{"entity": "journal", "iuid": "49ddae3b223d48118e335b2f1b104484", "timestamp": "2026-08-20T21:08:11.478Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Npj%20Viruses.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Npj%20Viruses"}}, "title": "Npj Viruses", "issn": "2948-1767", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "8578bff74edc41d0aa7d80b9bac1c675", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8578bff74edc41d0aa7d80b9bac1c675.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8578bff74edc41d0aa7d80b9bac1c675"}}, "title": "Lactoferricin enables adenovirus infection of human skeletal muscle cells.", "authors": [{"family": "Danskog", "given": "Katarina", "initials": "K"}, {"family": "Mistry", "given": "Nitesh", "initials": "N"}, {"family": "\u00c5rdahl", "given": "Carin", "initials": "C"}, {"family": "Durbeej", "given": "Madeleine", "initials": "M"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Arnberg", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2025-08-19", "journal": {"title": "Npj Viruses", "issn": "2948-1767", "volume": "3", "issue": "1", "pages": "62", "issn-l": null}, "abstract": "Although adenoviruses (AdVs) possess advantageous features as vectors, several challenges remain. These include a high prevalence of neutralizing antibodies against certain AdV types and the inability to efficiently transduce CAR-deficient cells and tissues. We showed previously that lactoferricin (Lfcin) enhances CAR-independent HAdV-C5 infection of epithelial and T-cells. Here, we assessed the ability of Lfcin to enable HAdV-C5 infection and transduction of human skeletal muscle cells. Lfcin increases HAdV-C5 infection and transduction of muscle myoblasts and myotubes by 10- to 30-fold. Enhanced infection correlates with increased cell binding, which differs mechanistically from that of coagulation factor X-mediated binding, as it remains unaffected by the removal of heparan sulfate. Additionally, Lfcin reduces the neutralizing effects of serum against HAdV-C5, suggesting it may shield key epitopes. By enabling viral binding to muscle cells and mitigating serum neutralization, Lfcin offers a novel strategy to improve the efficiency and durability of HAdV-C5-based gene delivery systems.", "doi": "10.1038/s44298-025-00144-7", "pmid": "40826223", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12361444"}, {"db": "pii", "key": "10.1038/s44298-025-00144-7"}], "notes": [], "created": "2026-08-20T09:26:38.886Z", "modified": "2026-08-20T09:26:38.960Z"}], "created": "2026-08-20T09:26:38.917Z", "modified": "2026-08-20T09:26:38.917Z"}