{"entity": "journal", "iuid": "440c6e0b657e4b2a883e8efa24d12c29", "timestamp": "2026-08-20T20:45:11.242Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Nat%20Biomed%20Eng.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Nat%20Biomed%20Eng"}}, "title": "Nat Biomed Eng", "issn": "2157-846X", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "92fda3626c7d480384ca394eb3cfea16", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/92fda3626c7d480384ca394eb3cfea16.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/92fda3626c7d480384ca394eb3cfea16"}}, "title": "Antibody-displaying extracellular vesicles for targeted cancer therapy.", "authors": [{"family": "Wiklander", "given": "Oscar P B", "initials": "OPB", "orcid": "0000-0003-1176-8114", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3ae515f9514277990420f29b08ffb8.json"}}, {"family": "Mamand", "given": "Doste R", "initials": "DR"}, {"family": "Mohammad", "given": "Dara K", "initials": "DK", "orcid": "0000-0001-9201-0991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad2bb4ba00204a9a8ff0c373b84f35c6.json"}}, {"family": "Zheng", "given": "Wenyi", "initials": "W", "orcid": "0000-0003-2416-5822", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfa28b56f07c4235bc2a481649accbda.json"}}, {"family": "Jawad Wiklander", "given": "Rim", "initials": "R"}, {"family": "Sych", "given": "Taras", "initials": "T"}, {"family": "Zickler", "given": "Antje M", "initials": "AM", "orcid": "0000-0001-5001-6586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8753529f7cc54455903782cb6570be90.json"}}, {"family": "Liang", "given": "Xiuming", "initials": "X"}, {"family": "Sharma", "given": "Heena", "initials": "H"}, {"family": "Lavado", "given": "Andrea", "initials": "A"}, {"family": "Bost", "given": "Jeremy", "initials": "J"}, {"family": "Roudi", "given": "Samantha", "initials": "S"}, {"family": "Corso", "given": "Giulia", "initials": "G", "orcid": "0000-0002-1145-0862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18d0bde251184eaf9acaa74fe44785fe.json"}}, {"family": "Lenna\u00e1rd", "given": "Angus J", "initials": "AJ"}, {"family": "Abedi-Valugerdi", "given": "Manuchehr", "initials": "M"}, {"family": "M\u00e4ger", "given": "Imre", "initials": "I", "orcid": "0000-0003-2242-7227", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ea0f05e6bfd498a97fc54d3df45a17e.json"}}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7bd3619c7fd48318bc4c1e7a9910df8.json"}}, {"family": "Nordin", "given": "Joel Z", "initials": "JZ", "orcid": "0000-0002-3653-7710", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8466e67693c342bf9bf88349e5670ca4.json"}}, {"family": "Gupta", "given": "Dhanu", "initials": "D"}, {"family": "G\u00f6rgens", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0001-9198-0857", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec898b76cd5f4e22b361d1d74b0e0b80.json"}}, {"family": "El Andaloussi", "given": "Samir", "initials": "S", "orcid": "0000-0003-4468-9113", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c9f9a3de1634032bbe84b1afc6eb69f.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "Nat Biomed Eng", "issn": "2157-846X", "volume": "8", "issue": "11", "pages": "1453-1468", "issn-l": null}, "abstract": "Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological signals across tissues. Here, by leveraging these functionalities, we show that EVs decorated with an antibody-binding moiety specific for the fragment crystallizable (Fc) domain can be used as a modular delivery system for targeted cancer therapy. The Fc-EVs can be decorated with different types of immunoglobulin G antibody and thus be targeted to virtually any tissue of interest. Following optimization of the engineered EVs by screening Fc-binding and EV-sorting moieties, we show the targeting of EVs to cancer cells displaying the human epidermal receptor 2 or the programmed-death ligand 1, as well as lower tumour burden and extended survival of mice with subcutaneous melanoma tumours when systemically injected with EVs displaying an antibody for the programmed-death ligand 1 and loaded with the chemotherapeutic doxorubicin. EVs with Fc-binding domains may be adapted to display other Fc-fused proteins, bispecific antibodies and antibody-drug conjugates.", "doi": "10.1038/s41551-024-01214-6", "pmid": "38769158", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11584392"}, {"db": "pii", "key": "10.1038/s41551-024-01214-6"}], "notes": [], "created": "2026-08-20T08:54:51.255Z", "modified": "2026-08-20T08:54:51.592Z"}, {"entity": "publication", "iuid": "43981b7005d4408b970786e4ef79a2af", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/43981b7005d4408b970786e4ef79a2af.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/43981b7005d4408b970786e4ef79a2af"}}, "title": "CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers.", "authors": [{"family": "Jin", "given": "Chuan", "initials": "C"}, {"family": "Ma", "given": "Jing", "initials": "J"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M", "orcid": "0000-0003-2685-0575", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd947633edf949aba9e680e63a1e178b.json"}}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Nat Biomed Eng", "issn": "2157-846X", "volume": "6", "issue": "7", "pages": "830-841", "issn-l": null}, "abstract": "Chimeric antigen receptor T cells (CAR T cells) are effective against haematologic malignancies. However, in solid tumours, their potency is hampered by local immunosuppression and by the heterogeneous expression of the antigen that the CAR targets. Here we show that CAR T cells expressing a pluripotent pro-inflammatory neutrophil-activating protein (NAP) from Helicobacter pylori trigger endogenous bystander T-cell responses against solid cancers. In mice with subcutaneous murine pancreatic ductal adenocarcinomas, neuroblastomas or colon carcinomas, CAR(NAP) T cells led to slower tumour growth and higher survival rates than conventional mouse CAR T cells, regardless of target antigen, tumour type and host haplotype. In tumours with heterogeneous antigen expression, NAP secretion induced the formation of an immunologically 'hot' microenvironment that supported dendritic cell maturation and bystander responses, as indicated by epitope spreading and infiltration of cytotoxic CD8+ T cells targeting tumour-associated antigens other than the CAR-targeted antigen. CAR T cells armed with NAP neither increased off-tumour toxicity nor hampered the efficacy of CAR T cells, and hence may have advantageous translational potential.", "doi": "10.1038/s41551-022-00875-5", "pmid": "35379957", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9288934"}, {"db": "pii", "key": "10.1038/s41551-022-00875-5"}], "notes": [], "created": "2026-08-20T08:54:49.254Z", "modified": "2026-08-20T08:54:49.396Z"}], "created": "2026-08-20T08:54:49.359Z", "modified": "2026-08-20T08:54:49.359Z"}