{"entity": "journal", "iuid": "fb8e110f80ab44cbbe72f0fac42f07f6", "timestamp": "2026-10-12T21:06:41.945Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Prog%20Neuropsychopharmacol%20Biol%20Psychiatry.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Prog%20Neuropsychopharmacol%20Biol%20Psychiatry"}}, "title": "Prog Neuropsychopharmacol Biol Psychiatry", "issn": "1878-4216", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "9ae7531fa9fd4822908954b7714623ed", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9ae7531fa9fd4822908954b7714623ed.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9ae7531fa9fd4822908954b7714623ed"}}, "title": "Genetic variation of the estrogen receptor and its association with depression and anxiety symptoms in young females.", "authors": [{"family": "Musaoglu", "given": "Mirac Nur", "initials": "MN"}, {"family": "Olofsdotter", "given": "Susanne", "initials": "S"}, {"family": "Vadlin", "given": "Sofia", "initials": "S"}, {"family": "\u00c5slund", "given": "Cecilia", "initials": "C"}, {"family": "Kimmig", "given": "Ann-Christin S", "initials": "AS", "orcid": "0000-0002-8353-6593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3ee0f1b0d0b4ebd9c9e66b4850b6600.json"}}, {"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Nilsson", "given": "Kent W", "initials": "KW", "orcid": "0000-0002-8853-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae97f7e5d3e7452d82e3f13e4c1a0a58.json"}}, {"family": "Nieratschker", "given": "Vanessa", "initials": "V"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-10-02", "journal": {"title": "Prog Neuropsychopharmacol Biol Psychiatry", "issn": "1878-4216", "volume": "142", "pages": "111485", "issn-l": null}, "abstract": "Estrogens are suggested to affect mood by binding to widespread estrogen receptors in the brain and therewith modulating a variety of neurosignaling pathways. Single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptors might influence these actions and thereby play a role in the genetic foundation of mood disorders. Several SNPs in the estrogen receptor 1 (ESR1) gene have been studied in relation to anxiety and depression, while confounders and interaction with psychosocial factors have largely been overlooked. The present study investigated the effect of the functional polymorphisms rs2234693 (PvuII) and rs9340799 (XbaI) in the ESR1 gene on depression and anxiety symptoms as well as their interaction with early life adversities and parenting in two independent female cohorts, considering relevant confounding factors. In adolescent females (n = 1036), the rs9340799 minor allele (G) was found to protect against increasing anxiety symptoms from age 14 to 17, whereas, in young adult females (n = 1314, mean age: 22.2 years), it was associated with a greater risk of experiencing above-threshold anxiety symptoms. No genetic effect was found for rs2234693 and depressive symptoms in either cohort. A significant three-way gene-environment interaction was observed between rs9340799, stressful early life events, and supportive parenting on anxiety symptoms in female adolescents. These findings suggest a potential differential plasticity of the G allele in relation to anxiety symptoms in female youth. By incorporating longitudinal assessments and gene-environment analyses, this study contributes to the literature on internalizing symptoms in females in the context of estrogen-related constitutive vulnerability.", "doi": "10.1016/j.pnpbp.2025.111485", "pmid": "40915344", "labels": {"SciLifeLab Fellow": "", "Erika Comasco": ""}, "xrefs": [{"db": "pii", "key": "S0278-5846(25)00239-8"}], "notes": [], "created": "2025-09-19T13:50:23.032Z", "modified": "2026-10-01T08:29:48.258Z"}, {"entity": "publication", "iuid": "2d418da0bf284e2095eeaa51b2eedcce", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2d418da0bf284e2095eeaa51b2eedcce.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2d418da0bf284e2095eeaa51b2eedcce"}}, "title": "White matter integrity upon progesterone antagonism in individuals with premenstrual dysphoric disorder: A randomized placebo-controlled diffusion tensor imaging study.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Gu", "given": "Xuan", "initials": "X"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Hahn", "given": "Andreas", "initials": "A"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R", "orcid": "0000-0003-4641-9539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0798fcfac19c499ca5288a5ac182340e.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-01-10", "journal": {"title": "Prog Neuropsychopharmacol Biol Psychiatry", "issn": "1878-4216", "volume": "136", "pages": "111179", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a depressive disorder triggered by fluctuations of progesterone and estradiol during the luteal phase of the menstrual cycle. Selective progesterone receptor modulation (SPRM), while exerting an antagonistic effect on progesterone and maintaining estradiol on moderate levels, has shown beneficial effects on the mental symptoms of PMDD. Progesterone is also known for its neuroprotective effects, while synthetic progestins have been suggested to promote myelination. However, the impact of SPRM treatment on white matter microstructure is unexplored.\n\nDiffusion tensor imaging was employed to collect data on white matter integrity in patients with PMDD, before and after treatment with ulipristal acetate (an SPRM) or placebo, as part of a double-blind randomized controlled-trial. Tract based spatial statistics were performed to investigate SPRM treatment vs. placebo longitudinal effects on fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), on the whole white matter skeleton.\n\nVoxel-wise analyses indicated no change over time in any white matter microstructure metrics in individuals treated with SPRM versus placebo. Improvement in PMDD symptoms did not correlate with changes in white matter microstructure. In secondary, exploratory, cross-sectional comparisons during treatment, the SPRM group displayed lower FA and higher MD, RD, and AD than the placebo group in several tracts.\n\nThe main findings suggest that SPRM treatment did not impact white matter microstructure compared with placebo. However, secondary exploratory analyses yielded between-group differences after treatment, which call for further investigation on the tracts potentially impacted by progesterone antagonism.\n\nEUDRA-CT 2016-001719-19; \"Selective progesterone receptor modulators for treatment of premenstrual dysphoric disorder. A randomized, double-blind, placebo-controlled study.\"; https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-001719-19/SE.", "doi": "10.1016/j.pnpbp.2024.111179", "pmid": "39454851", "labels": {"Erika Comasco": "", "SciLifeLab Fellow": ""}, "xrefs": [{"db": "pii", "key": "S0278-5846(24)00247-1"}], "notes": [], "created": "2024-10-29T09:13:36.610Z", "modified": "2026-09-23T13:22:11.309Z"}], "created": "2024-10-29T09:13:36.619Z", "modified": "2024-10-29T09:13:36.619Z"}