{"entity": "journal", "iuid": "1affb456365845c5977547f7b0b5ff65", "timestamp": "2026-09-06T14:55:35.532Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Neuropsychopharmacology.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Neuropsychopharmacology"}}, "title": "Neuropsychopharmacology", "issn": "1740-634X", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "f6173f42c0604b4ca0136687f67aad69", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f6173f42c0604b4ca0136687f67aad69.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f6173f42c0604b4ca0136687f67aad69"}}, "title": "Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.", "authors": [{"family": "Kaltsouni", "given": "Elisavet", "initials": "E"}, {"family": "Fisher", "given": "Patrick M", "initials": "PM"}, {"family": "Dubol", "given": "Manon", "initials": "M"}, {"family": "Hustad", "given": "Steinar", "initials": "S"}, {"family": "Lanzenberger", "given": "Rupert", "initials": "R", "orcid": "0000-0003-4641-9539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0798fcfac19c499ca5288a5ac182340e.json"}}, {"family": "Frokjaer", "given": "Vibe G", "initials": "VG"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Neuropsychopharmacology", "issn": "1740-634X", "volume": "46", "issue": "8", "pages": "1460-1467", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their reproductive age. Altered sensitivity of cognitive-affective brain circuits to progesterone and its downstream metabolite allopregnanolone is suggested to underlie PMDD symptomatology. Core mood symptoms include irritability and anger, with aggression being the behavioral outcome of these symptoms. The present study sought to investigate the neural correlates of reactive aggression during the premenstrual phase in women with PMDD, randomized to a selective progesterone receptor modulator (SPRM) or placebo. Self-reports on the Daily Record of Severity of Problems were used to assess PMDD symptoms and gonadal hormone levels were measured by liquid chromatography tandem mass spectrometry. Functional magnetic resonance imaging was performed in 30 women with PMDD, while performing the point subtraction aggression paradigm. Overall, a high SPRM treatment response rate was attained (93%), in comparison with placebo (53.3%). Women with PMDD randomized to SPRM treatment had enhanced brain reactivity in the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex during the aggressive response condition. The fronto-cingulate reactivity during aggressive responses depended on treatment, with a negative relationship between brain reactivity and task-related aggressiveness found in the placebo but not the SPRM group. The findings contribute to define the role of progesterone in PMDD symptomatology, suggesting a beneficial effect of progesterone receptor antagonism, and consequent anovulation, on top-down emotion regulation, i.e., greater fronto-cingulate activity in response to provocation stimuli.", "doi": "10.1038/s41386-021-01010-9", "pmid": "33927343", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8209206"}, {"db": "pii", "key": "10.1038/s41386-021-01010-9"}], "notes": [], "created": "2021-11-22T08:42:46.625Z", "modified": "2024-10-24T08:55:25.976Z"}, {"entity": "publication", "iuid": "c02a57a97f3a4e3686fd502efff11797", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c02a57a97f3a4e3686fd502efff11797.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c02a57a97f3a4e3686fd502efff11797"}}, "title": "Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition.", "authors": [{"family": "Vallianatou", "given": "Theodosia", "initials": "T"}, {"family": "Shariatgorji", "given": "Mohammadreza", "initials": "M"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Fridjonsdottir", "given": "Elva", "initials": "E", "orcid": "0000-0002-3779-3556", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749090040c9c451ba610b0e144fa75e7.json"}}, {"family": "K\u00e4llback", "given": "Patrik", "initials": "P"}, {"family": "Schintu", "given": "Nicoletta", "initials": "N"}, {"family": "Svenningsson", "given": "Per", "initials": "P"}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}], "type": "journal article", "published": "2019-11-00", "journal": {"title": "Neuropsychopharmacology", "issn": "1740-634X", "volume": "44", "issue": "12", "pages": "2091-2098", "issn-l": null}, "abstract": "The neurotransmitter of the cholinergic system, acetylcholine plays a major role in the brain's cognitive function and is involved in neurodegenerative disorders. Here, we present age-related alterations of acetylcholine levels after administration of the acetylcholinesterase inhibitor drug tacrine in normal mice. Using a quantitative, robust and molecular-specific mass spectrometry imaging method we found that tacrine administration significantly raised acetylcholine levels in most areas of sectioned mice brains, inter alia the striatum, hippocampus and cortical areas. However, acetylcholine levels in retrosplenial cortex were significantly lower in 14-month-old than in 12-week-old animals following its administration, indicating that normal aging affects the cholinergic system's responsivity. This small brain region is interconnected with an array of brain networks and is involved in numerous cognitive tasks. Simultaneous visualization of distributions of tacrine and its hydroxylated metabolites in the brain revealed a significant decrease in levels of the metabolites in the 14-month-old mice. The results highlight strengths of the imaging technique to simultaneously investigate multiple molecular species and the drug-target effects in specific regions of the brain. The proposed approach has high potential in studies of neuropathological conditions and responses to neuroactive treatments.", "doi": "10.1038/s41386-019-0397-5", "pmid": "31009936", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6887892"}, {"db": "pii", "key": "10.1038/s41386-019-0397-5"}], "notes": [], "created": "2026-08-20T08:48:11.409Z", "modified": "2026-08-20T08:48:11.517Z"}], "created": "2021-11-22T08:42:46.706Z", "modified": "2021-11-22T08:42:46.707Z"}