{"entity": "journal", "iuid": "c809af533e85404683d1d3221899237b", "timestamp": "2026-08-22T06:56:01.878Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Scand%20J%20Rheumatol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Scand%20J%20Rheumatol"}}, "title": "Scand J Rheumatol", "issn": "1502-7732", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "9e501bf7df1d4f32957c7bd05a5c02f8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9e501bf7df1d4f32957c7bd05a5c02f8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9e501bf7df1d4f32957c7bd05a5c02f8"}}, "title": "Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice.", "authors": [{"family": "Drevinge", "given": "C", "initials": "C", "orcid": "0000-0002-6442-1328", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68561ef17a0b4d0585715ea0af5d10e0.json"}}, {"family": "Scheffler", "given": "J M", "initials": "JM"}, {"family": "Nordqvist", "given": "J", "initials": "J", "orcid": "0000-0002-2567-228X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/920bbde7700b4e13af874a4e8fcc6022.json"}}, {"family": "Engdahl", "given": "C", "initials": "C", "orcid": "0000-0002-8914-0178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2ae612ebc00449794853a6912f3f1f5.json"}}, {"family": "Carlsten", "given": "H", "initials": "H", "orcid": "0000-0002-9321-5152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/186ca5dcea53467fa3e6c363d2841882.json"}}, {"family": "Islander", "given": "U", "initials": "U", "orcid": "0000-0002-8493-1739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/344771532a2b4cb080d8451e5c9e5c72.json"}}], "type": "journal article", "published": "2024-01-00", "journal": {"title": "Scand J Rheumatol", "issn": "1502-7732", "volume": "53", "issue": "1", "pages": "49-58", "issn-l": null}, "abstract": "Systemic lupus erythematosus (SLE or lupus) is an autoimmune disease characterized by B-cell dysfunction, production of autoantibodies, and immune complex formation. Lupus is overrepresented in females, indicating that sex hormones play a role in the pathophysiology. Treatment with a tissue-selective oestrogen complex (TSEC) containing conjugated oestrogens and the selective oestrogen receptor modulator bazedoxifene (BZA) protects against postmenopausal vasomotor symptoms and osteoporosis, but its impact on organ damage in lupus is not fully understood.\n\nWe used ovariectomized MRL/lpr mice, treated with two different physiological doses of 17\u03b2-oestradiol-3-benzoate (E2), BZA, or TSEC (E2 plus BZA), to assess early and late B-cell development and to determine histological disease manifestations in the kidneys and salivary glands.\n\nTSEC treatment reduced the frequency of the pre-BI population in bone marrow to levels equivalent to treatment with physiological doses of E2 alone but did not affect any of the other examined B-cell populations. Our earlier studies indicated that TSEC treatment did not aggravate disease development in ovariectomized MRL/lpr mice, while protecting against trabecular bone loss. Here, we follow up on our previous study and show that neither ovariectomy alone nor TSEC treatment of ovariectomized MRL/lpr mice influenced perivascular lymphocyte infiltration to the kidneys or salivary glands.\n\nTSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.", "doi": "10.1080/03009742.2023.2251753", "pmid": "37722827", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:04:40.666Z", "modified": "2026-08-21T12:04:40.937Z"}, {"entity": "publication", "iuid": "35232d84f22c4e849e43c67fd7c9dfac", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/35232d84f22c4e849e43c67fd7c9dfac.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/35232d84f22c4e849e43c67fd7c9dfac"}}, "title": "Allele frequency spectrum of known ankylosing spondylitis associated variants in a Swedish population.", "authors": [{"family": "Mathioudaki", "given": "A", "initials": "A"}, {"family": "Nordin", "given": "J", "initials": "J"}, {"family": "Kastbom", "given": "A", "initials": "A"}, {"family": "S\u00f6derkvist", "given": "P", "initials": "P"}, {"family": "Eriksson", "given": "P", "initials": "P"}, {"family": "Cedergren", "given": "J", "initials": "J"}, {"family": "Lindblad-Toh", "given": "K", "initials": "K"}, {"family": "Meadows", "given": "Jrs", "initials": "J"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Scand J Rheumatol", "issn": "1502-7732", "volume": "51", "issue": "1", "pages": "21-24", "issn-l": null}, "abstract": "Objective: The genetic predisposition to ankylosing spondylitis (AS) has been most widely studied in cohorts with European ancestry. However, within Europe, disease prevalence is higher in Sweden. Given this, we aimed to characterize known AS susceptibility variants in a homogeneous Swedish data set, assessing reproducibility and direction of effect.Method: The power to detect association within an existing Swedish targeted sequencing study (381 controls; 310 AS cases) was examined, and a set of published associations (n = 151) was intersected with available genotypes. Association to disease was calculated using logistic regression accounting for population structure, and HLA-B27 status was determined with direct polymerase chain reaction genotyping.Results: The cases were found to be 92.3% HLA-B27 positive, with the data set showing \u2265 80% predictive power to replicate associations, with odds ratios \u2265 1.6 over a range of allele frequencies (0.1-0.7). Thirty-four markers, representing 23 gene loci, were available for investigation. The replicated variants tagged MICA and IL23R loci (p < 1.47 \u00d7 10-3), with variable direction of effect noted for gene loci IL1R1 and MST1.Conclusion: The Swedish data set successfully replicated both major histocompatibility complex (MHC) and non-MHC loci, and revealed a different replication pattern compared to discovery data sets. This was possibly due to population demographics, including HLA-B27 frequency and measured comorbidities.", "doi": "10.1080/03009742.2021.1916202", "pmid": "34169791", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:35:07.426Z", "modified": "2026-08-20T09:35:07.464Z"}], "created": "2026-08-20T09:35:07.435Z", "modified": "2026-08-20T09:35:07.435Z"}