{"entity": "journal", "iuid": "8ece1bf581cb4cb6a948c4ef26276bb8", "timestamp": "2026-07-20T22:18:52.085Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Nat.%20Neurosci..json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Nat.%20Neurosci."}}, "title": "Nat. Neurosci.", "issn": "1546-1726", "issn-l": "1097-6256", "publications_count": 9, "publications": [{"entity": "publication", "iuid": "7c4dbb3ec87c44768127c6c809896f63", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7c4dbb3ec87c44768127c6c809896f63.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7c4dbb3ec87c44768127c6c809896f63"}}, "title": "Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity.", "authors": [{"family": "Ng", "given": "Bernard", "initials": "B", "orcid": "0000-0002-8688-3873", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/884fbc328a1d455da6d651463bd632b1.json"}}, {"family": "Tasaki", "given": "Shinya", "initials": "S", "orcid": "0000-0003-3656-7394", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/741c7fb0f6044af6a9cae7b128972b10.json"}}, {"family": "Greathouse", "given": "Kelsey M", "initials": "KM"}, {"family": "Walker", "given": "Courtney K", "initials": "CK", "orcid": "0000-0002-7826-4044", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09c969f96f9645f59737d479b409ab00.json"}}, {"family": "Zhang", "given": "Ada", "initials": "A"}, {"family": "Covitz", "given": "Sydney", "initials": "S"}, {"family": "Cieslak", "given": "Matt", "initials": "M", "orcid": "0000-0002-1931-4734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb84822ea2c34c73bba1786bfb3dc2d3.json"}}, {"family": "Weber", "given": "Audrey J", "initials": "AJ"}, {"family": "Adamson", "given": "Ashley B", "initials": "AB", "orcid": "0000-0001-6231-6279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/438ba2245484423b9cb45f29a1f9410f.json"}}, {"family": "Andrade", "given": "Julia P", "initials": "JP"}, {"family": "Poovey", "given": "Emily H", "initials": "EH"}, {"family": "Curtis", "given": "Kendall A", "initials": "KA"}, {"family": "Muhammad", "given": "Hamad M", "initials": "HM"}, {"family": "Seidlitz", "given": "Jakob", "initials": "J", "orcid": "0000-0002-8164-7476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c3df5734dc0499ab7930fb5a7627bf0.json"}}, {"family": "Satterthwaite", "given": "Ted", "initials": "T", "orcid": "0000-0001-7072-9399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/461c3637946f4ed8956764658711fca7.json"}}, {"family": "Bennett", "given": "David A", "initials": "DA"}, {"family": "Seyfried", "given": "Nicholas T", "initials": "NT", "orcid": "0000-0002-4507-624X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/299b298ea1b44a30908d9acff917bfa1.json"}}, {"family": "Vogel", "given": "Jacob", "initials": "J"}, {"family": "Gaiteri", "given": "Chris", "initials": "C", "orcid": "0000-0001-7838-8664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57b5cabb25e64146aab142810dd49972.json"}}, {"family": "Herskowitz", "given": "Jeremy H", "initials": "JH", "orcid": "0000-0002-7227-1470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22f6d39ddf5f49209c2c6066a1205165.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "27", "issue": "11", "pages": "2240-2252", "issn-l": "1097-6256"}, "abstract": "Brain connectivity arises from interactions across biophysical scales, ranging from molecular to cellular to anatomical to network level. To date, there has been little progress toward integrated analysis across these scales. To bridge this gap, from a unique cohort of 98 individuals, we collected antemortem neuroimaging and genetic data, as well as postmortem dendritic spine morphometric, proteomic and gene expression data from the superior frontal and inferior temporal gyri. Through the integration of the molecular and dendritic spine morphology data, we identified hundreds of proteins that explain interindividual differences in functional connectivity and structural covariation. These proteins are enriched for synaptic structures and functions, energy metabolism and RNA processing. By integrating data at the genetic, molecular, subcellular and tissue levels, we link specific biochemical changes at synapses to connectivity between brain regions. These results demonstrate the feasibility of integrating data from vastly different biophysical scales to provide a more comprehensive understanding of brain connectivity.", "doi": "10.1038/s41593-024-01788-z", "pmid": "39482360", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11537986"}, {"db": "pii", "key": "10.1038/s41593-024-01788-z"}], "notes": [], "created": "2025-03-19T11:17:14.990Z", "modified": "2025-03-19T11:19:22.143Z"}, {"entity": "publication", "iuid": "1070918999b3451da1cb45b9ab4e789c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1070918999b3451da1cb45b9ab4e789c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1070918999b3451da1cb45b9ab4e789c"}}, "title": "Proteomic changes in Alzheimer's disease associated with progressive A\u03b2 plaque and tau tangle pathologies.", "authors": [{"family": "Pichet Binette", "given": "Alexa", "initials": "A", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Gaiteri", "given": "Chris", "initials": "C"}, {"family": "Wennstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Kumar", "given": "Atul", "initials": "A"}, {"family": "Hristovska", "given": "Ines", "initials": "I"}, {"family": "Spotorno", "given": "Nicola", "initials": "N"}, {"family": "Salvad\u00f3", "given": "Gemma", "initials": "G", "orcid": "0000-0002-5210-9230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3b7599000404d618d84b389ba47f19a.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Mathys", "given": "Hansruedi", "initials": "H", "orcid": "0000-0003-0186-2115", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38b5ab2013214cc7845021e2460b3433.json"}}, {"family": "Tsai", "given": "Li-Huei", "initials": "LH", "orcid": "0000-0003-1262-0592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd0b5f35b80a4fb580612e498d06c75b.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N"}, {"family": "Janelidze", "given": "Shorena", "initials": "S"}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Vogel", "given": "Jacob W", "initials": "JW"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2024-10-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "27", "issue": "10", "pages": "1880-1891", "issn-l": "1097-6256"}, "abstract": "Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer's disease (AD). Combining radioligands measuring \u03b2-amyloid (A\u03b2) plaques and tau tangles with cerebrospinal fluid proteomics, we uncover molecular events mirroring different stages of AD pathology in living humans. We found 127 differentially abundant proteins (DAPs) across the AD spectrum. The strongest A\u03b2-related proteins were mainly expressed in glial cells and included SMOC1 and ITGAM. A dozen proteins linked to ATP metabolism and preferentially expressed in neurons were independently associated with tau tangle load and tau accumulation. Only 20% of the DAPs were also altered in other neurodegenerative diseases, underscoring AD's distinct proteome. Two co-expression modules related, respectively, to protein metabolism and microglial immune response encompassed most DAPs, with opposing, staggered trajectories along the AD continuum. We unveil protein signatures associated with A\u03b2 and tau proteinopathy in vivo, offering insights into complex neural responses and potential biomarkers and therapeutics targeting different disease stages.", "doi": "10.1038/s41593-024-01737-w", "pmid": "39187705", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11452344"}, {"db": "pii", "key": "10.1038/s41593-024-01737-w"}], "notes": [], "created": "2025-03-19T11:17:10.669Z", "modified": "2025-03-19T11:19:18.053Z"}, {"entity": "publication", "iuid": "a8fa7a7e41e14c9f868233e3b29ce60c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a8fa7a7e41e14c9f868233e3b29ce60c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a8fa7a7e41e14c9f868233e3b29ce60c"}}, "title": "Esr1+ hypothalamic-habenula neurons shape aversive states.", "authors": [{"family": "Calvigioni", "given": "Daniela", "initials": "D"}, {"family": "Fuzik", "given": "Janos", "initials": "J", "orcid": "0000-0002-5408-4882", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb41e780c4244ded84b6c6740d971efa.json"}}, {"family": "Le Merre", "given": "Pierre", "initials": "P", "orcid": "0000-0003-4205-7411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ebebeabbd3a4bc89ea05d00cc47013a.json"}}, {"family": "Slashcheva", "given": "Marina", "initials": "M"}, {"family": "Jung", "given": "Felix", "initials": "F", "orcid": "0000-0002-7565-977X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/482ed1ec940c4b09aaf24e71403ac324.json"}}, {"family": "Ortiz", "given": "Cantin", "initials": "C"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5042d3005814ad0a2d1eaeee5d2de3b.json"}}, {"family": "Csillag", "given": "Veronika", "initials": "V"}, {"family": "Graziano", "given": "Marta", "initials": "M"}, {"family": "Nikolakopoulou", "given": "Ifigeneia", "initials": "I"}, {"family": "Weglage", "given": "Moritz", "initials": "M", "orcid": "0000-0002-9173-7459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0e6c7066d05464aa7270b87f9a08f51.json"}}, {"family": "Lazaridis", "given": "Iakovos", "initials": "I", "orcid": "0000-0002-4578-2347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5db088903a0452181c145009d6eace8.json"}}, {"family": "Kim", "given": "Hoseok", "initials": "H"}, {"family": "Lenzi", "given": "Irene", "initials": "I", "orcid": "0000-0002-9229-7301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ce77429076541e98927c8000ff1d2ae.json"}}, {"family": "Park", "given": "Hyunsoo", "initials": "H", "orcid": "0000-0001-5754-9617", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/216293b628d44f22a52c691d888adfd3.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7c1abacc8d446bf8855254246b8d899.json"}}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "26", "issue": "7", "pages": "1245-1255", "issn-l": "1097-6256"}, "abstract": "Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used patch-sequencing (Patch-seq) guided multimodal classification to define the structural and functional heterogeneity of the LHA-LHb pathway. Our classification identified six glutamatergic neuron types with unique electrophysiological properties, molecular profiles and projection patterns. We found that genetically defined LHA-LHb neurons signal distinct aspects of emotional or naturalistic behaviors, such as estrogen receptor 1-expressing (Esr1+) LHA-LHb neurons induce aversion, whereas neuropeptide Y-expressing (Npy+) LHA-LHb neurons control rearing behavior. Repeated optogenetic drive of Esr1+ LHA-LHb neurons induces a behaviorally persistent aversive state, and large-scale recordings showed a region-specific neural representation of the aversive signals in the prelimbic region of the prefrontal cortex. We further found that exposure to unpredictable mild shocks induced a sex-specific sensitivity to develop a stress state in female mice, which was associated with a specific shift in the intrinsic properties of bursting-type Esr1+ LHA-LHb neurons. In summary, we describe the diversity of LHA-LHb neuron types and provide evidence for the role of Esr1+ neurons in aversion and sexually dimorphic stress sensitivity.", "doi": "10.1038/s41593-023-01367-8", "pmid": "37349481", "labels": {"Antonio Lentini": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10322719"}, {"db": "pii", "key": "10.1038/s41593-023-01367-8"}], "notes": [], "created": "2025-03-28T07:09:46.854Z", "modified": "2025-03-28T07:09:47.130Z"}, {"entity": "publication", "iuid": "3fb34aa25ef941b8ab69d0b2a4f89a83", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3fb34aa25ef941b8ab69d0b2a4f89a83.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3fb34aa25ef941b8ab69d0b2a4f89a83"}}, "title": "A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.", "authors": [{"family": "\u00c4hrlund-Richter", "given": "Sofie", "initials": "S", "orcid": "0000-0002-7845-7831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe6a6174a14c425bac84b597cf420a0f.json"}}, {"family": "Xuan", "given": "Yang", "initials": "Y", "orcid": "0000-0003-0497-7137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae7a8f41efb949c187488f6dc0f505ae.json"}}, {"family": "van Lunteren", "given": "Josina Anna", "initials": "JA"}, {"family": "Kim", "given": "Hoseok", "initials": "H"}, {"family": "Ortiz", "given": "Cantin", "initials": "C", "orcid": "0000-0001-9564-0059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0cfad4461f843c4b1671515cfc6beac.json"}}, {"family": "Pollak Dorocic", "given": "Iskra", "initials": "I", "orcid": "0000-0002-6391-5377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36e47528fef34ecb9e8e195844ebc94e.json"}}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}], "type": "journal article", "published": "2019-04-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "22", "issue": "4", "pages": "657-668", "issn-l": "1097-6256"}, "abstract": "The local and long-range connectivity of cortical neurons are considered instrumental to the functional repertoire of the cortical region in which they reside. In cortical networks, distinct cell types build local circuit structures enabling computational operations. Computations in the medial prefrontal cortex (mPFC) are thought to be central to cognitive operation, including decision-making and memory. We used a retrograde trans-synaptic rabies virus system to generate brain-wide maps of the input to excitatory neurons as well as three inhibitory interneuron subtypes in the mPFC. On the global scale the input patterns were found to be mainly cell type independent, with quantitative differences in key brain regions, including the basal forebrain. Mapping of the local mPFC network revealed high connectivity between the different subtypes of interneurons. The connectivity mapping gives insight into the information that the mPFC processes and the structural architecture underlying the mPFC's unique functions.", "doi": "10.1038/s41593-019-0354-y", "pmid": "30886408", "labels": {"Iskra Pollak Dorocic": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41593-019-0354-y"}], "notes": [], "created": "2021-12-13T14:32:49.142Z", "modified": "2022-11-07T11:32:58.000Z"}, {"entity": "publication", "iuid": "34524351aeeb4db39e3656d0f839c83a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/34524351aeeb4db39e3656d0f839c83a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/34524351aeeb4db39e3656d0f839c83a"}}, "title": "Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing.", "authors": [{"family": "Hochgerner", "given": "Hannah", "initials": "H"}, {"family": "Zeisel", "given": "Amit", "initials": "A"}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Linnarsson", "given": "Sten", "initials": "S"}], "type": "journal article", "published": "2018-02-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "21", "issue": "2", "pages": "290-299", "issn-l": "1097-6256"}, "abstract": "The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into adulthood; however, the relationship between developmental and adult dentate gyrus neurogenesis has not been examined in detail. Here we used single-cell RNA sequencing to reveal the molecular dynamics and diversity of dentate gyrus cell types in perinatal, juvenile, and adult mice. We found distinct quiescent and proliferating progenitor cell types, linked by transient intermediate states to neuroblast stages and fully mature granule cells. We observed shifts in the molecular identity of quiescent and proliferating radial glia and granule cells during the postnatal period that were then maintained through adult stages. In contrast, intermediate progenitor cells, neuroblasts, and immature granule cells were nearly indistinguishable at all ages. These findings demonstrate the fundamental similarity of postnatal and adult neurogenesis in the hippocampus and pinpoint the early postnatal transformation of radial glia from embryonic progenitors to adult quiescent stem cells.", "doi": "10.1038/s41593-017-0056-2", "pmid": "29335606", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41593-017-0056-2"}], "notes": [], "created": "2018-12-05T12:49:10.238Z", "modified": "2018-12-05T12:49:10.258Z"}, {"entity": "publication", "iuid": "27f5af1fc3694cc7970916e50e2be144", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/27f5af1fc3694cc7970916e50e2be144.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/27f5af1fc3694cc7970916e50e2be144"}}, "title": "Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.", "authors": [{"family": "Romanov", "given": "Roman A", "initials": "RA"}, {"family": "Zeisel", "given": "Amit", "initials": "A"}, {"family": "Bakker", "given": "Joanne", "initials": "J"}, {"family": "Girach", "given": "Fatima", "initials": "F"}, {"family": "Hellysaz", "given": "Arash", "initials": "A"}, {"family": "Tomer", "given": "Raju", "initials": "R"}, {"family": "Alp\u00e1r", "given": "Al\u00e1n", "initials": "A"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Clotman", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Keimpema", "given": "Erik", "initials": "E"}, {"family": "Hsueh", "given": "Brian", "initials": "B"}, {"family": "Crow", "given": "Ailey K", "initials": "AK"}, {"family": "Martens", "given": "Henrik", "initials": "H"}, {"family": "Schwindling", "given": "Christian", "initials": "C"}, {"family": "Calvigioni", "given": "Daniela", "initials": "D"}, {"family": "Bains", "given": "Jaideep S", "initials": "JS"}, {"family": "M\u00e1t\u00e9", "given": "Zolt\u00e1n", "initials": "Z"}, {"family": "Szab\u00f3", "given": "G\u00e1bor", "initials": "G"}, {"family": "Yanagawa", "given": "Yuchio", "initials": "Y"}, {"family": "Zhang", "given": "Ming-Dong", "initials": "MD"}, {"family": "Rendeiro", "given": "Andre", "initials": "A"}, {"family": "Farlik", "given": "Matthias", "initials": "M"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Wulff", "given": "Peer", "initials": "P"}, {"family": "Bock", "given": "Christoph", "initials": "C"}, {"family": "Broberger", "given": "Christian", "initials": "C"}, {"family": "Deisseroth", "given": "Karl", "initials": "K"}, {"family": "H\u00f6kfelt", "given": "Tomas", "initials": "T"}, {"family": "Linnarsson", "given": "Sten", "initials": "S"}, {"family": "Horvath", "given": "Tamas L", "initials": "TL"}, {"family": "Harkany", "given": "Tibor", "initials": "T"}], "type": "journal article", "published": "2017-02-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "20", "issue": "2", "pages": "176-188", "issn-l": "1097-6256"}, "abstract": "The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S", "doi": "10.1038/nn.4462", "pmid": "27991900", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "nn.4462"}], "notes": [], "created": "2018-12-05T09:01:27.378Z", "modified": "2018-12-05T09:01:27.397Z"}, {"entity": "publication", "iuid": "b252b094f4584c578bd9431f29eb03ae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b252b094f4584c578bd9431f29eb03ae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b252b094f4584c578bd9431f29eb03ae"}}, "title": "Novel genetic loci underlying human intracranial volume identified through genome-wide association.", "authors": [{"family": "Adams", "given": "Hieab H H", "initials": "HH"}, {"family": "Hibar", "given": "Derrek P", "initials": "DP"}, {"family": "Chouraki", 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"Konstantinos", "initials": "K"}, {"family": "Aribisala", "given": "Benjamin S", "initials": "BS"}, {"family": "Armstrong", "given": "Nicola J", "initials": "NJ"}, {"family": "Athanasiu", "given": "Lavinia", "initials": "L"}, {"family": "Axelsson", "given": "Tomas", "initials": "T"}, {"family": "Beiser", "given": "Alexa", "initials": "A"}, {"family": "Bernard", "given": "Manon", "initials": "M"}, {"family": "Bis", "given": "Joshua C", "initials": "JC"}, {"family": "Blanken", "given": "Laura M E", "initials": "LM"}, {"family": "Blanton", "given": "Susan H", "initials": "SH"}, {"family": "Bohlken", "given": "Marc M", "initials": "MM"}, {"family": "Boks", "given": "Marco P", "initials": "MP"}, {"family": "Bralten", "given": "Janita", "initials": "J"}, {"family": "Brickman", "given": "Adam M", "initials": "AM"}, {"family": "Carmichael", "given": "Owen", "initials": "O"}, {"family": "Chakravarty", "given": "M Mallar", "initials": "MM"}, {"family": "Chauhan", "given": "Ganesh", "initials": "G"}, {"family": "Chen", "given": "Qiang", "initials": "Q"}, {"family": "Ching", "given": "Christopher R K", "initials": "CR"}, {"family": "Cuellar-Partida", "given": "Gabriel", "initials": "G"}, {"family": "Braber", "given": "Anouk Den", "initials": "AD"}, {"family": "Doan", "given": "Nhat Trung", "initials": "NT"}, {"family": "Ehrlich", "given": "Stefan", "initials": "S"}, {"family": "Filippi", "given": "Irina", "initials": "I"}, {"family": "Ge", "given": "Tian", "initials": "T"}, {"family": "Giddaluru", "given": "Sudheer", "initials": "S"}, {"family": "Goldman", "given": "Aaron L", "initials": "AL"}, {"family": "Gottesman", "given": "Rebecca F", "initials": "RF"}, {"family": "Greven", "given": "Corina U", "initials": "CU"}, {"family": "Grimm", "given": "Oliver", "initials": "O"}, {"family": "Griswold", "given": "Michael E", "initials": "ME"}, {"family": "Guadalupe", "given": "Tulio", "initials": "T"}, {"family": "Hass", "given": "Johanna", "initials": "J"}, {"family": "Haukvik", 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"DJ"}, {"family": "Vernooij", "given": "Meike W", "initials": "MW"}, {"family": "V\u00f6lzke", "given": "Henry", "initials": "H"}, {"family": "Walter", "given": "Henrik", "initials": "H"}, {"family": "Wardlaw", "given": "Joanna M", "initials": "JM"}, {"family": "Wassink", "given": "Thomas H", "initials": "TH"}, {"family": "Weale", "given": "Michael E", "initials": "ME"}, {"family": "Weinberger", "given": "Daniel R", "initials": "DR"}, {"family": "Weiner", "given": "Michael W", "initials": "MW"}, {"family": "Wen", "given": "Wei", "initials": "W"}, {"family": "Westman", "given": "Eric", "initials": "E"}, {"family": "White", "given": "Tonya", "initials": "T"}, {"family": "Wong", "given": "Tien Y", "initials": "TY"}, {"family": "Wright", "given": "Clinton B", "initials": "CB"}, {"family": "Zielke", "given": "H Ronald", "initials": "HR"}, {"family": "Zonderman", "given": "Alan B", "initials": "AB"}, {"family": "Deary", "given": "Ian J", "initials": "IJ"}, {"family": "DeCarli", "given": "Charles", "initials": "C"}, {"family": "Schmidt", "given": "Helena", "initials": "H"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG"}, {"family": "De Craen", "given": "Anton J M", "initials": "AJ"}, {"family": "Wright", "given": "Margaret J", "initials": "MJ"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Schumann", "given": "Gunter", "initials": "G"}, {"family": "Fornage", "given": "Myriam", "initials": "M"}, {"family": "Franke", "given": "Barbara", "initials": "B"}, {"family": "Debette", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Medland", "given": "Sarah E", "initials": "SE"}, {"family": "Ikram", "given": "M Arfan", "initials": "MA"}, {"family": "Thompson", "given": "Paul M", "initials": "PM"}], "type": "journal article", "published": "2016-12-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "19", "issue": "12", "pages": "1569-1582", "issn-l": "1097-6256"}, "abstract": "Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (\u03c1", "doi": "10.1038/nn.4398", "pmid": "27694991", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "nn.4398"}, {"db": "pmc", "key": "PMC5227112"}, {"db": "mid", "key": "NIHMS822505"}], "notes": [], "created": "2018-12-05T09:19:05.917Z", "modified": "2018-12-05T09:19:05.936Z"}, {"entity": "publication", "iuid": "d1dfcb0e85324fb99296950bfa2fab4a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d1dfcb0e85324fb99296950bfa2fab4a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d1dfcb0e85324fb99296950bfa2fab4a"}}, "title": "The age and genomic integrity of neurons after cortical stroke in humans.", "authors": [{"family": "Huttner", "given": "Hagen B", "initials": "HB"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Salehpour", "given": "Mehran", "initials": "M"}, {"family": "R\u00e1cz", "given": "Attila", "initials": "A"}, {"family": "Tatarishvili", "given": "Jemal", "initials": "J"}, {"family": "Lindgren", "given": "Emma", "initials": "E"}, {"family": "Csonka", "given": "Tam\u00e1s", "initials": "T"}, {"family": "Csiba", "given": "L\u00e1szl\u00f3", "initials": "L"}, {"family": "Hortob\u00e1gyi", "given": "Tibor", "initials": "T"}, {"family": "M\u00e9hes", "given": "G\u00e1bor", "initials": "G"}, {"family": "Englund", "given": "Elisabet", "initials": "E"}, {"family": "Solnestam", "given": "Beata Werne", "initials": "BW"}, {"family": "Zdunek", "given": "Sofia", "initials": "S"}, {"family": "Scharenberg", "given": "Christian", "initials": "C"}, {"family": "Str\u00f6m", "given": "Lena", "initials": "L"}, {"family": "St\u00e5hl", "given": "Patrik", "initials": "P"}, {"family": "Sigurgeirsson", "given": "Benjamin", "initials": "B"}, {"family": "Dahl", "given": "Andreas", "initials": "A"}, {"family": "Schwab", "given": "Stefan", "initials": "S"}, {"family": "Possnert", "given": "G\u00f6ran", "initials": "G"}, {"family": "Bernard", "given": "Samuel", "initials": "S"}, {"family": "Kokaia", "given": "Zaal", "initials": "Z"}, {"family": "Lindvall", "given": "Olle", "initials": "O"}, {"family": "Lundeberg", "given": "Joakim", "initials": "J"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2014-06-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "17", "issue": "6", "pages": "801-803", "issn-l": "1097-6256"}, "abstract": "It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival. ", "doi": "10.1038/nn.3706", "pmid": "24747576", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "nn.3706"}, {"db": "GEO", "key": "GSE56267"}, {"db": "SRA", "key": "SRP040676"}], "notes": [], "created": "2018-12-05T08:55:56.833Z", "modified": "2018-12-05T08:55:56.868Z"}, {"entity": "publication", "iuid": "3219a1df5ea642b681d04c45d3e0b1e4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3219a1df5ea642b681d04c45d3e0b1e4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3219a1df5ea642b681d04c45d3e0b1e4"}}, "title": "OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.", "authors": [{"family": "Le\u00e3o", "given": "Richardson N", "initials": "RN"}, {"family": "Mikulovic", "given": "Sanja", "initials": "S"}, {"family": "Le\u00e3o", "given": "Katarina E", "initials": "KE"}, {"family": "Munguba", "given": "Hermany", "initials": "H"}, {"family": "Gezelius", "given": "Henrik", "initials": "H"}, {"family": "Enjin", "given": "Anders", "initials": "A"}, {"family": "Patra", "given": "Kalicharan", "initials": "K"}, {"family": "Eriksson", "given": "Anders", "initials": "A"}, {"family": "Loew", "given": "Leslie M", "initials": "LM"}, {"family": "Tort", "given": "Adriano B L", "initials": "AB"}, {"family": "Kullander", "given": "Klas", "initials": "K"}], "type": "journal article", "published": "2012-11-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "15", "issue": "11", "pages": "1524-1530", "issn-l": "1097-6256"}, "abstract": "The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types has been hampered by the lack of cell-specific tools. We identified a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining transgenic mice and optogenetic tools, we found that OLM cells are important for gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex). Furthermore, we found that OLM cells were interconnected by gap junctions, received direct cholinergic inputs from subcortical afferents and accounted for the effect of nicotine on synaptic plasticity of the Schaffer collateral pathway. Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.", "doi": "10.1038/nn.3235", "pmid": "23042082", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "nn.3235"}, {"db": "pmc", "key": "PMC3483451"}, {"db": "mid", "key": "NIHMS407831"}], "notes": [], "created": "2018-12-05T08:37:54.093Z", "modified": "2018-12-05T08:37:54.124Z"}], "created": "2018-12-05T08:37:54.106Z", "modified": "2020-11-27T13:12:55.439Z"}