{"entity": "journal", "iuid": "dee3e5cb11ea48d5a7b7322c9b580783", "timestamp": "2026-08-22T09:12:48.338Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Lupus%20Sci%20Med.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Lupus%20Sci%20Med"}}, "title": "Lupus Sci Med", "issn": "2053-8790", "issn-l": null, "publications_count": 4, "publications": [{"entity": "publication", "iuid": "7fdaf83387f347b4beea8fc27c202ef7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7fdaf83387f347b4beea8fc27c202ef7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7fdaf83387f347b4beea8fc27c202ef7"}}, "title": "Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity.", "authors": [{"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Gunnarsson", "given": "Iva", "initials": "I", "orcid": "0000-0002-4514-7706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fad22fbcc212423b9bc9539482d723e8.json"}}, {"family": "Illescas-B\u00e4ckelin", "given": "Vera", "initials": "V"}, {"family": "Trysberg", "given": "Estelle", "initials": "E"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A", "orcid": "0000-0002-4418-5786", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bb7503e46d04e648d95e03e58a4b465.json"}}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Pettersson", "given": "Susanne", "initials": "S", "orcid": "0000-0001-7432-2756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49b93682e1a4420ba9249f467e35b729.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "Most indices of disease activity in SLE combine physicians' assessments and laboratory tests. However, there is also a need to capture patients' perspectives of disease activity. Consequently, we need new, preferably quick and easy instruments to collect this information, which can be very useful for online consultations and registry purposes. We compared patients' assessments of SLE disease impact/activity, as reported by a shorter version of the Quick Systemic Lupus Activity Questionnaire (Q-SLAQ), with physicians' assessments using SLE Activity Measure (SLAM) and SLE Disease Activity Index (SLEDAI-2K) and with the original Systemic Lupus Activity Questionnaire (SLAQ).\n\nPatients with SLE (n=115), with a disease duration of 15 years (IQR 17), completed the Q-SLAQ prior to physicians' assessments by SLAM and SLEDAI-2K. A second set of patients (n=85) with similar characteristics filled out Q-SLAQ and SLAQ. Spearman's \u03c1 correlations were explored between patients' total Q-SLAQ and subscales (Symptom Score, Patient's Global Disease Activity) and physicians' SLAM and SLEDAI-2K, with and without laboratory items (SLAM-nolab and SLEDAI-2K-nolab) and SLAQ. Corresponding items in Q-SLAQ and SLAM were compared.\n\nCorrelations between patients' and physicians' assessments were higher for SLAM-nolab (total Q-SLAQ, \u03c1=0.71; Symptom Score, \u03c1=0.67; and Patient's Global Disease Activity, \u03c1=0.68) than for the original SLAM (total Q-SLAQ, \u03c1=0.53; Symptom Score, \u03c1=0.50; and Patient's Global Disease Activity, \u03c1=0.53). Regarding specific symptoms, fatigue (\u03c1=0.72) and alopecia (\u03c1=0.71) correlated best, while pulmonary/respiratory symptoms correlated least (\u03c1=0.19, p=0.039). Physicians assessment with SLEDAI-2K-nolab correlated weakly with patients' assessments (total Q-SLAQ, \u03c1=0.30; Symptom Score, \u03c1=0.30; and Patient's Global Disease Activity, \u03c1=0.36). Bivariate correlations between Q-SLAQ and SLAQ were good (\u03c1=0.82-0.96).\n\nQ-SLAQ and the original SLAQ performed equally well, demonstrating that the shorter Q-SLAQ can safely be used to monitor patients' perception of disease impact/activity. We also noted an intriguing discrepancy between physicians' and patients' evaluations of pulmonary/respiratory symptoms, which requires further investigations.", "doi": "10.1136/lupus-2020-000471", "pmid": "33972457", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8112425"}, {"db": "pii", "key": "8/1/e000471"}], "notes": [], "created": "2026-08-21T12:27:33.947Z", "modified": "2026-08-21T12:27:34.175Z"}, {"entity": "publication", "iuid": "7a9583f5137a4078831662799515c1e2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7a9583f5137a4078831662799515c1e2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7a9583f5137a4078831662799515c1e2"}}, "title": "Type I interferons in host defence and inflammatory diseases.", "authors": [{"family": "Crow", "given": "Mary K", "initials": "MK"}, {"family": "Ronnblom", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2019-05-28", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "6", "issue": "1", "pages": "e000336", "issn-l": null}, "abstract": "Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are beneficial or detrimental to the individual depending on whether IFN pathway activation is transient or sustained. Determinants of IFN production and its functional consequences include the nature of the microbial or nucleic acid stimulus, the type of nucleic acid sensor involved in inducing IFN, the predominant subtype of type I IFN produced and the immune ecology of the tissue at the time of IFN expression. When dysregulated, the type I IFN system drives many autoimmune and non-autoimmune inflammatory diseases, including SLE and the tissue inflammation associated with chronic infection. The type I IFN system may also contribute to outcomes for patients affected by solid cancers or myocardial infarction. Significantly more research is needed to discern the mechanisms of induction and response to type I IFNs across these diseases, and patient endophenotyping may help determine whether the cytokine is acting as 'friend' or 'foe', within a particular patient, and at the time of treatment. This review summarises key concepts and discussions from the second International Summit on Interferons in Inflammatory Diseases, during which expert clinicians and scientists evaluated the evidence for the role of type I IFNs in autoimmune and other inflammatory diseases.", "doi": "10.1136/lupus-2019-000336", "pmid": "31205729", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6541752"}, {"db": "pii", "key": "lupus-2019-000336"}], "notes": [], "created": "2026-08-21T12:27:31.920Z", "modified": "2026-08-21T12:27:31.933Z"}, {"entity": "publication", "iuid": "c34772abddea47d686bdf627107fb9eb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c34772abddea47d686bdf627107fb9eb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c34772abddea47d686bdf627107fb9eb"}}, "title": "TNF-\u03b1 and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus.", "authors": [{"family": "Idborg", "given": "Helena", "initials": "H", "orcid": "0000-0003-4041-4729", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d1ad972e99b45c7b3c671231db9fbe3.json"}}, {"family": "Eketj\u00e4ll", "given": "Susanna", "initials": "S"}, {"family": "Pettersson", "given": "Susanne", "initials": "S"}, {"family": "Gustafsson", "given": "Johanna T", "initials": "JT"}, {"family": "Zickert", "given": "Agneta", "initials": "A"}, {"family": "Kvarnstr\u00f6m", "given": "Marika", "initials": "M"}, {"family": "Oke", "given": "Vilija", "initials": "V"}, {"family": "Jakobsson", "given": "Per-Johan", "initials": "PJ"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}], "type": "journal article", "published": "2018-06-04", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "5", "issue": "1", "pages": "e000260", "issn-l": null}, "abstract": "Composite criteria/indices are presently used to diagnose and monitor patients with systemic lupus erythematosus (SLE). Biomarkers for these purposes would be helpful in clinical practice. We therefore evaluated a large panel of cytokines and basic laboratory tests and investigated their performance as discriminators versus controls and as biomarkers of disease activity (DA).\n\nWe examined 437 patients with SLE, fulfilling American College of Rheumatology-82 criteria, and 322 matched controls. DA was assessed according to both SLE DA Index 2000 (SLEDAI-2K) and SLE Activity Measure (SLAM). British Isles Lupus Activity Group (BILAG) was used to assess renal DA. Additionally, 132 patients self-assessed their Global Disease Activity (PtGDA). Mesoscale Discovery 30-plex cytokine assay and routine blood chemistry was performed on fasting EDTA-plasma.\n\nOf 26 tested biomarkers, we identified TNF-\u03b1 as the superior discriminator between patients with SLE and controls (median=4.5 pg/mL, IQR=3.1-6.2 vs median=2.3 pg/mL, IQR=2.0-2.8). The strongest correlations to SLEDAI-2K and SLAM were obtained with TNF-\u03b1 (Spearman rho (\u03c1)=0.32 and \u03c1=0.34, respectively), partly driven by the nephritis subgroup, and with p-albumin (\u03c1=-0.33 and \u03c1=-0.31, respectively). P-albumin was decreased and TNF-\u03b1 was increased in patients with kidney involvement (renal BILAG A/B vs C/D/E, p=4\u00d710-16 and p=6\u00d710-9 respectively). IP-10 was increased in patients with joint involvement (SLAM item 24\u22652 vs \u22641, p=0.0005) but did not differ when comparing patients with active/inactive kidney involvement. The most powerful correlations to PtGDA was observed with p-albumin (\u03c1=-0.42), IL-6 (\u03c1=0.30) and TNF-\u03b1 (\u03c1=0.29).\n\nTNF-\u03b1 and p-albumin both performed well as discriminators between patients with SLE and controls and as proxies for DA according to both rheumatologists' and patients' assessments. In particular, renal DA was well reflected by TNF-\u03b1. We propose that the TNF-\u03b1 and p-albumin merit further investigations as clinically useful biomarkers in SLE. We also observed that the pattern of activated cytokines varies with organ involvement.", "doi": "10.1136/lupus-2018-000260", "pmid": "29955370", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6018889"}, {"db": "pii", "key": "lupus-2018-000260"}], "notes": [], "created": "2026-08-21T12:27:20.168Z", "modified": "2026-08-21T12:27:20.298Z"}, {"entity": "publication", "iuid": "d3ac318528b7440dbd48b07ee83f9f35", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d3ac318528b7440dbd48b07ee83f9f35.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d3ac318528b7440dbd48b07ee83f9f35"}}, "title": "Report of the inaugural Interferon Research Summit: interferon in inflammatory diseases", "authors": [{"family": "Crow", "given": "Mary K", "initials": "MK"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}], "type": "journal-article", "published": "2018-06-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "5", "issue": "1", "pages": "e000276", "issn-l": null}, "abstract": null, "doi": "10.1136/lupus-2018-000276", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:27:22.174Z", "modified": "2026-08-21T12:27:22.198Z"}], "created": "2026-08-21T12:27:20.250Z", "modified": "2026-08-21T12:27:20.250Z"}