{"entity": "journal", "iuid": "2e500e5e97a5444f84cf4fed3930d30e", "timestamp": "2026-05-12T22:38:20.843Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Scand.%20J.%20Gastroenterol..json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Scand.%20J.%20Gastroenterol."}}, "title": "Scand. J. Gastroenterol.", "issn": "1502-7708", "issn-l": "0036-5521", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "2195d3173411440cbf65e96d7e61cb60", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2195d3173411440cbf65e96d7e61cb60.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2195d3173411440cbf65e96d7e61cb60"}}, "title": "Gastrointestinal cancer precursor risk and mortality in pancreatic intraductal papillary mucinous neoplasms: a nationwide cohort study.", "authors": [{"family": "Vujasinovic", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-6496-295X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/df1d05afd7a649e6b62a3a9ee6784ea8.json"}}, {"family": "Elbe", "given": "Peter", "initials": "P"}, {"family": "Ekheden", "given": "Isabella", "initials": "I"}, {"family": "Wang", "given": "Qiao-Li", "initials": "QL"}, {"family": "Thuresson", "given": "Marcus", "initials": "M"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Ghazi", "given": "Sam", "initials": "S"}, {"family": "L\u00f6hr", "given": "J-Matthias", "initials": "JM"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bbd74e2ef664d9687a2c8bc616dec07.json"}}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Scand. J. Gastroenterol.", "issn": "1502-7708", "volume": "59", "issue": "5", "pages": "600-607", "issn-l": "0036-5521"}, "abstract": "Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a precursor of pancreatic cancer. While earlier research has shown a high prevalence of synchronous/metachronous extrapancreatic tumors in IPMN patients, these studies have often been small with retrospective data collection. The aim of the study was to examine absolute and relative risks of non-pancreatic gastrointestinal (GI) cancer precursors and mortality in histologically confirmed IPMN.\n\nThrough the nationwide ESPRESSO histopathology cohort, we retrieved data on IPMN between 1965 and 2016. Each index case was matched to \u22645 general population controls. Through Cox regression, we estimated hazard ratios (HRs) for future GI cancer precursors and death.\n\nA total of 117 patients with IPMN and 539 age- and sex-matched controls were included. Over a median of 2.1 years of follow up, we confirmed two (1.7%) incident GI cancer precursors in IPMN vs. four (0.7%) in controls, corresponding to an HR of 1.89 (95%CI = 0.34-10.55). By contrast, IPMN patients were at increased risk of death (HR 3.61 (95%CI = 1.79-7.27)). The most common cause of death in IPMN was pancreatic cancer (n = 14; 45.2% of all deaths).\n\nWe found no association between IPMN and other GI cancer precursors. This argues against comprehensive routine surveillance for other GI cancer precursors in IPMN patients. Mortality was increased in IPMN with pancreatic cancer being the most common cause of death, indicating the need for lifelong follow up in all resected and non-resected patients with IPMN. However, results should be confirmed in larger cohorts.", "doi": "10.1080/00365521.2024.2310162", "pmid": "38351653", "labels": {"DDLS Fellow": null, "Qiaoli Wang": null}, "xrefs": [], "notes": [], "created": "2025-11-28T12:24:34.540Z", "modified": "2025-11-28T12:24:34.584Z"}, {"entity": "publication", "iuid": "717022265f074bd6998670aa2f225090", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/717022265f074bd6998670aa2f225090.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/717022265f074bd6998670aa2f225090"}}, "title": "Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study.", "authors": [{"family": "Alexandersson", "given": "Bjarki T", "initials": "BT"}, {"family": "Hugerth", "given": "Luisa W", "initials": "LW"}, {"family": "Hedin", "given": "Charlotte", "initials": "C"}, {"family": "Forsberg", "given": "Anna", "initials": "A"}, {"family": "Talley", "given": "Nicholas J", "initials": "NJ"}, {"family": "Agreus", "given": "Lars", "initials": "L"}, {"family": "J\u00e4rbrink-Sehgal", "given": "Ellionore", "initials": "E"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Andreasson", "given": "Anna", "initials": "A", "orcid": "0000-0003-0203-7977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee0ba3e533b6411eb61bdfad641ef474.json"}}, {"family": "Schmidt", "given": "Peter T", "initials": "PT", "orcid": "0000-0001-8338-5468", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e891fe37f73f49c798aa7ccc39e35417.json"}}], "type": "journal article", "published": "2023-03-29", "journal": {"title": "Scand. J. Gastroenterol.", "issn": "1502-7708", "pages": "1131-1138", "volume": "58", "issue": "10", "issn-l": "0036-5521"}, "abstract": "The etiopathogenesis of diverticular disease is unknown.\n\nTo compare the fecal and mucosa-associated microbiota between participants with and without diverticulosis and participants who later developed diverticulitis versus those that did not from a population-based study.\n\nThe PopCol study, conducted in Stockholm, Sweden, invited a random sample of 3556 adults to participate, of which 745 underwent colonoscopy. Overall, 130 participants (17.5%) had diverticulosis. 16S rRNA gene sequencing was conducted on available sigmoid biopsy samples from 529 and fecal samples from 251 individuals. We identified individuals who subsequently developed acute diverticulitis up to 13 years after sample collection. In a case-control design matching for gender, age (+/-5 years), smoking and antibiotic exposure, we compared taxonomic composition, richness and diversity of the microbiota between participants with or without diverticulosis, and between participants who later developed acute diverticulitis versus those who did not.\n\nNo differences in microbiota richness or diversity were observed between participants with or without diverticulosis, nor for those who developed diverticulitis compared with those who did not. No bacterial taxa were significantly different between participants with diverticulosis compared with those without diverticulosis. Individuals who later developed acute diverticulitis (2.8%) had a higher abundance of genus Comamonas than those who did not (p = .027).\n\nIn a population-based cohort study the only significant difference was that those who later develop diverticulitis had more abundance of genus Comamonas. The significance of Comamonas is unclear, suggesting a limited role for the gut microbiota in the etiopathogenesis of diverticular disease.", "doi": "10.1080/00365521.2023.2194010", "pmid": "36987880", "labels": {"DDLS Fellow": null, "Luisa Hugerth": null}, "xrefs": [], "notes": [], "created": "2023-05-12T13:19:58.189Z", "modified": "2023-10-27T09:27:44.352Z"}, {"entity": "publication", "iuid": "5e127f73b6c64763a2babe032cd5c160", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5e127f73b6c64763a2babe032cd5c160.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5e127f73b6c64763a2babe032cd5c160"}}, "title": "Helicobacter pylori eradication in the Swedish population.", "authors": [{"family": "Doorakkers", "given": "Eva", "initials": "E"}, {"family": "Lagergren", "given": "Jesper", "initials": "J"}, {"family": "Gajulapuri", "given": "Vijaya Krishna", "initials": "VK"}, {"family": "Callens", "given": "Steven", "initials": "S"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}], "type": "journal article", "published": "2017-03-21", "journal": {"title": "Scand. J. Gastroenterol.", "issn": "1502-7708", "volume": "52", "issue": "6-7", "pages": "678-685", "issn-l": "0036-5521"}, "abstract": "Helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7\u00a0days. Yet, other antibiotic regimens are sometimes prescribed. We aimed to assess the use of eradication therapy for H. pylori in the Swedish population during the last decade.\n\nThis population-based study used data from the Swedish Prescribed Drug Register. From July 2005 until December 2014, all regimens that can eradicate H. pylori were identified and evaluated according to patients' age and sex and calendar year of eradication.\n\nWe identified 157,915 eradication episodes in 140,391 individuals (53.8% women, 42.6% older than 60\u00a0years), who correspond to 1.5% of the Swedish population. The absolute number and incidence of eradications decreased over the study period. Overall, 91.0% had one eradication and 0.1% had more than three. Of all eradications, 95.4% followed the recommended regimen, while 4.7% did not. The latter group was overrepresented among individuals aged \u226580\u00a0years (7.8%). Amoxicillin and clarithromycin were most frequently prescribed, while metronidazole was rarely used (0.01%). Other prescribed antibiotics were ciprofloxacin (2.4%), doxycycline (1.4%), nitrofurantoin (0.7%), norfloxacin (0.5%) and erythromycin (0.3%).\n\nDuring the last decade in Sweden H. pylori eradication has been frequently prescribed, but the incidence of eradication has slowly declined. Most eradications followed the recommended regimen, including those occurring after a previous eradication.", "doi": "10.1080/00365521.2017.1303844", "pmid": "28323552", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T11:58:12.662Z", "modified": "2018-12-05T11:58:12.692Z"}], "created": "2018-12-05T11:58:12.676Z", "modified": "2020-11-27T13:12:54.624Z"}