{"entity": "journal", "iuid": "234f2b9ed9f34975909b99d1c6886afc", "timestamp": "2026-09-03T05:14:47.218Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Invertebr%20Pathol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Invertebr%20Pathol"}}, "title": "J Invertebr Pathol", "issn": "1096-0805", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "ab4fd38d3ea5421b8ffd02eaae965d6b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ab4fd38d3ea5421b8ffd02eaae965d6b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ab4fd38d3ea5421b8ffd02eaae965d6b"}}, "title": "The stress-immunity axis in shellfish.", "authors": [{"family": "Coates", "given": "Christopher J", "initials": "CJ"}, {"family": "S\u00f6derh\u00e4ll", "given": "Kenneth", "initials": "K"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "J Invertebr Pathol", "issn": "1096-0805", "volume": "186", "pages": "107492", "issn-l": null}, "abstract": "It is a difficult task to describe what constitutes a 'healthy' shellfish (e.g., crustacean, bivalve). Visible defects such as discolouration, missing limbs or spines, fouling, lesions, and exoskeletal fractures can be indicative of underlying issues, senescence, or a 'stressed' animal. The absence of such symptoms is not evidence of a disease-free or a stress-free state. Now, more than ever, aquatic invertebrates must cope with acute and chronic environmental perturbations, such as, heatwaves and cold shocks, xenobiotic contaminants, intoxication events, and promiscuous pathogens expanding their host and geographic ranges. With that in mind, how does one determine the extent to which shellfish become stressed in situ (natural) or in cultured (artificial) settings to enhance disease susceptibility? Many biomarkers - predominantly biochemical and cellular measures of shellfish blood (haemolymph) - are considered to gauge immunosuppression and immunocompetence. Such measures range from immune cell (haemocyte) counts to enzymic activities and metabolite quantitation. Stressed invertebrates often reflect degraded conditions of their ecosystems, referred to as environmental indicators. We audit briefly the broad immune functions of shellfish, how they are modulated by known and emerging stressors, and discuss these concepts with respect to neuroendocrinology and immunotoxicology. We assert that chronic stress, alone or in combination with microbial, chemical and abiotic factors, increases the risk of infectious disease in shellfish, exacerbates idiopathic morbidity, and reduces the likelihood of recovery. Acute stress events can lead to immunomodulation, but these effects are largely transient. Enhancing our understanding of shellfish health and immunity is imperative for tackling losses at each stage of the aquatic food cycle and disease outbreaks in the wild.", "doi": "10.1016/j.jip.2020.107492", "pmid": "33086084", "labels": [], "xrefs": [{"db": "pii", "key": "S0022-2011(20)30198-1"}], "notes": [], "created": "2026-08-21T11:22:37.419Z", "modified": "2026-08-21T11:22:37.433Z"}, {"entity": "publication", "iuid": "580e0ebf80084887906c9cfcb8cb349f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/580e0ebf80084887906c9cfcb8cb349f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/580e0ebf80084887906c9cfcb8cb349f"}}, "title": "Vibrio areninigrae as a pathogenic bacterium in a crustacean.", "authors": [{"family": "Hern\u00e1ndez-P\u00e9rez", "given": "Ariadne", "initials": "A"}, {"family": "S\u00f6derh\u00e4ll", "given": "Kenneth", "initials": "K"}, {"family": "Sirikharin", "given": "Ratchanok", "initials": "R"}, {"family": "Jiravanichpaisal", "given": "Pikul", "initials": "P"}, {"family": "S\u00f6derh\u00e4ll", "given": "Irene", "initials": "I"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "J Invertebr Pathol", "issn": "1096-0805", "volume": "178", "pages": "107517", "issn-l": null}, "abstract": "The occurrence of infectious diseases poses a significant threat to the aquaculture industry worldwide. Therefore, characterization of potentially harmful pathogens is one of the most important strategies to control disease outbreaks. In the present study, we investigated for the first time the pathogenicity of two Vibrio species, Vibrio metschnikovii, a foodborne pathogen that causes fatalities in humans, and Vibrio areninigrae, a bacteria isolated from black sand in Korea, using a crustacean model, the signal crayfish Pacifastacus leniusculus. Mortality challenges indicated that injection of V. metschnikovii (108 CFU/crayfish) has a mortality percentage of 22% in crayfish. In contrast, injection of P. leniusculus with 108 or 107 CFU of V. areninigrae resulted in 100% mortality within one and two days post-injection, respectively. V. areninigrae was successfully re-isolated from hepatopancreas of infected crayfish and caused 100% mortality when reinjected into new healthy crayfish. As a consequence of this infection, histopathological analysis revealed nodule formation in crayfish hepatopancreas, heart, and gills, as well as sloughed cells inside hepatopancreatic tubules and atrophy. Moreover, extracellular crude products (ECP's) were obtained from V. areninigrae in order to investigate putative virulence factors. In vivo challenges with ECP's caused >90% mortalities within the first 24 h. In vitro challenges with ECP's of hemocytes induced cytotoxicity of hemocytes within the first hour of exposure. These findings represent the first report that V. areninigrae is a highly pathogenic bacterium that can cause disease in crustaceans. On the contrary, V. metschnikovii could not represent a threat for freshwater crayfish.", "doi": "10.1016/j.jip.2020.107517", "pmid": "33333063", "labels": [], "xrefs": [{"db": "pii", "key": "S0022-2011(20)30223-8"}], "notes": [], "created": "2026-08-21T11:22:39.626Z", "modified": "2026-08-21T11:22:39.639Z"}, {"entity": "publication", "iuid": "ff993db5187746a28200a75450d5e4d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ff993db5187746a28200a75450d5e4d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ff993db5187746a28200a75450d5e4d3"}}, "title": "The effect of temperature on bacteria-host interactions in the freshwater crayfish, Pacifastacus leniusculus.", "authors": [{"family": "Korkut", "given": "G\u00fcl Gizem", "initials": "GG"}, {"family": "S\u00f6derh\u00e4ll", "given": "Irene", "initials": "I"}, {"family": "S\u00f6derh\u00e4ll", "given": "Kenneth", "initials": "K"}, {"family": "Noonin", "given": "Chadanat", "initials": "C"}], "type": "journal article", "published": "2018-09-00", "journal": {"title": "J Invertebr Pathol", "issn": "1096-0805", "volume": "157", "pages": "67-73", "issn-l": null}, "abstract": "Water temperature is known to affect many aspects of aquatic life including immune responses and susceptibility to diseases. In this context, we studied the effect of temperature on the defense system of the freshwater crayfish Pacifastacus leniusculus. Animals were challenged with two pathogenic Gram-negative bacteria, Aeromonas hydrophila and Pseudomonas gessardii, as well as the bacterial cell wall component lipopolysaccharide (LPS) at two different temperatures, cold (6 \u00b0C) and room temperature (22 \u00b0C). The immune responses were compared by means of differences in mortality, phagocytosis, bacterial clearance, and the melanization reaction of the hemolymph at these two temperatures. We observed that crayfish survival was higher at cold temperature. The mortality rate was zero at 6 \u00b0C following A. hydrophila or LPS injections. Furthermore, the bacteria were completely cleared from crayfish after they had been held at 6 \u00b0C for more than 9 days. We also observed a strong melanization reaction of hemolymph at 22 \u00b0C when stimulated with LPS, as well as with bacteria. Taken together, our results suggest that the cellular immunity is more effective at low temperature in this cold-adapted animal and pathogens are efficiently removed from the body by mean of phagocytosis.", "doi": "10.1016/j.jip.2018.08.001", "pmid": "30077692", "labels": [], "xrefs": [{"db": "pii", "key": "S0022-2011(18)30179-4"}], "notes": [], "created": "2026-08-21T11:22:35.463Z", "modified": "2026-08-21T11:22:35.511Z"}], "created": "2026-08-21T11:22:35.471Z", "modified": "2026-08-21T11:22:35.471Z"}