{"entity": "journal", "iuid": "cbc19c10b5884cfb8dd2e5a7a38a3a49", "timestamp": "2026-07-20T23:12:17.211Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Nat%20Metab.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Nat%20Metab"}}, "title": "Nat Metab", "issn": "2522-5812", "issn-l": "2522-5812", "publications_count": 4, "publications": [{"entity": "publication", "iuid": "ab2eb6110d914640b7efbcc4324a00b0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ab2eb6110d914640b7efbcc4324a00b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ab2eb6110d914640b7efbcc4324a00b0"}}, "title": "Revisiting the role of serine metabolism in hepatic lipogenesis.", "authors": [{"family": "Yang", "given": "Hong", "initials": "H", "orcid": "0009-0002-0414-2471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f6b6c1901bc4c4daf3101f3de8b7029.json"}}, {"family": "Zhang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-3721-8586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46e4161be08458994efddb75ed75874.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Uhlen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Boren", "given": "Jan", "initials": "J", "orcid": "0000-0003-0786-8091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73a770eb9e614448a046b8e9199052e9.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "5", "issue": "5", "pages": "760-761", "issn-l": "2522-5812"}, "abstract": null, "doi": "10.1038/s42255-023-00792-0", "pmid": "37169876", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s42255-023-00792-0"}], "notes": [], "created": "2023-12-04T14:49:50.726Z", "modified": "2023-12-04T14:49:50.813Z"}, {"entity": "publication", "iuid": "b436447782154e4d8b72068ac6711bfb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b436447782154e4d8b72068ac6711bfb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b436447782154e4d8b72068ac6711bfb"}}, "title": "PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.", "authors": [{"family": "Cikes", "given": "Domagoj", "initials": "D", "orcid": "0000-0003-0350-5672", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04b1713531d24e25aff51715d7d0f4cf.json"}}, {"family": "Elsayad", "given": "Kareem", "initials": "K"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7bd3619c7fd48318bc4c1e7a9910df8.json"}}, {"family": "Koitai", "given": "Erika", "initials": "E", "orcid": "0000-0002-1370-2955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638ff8aa9fbd4074bcfb37df52229f1d.json"}}, {"family": "Torma", "given": "Ferenc", "initials": "F", "orcid": "0000-0003-1331-8643", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ba5ed9f5d944a179cf0c9a203b68cd3.json"}}, {"family": "Orthofer", "given": "Michael", "initials": "M"}, {"family": "Yarwood", "given": "Rebecca", "initials": "R"}, {"family": "Heinz", "given": "Leonhard X", "initials": "LX"}, {"family": "Sedlyarov", "given": "Vitaly", "initials": "V"}, {"family": "Miranda", "given": "Nasser Darwish", "initials": "ND", "orcid": "0000-0002-8821-8236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fae2cac17074f359f28a4b206f235af.json"}}, {"family": "Taylor", "given": "Adrian", "initials": "A"}, {"family": "Grapentine", "given": "Sophie", "initials": "S", "orcid": "0000-0003-2307-4363", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c99aa24130ed4da5a00cb19b6627d5a9.json"}}, {"family": "Al-Murshedi", "given": "Fathiya", "initials": "F"}, {"family": "Abot", "given": "Anne", "initials": "A"}, {"family": "Weidinger", "given": "Adelheid", "initials": "A", "orcid": "0000-0002-2759-211X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7eb7308571dd458ab5bac42a7e7eab5c.json"}}, {"family": "Kutchukian", "given": "Candice", "initials": "C", "orcid": "0000-0003-1142-7109", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2af15deffb674ad4811f7818c7e577e3.json"}}, {"family": "Sanchez", "given": "Colline", "initials": "C"}, {"family": "Cronin", "given": "Shane J F", "initials": "SJF"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Kavirayani", "given": "Anoop", "initials": "A", "orcid": "0000-0003-3874-3101", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc3b7fff03cb470da6d0e79c2deb63dd.json"}}, {"family": "Schuetz", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9211-8345", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15449a6aa73040d9a015a9593508e39a.json"}}, {"family": "Haubner", "given": "Bernhard", "initials": "B"}, {"family": "Haas", "given": "Lisa", "initials": "L"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A", "orcid": "0000-0003-3015-4038", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4b00dea21d446c0af4c0cd542d24907.json"}}, {"family": "Jackowski", "given": "Suzanne", "initials": "S"}, {"family": "Kozlov", "given": "Andrey V", "initials": "AV", "orcid": "0000-0002-0834-4997", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67c0a307da9a448a958fd90e0a8be55f.json"}}, {"family": "Jacquemond", "given": "Vincent", "initials": "V", "orcid": "0000-0003-4944-270X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a82711608ac14246825a8729909ef65e.json"}}, {"family": "Knauf", "given": "Claude", "initials": "C", "orcid": "0000-0001-5213-5378", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2d6169ca6f44289baaa9b0a4df0d882.json"}}, {"family": "Superti-Furga", "given": "Giulio", "initials": "G", "orcid": "0000-0002-0570-1768", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfdf094156594f40a3900cbaadefa817.json"}}, {"family": "Rullman", "given": "Eric", "initials": "E", "orcid": "0000-0003-2854-7262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4cfc8153e584034b3334e727c6bade4.json"}}, {"family": "Gustafsson", "given": "Thomas", "initials": "T"}, {"family": "McDermot", "given": "John", "initials": "J"}, {"family": "Lowe", "given": "Martin", "initials": "M"}, {"family": "Radak", "given": "Zsolt", "initials": "Z"}, {"family": "Chamberlain", "given": "Jeffrey S", "initials": "JS", "orcid": "0000-0001-5299-0059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5bb089d221e408a8298d85391081588.json"}}, {"family": "Bakovic", "given": "Marica", "initials": "M"}, {"family": "Banka", "given": "Siddharth", "initials": "S", "orcid": "0000-0002-8527-2210", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/491aecbac6094f10be801a6a7803fd8f.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2a049a261eb46c79066a817f5cd4d5b.json"}}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "5", "issue": "3", "pages": "495-515", "issn-l": "2522-5812"}, "abstract": "Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective treatments for muscle diseases, represents an important goal in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency in PCYT2 causes a severe disease with failure to thrive and progressive weakness. pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the participant phenotypes, with failure to thrive, progressive muscle weakness and accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing. Thus, PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.", "doi": "10.1038/s42255-023-00766-2", "pmid": "36941451", "labels": {"SciLifeLab Fellow": null, "Erdinc Sezgin": null}, "xrefs": [{"db": "pii", "key": "10.1038/s42255-023-00766-2"}], "notes": [], "created": "2023-05-26T17:17:58.946Z", "modified": "2023-05-26T17:17:59.492Z"}, {"entity": "publication", "iuid": "8b8fb21585b14fcdb6b49e0ae3cca926", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8b8fb21585b14fcdb6b49e0ae3cca926.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8b8fb21585b14fcdb6b49e0ae3cca926"}}, "title": "BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH.", "authors": [{"family": "Baboota", "given": "Ritesh K", "initials": "RK"}, {"family": "Rawshani", "given": "Aidin", "initials": "A"}, {"family": "Bonnet", "given": "Laurianne", "initials": "L"}, {"family": "Li", "given": "Xiangyu", "initials": "X", "orcid": "0000-0002-8301-9959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c452ad4e8bb4302a572693103742047.json"}}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Tchkonia", "given": "Tamar", "initials": "T", "orcid": "0000-0003-4623-7145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/190bea8a95ab4008abdb810dff857198.json"}}, {"family": "Kirkland", "given": "James L", "initials": "JL", "orcid": "0000-0003-1676-4905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0210f3779854f92a4b1c80003be052f.json"}}, {"family": "Hoffmann", "given": "Anne", "initials": "A"}, {"family": "Dietrich", "given": "Arne", "initials": "A"}, {"family": "Boucher", "given": "Jeremie", "initials": "J"}, {"family": "Bl\u00fcher", "given": "Matthias", "initials": "M", "orcid": "0000-0003-0208-2065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/587f009a96714fa3910730cf316b5031.json"}}, {"family": "Smith", "given": "Ulf", "initials": "U", "orcid": "0000-0002-1439-4608", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/908ff4c3bfde48c0a1bdbdd845b765dd.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "4", "issue": "8", "pages": "1007-1021", "issn-l": "2522-5812"}, "abstract": "The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed liver biopsies and extensive characterization of 58 individuals with or without NAFLD/NASH. Here, we show that hepatic cell senescence is strongly related to NAFLD/NASH severity, and machine learning analysis identified senescence markers, the BMP4 inhibitor Gremlin 1 in liver and visceral fat, and the amount of visceral adipose tissue as strong predictors. Studies in liver cell spheroids made from human stellate and hepatocyte cells show BMP4 to be anti-senescent, anti-steatotic, anti-inflammatory and anti-fibrotic, whereas Gremlin 1, which is particularly highly expressed in visceral fat in humans, is pro-senescent and antagonistic to BMP4. Both senescence and anti-senescence factors target the YAP/TAZ pathway, making this a likely regulator of senescence and its effects. We conclude that senescence is an important driver of human NAFLD/NASH and that BMP4 and Gremlin 1 are novel therapeutic targets.", "doi": "10.1038/s42255-022-00620-x", "pmid": "35995996", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9398907"}, {"db": "pii", "key": "10.1038/s42255-022-00620-x"}], "notes": [], "created": "2023-12-04T14:58:12.238Z", "modified": "2023-12-04T14:58:12.414Z"}, {"entity": "publication", "iuid": "0f028de7aff94d5b97cb83e61037bdca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0f028de7aff94d5b97cb83e61037bdca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0f028de7aff94d5b97cb83e61037bdca"}}, "title": "Liver macrophages regulate systemic metabolism through non-inflammatory factors.", "authors": [{"family": "Morgantini", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-3142-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5505bf28316b4ee98a1b774b38d78613.json"}}, {"family": "Jager", "given": "Jennifer", "initials": "J"}, {"family": "Li", "given": "Xidan", "initials": "X"}, {"family": "Levi", "given": "Laura", "initials": "L"}, {"family": "Azzimato", "given": "Valerio", "initials": "V"}, {"family": "Sulen", "given": "Andr\u00e9", "initials": "A"}, {"family": "Barreby", "given": "Emelie", "initials": "E"}, {"family": "Xu", "given": "Connie", "initials": "C"}, {"family": "Tencerova", "given": "Michaela", "initials": "M"}, {"family": "N\u00e4slund", "given": "Erik", "initials": "E"}, {"family": "Kumar", "given": "Chanchal", "initials": "C"}, {"family": "Verdeguer", "given": "Francisco", "initials": "F"}, {"family": "Straniero", "given": "Sara", "initials": "S"}, {"family": "Hultenby", "given": "Kjell", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ded8cd7038b4c42ac16f62f89b9229c.json"}}, {"family": "Ellis", "given": "Ewa", "initials": "E"}, {"family": "Ryd\u00e9n", "given": "Mikael", "initials": "M", "orcid": "0000-0003-4785-1876", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b304b5aa66b40629b47d4a070e27f24.json"}}, {"family": "Kutter", "given": "Claudia", "initials": "C"}, {"family": "Hurrell", "given": "Tracey", "initials": "T"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}, {"family": "Boucher", "given": "Jeremie", "initials": "J"}, {"family": "Tom\u010dala", "given": "Ale\u0161", "initials": "A"}, {"family": "Krej\u010dov\u00e1", "given": "Gabriela", "initials": "G"}, {"family": "Bajgar", "given": "Adam", "initials": "A"}, {"family": "Aouadi", "given": "Myriam", "initials": "M", "orcid": "0000-0001-6256-7107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83df5589b88140ec8819309df4ddff95.json"}}], "type": "journal article", "published": "2019-04-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "issn-l": "2522-5812", "volume": "1", "issue": "4", "pages": "445-459"}, "abstract": "Liver macrophages (LMs) have been proposed to contribute to metabolic disease through secretion of inflammatory cytokines. However, anti-inflammatory drugs lead to only modest improvements in systemic metabolism. Here we show that LMs do not undergo a proinflammatory phenotypic switch in obesity-induced insulin resistance in flies, mice and humans. Instead, we find that LMs produce non-inflammatory factors, such as insulin-like growth factor-binding protein 7 (IGFBP7), that directly regulate liver metabolism. IGFBP7 binds to the insulin receptor and induces lipogenesis and gluconeogenesis via activation of extracellular-signal-regulated kinase (ERK) signalling. We further show that IGFBP7 is subject to RNA editing at a higher frequency in insulin-resistant than in insulin-sensitive obese patients (90% versus 30%, respectively), resulting in an IGFBP7 isoform with potentially higher capacity to bind to the insulin receptor. Our study demonstrates that LMs can contribute to insulin resistance independently of their inflammatory status and indicates that non-inflammatory factors produced by macrophages might represent new drug targets for the treatment of metabolic diseases.", "doi": "10.1038/s42255-019-0044-9", "pmid": "32694874", "labels": {"Claudia Kutter": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s42255-019-0044-9"}], "notes": [], "created": "2020-09-25T14:31:21.958Z", "modified": "2023-06-19T14:02:12.267Z"}], "created": "2020-09-25T14:31:21.970Z", "modified": "2020-11-27T13:13:00.164Z"}