{"entity": "journal", "iuid": "99c295e5016241d8b998483c602e8ea4", "timestamp": "2026-10-01T11:57:41.139Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Lancet%20Healthy%20Longev.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Lancet%20Healthy%20Longev"}}, "title": "Lancet Healthy Longev", "issn": "2666-7568", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "aae5c1368f134669ac6deda2146ec865", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aae5c1368f134669ac6deda2146ec865.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aae5c1368f134669ac6deda2146ec865"}}, "title": "Blood biomarkers of Alzheimer's disease and 12-year muscle strength trajectories in community-dwelling older adults: a cohort study.", "authors": [{"family": "Ornago", "given": "Alice M", "initials": "AM"}, {"family": "Pinardi", "given": "Elena", "initials": "E"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Valletta", "given": "Martina", "initials": "M"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Andersson", "given": "Sarah", "initials": "S"}, {"family": "Calvani", "given": "Riccardo", "initials": "R"}, {"family": "Picca", "given": "Anna", "initials": "A"}, {"family": "Marzetti", "given": "Emanuele", "initials": "E"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Bellelli", "given": "Giuseppe", "initials": "G"}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}], "type": "journal article", "published": "2025-05-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "6", "issue": "5", "pages": "100715", "issn-l": null}, "abstract": "Age-related muscle function decline is a major impediment to healthy ageing. We aimed to investigate the association between a panel of Alzheimer's disease-related biomarkers and longitudinal trajectories of muscle strength, while exploring the influence of cognitive function.\n\nIn this cohort study, we gathered data from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K), an ongoing prospective study that includes adults aged 60 years and older, from central Stockholm, Sweden. We included data from baseline to the fourth follow-up (March 21, 2001, to Dec 31, 2016). Seven Alzheimer's disease-related blood biomarkers were measured in dementia-free, community dwelling participants: total tau, phosphorylated tau181 (p-tau181), phosphorylated tau217 (p-tau217), amyloid \u03b2 40 and 42, neurofilament light chain, and glial fibrillary acidic protein (GFAP). Muscle strength was measured through the handgrip strength and chair-stand tests. Linear mixed models were used to explore the association between baseline Alzheimer's disease-related biomarkers and muscle strength trajectories.\n\nThe baseline SNAC-K cohort included 3363 individuals, of whom 1953 participants were included in our analyses (mean age 70\u00b72 [SD 9\u00b71] years; 780 [39\u00b79%] male and 1173 [60\u00b71%] female participants). In adjusted models, higher concentrations of p-tau181 (\u03b2 per year 0\u00b793 [95% CI 0\u00b771 to 1\u00b716]; p<0\u00b70001), p-tau217 (\u03b2 per year 1\u00b731 [1\u00b703 to 1\u00b758]; p<0\u00b70001), neurofilament light chain (\u03b2 per year 0\u00b776 [0\u00b756 to 0\u00b796]; p<0\u00b70001), and GFAP (\u03b2 per year 0\u00b737 [0\u00b721 to 0\u00b753]; p<0\u00b70001) were associated with an accelerated decline of chair-stand performance over time. The adjustment for Mini-Mental State Examination (MMSE) score led to the attenuation of these associations. Higher concentrations of p-tau181 (\u03b2 per year -0\u00b712 [95% CI -0\u00b717 to -0\u00b707]; p<0\u00b70001), p-tau217 (\u03b2 per year -0\u00b713 [-0\u00b720 to -0\u00b707]; p<0\u00b70001), and neurofilament light chain (\u03b2 per year -0\u00b705 [-0\u00b709 to -0\u00b7001]; p=0\u00b7047) were also associated with faster handgrip strength decline, with no attenuation after adjusting for MMSE score. Sex-specific differences were observed, with female participants showing a stronger association between biomarker concentrations and muscle strength decline than male participants, particularly in the chair-stand test.\n\nOur findings suggest that blood Alzheimer's disease-related biomarkers might help estimate progressive muscle strength decline among older adults, elucidating the influence of brain pathology and cognitive ageing on this association. These Alzheimer's disease-related biomarkers could aid in identifying individuals for early intervention to prevent sarcopenia.\n\nThe Swedish Research Council, the Swedish Ministry of Health and Social Affairs, and the County Councils and Municipalities.", "doi": "10.1016/j.lanhl.2025.100715", "pmid": "40414227", "labels": [], "xrefs": [{"db": "pii", "key": "S2666-7568(25)00034-0"}], "notes": [], "created": "2026-10-01T08:24:46.584Z", "modified": "2026-10-01T08:24:46.645Z"}], "created": "2026-10-01T08:24:46.608Z", "modified": "2026-10-01T08:24:46.608Z"}