{"entity": "journal", "iuid": "00facab3abea406a920ae678a9857dc0", "timestamp": "2026-09-26T23:26:16.261Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Psychiatry%20Res%20Neuroimaging.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Psychiatry%20Res%20Neuroimaging"}}, "title": "Psychiatry Res Neuroimaging", "issn": "1872-7506", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "ed721de0d20e41ccbf5b98a469699fe7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed721de0d20e41ccbf5b98a469699fe7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed721de0d20e41ccbf5b98a469699fe7"}}, "title": "Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder.", "authors": [{"family": "Kraus", "given": "Jakub", "initials": "J"}, {"family": "Frick", "given": "Andreas", "initials": "A"}, {"family": "Fischer", "given": "H\u00e5kan", "initials": "H"}, {"family": "Howner", "given": "Katarina", "initials": "K"}, {"family": "Fredrikson", "given": "Mats", "initials": "M"}, {"family": "Furmark", "given": "Tomas", "initials": "T"}], "type": "journal article", "published": "2018-10-30", "journal": {"title": "Psychiatry Res Neuroimaging", "issn": "1872-7506", "volume": "280", "pages": "56-61", "issn-l": null}, "abstract": "Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.", "doi": "10.1016/j.pscychresns.2018.08.012", "pmid": "30165271", "labels": [], "xrefs": [{"db": "pii", "key": "S0925-4927(18)30065-9"}], "notes": [], "created": "2026-09-23T11:47:49.551Z", "modified": "2026-09-23T11:47:49.605Z"}, {"entity": "publication", "iuid": "23deeabcd334411084f1c0c071fe3238", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/23deeabcd334411084f1c0c071fe3238.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/23deeabcd334411084f1c0c071fe3238"}}, "title": "Within-session effect of repeated stress exposure on extinction circuitry function in social anxiety disorder.", "authors": [{"family": "\u00c5hs", "given": "Fredrik", "initials": "F"}, {"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Furmark", "given": "Tomas", "initials": "T"}, {"family": "Fredrikson", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2017-03-30", "journal": {"title": "Psychiatry Res Neuroimaging", "issn": "1872-7506", "volume": "261", "pages": "85-90", "issn-l": null}, "abstract": "Anxiety reduction following repeated exposure to stressful experiences is generally held to depend on neural processes involved in extinction of conditioned fear. We predicted that repeated exposure to stressful experiences would change activity throughout the circuitry serving extinction, including ventromedial prefrontal cortex (vmPFC), the hippocampus and the amygdala. To test this prediction, 36 participants diagnosed with SAD performed two successive speeches in front of an observing audience while regional cerebral blood flow (rCBF) was recorded using positron emission tomography. To control for non-anxiolytic effects of repeated exposure, rCBF was also measured during repeated presentations of neutral and angry facial expressions. Results showed that anxiety ratings and heart rate decreased from the first to the second speech, indicating an anxiolytic effect of repeated exposure. Exposure attenuated rCBF in the amygdala whereas no change in rCBF was observed in the vmPFC or hippocampus. The rCBF-reductions in the amygdala were greater following repetition of the speech task than repetition of face exposure indicating that they were specific to anxiety attenuation and not due to a reduced novelty. Our findings suggest that amygdala-related attenuation processes are key to understanding the working mechanisms of exposure therapy.", "doi": "10.1016/j.pscychresns.2017.01.009", "pmid": "28167379", "labels": [], "xrefs": [{"db": "pii", "key": "S0925-4927(16)30357-2"}], "notes": [], "created": "2026-09-23T12:47:30.441Z", "modified": "2026-09-23T12:47:30.476Z"}], "created": "2026-09-23T11:47:49.563Z", "modified": "2026-09-23T11:47:49.563Z"}