials": "M"}, {"family": "Saccone", "given": "Nancy L", "initials": "NL"}, {"family": "Bierut", "given": "Laura J", "initials": "LJ"}, {"family": "5-HTTLPR, Stress, and Depression Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2013-11-12", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "13", "issue": null, "pages": "304", "issn-l": "1471-244X"}, "abstract": "Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions.\n\nTo improve understanding of the combined roles of 5-HTTLPR variation and stress in the development of depression, we are conducting a meta-analysis of multiple independent datasets. This coordinated approach utilizes new analyses performed with centrally-developed, standardized scripts. This publication documents the protocol for this collaborative, consortium-based meta-analysis of 5-HTTLPR variation, stress, and depression.\n\nOur goal is to invite all datasets, published or unpublished, with 5-HTTLPR genotype and assessments of stress and depression for at least 300 subjects. This inclusive approach is to minimize potential impact from publication bias.\n\nThis project currently includes investigators from 35 independent groups, providing data on at least N = 33,761 participants.The analytic plan was determined prior to starting data analysis. Analyses of individual study datasets will be performed by the investigators who collected the data using centrally-developed standardized analysis scripts to ensure a consistent analytical approach across sites. The consortium as a group will review and interpret the meta-analysis results.\n\nVariation in 5-HTTLPR is hypothesized to moderate the response to stress on depression. To test specific hypotheses about the role of 5-HTTLPR variation on depression, we will perform coordinated meta-analyses of de novo results obtained from all available data, using variables and analyses determined a priori. Primary analyses, based on the original 2003 report by Caspi and colleagues of a GxE interaction will be supplemented by secondary analyses to help interpret and clarify issues ranging from the mechanism of effect to heterogeneity among the contributing studies. Publication of this protocol serves to protect this project from biased reporting and to improve the ability of readers to interpret the results of this specific meta-analysis upon its completion.", "doi": "10.1186/1471-244X-13-304", "pmid": "24219410", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC3840571"}, {"db": "pii", "key": "1471-244X-13-304"}], "notes": [], "created": "2020-11-20T09:30:16.114Z", "modified": "2024-10-24T11:29:59.669Z"}, {"entity": "publication", "iuid": "fe8761b731c74bc5a89845d14aa86ab1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fe8761b731c74bc5a89845d14aa86ab1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fe8761b731c74bc5a89845d14aa86ab1"}}, "title": "Neuropsychiatric deep brain stimulation for translational neuroimaging.", "authors": [{"family": "H\u00f6flich", "given": "Anna", "initials": "A"}, {"family": "Savli", "given": "Markus", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Moser", "given": "Ulrike", "initials": "U"}, {"family": "Novak", "given": "Klaus", "initials": "K"}, {"family": "Kasper", "given": "Siegfried", "initials": "S"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R"}], "type": "journal article", "published": "2013-10-01", "journal": {"title": "NeuroImage", "issn": "1095-9572", "volume": "79", "issue": null, "pages": "30-41", "issn-l": "1053-8119"}, "abstract": "From a neuroimaging point of view, deep brain stimulation (DBS) in psychiatric disorders represents a unique source of information to probe results gained in functional, structural and molecular neuroimaging studies in vivo. However, the implementation has, up to now, been restricted by the heterogeneity of the data reported in DBS studies. The aim of the present study was therefore to provide a comprehensive and standardized database of currently used DBS targets in selected psychiatric disorders (obsessive-compulsive disorder (OCD), treatment-resistant depression (TRD), Gilles de la Tourette syndrome (GTS)) to enable topological comparisons between neuroimaging results and stimulation areas. A systematic literature research was performed and all peer-reviewed publications until the year 2012 were included. Literature research yielded a total of 84 peer-reviewed studies including about 296 psychiatric patients. The individual stimulation data of 37 of these studies meeting the inclusion criteria which included a total of 202 patients (63 OCD, 89 TRD, 50 GTS) was translated into MNI stereotactic space with respect to AC origin in order to identify key targets. The created database can be used to compare DBS target areas in MNI stereotactic coordinates with: 1) activation patterns in functional brain imaging (fMRI, phfMRI, PET, MET, EEG); 2) brain connectivity data (e.g., MR-based DTI/tractography, functional and effective connectivity); 3) quantitative molecular distribution data (e.g., neuroreceptor PET, post-mortem neuroreceptor mapping); 4) structural data (e.g., VBM for neuroplastic changes). Vice versa, the structural, functional and molecular data may provide a rationale to define new DBS targets and adjust/fine-tune currently used targets in DBS based on this overview in stereotactic coordinates. Furthermore, the availability of DBS data in stereotactic space may facilitate the investigation and interpretation of treatment effects and side effect of DBS by comparing these to neuroimaging results. The present study thus improves comparability between functional, structural and molecular data in standard stereotactic space gained in neuroimaging studies with surgical targets for DBS, which is among other possible implications of crucial importance for the definition of new targets for effective DBS.", "doi": "10.1016/j.neuroimage.2013.04.065", "pmid": "23631986", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S1053-8119(13)00412-6"}], "notes": [], "created": "2020-11-20T09:30:18.585Z", "modified": "2024-10-24T11:30:01.959Z"}, {"entity": "publication", "iuid": "9b8afde479d84f4785de6f8deae72cb9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9b8afde479d84f4785de6f8deae72cb9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9b8afde479d84f4785de6f8deae72cb9"}}, "title": "Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2013-10-00", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "23", "issue": "10", "pages": "1300-1306", "issn-l": "0924-977X"}, "abstract": "Both the serotonin transporter linked promoter region (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms have been shown to interact with unfavourable environment in relation to depression symptoms and to depression diagnosis. Several attempts have been made to study a three-way interaction effect of these factors on depression, however with contradictory results. We aimed to test the hypothesis of a three-way interaction effect and to attempt at replication in an independent population-based sample. Family maltreatment, sexual abuse and depression were self-reported by an adolescent population-based cohort (N=1393) from the county of V\u00e4stmanland, Sweden. DNA was isolated from saliva, and used for genotyping of the 5-HTTLPR and BDNF Val66Met polymorphisms. Neither 5-HTTLPR or BDNF genotypes separately, nor in interaction with each other had any relation to depression, however in an environment adjusted model a two-way interaction and a three-way interaction effect was found. Both 5-HTTLPR and BDNF Val66Met interacted with unfavourable environment in relation to depressive symptoms (Adj R\u00b2=0.19). Depressive symptoms and depression were more common among carriers of either the ss/sl+Val/Val or the ll+Met genotypes in the presence of early-life adversities. This three-way effect was more pronounced among girls. The current study, with a virtually similar set-up compared to previous studies, can partially confirm previous findings and their generalizability. The study also shows the importance of genetic plasticity in individuals with different environmental exposure, for different phenotypic expression.", "doi": "10.1016/j.euroneuro.2013.01.010", "pmid": "23481907", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(13)00049-7"}], "notes": [], "created": "2020-11-20T09:30:21.067Z", "modified": "2024-10-24T11:29:42.370Z"}, {"entity": "publication", "iuid": "a22aea9911894c4ca579ed96e4b3fe08", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a22aea9911894c4ca579ed96e4b3fe08.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a22aea9911894c4ca579ed96e4b3fe08"}}, "title": "Adipocytokines levels at delivery, functional variation of TFAP2\u03b2, and maternal and neonatal anthropometric parameters.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Iliadis", "given": "Stavros I", "initials": "SI"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Olovsson", "given": "Matts", "initials": "M"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2013-10-00", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-739X", "volume": "21", "issue": "10", "pages": "2130-2137", "issn-l": "1930-7381"}, "abstract": "Adipocytokines participate in the regulation of glucose metabolism and fetal development. The transcription factor activating protein 2B (TFAP2\u03b2) has been associated with adipocytokine regulation, and gene variations with type 2 diabetes and obesity. This study investigated associations between maternal TFAP2B variation, adipocytokine levels, and maternal and neonatal anthropometric characteristics.\n\nA population-based sample of women was followed from delivery to 6 months postpartum. Adiponectin, leptin, and interleukin-6 levels at delivery, and maternal as well as neonatal anthropometric variables were assessed. The TFAP2\u03b2 intron 1 variable number tandem repeat (VNTR) was genotyped.\n\nMaternal interleukin-6 correlated positively with leptin at delivery, with peripartum weight changes and weight of newborn males, adjusted for potential confounders. Leptin at delivery was associated with TFAP2\u03b2 intron 1 VNTR genotype, adjusted for confounders, maternal weight and negatively with birth weight among female neonates. A path model suggested a link between TFAP2\u03b2 genotype, leptin levels, and newborn females' weight.\n\nThe present results stress a role for the TFAP2 \u03b2 in adiposity-related conditions and intrauterine growth. The association between neonatal birth weight and maternal adipocytokine levels, together with the observed sex effect, call for further studies on the mechanisms behind neuroendocrine fetal programming.", "doi": "10.1002/oby.20349", "pmid": "23408462", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:30:22.188Z", "modified": "2024-10-24T11:29:43.371Z"}, {"entity": "publication", "iuid": "5b251dd94f88448ca48664709c27dfd1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5b251dd94f88448ca48664709c27dfd1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5b251dd94f88448ca48664709c27dfd1"}}, "title": "Influence of catechol-O-methyltransferase Val158Met polymorphism on startle response in the presence of high estradiol levels.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2013-07-00", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "23", "issue": "7", "pages": "629-635", "issn-l": "0924-977X"}, "abstract": "both human and animal studies have shown a somewhat complex COMT-by-sex interaction effect on brain function and dysfunction. A functional variation in the gene coding for the catechol-O-methyltransferase (COMT) enzyme, which metabolizes dopamine and noradrenaline, has been related to executive and emotional functions, and to sex dimorphism.\n\nto investigate if COMT Val158Met genotype influences startle response in pregnant women, given their physiologically elevated estradiol levels.\n\nseventy-three pregnant women were assessed in gestational week 38 for acoustic startle response, measured by electromyography of the blink reflex, during control condition, positive and negative anticipation stimuli, and pleasant and unpleasant image stimuli. A blood sample was taken for measurement of estradiol levels and genetic analysis.\n\nthe results indicated a COMT Val158Met effect on startle response across all conditions (main effect of genotype, F(2,70=3.58), p=0.033), where Val/Val women displayed higher startle magnitudes than Val/Met carriers (Cohen's d=0.71). No significant difference by genotype was found in affective modulation. The findings also suggested an estrogen dose-dependent effect of COMT Val158Met on startle reflex. Among women with higher pregnancy-induced estradiol levels, Val/Val carriers had markedly higher startle response across conditions than heterozygotes (Cohen's d=1.36; F(4,21=11.07); p=0.003), while this effect was not present in women with estradiol levels under the median concentration.\n\nthe observed effect of COMT Val158Met by estradiol on overall startle response is likely to be due to a variable noradrenergic transmission depending on COMT activity in a possible interaction with estradiol.", "doi": "10.1016/j.euroneuro.2012.06.015", "pmid": "22831878", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(12)00177-0"}], "notes": [], "created": "2020-11-20T09:31:19.513Z", "modified": "2024-10-24T11:29:47.562Z"}, {"entity": "publication", "iuid": "0935b9ab56b14ffe9de297214a3d5df1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0935b9ab56b14ffe9de297214a3d5df1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0935b9ab56b14ffe9de297214a3d5df1"}}, "title": "Serotonin transporter genotype by environment: Studies on alcohol use and misuse in non-human and human primates", "authors": [{"family": "Todkar", "given": "Aniruddha", "initials": "A"}, {"family": "Nilsson", "given": "Kent", "initials": "K"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Hodgins", "given": "Sheilagh", "initials": "S"}, {"family": "Comasco", "given": "Erika", "initials": "E"}], "type": "journal-article", "published": "2013-06-01", "journal": {"issn": "2081-6936", "volume": "4", "issue": "2", "pages": "241-250", "issn-l": null}, "abstract": null, "doi": "10.2478/s13380-013-0121-6", "pmid": null, "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2024-10-24T20:21:24.666Z", "modified": "2025-12-04T16:54:06.884Z"}, {"entity": "publication", "iuid": "f0a10c2dd51f469a9bd3626b3fa00710", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f0a10c2dd51f469a9bd3626b3fa00710.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f0a10c2dd51f469a9bd3626b3fa00710"}}, "title": "Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems - a longitudinal study.", "authors": [{"family": "Agnafors", "given": "Sara", "initials": "S"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Bladh", "given": "Marie", "initials": "M"}, {"family": "Sydsj\u00f6", "given": "Gunilla", "initials": "G"}, {"family": "Dekeyser", "given": "Linda", "initials": "L"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}], "type": "journal article", "published": "2013-03-22", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "7", "issue": "1", "pages": "10", "issn-l": "1753-2000"}, "abstract": "Depression is a common and disabling condition with a high relapse frequency. Maternal mental health problems and experience of traumatic life events are known to increase the risk of behavior problems in children. Recently, genetic factors, in particular gene-by-environment interaction models, have been implicated to explain depressive etiology. However, results are inconclusive.\n\nStudy participants were members of the SESBiC-study. A total of 889 mothers and their children were followed during the child's age of 3 months to 12 years. Information on maternal depressive symptoms was gathered postpartum and at a 12 year follow-up. Mothers reported on child behavior and traumatic life events experienced by the child at age 12. Saliva samples were obtained from children for analysis of 5-HTTLPR and BDNF Val66Met polymorphisms.\n\nMultivariate analysis showed a significant association between maternal symptoms of depression and anxiety, and internalizing problems in 12-year-old children (OR 5.72, 95% CI 3.30-9.91). Furthermore, carriers of two short alleles (s/s) of the 5-HTTLPR showed a more than 4-fold increased risk of internalizing problems at age 12 compared to l/l carriers (OR 4.73, 95% CI 2.14-10.48). No gene-by-environment interaction was found and neither depressive symptoms postpartum or traumatic experiences during childhood stayed significant in the final model.\n\nConcurrent maternal symptoms of depression and anxiety are significant risk factors for behavior problems in children, which need to be taken into account in clinical practice. Furthermore, we found a main effect of 5-HTTLPR on internalizing symptoms in 12-year-old children, a finding that needs to be confirmed in future studies.", "doi": "10.1186/1753-2000-7-10", "pmid": "23518193", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC3615948"}, {"db": "pii", "key": "1753-2000-7-10"}], "notes": [], "created": "2020-11-20T09:30:19.823Z", "modified": "2024-10-24T11:30:03.084Z"}, {"entity": "publication", "iuid": "d27f9f8f31714ff88c41423a3d098eda", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d27f9f8f31714ff88c41423a3d098eda.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d27f9f8f31714ff88c41423a3d098eda"}}, "title": "Self-reported family socioeconomic status, the 5-HTTLPR genotype, and delinquent behavior in a community-based adolescent population.", "authors": [{"family": "Aslund", "given": "Cecilia", "initials": "C"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Leppert", "given": "Jerzy", "initials": "J"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2013-01-00", "journal": {"title": "Aggress Behav", "issn": "1098-2337", "volume": "39", "issue": "1", "pages": "52-63", "issn-l": "0096-140X"}, "abstract": "Twin and adoption studies have demonstrated a significant contribution of both genetic and environmental factors to antisocial and delinquent behavior. Associations have been reported between the serotonin transporter (5-HTT) and aggression, and between socioeconomic status (SES), aggression, and serotonergic functions of the brain. We aimed to investigate associations between the 5-HTTLPR genotype and family SES in relation to delinquent behavior among adolescents. A total of 1,467 17- to 18-year-old students in the county of V\u00e4stmanland, Sweden, anonymously completed a questionnaire and gave a saliva sample. Family SES had a U-shaped relation to delinquency, where adolescents with low and high family SES were the most delinquent. There were curvilinear interactions between the 5-HTTLPR genotype and family SES in relation to delinquency. Among individuals having high family SES, boys with the LL (homozygous for the long allele) or LS (heterozygous) genotypes and girls with the SS (homozygous for the short allele) or LS (heterozygous) genotypes showed the highest delinquency scores. Among individuals having low family SES, boys with the LL (homozygous for the long allele) genotype and girls with the LS (heterozygous) genotype showed the highest delinquency scores. The present study suggests evidence for an interaction between family SES and the 5-HTTLPR genotype in relation to juvenile delinquency.", "doi": "10.1002/ab.21451", "pmid": "22987641", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:31:17.096Z", "modified": "2024-10-24T11:29:45.417Z"}, {"entity": "publication", "iuid": "23e53525146f47ceae9c43ade2f4d5e1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/23e53525146f47ceae9c43ade2f4d5e1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/23e53525146f47ceae9c43ade2f4d5e1"}}, "title": "The effect of premenstrual dysphoric disorder and menstrual cycle phase on brain activity during response inhibition.", "authors": [{"family": "Bannbers", "given": "Elin", "initials": "E"}, {"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Engman", "given": "Jonas", "initials": "J"}, {"family": "Morell", "given": "Arvid", "initials": "A"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Kask", "given": "Kristiina", "initials": "K"}, {"family": "Garavan", "given": "Hugh", "initials": "H"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}], "type": "controlled clinical trial", "published": "2012-12-15", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "142", "issue": "1-3", "pages": "347-350", "issn-l": "0165-0327"}, "abstract": "Premenstrual dysphoric disorder (PMDD) has generally not been associated with impulsive behavior. However, some studies suggest that women with PMDD have higher impulsivity scores than healthy controls and that brain activity during response inhibition may vary across the menstrual cycle. Therefore, our aim was to unravel potentially important cognitive aspects of PMDD by investigating brain activity during response inhibition in women with PMDD and healthy controls in relation to menstrual cycle phase.\n\nFourteen PMDD patients and 13 healthy controls performed a Go/NoGo task to measure brain activity during response inhibition by use of event-related functional magnetic resonance imaging.\n\nWomen with PMDD displayed decreased activity during both menstrual cycle phases compared to healthy controls in several task-related parietal areas. A significant group by phase interactions was found in the left insula, driven by enhanced activity among healthy controls in the follicular phase and by enhanced insula activity during the luteal phase among PMDD patients.\n\nThe limitations of the present study are the relatively limited sample size, the relatively small number of NoGo trials and the lack of a baseline contrast for the NoGo trials.\n\nDuring response inhibition women with PMDD have reduced activity in areas associated with attention and motor function which is unrelated to menstrual cycle phase. Insular cortex activity, involved in both affective and cognitive processing, was significantly activated during the luteal phase among PMDD women. These findings are relevant for the understanding of how ovarian steroids influence mood symptoms in women.", "doi": "10.1016/j.jad.2012.04.006", "pmid": "22840469", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(12)00246-7"}], "notes": [], "created": "2020-11-20T09:31:18.284Z", "modified": "2024-10-24T11:29:46.498Z"}, {"entity": "publication", "iuid": "9326edf113f34d958458a34ee1bdcbd5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9326edf113f34d958458a34ee1bdcbd5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9326edf113f34d958458a34ee1bdcbd5"}}, "title": "Biological aspects of postpartum depression.", "authors": [{"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sylv\u00e9n", "given": "Sara", "initials": "S"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2012-11-00", "journal": {"title": "Womens Health (Lond)", "issn": "1745-5065", "volume": "8", "issue": "6", "pages": "659-672", "issn-l": "1745-5057"}, "abstract": "In comparison with the vast epidemiological literature on postpartum depression (PPD), relatively few studies have examined the biological aspects of the disorder. However, research into the biological mechanisms of PPD is a challenging task, as normal pregnancy and the postpartum period cause adaptive endocrine changes, which would otherwise be considered pathological in nonpregnant women. This review focuses on the adaptive changes of childbearing and nursing, which ultimately may put women at increased risk of PPD. In light of the normal physiology, the authors also attempt to describe the current evidence of the biological changes associated with the development of depression in the postpartum period, including ovarian steroids, the hypothalamic-pituitary-adrenal axis, the serotonergic neurotransmitter system, the thyroid system and inflammatory markers. In addition, current knowledge on candidate genes associated with PPD is reviewed.", "doi": "10.2217/whe.12.55", "pmid": "23181531", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:30:23.308Z", "modified": "2024-10-24T11:29:44.407Z"}, {"entity": "publication", "iuid": "e1ba467e2ba44c14bc053819d46d6780", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e1ba467e2ba44c14bc053819d46d6780.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e1ba467e2ba44c14bc053819d46d6780"}}, "title": "Alcohol consumption among pregnant women in a Swedish sample and its effects on the newborn outcomes.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Hallberg", "given": "Gunilla", "initials": "G"}, {"family": "Helander", "given": "Anders", "initials": "A"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Sundelin-Wahlsten", "given": "Viveka", "initials": "V"}], "type": "journal article", "published": "2012-10-00", "journal": {"title": "Alcohol Clin Exp Res", "issn": "1530-0277", "volume": "36", "issue": "10", "pages": "1779-1786", "issn-l": "0145-6008"}, "abstract": "Little is known about the effects of low levels of maternal alcohol intake on the neuropsychological development of the child. This study is part of an ongoing investigation on maternal drinking and presents data on demographic variables, maternal alcohol use, and birth outcomes from that study.\n\nThe sample comprised 2,264 women from a Swedish antenatal clinic. Retrospective self-report data were collected on alcohol consumption before and during pregnancy, using the Alcohol Use Disorders Identification Test (AUDIT), and on nicotine use. Specific alcohol biomarkers for excessive drinking, carbohydrate-deficient transferrin (CDT) in serum and phosphatidylethanol (PEth) in whole blood, were determined during mid-pregnancy in a subsample of the women. Data on labor and early characteristics of the child were also assessed.\n\nBefore pregnancy, 89% of the women regularly consumed alcohol and 49% reported occasional or frequent binge drinking. Nicotine was used by 15% before and by 5% during pregnancy. During pregnancy, 12% continued using alcohol and 5% also admitted binge drinking. However, all alcohol biomarker values were below the reporting limits (CDT \u2264 1.7% disialotransferrin; total PEth < 0.1 \u03bcmol/L). Self-reported drinking during pregnancy was associated with a higher AUDIT score before pregnancy, nicotine use at the time of the first prenatal visit, older age, and previous legal abortions.\n\nThe AUDIT questionnaire and 2 specific alcohol biomarkers were used in routine maternity care to collect information about drinking during pregnancy and thereby to identify children at risk for alcohol-related complications. While the AUDIT results suggested that a significant number of women continued using alcohol during pregnancy, implying a risk for fetal disorders, the biomarkers showed negative test values thus indicating only modest drinking levels.", "doi": "10.1111/j.1530-0277.2012.01783.x", "pmid": "22486280", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:31:20.755Z", "modified": "2024-10-24T11:29:48.613Z"}, {"entity": "publication", "iuid": "26ad0e89eeed448a8b8cf1e4706eaa09", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/26ad0e89eeed448a8b8cf1e4706eaa09.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/26ad0e89eeed448a8b8cf1e4706eaa09"}}, "title": "Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sylv\u00e9n", "given": "Sara M", "initials": "SM"}, {"family": "Papadopoulos", "given": "Fotios C", "initials": "FC"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "comparative study", "published": "2011-12-00", "journal": {"title": "Arch Womens Ment Health", "issn": "1435-1102", "volume": "14", "issue": "6", "pages": "453-463", "issn-l": "1434-1816"}, "abstract": "Postpartum depression (PPD) is an often underdiagnosed and undertreated mood disorder, with negative impact on the mother's and infant's health. Seasonal variation has been discussed as a risk factor for PPD. Candidate genes, such as those encoding for the brain-derived neurotrophic factor (BDNF), serotonin transporter (5-HTT), and Period2 (PER2), have been associated with depression and seasonal disorders. The present study is aimed to examine whether functional polymorphic variants, BDNF Val66Met, 5-HTTLPR, or PER2 SNP 10870, are associated with PPD symptoms and whether these genetic polymorphisms interact with season in predicting PPD symptoms. This case-control study comprised of 275 women from a population-based cohort of delivering women in Sweden, who completed a questionnaire containing the Edinburgh postnatal depression scale (EPDS) at 6 weeks and 6 months postpartum. Stressful life events (SLEs) and maternity stressors were also assessed. The results did not reveal any statistically significant overall association between the studied genetic polymorphisms and PPD symptoms. However, a significant association between BDNF Met66 carrier status and development of PPD symptoms at 6 weeks postpartum, even when controlling for prepartum and postpartum environmental risk factors, was evident among mothers delivering during autumn/winter. No gene-gene interactions were found but a cumulative effect was detected with carriers of a greater number of 5-HTTLPR S and BDNFVal66Met Met alleles reporting higher EPDS scores, if delivered during autumn/winter. Our findings propose a role of the BDNF gene in the development of PPD symptoms, potentially mediated by season of delivery.", "doi": "10.1007/s00737-011-0239-x", "pmid": "21997575", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:31:21.873Z", "modified": "2024-10-24T11:29:49.702Z"}, {"entity": "publication", "iuid": "26121f40be6049cbab3c4052adb8bb29", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/26121f40be6049cbab3c4052adb8bb29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/26121f40be6049cbab3c4052adb8bb29"}}, "title": "MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption.", "authors": [{"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Leppert", "given": "Jerzy", "initials": "J"}, {"family": "Oreland", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2011-04-00", "journal": {"title": "Addict Biol", "issn": "1369-1600", "volume": "16", "issue": "2", "pages": "347-355", "issn-l": "1355-6215"}, "abstract": "The aim of the present study was to investigate MAOA gene-environment (G*E) interactions in relation to adolescent alcohol consumption. In the county of V\u00e4stmanland, Sweden, all 17-18-year-old students were asked to complete an anonymous questionnaire and provide a saliva sample during class hours. A total of 2263 students completed the questionnaire (77.4%) and a saliva sample was provided by 2131 participants. Failed MAOA u-variable number of tandem repeats (VNTR) genotype analyses and internal non-responses left 851 boys and 735 girls (total n=1586) to be investigated. Alcohol use disorder identification test was used to measure hazardous alcohol consumption. MAOA u-VNTR was used to measure biological risk in interaction with poor family relations and experience of sexual abuse. The model was also adjusted for non-independent socioeconomic variables, separated parents, type of housing and parental unemployment. Results showed that the MAOA u-VNTR, in interaction with psychosocial risk factors, such as the quality of family relations and sexual abuse, was related to high alcohol consumption among adolescents. Girls, carrying the long MAOA u-VNTR variant showed a higher risk of being high alcohol consumers, whereas among boys, the short allele was related to higher alcohol consumption. The present study supports the hypothesis that there is a relation between MAOA u-VNTR and alcohol consumption and that this relation is modulated by environmental factors. Furthermore, the present study also supports the hypothesis that there is a sex difference in the G*E interaction.", "doi": "10.1111/j.1369-1600.2010.00238.x", "pmid": "20731636", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "ADB238"}], "notes": [], "created": "2020-11-20T09:31:25.294Z", "modified": "2024-10-24T08:56:51.225Z"}, {"entity": "publication", "iuid": "43c753b89dc045dcb8e0b0daae3169fc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/43c753b89dc045dcb8e0b0daae3169fc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/43c753b89dc045dcb8e0b0daae3169fc"}}, "title": "Maltreatment, MAOA, and delinquency: sex differences in gene-environment interaction in a large population-based cohort of adolescents.", "authors": [{"family": "Aslund", "given": "C", "initials": "C"}, {"family": "Nordquist", "given": "N", "initials": "N"}, {"family": "Comasco", "given": "E", "initials": "E"}, {"family": "Leppert", "given": "J", "initials": "J"}, {"family": "Oreland", "given": "L", "initials": "L"}, {"family": "Nilsson", "given": "K W", "initials": "KW"}], "type": "journal article", "published": "2011-03-00", "journal": {"title": "Behav. Genet.", "issn": "1573-3297", "volume": "41", "issue": "2", "pages": "262-272", "issn-l": "0001-8244"}, "abstract": "The present study investigated a possible interaction between a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and childhood maltreatment in the prediction of adolescent male and female delinquency. A cohort of 1,825 high school students, 17-18 years old, completed an anonymous questionnaire during class hours which included questions on childhood maltreatment, sexual abuse, and delinquency. Saliva samples were collected for DNA isolation, and analyzed for the MAOA-VNTR polymorphism. Self-reported maltreatment was a strong risk factor for adolescent delinquent behavior. The MAOA genotype also showed a significant main effect when controlled for maltreatment. Boys with a short variant and girls with one or two long variants of the polymorphism showed a higher risk for delinquency when exposed to maltreatment. Our results confirm previous findings of an interaction between the MAOA-VNTR polymorphism and self-reported maltreatment. Results for boys and girls differ according to MAOA-VNTR genotype and direction of phenotypic expression.", "doi": "10.1007/s10519-010-9356-y", "pmid": "20734127", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:31:24.159Z", "modified": "2024-10-24T11:29:51.956Z"}, {"entity": "publication", "iuid": "3500e97cb001475b880a9b998c834f52", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3500e97cb001475b880a9b998c834f52.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3500e97cb001475b880a9b998c834f52"}}, "title": "Postpartum depression symptoms: a case-control study on monoaminergic functional polymorphisms and environmental stressors.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Sylv\u00e9n", "given": "Sara M", "initials": "SM"}, {"family": "Papadopoulos", "given": "Fotios C", "initials": "FC"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2011-02-00", "journal": {"title": "Psychiatr Genet", "issn": "1473-5873", "volume": "21", "issue": "1", "pages": "19-28", "issn-l": "0955-8829"}, "abstract": "Postpartum depression (PPD) is an under diagnosed and under treated mood disorder, with negative impact on both the mother and the infant's health. The aim of this study is to examine whether genetic variations in the monoaminergic neurotransmitter system, together with environmental stressors, contribute to the development of PPD symptoms.\n\nThis nested case-control study included 275 women from a population-based cohort of delivering women in Sweden. A questionnaire containing the Edinburgh Postnatal Depression Scale was collected at 6 weeks and 6 months postpartum. Three functional polymorphisms were genotyped, catechol-O-methyltransferase (COMT)-Val158Met, monoamine oxidase A (MAOA)-upstream variable number tandem repeat (uVNTR) and serotonin transporter linked polymorphic region (5HTT-LPR). Stressful life events, maternity stressors and previous psychiatric contact were considered as potential risk factors.\n\nCOMT-Val158Met was significantly associated with PPD symptoms at 6 weeks, but not at 6 months postpartum. A significant gene-gene interaction effect was present between COMT-Val158Met and MAOA-uVNTR. In a gene-environment multivariate model, COMT-Val158Met, psychiatric contact and maternity stressors were significantly associated with PPD symptoms. Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LPR risk variants were associated with PPD symptoms, whereas in the absence of previous psychiatric contact only maternity stressors were related to PPD symptoms.\n\nThe interaction effect between monoaminergic genes and environmental stressors is likely to contribute to vulnerability for PPD. The different patterns of association according to history of psychiatric problems, if replicated, might be helpful in screening strategies.", "doi": "10.1097/YPG.0b013e328341a3c1", "pmid": "21099450", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:31:23.006Z", "modified": "2024-10-24T11:29:50.889Z"}, {"entity": "publication", "iuid": "33958fdaba7a489b9d0204b8b59053ed", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/33958fdaba7a489b9d0204b8b59053ed.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/33958fdaba7a489b9d0204b8b59053ed"}}, "title": "Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR.", "authors": [{"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Fredrikson", "given": "Mats", "initials": "M"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2010-10-00", "journal": {"title": "Arch Womens Ment Health", "issn": "1435-1102", "volume": "13", "issue": "5", "pages": "417-423", "issn-l": "1434-1816"}, "abstract": "Neuroticism has been linked to a functional polymorphism in the serotonin transporter gene (5-HTTLPR), with short-allele carriers being overrepresented among high-scorers on neuroticism. Studies evaluating neuroticism-related personality traits in relation to the 5-HTTLPR polymorphism among patients with premenstrual dysphoric disorder (PMDD) and are lacking. The primary aim of this study was to evaluate the relationship between PMDD and neuroticism-related personality traits, and secondly, to relate the personality trait scores of PMDD patients to experienced symptom severity and to the 5-HTTLPR short allele. Thirty PMDD patients and 55 asymptomatic healthy controls were included in the study. The Swedish Universities Scale of Personality was used to evaluate personality traits. Genotype analyses were available in 27 PMDD patients and 18 healthy controls. Women with PMDD displayed higher levels of neuroticism-related personality traits (psychic trait anxiety, somatic trait anxiety, embitterment, stress susceptibility and mistrust) than healthy controls, and these effects were most prominent in women with more severe luteal phase symptoms. Furthermore, PMDD patients with at least one copy of the short allele of the 5-HTTLPR polymorphism scored higher on psychic trait anxiety and lack of assertiveness than PMDD patients who were homozygous for the long allele. PMDD patients who suffer from more severe luteal phase symptoms also display increased scores of neuroticism-related personality traits in comparison with healthy controls. Within the group of PMDD patients, differences in certain personality trait scores are associated with the short allele of the 5-HTTLPR polymorphism.", "doi": "10.1007/s00737-010-0164-4", "pmid": "20440524", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC2941046"}], "notes": [], "created": "2020-11-20T09:31:27.762Z", "modified": "2024-10-24T08:56:53.342Z"}, {"entity": "publication", "iuid": "5a88f0c63cd94972a4ad9f89d91505c4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5a88f0c63cd94972a4ad9f89d91505c4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5a88f0c63cd94972a4ad9f89d91505c4"}}, "title": "Why do adolescents drink? Motivational patterns related to alcohol consumption and alcohol-related problems.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Berglund", "given": "Kenneth", "initials": "K"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2010-08-00", "journal": {"title": "Subst Use Misuse", "issn": "1532-2491", "volume": "45", "issue": "10", "pages": "1589-1604", "issn-l": "1082-6084"}, "abstract": "The present study was designed to investigate motivational patterns for drinking alcohol and their relation about alcohol consumption and problems related to alcohol consumption. Data were collected by semistructured interviews and questionnaires, containing questions about reasons for drinking, alcohol consumption, and problems related to alcohol consumption during the years 2001, 2004, and 2005. Three independent population samples from two different counties of central Sweden were included. A total of 11,167 adolescents participated. Data on reasons for drinking were analyzed by factor analysis to extract components explaining drinking motives. Relationships between motivational patterns and alcohol use were examined with correlation analysis. Three drinking motives emerged (social-enhancement, coping, and dominance motives) and related to alcohol consumption and problems related to alcohol consumption. Limitations of the study are noted and discussed.", "doi": "10.3109/10826081003690159", "pmid": "20590377", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:31:26.527Z", "modified": "2024-10-24T08:56:52.272Z"}, {"entity": "publication", "iuid": "ca62411b1e5445d89801037afa0d7fd9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ca62411b1e5445d89801037afa0d7fd9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ca62411b1e5445d89801037afa0d7fd9"}}, "title": "The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "G\u00f6kt\u00fcrk", "given": "Camilla", "initials": "C"}, {"family": "Aslund", "given": "Cecilia", "initials": "C"}, {"family": "Hallman", "given": "Jarmila", "initials": "J"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2010-02-00", "journal": {"title": "Ups. J. Med. Sci.", "issn": "2000-1967", "volume": "115", "issue": "1", "pages": "41-48", "issn-l": "0300-9734"}, "abstract": "Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in the PER2 gene is associated with alcohol consumption in interaction with sleep problems among adolescents.\n\nThe Survey of Adolescent Life and Health in V\u00e4stmanland 2006, a Swedish county, including 1254 students 17-18 years old, was used as a population-representative sample of adolescents. We investigated the PER2 Single Nucleotide polymorphism (SNP) 10870 (A/G) in the cohort together with an assessment of alcohol consumption according to the AUDIT-C questionnaire, and sleep problems using a survey consisting of 18 items. Furthermore, we carried out an exploratory analysis on the PER2 Single Nucleotide Polymorphism 10870 polymorphism in a group of severely alcoholic females.\n\nWe found a significant association of the SNP 10870 in adolescent boys, where the genotype AA, in the presence of several and frequent sleep problems, was associated with increased alcohol consumption. Among adolescent girls, only sleep problems were related to alcohol consumption. A non-significant trend was observed among the severely alcoholic females, with the G allele being over-represented in the severely alcoholic females group in comparision to the control females.\n\nThese results indicate that PER2 gene variation is associated with alcohol consumption in interaction with sleep problems among Swedish adolescent boys.", "doi": "10.3109/03009731003597127", "pmid": "20187847", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC2853353"}], "notes": [], "created": "2020-11-20T09:32:05.402Z", "modified": "2024-10-24T08:56:54.437Z"}, {"entity": "publication", "iuid": "3decbd6039df4aa69f2dba545ac82411", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3decbd6039df4aa69f2dba545ac82411.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3decbd6039df4aa69f2dba545ac82411"}}, "title": "Transcription factor AP2 beta involved in severe female alcoholism.", "authors": [{"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "G\u00f6kt\u00fcrk", "given": "Camilla", "initials": "C"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Hallman", "given": "Jarmila", "initials": "J"}], "type": "journal article", "published": "2009-12-11", "journal": {"title": "Brain Res", "issn": "1872-6240", "volume": "1305 Suppl", "issue": null, "pages": "S20-S26", "issn-l": "0006-8993"}, "abstract": "Susceptibility to alcoholism and antisocial behavior exhibits an evident link to monoaminergic neurotransmission. The serotonin system in particular, which is associated with regulation of mood and behavior, has an influence on personality characters that are firmly connected to risk of developing alcoholism and antisocial behavior, such as impulsiveness, and aggression. The transcription factor TFAP2b has repeatedly been shown to be involved in monoaminergic transmission, likely due to a regulatory effect on genes that are fundamental to this system, e.g. monoamine oxidase type A, and the serotonin transporter. Recent research has identified a functional polymorphism in the gene encoding TFAP2B that regulates its level of expression. In the present study we have compared a sample of female alcoholics (n=107), sentenced to institutional care for their severe addiction, contrasted against a control sample of adolescent females (n=875). The results showed that parental alcohol misuse was significantly more common among the alcoholic females, and also that parental alcohol misuse was associated with a reduction in age of alcohol debut. We also addressed the question of whether a functional TFAP2b polymorphism was associated with alcoholism. Results showed that the high-functioning allele was significantly more common among the female alcoholics, compared to the non-alcoholic controls. Furthermore, the results also indicated that psychosocial factors, in terms of parental alcohol misuse, depression or psychiatric disorder, had an influence on the association. It was observed that the genetic association was restricted to the subset of cases that had not experienced these negative psychosocial factors.", "doi": "10.1016/j.brainres.2009.09.054", "pmid": "19778525", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0006-8993(09)01985-4"}], "notes": [], "created": "2020-11-20T09:32:06.644Z", "modified": "2024-10-24T08:56:55.482Z"}, {"entity": "publication", "iuid": "4cec93703d014152850ea7e5243efef7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4cec93703d014152850ea7e5243efef7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4cec93703d014152850ea7e5243efef7"}}, "title": "The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents.", "authors": [{"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "G\u00f6kt\u00fcrk", "given": "Camilla", "initials": "C"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Eensoo", "given": "Diva", "initials": "D"}, {"family": "Meren\u00e4kk", "given": "Liis", "initials": "L"}, {"family": "Veidebaum", "given": "Toomas", "initials": "T"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Harro", "given": "Jaanus", "initials": "J", "orcid": "0000-0002-4484-2096", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330.json"}}], "type": "journal article", "published": "2009-09-00", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-7381", "volume": "17", "issue": "9", "pages": "1762-1767", "issn-l": null}, "abstract": "Insulin resistance and central adiposity are strong risk indicators for type 2 diabetes and coronary heart disease. An important role for adipose tissue in the etiology and progression of these conditions has recently become more evident. A transcription factor, TFAP2B, has been shown to participate in the regulation of adipocyte metabolism, by facilitating glucose uptake and lipid accumulation, while simultaneously reducing insulin sensitivity, and recently a direct function for TFAP2B as an inhibitor of adiponectin expression was observed. In this study, we have investigated how insulin resistance, plasma adiponectin, and central adiposity, in a normal population of adolescents, are affected by genetic variability in TFAP2B. Our results show that both insulin sensitivity, as measured from levels of fasting glucose and insulin, and central adiposity, estimated by subscapular skinfold thickness, were significantly associated to genetic variability in TFAP2B. This association was restricted to males only, where carriers of the 4-repeat allele of intron 2 had higher insulin sensitivity and lower subscapular skinfold thickness. Levels of adiponectin did not show any association to the TFAP2B polymorphism, but was negatively correlated to central adiposity in females. These results suggest that reduction of TFAP2B expression could have a protective effect against future risk of complications associated with decreased insulin sensitivity and central adiposity, such as type 2 diabetes and coronary heart disease.", "doi": "10.1038/oby.2009.83", "pmid": "19325541", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "oby200983"}], "notes": [], "created": "2020-11-20T09:32:11.171Z", "modified": "2026-08-27T07:56:12.569Z"}, {"entity": "publication", "iuid": "69d11789492f48b8a4604bfb678c2a60", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/69d11789492f48b8a4604bfb678c2a60.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/69d11789492f48b8a4604bfb678c2a60"}}, "title": "Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study.", "authors": [{"family": "Aslund", "given": "Cecilia", "initials": "C"}, {"family": "Leppert", "given": "Jerzy", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "journal article", "published": "2009-09-00", "journal": {"title": "Behav. Genet.", "issn": "1573-3297", "volume": "39", "issue": "5", "pages": "524-531", "issn-l": "0001-8244"}, "abstract": "Serotonin plays a central role in mood regulation and the development of depressive disorders. The present study investigated whether a functional polymorphism (5HTTLPR) of the serotonin transporter gene interacts with maltreatment in the prediction of depression. A cohort of 17-18 years old students (n = 1,482) anonymously completed the Survey of Adolescent Life and Health in Vestmanland 2006 and gave a saliva sample for DNA extraction. An association between maltreatment and adolescent depression was found independent of sex. When the whole population was analyzed, no main effect of 5HTTLPR in association with depression was found. When separated by sex, a significant main effect and a G x E interaction effect of the SS allele was found among girls. No gene main effect or G x E interaction effect was found among boys. The present study confirms previous findings of sex differences in interaction effects between the 5HTTLPR polymorphism and maltreatment in the prediction of adolescent depression.", "doi": "10.1007/s10519-009-9285-9", "pmid": "19582567", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:32:08.897Z", "modified": "2024-10-24T08:56:57.552Z"}, {"entity": "publication", "iuid": "03d92791edae40d29e842c28dd7bad4e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/03d92791edae40d29e842c28dd7bad4e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/03d92791edae40d29e842c28dd7bad4e"}}, "title": "Adolescent alcohol consumption: biomarkers PEth and FAEE in relation to interview and questionnaire data.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Leppert", "given": "Jerzy", "initials": "J"}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Kronstrand", "given": "Robert", "initials": "R"}, {"family": "Alling", "given": "Christer", "initials": "C"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW"}], "type": "comparative study", "published": "2009-09-00", "journal": {"title": "J Stud Alcohol Drugs", "issn": "1938-4114", "volume": "70", "issue": "5", "pages": "797-804", "issn-l": "1937-1888"}, "abstract": "The aim of this study was to investigate the congruence of biomarkers, questionnaires, and interviews as instruments to assess adolescent alcohol consumption.\n\nThe methodology used was a cross-sectional study with a randomized sample. Four different methods were used to estimate high adolescent alcohol consumption. The concordance of the results was investigated. Surveys were performed, and biological specimens were collected at all schools in the county of V\u00e4stmanland, Sweden, in 2001. Eighty-one boys and 119 girls from a population of 16- and 19-year-old adolescents were randomly selected from quartiles of volunteers representing various degrees of psychosocial risk behaviors. Using a questionnaire (for a 1-hour session) and in-depth interviews, subjects were assessed regarding their alcohol-use habits. Blood and hair samples were analyzed for phosphatidylethanol (PEth) and fatty acid ethyl esters (FAEEs), respectively.\n\nHigh alcohol consumption was underreported in the questionnaire compared with the interviews. PEth and FAEE analyses weakly confirmed the self-reports, and the results of the two biochemical tests did not overlap. The PEth blood test was the most specific but the least sensitive, whereas the FAEE hair test revealed low specificity and an overrepresentation of positive results in girls.\n\nThe expected higher self-report of high alcohol consumption by interview rather than by questionnaire was confirmed partly because of the influence of a bogus pipeline procedure. The absence of overlap between PEth and FAEE results and their poor agreement with self-reports suggested that biomarkers are unsuitable as screening tools for alcohol consumption in adolescents.", "doi": "10.15288/jsad.2009.70.797", "pmid": "19737505", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-20T09:32:07.765Z", "modified": "2024-10-24T08:56:56.515Z"}, {"entity": "publication", "iuid": "ba043fdd068549f3bfd4e065baefeb9a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ba043fdd068549f3bfd4e065baefeb9a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ba043fdd068549f3bfd4e065baefeb9a"}}, "title": "Personality and the serotonin transporter gene: Associations in a longitudinal population-based study.", "authors": [{"family": "Harro", "given": "Jaanus", "initials": "J", "orcid": "0000-0002-4484-2096", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330.json"}}, {"family": "Meren\u00e4kk", "given": "Liis", "initials": "L"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Konstabel", "given": "Kenn", "initials": "K"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Oreland", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2009-04-00", "journal": {"title": "Biol Psychol", "issn": "1873-6246", "volume": "81", "issue": "1", "pages": "9-13", "issn-l": "0301-0511"}, "abstract": "Associations between the promoter polymorphism of the serotonin transporter gene (5-HTTLPR) and anxiety-related personality traits in healthy adult subjects have been inconsistent. We assessed personality in participants of the Estonian Children Personality Behaviour and Health Study, using parental reports and self-reports. In the younger cohort, according to parental assessments at ages 9 and 15, children homozygous for the S allele had significantly higher scores of Neuroticism and lower scores of Openness, Agreeableness and Conscientiousness. Parental assessment of the older cohort at ages 15 and 18 did not yield any genotype effect on personality; however, interaction of cohort and genotype was not significant. According to self-reports, SS homozygotes had higher Neuroticism at age 15 but not at age 18. Thus, homozygocity for the S allele of the 5-HTTLPR is related to anxiety-related personality traits in general population, but this is easier to detect before adolescence.", "doi": "10.1016/j.biopsycho.2009.01.001", "pmid": "19437595", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0301-0511(09)00002-7"}], "notes": [], "created": "2025-09-10T18:13:51.587Z", "modified": "2025-10-23T08:53:20.720Z"}]}