{"entity": "journal", "iuid": "ff4fbe68ea5442b4b708eb098ed02539", "timestamp": "2026-08-23T10:18:59.445Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Medicina%20%28Kaunas%29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Medicina%20%28Kaunas%29"}}, "title": "Medicina (Kaunas)", "issn": "1648-9144", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "6a3b0c9ce07f4a68a9a63574763057bd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6a3b0c9ce07f4a68a9a63574763057bd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6a3b0c9ce07f4a68a9a63574763057bd"}}, "title": "Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Selvitopi", "given": "Harun", "initials": "H"}, {"family": "Kadi", "given": "Abdurrahim", "initials": "A", "orcid": "0000-0001-9250-9397", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5abbff5bc3084711a38e85f42c15c6af.json"}}, {"family": "Oner", "given": "Sena", "initials": "S"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2023-12-30", "journal": {"title": "Medicina (Kaunas)", "issn": "1648-9144", "volume": "60", "issue": "1", "issn-l": null}, "abstract": "Background and Objectives: Favipiravir (FPV) is an antiviral medication and has an inhibitory effect on Cytochrome P450 (CYP2C8) protein, which is mainly involved in drug metabolism in the liver, and the expression of this gene is known to be enhanced in neuronal cells. The metabolization of Paclitaxel (PTX), a chemotherapeutic drug used in cancer patients, was analyzed for the first time in the human SH-SY5Y neuroblastoma cell line for monitoring possible synergistic effects when administered with FPV. Materials and Methods: Further, in vitro cytotoxic and genotoxic evaluations of FPV and PTX were also performed using wide concentration ranges in a human fibroblast cell culture (HDFa). Nuclear abnormalities were examined under a fluorescent microscope using the Hoechst 33258 fluorescent staining technique. In addition, the synergistic effects of these two drugs on cultured SH-SY5Y cells were determined by MTT cell viability assay. In addition, the death mechanisms that can occur in SHSY-5Y were revealed by using the flow cytometry technique. Results: Cell viability analyses on the HDFa healthy cell culture showed that both FPV and PTX have inhibitory effects at higher concentrations. On the other hand, there were no significant differences in nuclear abnormality numbers when both of the compounds were applied together. Cell viability analyses showed that FPV and PTX applications have higher cytotoxicity, which indicated synergistic toxicity against the SHSY-5Y cell line. Also, PTX exhibited higher anticancer properties against the neuroblastoma cell line when applied with FPV, as shown in both cytotoxicity and flow cytometry analyses. Conclusions: In light of our findings, the anticancer properties of PTX can be enhanced when the drug application is coupled with FPV exposure. Moreover, these results put forth that the anticancer drug dosage should be evaluated carefully in cancer patients who take COVID-19 treatment with FPV.", "doi": "10.3390/medicina60010082", "pmid": "38256343", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10820816"}, {"db": "pii", "key": "medicina60010082"}], "notes": [], "created": "2026-08-20T13:42:12.397Z", "modified": "2026-08-20T13:42:12.495Z"}, {"entity": "publication", "iuid": "d47b6407f8c34394907d965ae701ea83", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d47b6407f8c34394907d965ae701ea83.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d47b6407f8c34394907d965ae701ea83"}}, "title": "A Novel Mutation of ATP7B Gene in a Case of Wilson Disease.", "authors": [{"family": "Kahraman", "given": "Cigdem Yuce", "initials": "CY", "orcid": "0000-0003-1957-9596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f608344b0340d0a12e82dd5a918dce.json"}}, {"family": "Islek", "given": "Ali", "initials": "A"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "\u00d6zdemir", "given": "\u00d6zlem", "initials": "\u00d6", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "Mardinglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}], "type": "case reports", "published": "2021-01-29", "journal": {"title": "Medicina (Kaunas)", "issn": "1648-9144", "volume": "57", "issue": "2", "issn-l": null}, "abstract": "Wilson disease (WD) (OMIM# 277900) is an autosomal recessive inherited disorder characterized by excess copper (Cu) storage in different human tissues, such as the brain, liver, and the corneas of the eyes. It is a rare disorder that occurs in approximately 1 in 30,000 individuals. The clinical presentations of WD are highly varied, primarily consisting of hepatic and neurological conditions. WD is caused by homozygous or compound heterozygous mutations in the ATP7B gene. The diagnosis of the disease is complicated because of its heterogeneous phenotypes. The molecular genetic analysis encourages early diagnosis, treatment, and the opportunity to screen individuals at risk in the family. In this paper, we reported a case with a novel, hotspot-located mutation in WD. We have suggested that this mutation in the ATP7B gene might contribute to liver findings, progressing to liver failure with a loss of function effect. Besides this, if patients have liver symptoms in childhood and/or are children of consanguineous parents, WD should be considered during the evaluation of the patients.", "doi": "10.3390/medicina57020123", "pmid": "33573009", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7912016"}, {"db": "pii", "key": "medicina57020123"}], "notes": [], "created": "2026-08-21T13:04:09.452Z", "modified": "2026-08-21T13:04:09.539Z"}, {"entity": "publication", "iuid": "b8ddce99267a4f8db2b00ca1dc5223bd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b8ddce99267a4f8db2b00ca1dc5223bd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b8ddce99267a4f8db2b00ca1dc5223bd"}}, "title": "Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet.", "authors": [{"family": "Thomas", "given": "R\u03ccis\u00edn C", "initials": "RC"}, {"family": "Kheder", "given": "Ramiar", "initials": "R", "orcid": "0000-0003-3039-4920", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/994192dfa1694e0eb1cf6e0648b45efb.json"}}, {"family": "Alaridhee", "given": "Hasanain", "initials": "H"}, {"family": "Martin", "given": "Naomi", "initials": "N", "orcid": "0000-0002-6242-6977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61f5881f9bec44de91a91b9f2e091117.json"}}, {"family": "Stover", "given": "Cordula M", "initials": "CM", "orcid": "0000-0002-0125-4868", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c6c7aec805c84b5faf377a58bb5e743a.json"}}], "type": "journal article", "published": "2020-09-22", "journal": {"title": "Medicina (Kaunas)", "issn": "1648-9144", "volume": "56", "issue": "9", "issn-l": null}, "abstract": "Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products. Its absence has previously been shown to lead to increased obesity in mice on a high fat diet. The aim of this study was to determine ways in which properdin contributes to a less pronounced obese phenotype. Materials and Methods: Wild type (WT) and properdin deficient mice (KO) were fed a high-fat diet (HFD) for up to 12 weeks. Results: There was a significant increase in liver triglyceride content in the KO HFD group compared to WT on HFD. WT developed steatosis. KO had an additional inflammatory component (steatohepatitis). Analysis of AKT signalling by phosphorylation array supported a decrease in insulin sensitivity which was greater for KO than WT in liver and kidney. There was a significant decrease of C5L2 in the fat membranes of the KO HFD group compared to the WT HFD group. Circulating microparticles in KO HFD group showed lower presence of C5L2. Expression of the fatty acid transporter CD36 in adipose tissue was increased in KO on HFD and was also significantly increased in plasma of KO HFD mice compared to WT on HFD. CD36 was elevated on microparticles from KO on HFD. Ultrastructural changes consistent with obesity-associated glomerulopathy were observed for both HFD fed genotypes, but tubular strain was greater in KO. Conclusion: Our work demonstrates that complement properdin is a dominant factor in limiting the severity of obesity-associated conditions that impact on liver and kidney. The two receptors, C5L2 and CD36, are downstream of the activity exerted by properdin.", "doi": "10.3390/medicina56090484", "pmid": "32971872", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7558790"}, {"db": "pii", "key": "medicina56090484"}], "notes": [], "created": "2026-08-21T13:04:07.134Z", "modified": "2026-08-21T13:04:07.295Z"}], "created": "2026-08-20T13:42:12.456Z", "modified": "2026-08-20T13:42:12.456Z"}