{"entity": "journal", "iuid": "ab8eba2870494046a75c456267800b57", "timestamp": "2026-09-24T14:44:46.139Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Lancet%20Psychiatry.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Lancet%20Psychiatry"}}, "title": "Lancet Psychiatry", "issn": "2215-0374", "issn-l": null, "publications_count": 6, "publications": [{"entity": "publication", "iuid": "f6c34066018e45e1b9ebc060085ec9f3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f6c34066018e45e1b9ebc060085ec9f3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f6c34066018e45e1b9ebc060085ec9f3"}}, "title": "Cost-effectiveness of therapist-assisted internet-delivered psychological therapies for PTSD differing in trauma focus in England: an economic evaluation based on the STOP-PTSD trial.", "authors": [{"family": "Penington", "given": "Ed", "initials": "E"}, {"family": "Wild", "given": "Jennifer", "initials": "J"}, {"family": "Warnock-Parkes", "given": "Emma", "initials": "E"}, {"family": "Grey", "given": "Nick", "initials": "N"}, {"family": "Murray", "given": "Hannah", "initials": "H"}, {"family": "Kerr", "given": "Alice", "initials": "A"}, {"family": "Stott", "given": "Richard", "initials": "R"}, {"family": "Rozental", "given": "Alexander", "initials": "A"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Clark", "given": "David M", "initials": "DM"}, {"family": "Tsiachristas", "given": "Apostolos", "initials": "A"}, {"family": "Ehlers", "given": "Anke", "initials": "A"}], "type": "randomized controlled trial", "published": "2024-05-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "11", "issue": "5", "pages": "339-347", "issn-l": null}, "abstract": "Although there are effective psychological treatments for post-traumatic stress disorder (PTSD), they remain inaccessible for many people. Digitally enabled therapy is a way to overcome this problem; however, there is little evidence on which forms of these therapies are most cost effective in PTSD. We aimed to assess the cost-effectiveness of the STOP-PTSD trial, which evaluated two therapist-assisted, internet-delivered cognitive behavioural therapies: cognitive therapy for PTSD (iCT-PTSD) and a programme focusing on stress management (iStress-PTSD).\n\nIn this health economic evaluation, we used data from the STOP-PTSD trial (n=217), a single-blind, randomised controlled trial, to compare iCT-PTSD and iStress-PTSD in terms of resource use and health outcomes. In the trial, participants (aged \u226518 years) who met DSM-5 criteria for PTSD were recruited from primary care therapy services in South East England. The interventions were delivered online with therapist support for the first 12 weeks, and three telephone calls over the next 3 months. Participants completed questionnaires on symptoms, wellbeing, quality of life, and resource use at baseline, 13 weeks, 26 weeks, and 39 weeks after randomisation. We used a cost-effectiveness analysis to assess cost per quality-adjusted life year (QALY) at 39 weeks post-randomisation, from the perspective of the English National Health Service (NHS) and personal social services and on the basis of intention-to-treat for complete cases. Treatment modules and the platform design were developed with extensive input from service users: service users also advised on the trial protocol and methods, including the health economic measures. This is a pre-planned analysis of the STOP-PTSD trial; the trial was registered prospectively on the ISRCTN Registry (ISRCTN16806208).\n\nNHS costs were similar across treatment groups, but clinical outcomes were superior for iCT-PTSD compared with iStress-PTSD. The incremental cost-effectiveness ratio for NHS costs and personal social services was estimated as \u00a31921 per QALY. iCT-PTSD had an estimated 91\u00b76% chance of being cost effective at the \u00a320 000 per QALY threshold. From the societal perspective, iCT-PTSD was cost saving compared with iStress-PTSD.\n\niCT-PTSD is a cost-effective form of therapist-assisted, internet-delivered psychological therapy relative to iStress-PTSD, and it could be considered for clinical implementation.\n\nWellcome Trust and National Institute of Health Research Oxford Health Biomedical Research Centre.", "doi": "10.1016/S2215-0366(24)00055-5", "pmid": "38554731", "labels": [], "xrefs": [{"db": "pii", "key": "S2215-0366(24)00055-5"}], "notes": [], "created": "2026-09-23T12:58:38.169Z", "modified": "2026-09-23T12:58:38.199Z"}, {"entity": "publication", "iuid": "2b22b960dece4af8bb55d50d137492e3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2b22b960dece4af8bb55d50d137492e3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2b22b960dece4af8bb55d50d137492e3"}}, "title": "Therapist-assisted online psychological therapies differing in trauma focus for post-traumatic stress disorder (STOP-PTSD): a UK-based, single-blind, randomised controlled trial.", "authors": [{"family": "Ehlers", "given": "Anke", "initials": "A"}, {"family": "Wild", "given": "Jennifer", "initials": "J"}, {"family": "Warnock-Parkes", "given": "Emma", "initials": "E"}, {"family": "Grey", "given": "Nick", "initials": "N"}, {"family": "Murray", "given": "Hannah", "initials": "H"}, {"family": "Kerr", "given": "Alice", "initials": "A"}, {"family": "Rozental", "given": "Alexander", "initials": "A"}, {"family": "Thew", "given": "Graham", "initials": "G"}, {"family": "Janecka", "given": "Magdalena", "initials": "M"}, {"family": "Beierl", "given": "Esther T", "initials": "ET"}, {"family": "Tsiachristas", "given": "Apostolos", "initials": "A"}, {"family": "Perera-Salazar", "given": "Rafael", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Clark", "given": "David M", "initials": "DM"}], "type": "randomized controlled trial", "published": "2023-08-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "10", "issue": "8", "pages": "608-622", "issn-l": null}, "abstract": "Many patients are currently unable to access psychological treatments for post-traumatic stress disorder (PTSD), and it is unclear which types of therapist-assisted internet-based treatments work best. We aimed to investigate whether a novel internet-delivered cognitive therapy for PTSD (iCT-PTSD), which implements all procedures of a first-line, trauma-focused intervention recommended by the UK National Institute for Health and Care Excellence (NICE) for PTSD, is superior to internet-delivered stress management therapy for PTSD (iStress-PTSD), a comprehensive cognitive behavioural treatment programme focusing on a wide range of coping skills.\n\nWe did a single-blind, randomised controlled trial in three locations in the UK. Participants (\u226518 years) were recruited from UK National Health Service (NHS) Improving Access to Psychological Therapies (IAPT) services or by self-referral and met DSM-5 criteria for PTSD to single or multiple events. Participants were randomly allocated by a computer programme (3:3:1) to iCT-PTSD, iStress-PTSD, or a 3-month waiting list with usual NHS care, after which patients who still met PTSD criteria were randomly allocated (1:1) to iCT-PTSD or iStress-PTSD. Randomisation was stratified by location, duration of PTSD (<18 months or \u226518 months), and severity of PTSD symptoms (high vs low). iCT-PTSD and iStress-PTSD were delivered online with therapist support by messages and short weekly phone calls over the first 12 weeks (weekly treatment phase), and three phone calls over the next 3 months (booster phase). The primary outcome was the severity of PTSD symptoms at 13 weeks after random assignment, measured by self-report on the PTSD Checklist for DSM-5 (PCL-5), and analysed by intention-to-treat. Safety was assessed in all participants who started treatment. Process analyses investigated acceptability and compliance with treatment, and candidate moderators and mediators of outcome. The trial was prospectively registered with the ISRCTN registry, ISRCTN16806208.\n\nOf the 217 participants, 158 (73%) self-reported as female, 57 (26%) as male, and two (1%) as other; 170 (78%) were White British, 20 (9%) were other White, six (3%) were Asian, ten (5%) were Black, eight (4%) had a mixed ethnic background, and three (1%) had other ethnic backgrounds. Mean age was 36\u00b736 years (SD 12\u00b711; range 18-71 years). 52 (24%) participants met self-reported criteria for ICD-11 complex PTSD. Fewer than 10% of participants dropped out of each treatment group. iCT-PTSD was superior to iStress-PTSD in reducing PTSD symptoms, showing an adjusted difference on the PCL-5 of -4\u00b792 (95% CI -8\u00b792 to -0\u00b792; p=0\u00b7016; standardised effect size d=0\u00b738 [0\u00b707 to 0\u00b769]) for immediate allocations and -5\u00b782 (-9\u00b759 to -2\u00b704; p=0\u00b70027; d=0\u00b744 [0\u00b715 to 0\u00b772]) for all treatment allocations. Both treatments were superior to the waiting list for PCL-5 at 13 weeks (d=1\u00b767 [1\u00b723 to 2\u00b710] for iCT-PTSD and 1\u00b729 [0\u00b785 to 1\u00b772] for iStress-PTSD). The advantages in outcome for iCT-PTSD were greater for participants with high dissociation or complex PTSD symptoms, and mediation analyses showed both treatments worked by changing negative meanings of the trauma, unhelpful coping, and flashback memories. No serious adverse events were reported.\n\nTrauma-focused iCT-PTSD is effective and acceptable to patients with PTSD, and superior to a non-trauma-focused cognitive behavioural stress management therapy, suggesting that iCT-PTSD is an effective way of delivering the contents of CT-PTSD, one of the NICE-recommended first-line treatments for PTSD, while reducing therapist time compared with face-to-face therapy.\n\nWellcome Trust, UK National Institute for Health and Care Research Oxford Health Biomedical Research Centre.", "doi": "10.1016/S2215-0366(23)00181-5", "pmid": "37479341", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10789612"}, {"db": "pii", "key": "S2215-0366(23)00181-5"}], "notes": [], "created": "2026-09-23T08:35:18.631Z", "modified": "2026-09-23T08:35:18.661Z"}, {"entity": "publication", "iuid": "d04f5bd961354bbbb566169261bb5c04", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d04f5bd961354bbbb566169261bb5c04.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d04f5bd961354bbbb566169261bb5c04"}}, "title": "Digital psychological first aid for Ukraine.", "authors": [{"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Vermetten", "given": "Eric", "initials": "E"}, {"family": "Shalev", "given": "Arieh Y", "initials": "AY"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Ursano", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Ulrike", "initials": "U"}, {"family": "Zohar", "given": "Joseph", "initials": "J"}], "type": "letter", "published": "2022-07-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "9", "issue": "7", "pages": "e33", "issn-l": null}, "abstract": null, "doi": "10.1016/S2215-0366(22)00147-X", "pmid": "35526557", "labels": [], "xrefs": [{"db": "pii", "key": "S2215-0366(22)00147-X"}], "notes": [], "created": "2026-09-23T10:04:04.340Z", "modified": "2026-09-23T10:42:39.135Z"}, {"entity": "publication", "iuid": "d9cd13cea1ca422cb95f5dfd87ed17db", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d9cd13cea1ca422cb95f5dfd87ed17db.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d9cd13cea1ca422cb95f5dfd87ed17db"}}, "title": "Mapping phenotypic and aetiological associations between ADHD and physical conditions in adulthood in Sweden: a genetically informed register study.", "authors": [{"family": "Du Rietz", "given": "Ebba", "initials": "E"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Butwicka", "given": "Agnieszka", "initials": "A"}, {"family": "Leone", "given": "Marica", "initials": "M"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "D'Onofrio", "given": "Brian M", "initials": "BM"}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "Lichtenstein", "given": "Paul", "initials": "P"}, {"family": "Faraone", "given": "Stephen V", "initials": "SV"}, {"family": "Kuja-Halkola", "given": "Ralf", "initials": "R"}, {"family": "Larsson", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "8", "issue": "9", "pages": "774-783", "issn-l": null}, "abstract": "Emerging evidence suggests increased risk of several physical health conditions in people with ADHD. Only a few physical conditions have been thoroughly studied in relation to ADHD, and there is little knowledge on associations in older adults in particular. We aimed to investigate the phenotypic and aetiological associations between ADHD and a wide range of physical health conditions across adulthood.\n\nWe did a register study in Sweden and identified full-sibling and maternal half-sibling pairs born between Jan 1, 1932, and Dec 31, 1995, through the Population and Multi-Generation Registers. We excluded individuals who died or emigrated before Jan 1, 2005, and included full-siblings who were not twins and did not have half-siblings. ICD diagnoses were obtained from the National Patient Register. We extracted ICD diagnoses for physical conditions, when participants were aged 18 years or older, from inpatient (recorded 1973-2013) and outpatient (recorded 2001-13) services. Diagnoses were regarded as lifetime presence or absence. Logistic regression models were used to estimate the associations between ADHD (exposure) and 35 physical conditions (outcomes) in individuals and across sibling pairs. Quantitative genetic modelling was used to estimate the extent to which genetic and environmental factors accounted for the associations with ADHD.\n\n4 789 799 individuals were identified (2 449 146 [51%] men and 2 340 653 [49%] women), who formed 4 288 451 unique sibling pairs (3 819 207 full-sibling pairs and 469 244 maternal half-sibling pairs) and 1 841 303 family clusters (siblings, parents, cousins, spouses). The mean age at end of follow-up was 47 years (range 18-81; mean birth year 1966); ethnicity data were not available. Adults with ADHD had increased risk for most physical conditions (34 [97%] of 35) compared with adults without ADHD; the strongest associations were with nervous system disorders (eg, sleep disorders, epilepsy, dementia; odds ratios [ORs] 1\u00b750-4\u00b762) and respiratory diseases (eg, asthma, chronic obstructive pulmonary disease; ORs 2\u00b742-3\u00b724). Sex-stratified analyses showed similar patterns of results in men and women. Stronger cross-disorder associations were found between full-siblings than between half-siblings for nervous system, respiratory, musculoskeletal, and metabolic diseases (p<0\u00b7007). Quantitative genetic modelling showed that these associations were largely explained by shared genetic factors (60-69% of correlations), except for associations with nervous system disorders, which were mainly explained by non-shared environmental factors.\n\nThis mapping of aetiological sources of cross-disorder overlap can guide future research aiming to identify specific mechanisms contributing to risk of physical conditions in people with ADHD, which could ultimately inform preventive and lifestyle intervention efforts. Our findings highlight the importance of assessing the presence of physical conditions in patients with ADHD.\n\nSwedish Research Council; Swedish Brain Foundation; Swedish Research Council for Health, Working Life, and Welfare; Stockholm County Council; StratNeuro; EU Horizon 2020 research and innovation programme; National Institute of Mental Health.", "doi": "10.1016/S2215-0366(21)00171-1", "pmid": "34242595", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8376653"}, {"db": "pii", "key": "S2215-0366(21)00171-1"}], "notes": [], "created": "2026-09-23T07:36:18.295Z", "modified": "2026-09-23T07:36:18.318Z"}, {"entity": "publication", "iuid": "caeebd111752492da4f0bc80b45877f0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/caeebd111752492da4f0bc80b45877f0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/caeebd111752492da4f0bc80b45877f0"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic - Authors' reply.", "authors": [{"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Silver", "given": "Roxane Cohen", "initials": "RC"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Simpson", "given": "Alan", "initials": "A"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "7", "pages": "e44-e45", "issn-l": null}, "abstract": null, "doi": "10.1016/S2215-0366(20)30247-9", "pmid": "32563319", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7302786"}, {"db": "pii", "key": "S2215-0366(20)30247-9"}], "notes": [], "created": "2026-09-23T13:43:37.863Z", "modified": "2026-09-23T13:43:37.892Z"}, {"entity": "publication", "iuid": "b9b23a4bfea44e629618ef14a6a28cdb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b9b23a4bfea44e629618ef14a6a28cdb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b9b23a4bfea44e629618ef14a6a28cdb"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.", "authors": [{"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Cohen Silver", "given": "Roxane", "initials": "R"}, {"family": "Everall", "given": "Ian", "initials": "I"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Michie", "given": "Susan", "initials": "S"}, {"family": "Przybylski", "given": "Andrew K", "initials": "AK"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sweeney", "given": "Angela", "initials": "A"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Yardley", "given": "Lucy", "initials": "L"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Cope", "given": "Claire", "initials": "C"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "6", "pages": "547-560", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.", "doi": "10.1016/S2215-0366(20)30168-1", "pmid": "32304649", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7159850"}, {"db": "pii", "key": "S2215-0366(20)30168-1"}], "notes": [], "created": "2026-09-22T19:53:32.012Z", "modified": "2026-09-22T19:57:23.213Z"}], "created": "2026-09-22T19:53:32.033Z", "modified": "2026-09-22T19:53:32.033Z"}