{"entity": "journal", "iuid": "62863e3ca92f42de80a84c16bfe446df", "timestamp": "2026-05-09T17:40:35.871Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Trends%20in%20Immunology.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Trends%20in%20Immunology"}}, "title": "Trends in Immunology", "issn": "1471-4906", "issn-l": "1471-4906", "publications_count": 1, "publications": [{"entity": "publication", "iuid": "bf0ee65795124205abadcf201b07d47b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf0ee65795124205abadcf201b07d47b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf0ee65795124205abadcf201b07d47b"}}, "title": "Inflammasomes of the intestinal epithelium", "authors": [{"family": "Sellin", "given": "Mikael E", "initials": "ME"}, {"family": "Maslowski", "given": "Kendle M", "initials": "KM"}, {"family": "Maloy", "given": "Kevin J", "initials": "KJ"}, {"family": "Hardt", "given": "Wolf Dietrich", "initials": "WD"}], "type": "journal-article", "published": "2015-08-00", "journal": {"volume": "36", "issn": "1471-4906", "issue": "8", "pages": "442-450", "title": "Trends in Immunology", "issn-l": "1471-4906"}, "abstract": "While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria. ", "doi": "10.1016/j.it.2015.06.002", "pmid": "26166583", "labels": {"Mikael Sellin": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2018-12-03T14:37:53.553Z", "modified": "2022-11-07T11:35:37.959Z"}], "created": "2018-12-03T14:37:53.566Z", "modified": "2020-11-27T13:12:54.241Z"}