{"entity": "journal", "iuid": "c534634687314024be12250882b73a91", "timestamp": "2026-09-26T23:02:50.798Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Nutr%20Metab%20Cardiovasc%20Dis.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Nutr%20Metab%20Cardiovasc%20Dis"}}, "title": "Nutr Metab Cardiovasc Dis", "issn": "1590-3729", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "4e71edfe55b041cdbc2418c683b59375", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4e71edfe55b041cdbc2418c683b59375.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4e71edfe55b041cdbc2418c683b59375"}}, "title": "No association between coffee consumption and risk of atrial fibrillation: A Mendelian randomization study.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "journal article", "published": "2019-11-00", "journal": {"title": "Nutr Metab Cardiovasc Dis", "issn": "1590-3729", "volume": "29", "issue": "11", "pages": "1185-1188", "issn-l": null}, "abstract": "Some observational studies have found that habitual coffee and caffeine consumption might reduce the risk of atrial fibrillation (AF). We conducted a two-sample Mendelian randomization study to explore the potential association between coffee consumption and AF.\n\nThis study was based on summary-level data from the Atrial Fibrillation Consortium, including 588 190 individuals (65 446 cases and 522 744 non-cases). Nine single-nucleotide polymorphisms associated with coffee consumption at significance level of P < 5 \u00d7 10-8 were used as instrumental variables and were obtained from a genome-wide association study that included up to 375 833 individuals. The odds ratio of AF per genetically-predicted 50% increase of coffee consumption was 0.98 (95% confidence interval, 0.88, 1.10; P = 0.80) in the standard inverse-variance weighted analysis. Results were consistent in sensitivity analyses using the weighted median and MR-Egger methods, and no directional pleiotropy (P = 0.37) was observed. Moreover, complementary analyses that separated the coffee-related single-nucleotide polymorphisms based on their association with blood levels of caffeine metabolites (lower, higher, unrelated or unknown association) revealed no association with AF.\n\nThis study does not support a causal association between habitual coffee consumption and risk of AF.", "doi": "10.1016/j.numecd.2019.07.015", "pmid": "31558414", "labels": [], "xrefs": [{"db": "pii", "key": "S0939-4753(19)30283-2"}], "notes": [], "created": "2026-09-23T10:05:17.907Z", "modified": "2026-09-23T10:43:57.603Z"}, {"entity": "publication", "iuid": "a9e15ec12ce345d9a4044c60ddcfa1e0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a9e15ec12ce345d9a4044c60ddcfa1e0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a9e15ec12ce345d9a4044c60ddcfa1e0"}}, "title": "Coffee consumption and risk of aortic valve stenosis: A prospective study.", "authors": [{"family": "Larsson", "given": "S C", "initials": "SC"}, {"family": "Wolk", "given": "A", "initials": "A"}, {"family": "H\u00e5kansson", "given": "N", "initials": "N"}, {"family": "B\u00e4ck", "given": "M", "initials": "M"}], "type": "journal article", "published": "2018-08-00", "journal": {"title": "Nutr Metab Cardiovasc Dis", "issn": "1590-3729", "volume": "28", "issue": "8", "pages": "803-807", "issn-l": null}, "abstract": "Coffee contains many biologically active compounds with potential adverse or beneficial effects on the cardiovascular system. Whether coffee consumption is associated with the risk of aortic valve stenosis (AVS) is unknown. The purpose of this study was therefore to examine the association between coffee consumption and AVS incidence.\n\nThis prospective study included 71 178 men and women who provided information on their coffee consumption through a questionnaire at baseline. Incident cases of AVS were identified through linkage with the Swedish National Patient and Cause of Death Registers. During a mean follow-up of 15.2 years, 1295 participants (777 men and 518 women) were diagnosed with AVS. Coffee consumption was positively associated with risk of AVS in a dose-response manner after adjustment for age, sex, smoking, and other risk factors (P-trend = 0.005). The multivariable hazard ratios were was 1.11 (95% confidence interval 1.04-1.19) per 2 cups/day increase of coffee consumption and 1.65 (95% confidence interval 1.10-2.48) when comparing the highest (\u22656 cups/day) with the lowest (<0.5 cup/day) category of coffee consumption. The association was not modified by other risk factors.\n\nThis study provides novel evidence that high coffee consumption is associated with an increased risk of AVS.", "doi": "10.1016/j.numecd.2018.01.016", "pmid": "29627121", "labels": [], "xrefs": [{"db": "pii", "key": "S0939-4753(18)30051-6"}], "notes": [], "created": "2026-09-23T12:47:38.450Z", "modified": "2026-09-23T12:47:38.506Z"}], "created": "2026-09-23T10:05:17.918Z", "modified": "2026-09-23T10:05:17.918Z"}