{"entity": "journal", "iuid": "ba4db37176b84336b0c563b562461b1e", "timestamp": "2026-09-06T10:42:26.159Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Mater%20Chem%20B.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Mater%20Chem%20B"}}, "title": "J Mater Chem B", "issn": "2050-7518", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "eeffdc9e3a634d13bc8a97f1eb3d5f0c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eeffdc9e3a634d13bc8a97f1eb3d5f0c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eeffdc9e3a634d13bc8a97f1eb3d5f0c"}}, "title": "Bioceramic microneedle arrays are able to deliver OVA to dendritic cells in human skin.", "authors": [{"family": "Vallhov", "given": "Helen", "initials": "H"}, {"family": "Xia", "given": "Wei", "initials": "W"}, {"family": "Engqvist", "given": "H\u00e5kan", "initials": "H"}, {"family": "Scheynius", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2018-11-14", "journal": {"title": "J Mater Chem B", "issn": "2050-7518", "volume": "6", "issue": "42", "pages": "6808-6816", "issn-l": null}, "abstract": "Microneedle-based vaccination into skin has several advantages over vaccination using conventional needles for intramuscular or subcutaneous injections. Microneedle (MN) arrays allow the vaccine to be delivered in a minimally invasive manner and directly into the skin, whereby the skin's superficial immune cells are not by-passed. Additionally, a systemic distribution of the vaccine may be avoided, which implies less side effects and less amount of vaccine needed. For a successful delivery, the needles need to penetrate the stratum corneum and reach the potent network of antigen-presenting dendritic cells (DCs). In this study, we evaluated patches covered with biodegradable ceramic (calcium sulphate) MNs with a tip diameter of approximately 3 \u03bcm and with two different lengths (300 and 600 \u03bcm) for their ability to penetrate and transfer the model allergen ovalbumin (OVA) into epidermis. MNs with a length of 600 \u03bcm (MN-600) and a volume average pore size of 12 \u00b1 1 \u03bcm were more efficient in crossing the stratum corneum and to deliver OVA into CD1a+ DCs residing in the epidermis of human ex vivo skin, in comparison to MNs with a length of 300 \u03bcm. Quantitative in vitro release studies showed that approximately 90% of the loaded OVA could be released from MN-600 within 1 h. These findings support the further development of ceramic MNs for transcutaneous immunization.", "doi": "10.1039/c8tb01476k", "pmid": "32254697", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T11:57:45.276Z", "modified": "2026-08-21T11:57:45.368Z"}], "created": "2026-08-21T11:57:45.310Z", "modified": "2026-08-21T11:57:45.310Z"}