{"entity": "journal", "iuid": "eb33dd7e71894f8da85a99eb465c1828", "timestamp": "2026-08-20T21:22:35.921Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Vaccines%20%28Basel%29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Vaccines%20%28Basel%29"}}, "title": "Vaccines (Basel)", "issn": "2076-393X", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "a71c46f25a9c401b977281217cb18601", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a71c46f25a9c401b977281217cb18601.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a71c46f25a9c401b977281217cb18601"}}, "title": "Long-Term Survival and Immune Response Dynamics in Melanoma Patients Undergoing TAPCells-Based Vaccination Therapy.", "authors": [{"family": "Tittarelli", "given": "Andr\u00e9s", "initials": "A", "orcid": "0000-0003-4129-9734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4b33ae07f33248c2b87955e83d5fc6de.json"}}, {"family": "Pereda", "given": "Cristian", "initials": "C", "orcid": "0009-0000-1033-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aab236d1354243cc942b474809e714ec.json"}}, {"family": "Gleisner", "given": "Mar\u00eda A", "initials": "MA", "orcid": "0000-0002-4172-9709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa028fc3b7b54583805e12ba55ef11da.json"}}, {"family": "L\u00f3pez", "given": "Mercedes N", "initials": "MN"}, {"family": "Flores", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Tempio", "given": "Fabi\u00e1n", "initials": "F"}, {"family": "Lladser", "given": "Alvaro", "initials": "A", "orcid": "0000-0002-5576-1478", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67fcde9ec88d497e91d5e64a2d785549.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Gonz\u00e1lez", "given": "Ferm\u00edn E", "initials": "FE", "orcid": "0000-0002-4212-1009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9671a5793684845a35362cea70d03df.json"}}, {"family": "Dur\u00e1n-Aniotz", "given": "Claudia", "initials": "C", "orcid": "0000-0003-2503-8366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f0c51284b534d0ab63339baa9f07682.json"}}, {"family": "Miranda", "given": "Juan P", "initials": "JP"}, {"family": "Larrondo", "given": "Milton", "initials": "M"}, {"family": "Salazar-Onfray", "given": "Flavio", "initials": "F", "orcid": "0000-0002-1848-5697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d4f0919a9b444a1a690c9fb6cb9c25f.json"}}], "type": "journal article", "published": "2024-03-27", "journal": {"title": "Vaccines (Basel)", "issn": "2076-393X", "volume": "12", "issue": "4", "issn-l": null}, "abstract": "Cancer vaccines present a promising avenue for treating immune checkpoint blockers (ICBs)-refractory patients, fostering immune responses to modulate the tumor microenvironment. We revisit a phase I/II trial using Tumor Antigen-Presenting Cells (TAPCells) (NCT06152367), an autologous antigen-presenting cell vaccine loaded with heat-shocked allogeneic melanoma cell lysates. Initial findings showcased TAPCells inducing lysate-specific delayed-type hypersensitivity (DTH) reactions, correlating with prolonged survival. Here, we extend our analysis over 15 years, categorizing patients into short-term (<36 months) and long-term (\u226536 months) survivors, exploring novel associations between clinical outcomes and demographic, genetic, and immunologic parameters. Notably, DTHpos patients exhibit a 53.1% three-year survival compared to 16.1% in DTHneg patients. Extended remissions are observed in long-term survivors, particularly DTHpos/M1cneg patients. Younger age, stage III disease, and moderate immune events also benefit short-term survivors. Immunomarkers like increased C-type lectin domain family 2 member D on CD4+ T cells and elevated interleukin-17A were detected in long-term survivors. In contrast, toll-like receptor-4 D229G polymorphism and reduced CD32 on B cells are associated with reduced survival. TAPCells achieved stable long remissions in 35.2% of patients, especially M1cneg/DTHpos cases. Conclusions: Our study underscores the potential of vaccine-induced immune responses in melanoma, emphasizing the identification of emerging biological markers and clinical parameters for predicting long-term remission.", "doi": "10.3390/vaccines12040357", "pmid": "38675738", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11053591"}, {"db": "pii", "key": "vaccines12040357"}], "notes": [], "created": "2026-08-20T13:43:21.587Z", "modified": "2026-08-20T13:43:21.931Z"}, {"entity": "publication", "iuid": "8c2fc42b1fa44b0ea79efff3fc480a45", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8c2fc42b1fa44b0ea79efff3fc480a45.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8c2fc42b1fa44b0ea79efff3fc480a45"}}, "title": "HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.", "authors": [{"family": "R\u00f6hl", "given": "Maria", "initials": "M"}, {"family": "Tjernlund", "given": "Annelie", "initials": "A"}, {"family": "Lajoie", "given": "Julie", "initials": "J"}, {"family": "Edfeldt", "given": "Gabriella", "initials": "G", "orcid": "0000-0003-0366-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc30318aa3ca4720ac5aa3a982c9f730.json"}}, {"family": "Bradley", "given": "Frideborg", "initials": "F"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Kaldhusdal", "given": "Vilde", "initials": "V"}, {"family": "\u00c5hlberg", "given": "Alexandra", "initials": "A"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Omollo", "given": "Kenneth", "initials": "K"}, {"family": "Boily-Larouche", "given": "Genevi\u00e8ve", "initials": "G"}, {"family": "Asghar", "given": "Muhammad", "initials": "M"}, {"family": "Kwon", "given": "Douglas S", "initials": "DS"}, {"family": "Oyugi", "given": "Julius", "initials": "J"}, {"family": "Kimani", "given": "Joshua", "initials": "J"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Fowke", "given": "Keith R", "initials": "KR"}, {"family": "Broliden", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "Vaccines (Basel)", "issn": "2076-393X", "volume": "9", "issue": "3", "issn-l": null}, "abstract": "Immunological correlates of natural resistance to HIV have been identified in HIV-exposed seronegative (HESN) individuals and include a low-inflammatory genital mucosal status. The cervicovaginal epithelium has not been studied for such correlates despite constituting an important barrier against sexual HIV transmission. To fill this gap in knowledge, we collected samples of blood, cervical mononuclear cells, cervicovaginal lavage, and ectocervical tissue from Kenyan HESN sex workers (n = 29) and controls (n = 33). The samples were analyzed by flow cytometry, protein profiling, 16S rRNA gene sequencing, in situ image analysis, and tissue-based RNA sequencing. A significantly higher relative proportion of regulatory T cells in blood (B7+CD25hiFoxP3+CD127loCD4+ and B7+Helios+FoxP3+CD4+), and a significantly lower proportion of activated cervical T cells (CCR5+CD69+CD4+ and CCR5+CD69+CD8+), were found in the HESN group compared with the controls. In contrast, there were no statistically significant differences between the study groups in cervicovaginal protein and microbiome compositions, ectocervical epithelial thickness, E-cadherin expression, HIV receptor expression, and tissue RNA transcriptional profiles. The identification of an intact ectocervical microenvironment in HESN individuals add new data to current knowledge about natural resistance to sexual transmission of HIV.", "doi": "10.3390/vaccines9030217", "pmid": "33806390", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7998094"}, {"db": "pii", "key": "vaccines9030217"}], "notes": [], "created": "2026-08-20T13:43:23.854Z", "modified": "2026-08-20T13:43:23.970Z"}], "created": "2026-08-20T13:43:21.896Z", "modified": "2026-08-20T13:43:21.896Z"}