{"entity": "journal", "iuid": "28aab918ff2a4a699b94e40247cec03e", "timestamp": "2026-08-23T09:25:40.764Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Nucleosides%20Nucleotides%20Nucleic%20Acids.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Nucleosides%20Nucleotides%20Nucleic%20Acids"}}, "title": "Nucleosides Nucleotides Nucleic Acids", "issn": "1532-2335", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "6e044f8f105d42508e81081e3780eccc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6e044f8f105d42508e81081e3780eccc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6e044f8f105d42508e81081e3780eccc"}}, "title": "The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342.", "authors": [{"family": "Dirks", "given": "Christopher", "initials": "C"}, {"family": "Bwanika", "given": "Henri Colyn", "initials": "HC"}, {"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Zhang", "given": "Si Min", "initials": "SM"}, {"family": "Rudd", "given": "Sean G", "initials": "SG"}], "type": "journal article", "published": "2024-06-03", "journal": {"title": "Nucleosides Nucleotides Nucleic Acids", "issn": "1532-2335", "volume": "43", "issue": "8", "pages": "831-836", "issn-l": null}, "abstract": "Sterile alpha motif and histidine-aspartic acid domain containing protein-1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) hydrolase that controls dNTP pools and detoxifies cancer cells of chemotherapy metabolites. TH6342 is a recently reported small molecule inhibitor of SAMHD1 that interacts with the protein in vitro and non-competitively prevents dimerisation, a prerequisite for catalysis. The binding site of TH6342 on SAMHD1 is currently unknown. In the present study we demonstrate that the N-terminal SAM domain of SAMHD1 is not required for inhibition by TH6342.", "doi": "10.1080/15257770.2024.2325439", "pmid": "38830230", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:36:42.737Z", "modified": "2026-08-20T09:36:42.783Z"}], "created": "2026-08-20T09:36:42.747Z", "modified": "2026-08-20T09:36:42.747Z"}