{"entity": "journal", "iuid": "5cd088e5249441659d6621d12798542a", "timestamp": "2026-07-14T03:18:19.471Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Neurogenetics.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Neurogenetics"}}, "title": "Neurogenetics", "issn": "1364-6753", "issn-l": "1364-6745", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "d46699fb4eb6446580f45ef093a38e97", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d46699fb4eb6446580f45ef093a38e97.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d46699fb4eb6446580f45ef093a38e97"}}, "title": "Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight.", "authors": [{"family": "Ka", "given": "Sojeong", "initials": "S"}, {"family": "Albert", "given": "Frank W", "initials": "FW"}, {"family": "Denbow", "given": "D Michael", "initials": "DM"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}, {"family": "Siegel", "given": "Paul B", "initials": "PB"}, {"family": "Andersson", "given": "Leif", "initials": "L"}, {"family": "Hallb\u00f6\u00f6k", "given": "Finn", "initials": "F"}], "type": "journal article", "published": "2011-08-00", "journal": {"title": "Neurogenetics", "issn": "1364-6753", "volume": "12", "issue": "3", "pages": "211-221", "issn-l": "1364-6745"}, "abstract": "Long-term divergent selection for low or high body weight from the same founder population has generated two extremely divergent lines of chickens, the high- (HWS) and low-weight (LWS) selected lines. At selection age (56\u00a0days), the lines differ by more than nine times in body weight. The HWS line chickens are compulsive feeders, whereas in the LWS line, some individuals are anorexic and others have very low appetite. Previous studies have implicated the central nervous system and particularly the hypothalamus in these behavioural differences. Here, we compared the mRNA expression in hypothalamus tissue from chickens on day\u00a04 post-hatch using oligonucleotide arrays and found that the divergent selection had resulted in minor but multiple expression differences. Differentially expressed genes were enriched in processes 'DNA metabolism, repair, induction of apoptosis and metabolism'. Several differentially expressed genes participate in the regulation of neuronal plasticity and development, including apoptosis, or are neurotransmittor receptor subtypes. Less change was seen when comparing hypothalamic neuropeptide mediators of appetite such as the melanocortin receptors. The genomic locations of these differentially expressed genes were then compared to the locations of growth QTLs and to a genome-wide map of chromosomal regions that have been under divergent selection between the lines. The results indicate which differentially expressed hypothalamic genes have responded to the divergent selection and that the results predict that it is more likely to find causative genes among these most differentially expressed genes. Because of such differential gene expression in hypothalamus, the lines may adapt behaviourally different particularly to the post-hatch situation when independent feeding to obtain energy is established.", "doi": "10.1007/s10048-011-0290-9", "pmid": "21748255", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T10:08:51.744Z", "modified": "2018-12-05T10:08:51.763Z"}, {"entity": "publication", "iuid": "918b9b751e15483cadd23487931a1706", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/918b9b751e15483cadd23487931a1706.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/918b9b751e15483cadd23487931a1706"}}, "title": "Genomic duplications mediate overexpression of lamin B1 in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms.", "authors": [{"family": "Schuster", "given": "Jens", "initials": "J"}, {"family": "Sundblom", "given": "Jimmy", "initials": "J"}, {"family": "Thuresson", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Hassin-Baer", "given": "Sharon", "initials": "S"}, {"family": "Klopstock", "given": "Thomas", "initials": "T"}, {"family": "Dichgans", "given": "Martin", "initials": "M"}, {"family": "Cohen", "given": "Oren S", "initials": "OS"}, {"family": "Raininko", "given": "Raili", "initials": "R"}, {"family": "Melberg", "given": "Atle", "initials": "A"}, {"family": "Dahl", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2011-02-00", "journal": {"title": "Neurogenetics", "issn": "1364-6753", "volume": "12", "issue": "1", "pages": "65-72", "issn-l": "1364-6745"}, "abstract": "Adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms features micturition urgency, constipation, erectile dysfunction, and orthostatic hypotension, usually followed by pyramidal signs and ataxia. Peripheral nerve conduction is normal. The disease is often mistaken for multiple sclerosis in the initial phase. There is a characteristic pattern of white matter changes in the brain and spinal cord on magnetic resonance imaging (MRI), mild atrophy of the brain, and a more marked atrophy of the spinal cord. ADLD is associated with duplications of the lamin B1 (LMNB1) gene but the mechanism by which the rearrangement conveys the phenotype is not fully defined. We analyzed four unrelated families segregating ADLD with autonomic symptoms for duplications of the LMNB1 gene. A single nucleotide polymorphism (SNP) array analysis revealed novel duplications spanning the entire LMNB1 gene in probands from each of the four families. We then analyzed the expression of lamin B1 in peripheral leukocytes by Western blot analysis in five patients from two available families. The protein levels of lamin B1 were found significantly increased. These results indicate that the ADLD phenotype associated with LMNB1 duplications is mediated by increased levels of the lamin B1 protein. Furthermore, we show that a molecular diagnosis for ADLD with autonomic symptoms can be obtained by a direct analysis of lamin B1 in peripheral leukocytes.", "doi": "10.1007/s10048-010-0269-y", "pmid": "21225301", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T09:14:12.369Z", "modified": "2018-12-05T09:14:12.403Z"}], "created": "2018-12-05T09:14:12.384Z", "modified": "2020-11-27T13:12:53.246Z"}