{"entity": "journal", "iuid": "e06452573d704b81a200f3bd55917914", "timestamp": "2026-03-10T03:47:50.616Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Pharmaceutics.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Pharmaceutics"}}, "title": "Pharmaceutics", "issn": "1999-4923", "issn-l": null, "publications_count": 4, "publications": [{"entity": "publication", "iuid": "68170984235543e3a87033df2cf1f668", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/68170984235543e3a87033df2cf1f668.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/68170984235543e3a87033df2cf1f668"}}, "title": "[18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44.", "authors": [{"family": "Cheung", "given": "Pierre", "initials": "P", "orcid": "0000-0003-1330-9800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b8ff5c23c624f7b965e736f1f277c10.json"}}, {"family": "Amin", "given": "Mohammad A", "initials": "MA"}, {"family": "Zhang", "given": "Bo", "initials": "B", "orcid": "0000-0002-9199-1115", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ce4d3f145f14816a0c6f42481475c3a.json"}}, {"family": "Lechi", "given": "Francesco", "initials": "F"}, {"family": "Korsgren", "given": "Olle", "initials": "O", "orcid": "0000-0002-8524-9547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4f384eeb31a4b2dba5c9301bb34c156.json"}}, {"family": "Eriksson", "given": "Jonas", "initials": "J"}, {"family": "Odell", "given": "Luke R", "initials": "LR"}, {"family": "Eriksson", "given": "Olof", "initials": "O", "orcid": "0000-0002-2515-8790", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85991bf00e4b4a26ab15599d25c58601.json"}}], "type": "journal article", "published": "2023-02-02", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "volume": "15", "issue": "2", "issn-l": null}, "abstract": "The progressive loss of beta-cell mass is a hallmark of diabetes and has been suggested as a complementary approach to studying the progression of diabetes in contrast to the beta-cell function. Non-invasive nuclear medicinal imaging techniques such as Positron Emission Tomography using radiation emitting tracers have thus been suggested as more viable methodologies to visualize and quantify the beta-cell mass with sufficient sensitivity. The transmembrane G protein-coupled receptor GPR44 has been identified as a biomarker for monitoring beta-cell mass. MK-7246 is a GPR44 antagonist that selectively binds to GPR44 with high affinity and good pharmacokinetic properties. Here, we present the synthesis of MK-7246, radiolabeled with the positron emitter fluorine-18 for preclinical evaluation using cell lines, mice, rats and human pancreatic cells. Here, we have described a synthesis and radiolabeling method for producing [18F]MK-7246 and its precursor compound. Preclinical assessments demonstrated the strong affinity and selectivity of [18F]MK-7246 towards GPR44. Additionally, [18F]MK-7246 exhibited excellent metabolic stability, a fast clearance profile from blood and tissues, qualifying it as a promising radioactive probe for GPR44-directed PET imaging.", "doi": "10.3390/pharmaceutics15020499", "pmid": "36839820", "labels": {"SciLifeLab Fellow": null, "Olof Eriksson": null}, "xrefs": [{"db": "pmc", "key": "PMC9962486"}, {"db": "pii", "key": "pharmaceutics15020499"}], "notes": [], "created": "2023-05-14T14:50:44.384Z", "modified": "2023-05-14T14:50:44.482Z"}, {"entity": "publication", "iuid": "bf2e720a1d8245d6a6c7f3e0aa12254d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2e720a1d8245d6a6c7f3e0aa12254d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2e720a1d8245d6a6c7f3e0aa12254d"}}, "title": "Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes.", "authors": [{"family": "T\u00fcrkez", "given": "Hasan", "initials": "H"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "\u00d6zge \u00c7a\u011flar", "initials": "\u00d6\u00c7", "orcid": "0000-0003-1412-8411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513eed83e3b643088ebb66284a761ee5.json"}}, {"family": "\u00d6ner", "given": "Sena", "initials": "S"}, {"family": "Kad\u0131", "given": "Abdurrahim", "initials": "A"}, {"family": "Mete", "given": "Abdulkadir", "initials": "A"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "\u015eahin", "given": "\u0130rfan O\u011fuz", "initials": "\u0130O"}, {"family": "Yap\u00e7a", "given": "\u00d6mer Erkan", "initials": "\u00d6E"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-12-31", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "volume": "15", "issue": "1", "issn-l": null}, "abstract": "Complications of chronic non-healing wounds led to the emergence of nanotechnology-based therapies to enhance healing, facilitate tissue repair, and prevent wound-related complications like infections. Here, we design alpha lipoic acid (ALA) conjugated hexagonal boron nitride (hBN) and boron carbide (B4C) nanoparticles (NPs) to enhance wound healing in human dermal fibroblast (HDFa) cell culture and characterize its antimicrobial properties against Staphylococcus aureus (S. aureus, gram positive) and Escherichia coli (E. coli, gram negative) bacterial strains. ALA molecules are integrated onto hBN and C4B NPs through esterification procedure, and molecular characterizations are performed by using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and UV-vis spectroscopy. Wound healing and antimicrobial properties are investigated via the use of cell viability assays, scratch test, oxidative stress, and antimicrobial activity assays. Based on our analysis, we observe that ALA-conjugated hBN NPs have the highest wound-healing feature and antimicrobial activity compared to ALA-B4C. On the other hand, hBN, ALA-B4C, and ALA compounds showed promising regenerative and antimicrobial properties. Also, we find that ALA conjugation enhances wound healing and antimicrobial potency of hBN and B4C NPs. We conclude that the ALA-hBN conjugate is a potential candidate to stimulate regeneration process for injuries.", "doi": "10.3390/pharmaceutics15010149", "pmid": "36678778", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9863811"}, {"db": "pii", "key": "pharmaceutics15010149"}], "notes": [], "created": "2023-12-04T14:53:04.293Z", "modified": "2023-12-04T14:53:04.398Z"}, {"entity": "publication", "iuid": "8be6fd1873b64bea9a17c1d16ca03429", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8be6fd1873b64bea9a17c1d16ca03429.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8be6fd1873b64bea9a17c1d16ca03429"}}, "title": "The Influence of Drug\u2013Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles", "authors": [{"family": "Hempel", "given": "Nele Johanna", "initials": "NJ", "orcid": "0000-0002-1021-6898", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/817e99f5b11f4c768e493ed7d614367f.json"}}, {"family": "Merkl", "given": "Padryk", "initials": "P", "orcid": "0000-0002-8922-3774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef9f5d07bdb442c88ea767812cbfc8ca.json"}}, {"family": "Knopp", "given": "Matthias Manne", "initials": "MM"}, {"family": "Berthelsen", "given": "Ragna", "initials": "R", "orcid": "0000-0002-5992-9688", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe9efdd81a854ca8929fa01d240935cb.json"}}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}, {"family": "Sotiriou", "given": "Georgios A", "initials": "GA", "orcid": "0000-0001-5040-620X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4b529432ad344308c9529badf192efd.json"}}, {"family": "L\u00f6bmann", "given": "Korbinian", "initials": "K", "orcid": "0000-0002-8710-6347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed940056bb8248468f21964dba464f49.json"}}], "type": "journal-article", "published": "2021-06-21", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "volume": "13", "issue": "6", "pages": "917", "issn-l": null}, "abstract": "In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug-polymer combinations were studied with regard to the influence of (i) the physicochemical properties of the polymer, e.g., the glass transition temperature (Tg) and (ii) the drug-polymer solubility on the rate and degree of in situ drug amorphization. Compacts were prepared containing 30 wt% CCX, 69.25 wt% polymer, 0.5 wt% lubricant, and 0.25 wt% plasmonic nanoparticles (PNs) and exposed to near-infrared laser radiation. Upon exposure to laser radiation, the PNs generated heat, which allowed drug dissolution into the polymer at temperatures above its Tg, yielding an amorphous solid dispersion. It was found that in situ drug amorphization was possible for drug-polymer combinations, where the temperature reached during exposure to laser radiation was above the onset temperature for a dissolution process of the drug into the polymer, i.e., TDStart. The findings of this study showed that the concept of laser-induced in situ drug amorphization is applicable to a range of polymers if the drug is soluble in the polymer and temperatures during the process are above TDStart.", "doi": "10.3390/pharmaceutics13060917", "pmid": "34205754", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8234654"}, {"db": "pii", "key": "pharmaceutics13060917"}], "notes": [], "created": "2021-12-14T23:40:35.076Z", "modified": "2025-12-04T17:09:26.122Z"}, {"entity": "publication", "iuid": "5dba39f1e92245769428f523bfa87f92", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5dba39f1e92245769428f523bfa87f92.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5dba39f1e92245769428f523bfa87f92"}}, "title": "Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media.", "authors": [{"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}, {"family": "Nylander", "given": "Olivia", "initials": "O"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}], "type": "journal article", "published": "2020-05-28", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "issn-l": null, "volume": "12", "issue": "6", "pages": "493"}, "abstract": "The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine. Here, we developed a robust method for rapid, medium throughput screening of IDR and established the largest IDR dataset in open literature to date that can be used for pharmaceutical computational modeling. Eighteen compounds with diverse physicochemical properties were studied in both fasted and fed state simulated intestinal fluids. Dissolution profiles were measured in small-scale experimental assays using compound suspensions or discs. IDR measurements were not solely linked to API solubility in either dissolution media. Multivariate data analysis revealed that IDR strongly depends on compound partitioning into bile salt and phospholipid micelles in the simulated intestinal fluids, a process that in turn is governed by API lipophilicity, hydrophobicity, and ionization.", "doi": "10.3390/pharmaceutics12060493", "pmid": "32481718", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "pharmaceutics12060493"}, {"db": "pmc", "key": "PMC7356998"}], "notes": [], "created": "2020-11-30T21:39:19.046Z", "modified": "2022-11-04T11:32:14.941Z"}], "created": "2020-11-30T21:39:19.061Z", "modified": "2020-11-30T21:39:19.061Z"}