{"entity": "journal", "iuid": "05a6b814162c44109e1bc26be0f41ecc", "timestamp": "2026-04-13T05:08:37.804Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Materials%20%28Basel%29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Materials%20%28Basel%29"}}, "title": "Materials (Basel)", "issn": "1996-1944", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "58084cae6e974170ba9dbae04e128a08", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/58084cae6e974170ba9dbae04e128a08.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/58084cae6e974170ba9dbae04e128a08"}}, "title": "In Vitro Transcriptome Analysis of Cobalt Boride Nanoparticles on Human Pulmonary Alveolar Cells.", "authors": [{"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Tatar", "given": "Arzu", "initials": "A"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "\u00d6zge \u00c7a\u011flar", "initials": "\u00d6\u00c7", "orcid": "0000-0003-1412-8411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513eed83e3b643088ebb66284a761ee5.json"}}, {"family": "\u015eahin", "given": "\u0130rfan O\u011fuz", "initials": "\u0130O"}, {"family": "Ozdemir", "given": "Ozlem", "initials": "O", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "Sonmez", "given": "Erdal", "initials": "E"}, {"family": "Hac\u0131muftuoglu", "given": "Ahmet", "initials": "A"}, {"family": "Acikyildiz", "given": "Metin", "initials": "M"}, {"family": "Geyiko\u011flu", "given": "Fatime", "initials": "F"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "T\u00fcrkez", "given": "Hasan", "initials": "H"}], "type": "journal article", "published": "2022-12-06", "journal": {"title": "Materials (Basel)", "issn": "1996-1944", "volume": "15", "issue": "23", "issn-l": null}, "abstract": "Nanobiotechnology influences many different areas, including the medical, food, energy, clothing, and cosmetics industries. Considering the wide usage of nanomaterials, it is necessary to investigate the toxicity potentials of specific nanosized molecules. Boron-containing nanoparticles (NPs) are attracting much interest from scientists due to their unique physicochemical properties. However, there is limited information concerning the toxicity of boron-containing NPs, including cobalt boride (Co2B) NPs. Therefore, in this study, Co2B NPs were characterized using X-ray crystallography (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDX) techniques. Then, we performed 3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH) release, and neutral red (NR) assays for assessing cell viability against Co2B NP exposure on cultured human pulmonary alveolar epithelial cells (HPAEpiC). In addition, whole-genome microarray analysis was carried out to reveal the global gene expression differentiation of HPAEpiC cells after Co2B NP application. The cell viability tests unveiled an IC50 value for Co2B NPs of 310.353 mg/L. The results of our microarray analysis displayed 719 gene expression differentiations (FC \u2265 2) among the analyzed 40,000 genes. The performed visualization and integrated discovery (DAVID) analysis revealed that there were interactions between various gene pathways and administration of the NPs. Based on gene ontology biological processes analysis, we found that the P53 signaling pathway, cell cycle, and cancer-affecting genes were mostly affected by the Co2B NPs. In conclusion, we suggested that Co2B NPs would be a safe and effective nanomolecule for industrial applications, particularly for medical purposes.", "doi": "10.3390/ma15238683", "pmid": "36500178", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9740129"}, {"db": "pii", "key": "ma15238683"}], "notes": [], "created": "2023-12-04T14:53:08.498Z", "modified": "2023-12-04T14:53:08.593Z"}, {"entity": "publication", "iuid": "a49efe33765d420782d0888eab45a04f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a49efe33765d420782d0888eab45a04f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a49efe33765d420782d0888eab45a04f"}}, "title": "Molecular Genetics and Cytotoxic Responses to Titanium Diboride and Zinc Borate Nanoparticles on Cultured Human Primary Alveolar Epithelial Cells.", "authors": [{"family": "T\u00fcrkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Tatar", "given": "Arzu", "initials": "A"}, {"family": "\u00d6zdemir", "given": "\u00d6zlem", "initials": "\u00d6", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "S\u00f6nmez", "given": "Erdal", "initials": "E"}, {"family": "\u00c7adirci", "given": "Kenan", "initials": "K"}, {"family": "Hacim\u00fcft\u00fco\u011flu", "given": "Ahmet", "initials": "A"}, {"family": "Ceylan", "given": "Bahattin", "initials": "B"}, {"family": "A\u00e7ikyildiz", "given": "Metin", "initials": "M"}, {"family": "Kahraman", "given": "Cigdem Yuce", "initials": "CY", "orcid": "0000-0003-1957-9596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f608344b0340d0a12e82dd5a918dce.json"}}, {"family": "Geyiko\u011flu", "given": "Fatime", "initials": "F"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Materials (Basel)", "issn": "1996-1944", "volume": "15", "issue": "7", "issn-l": null}, "abstract": "Titanium diboride (TiB2) and zinc borate (Zn3BO6) have been utilized in wide spectrum industrial areas because of their favorable properties such as a high melting point, good wear resistance, high hardness and thermal conductivity. On the other hand, the biomedical potentials of TiB2 and Zn3BO6 are still unknown because there is no comprehensive analysis that uncovers their biocompatibility features. Thus, the toxicogenomic properties of TiB2 and Zn3BO6 nanoparticles (NPs) were investigated on human primary alveolar epithelial cell cultures (HPAEpiC) by using different cell viability assays and microarray analyses. Protein-Protein Interaction Networks Functional Enrichment Analysis (STRING) was used to associate differentially expressed gene probes. According to the results, up to 10 mg/L concentration of TiB2 and Zn3BO6 NPs application did not stimulate a cytotoxic effect on the HPAEpiC cell cultures. Microarray analysis revealed that TiB2 NPs exposure enhances cellular adhesion molecules, proteases and carrier protein expression. Furthermore, Zn3BO6 NPs caused differential gene expressions in the cell cycle, cell division and extracellular matrix regulators. Finally, STRING analyses put forth that inflammation, cell regeneration and tissue repair-related gene interactions were affected by TiB2 NPs application. Zn3BO6 NPs exposure significantly altered inflammation, lipid metabolism and infection response activator-related gene interactions. These investigations illustrated that TiB2 and Zn3BO6 NPs exposure may affect different aspects of cellular machineries such as immunogenic responses, tissue regeneration and cell survival. Thus, these types of cellular mechanisms should be taken into account before the use of the related NPs in further biomedical applications.", "doi": "10.3390/ma15072359", "pmid": "35407693", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9000154"}, {"db": "pii", "key": "ma15072359"}], "notes": [], "created": "2023-12-04T15:02:10.941Z", "modified": "2023-12-04T15:02:11.035Z"}, {"entity": "publication", "iuid": "0dc9074c569942edb5175f63a05cc16d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0dc9074c569942edb5175f63a05cc16d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0dc9074c569942edb5175f63a05cc16d"}}, "title": "An Image-Analysis-Based Method for the Prediction of Recombinant Protein Fiber Tensile Strength.", "authors": [{"family": "B\u00e4cklund", "given": "Fredrik G", "initials": "FG"}, {"family": "Schmuck", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-4021-6458", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/626e83f1834f4d8d9b4ee64c15f2764c.json"}}, {"family": "Miranda", "given": "Gisele H B", "initials": "GHB"}, {"family": "Greco", "given": "Gabriele", "initials": "G", "orcid": "0000-0003-3356-7081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef2f738e8fb04eb7b64ea56bf1239172.json"}}, {"family": "Pugno", "given": "Nicola M", "initials": "NM", "orcid": "0000-0003-2136-2396", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a355632865304b05b5f67fb52c8b5238.json"}}, {"family": "Ryd\u00e9n", "given": "Jesper", "initials": "J", "orcid": "0000-0002-5451-4563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7ce080046cd4b82967072d0db278ff9.json"}}, {"family": "Rising", "given": "Anna", "initials": "A", "orcid": "0000-0002-1872-1207", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21439efdc10449a4a6314610bef8f911.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Materials (Basel)", "issn": "1996-1944", "volume": "15", "issue": "3", "issn-l": null}, "abstract": "Silk fibers derived from the cocoon of silk moths and the wide range of silks produced by spiders exhibit an array of features, such as extraordinary tensile strength, elasticity, and adhesive properties. The functional features and mechanical properties can be derived from the structural composition and organization of the silk fibers. Artificial recombinant protein fibers based on engineered spider silk proteins have been successfully made previously and represent a promising way towards the large-scale production of fibers with predesigned features. However, for the production and use of protein fibers, there is a need for reliable objective quality control procedures that could be automated and that do not destroy the fibers in the process. Furthermore, there is still a lack of understanding the specifics of how the structural composition and organization relate to the ultimate function of silk-like fibers. In this study, we develop a new method for the categorization of protein fibers that enabled a highly accurate prediction of fiber tensile strength. Based on the use of a common light microscope equipped with polarizers together with image analysis for the precise determination of fiber morphology and optical properties, this represents an easy-to-use, objective non-destructive quality control process for protein fiber manufacturing and provides further insights into the link between the supramolecular organization and mechanical functionality of protein fibers.", "doi": "10.3390/ma15030708", "pmid": "35160653", "labels": {"SciLifeLab Fellow": null, "Gisele Miranda": null}, "xrefs": [{"db": "pmc", "key": "PMC8915176"}, {"db": "pii", "key": "ma15030708"}], "notes": [], "created": "2025-11-28T16:15:42.472Z", "modified": "2025-11-28T16:15:42.633Z"}], "created": "2023-12-04T14:53:08.582Z", "modified": "2023-12-04T14:53:08.582Z"}