{"entity": "journal", "iuid": "939934e6b9dd45de87e577404f138b48", "timestamp": "2026-08-26T22:46:51.195Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Hazard%20Mater.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Hazard%20Mater"}}, "title": "J Hazard Mater", "issn": "1873-3336", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "ed1dcf9967e24dac83759f90f39a78de", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed1dcf9967e24dac83759f90f39a78de.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed1dcf9967e24dac83759f90f39a78de"}}, "title": "Profiling trace organic chemical biotransformation genes, enzymes and associated bacteria in microbial model communities.", "authors": [{"family": "Cao", "given": "Lijia", "initials": "L"}, {"family": "Garcia", "given": "Sarahi L", "initials": "SL"}, {"family": "Wurzbacher", "given": "Christian", "initials": "C"}], "type": "journal article", "published": "2025-03-05", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "volume": "485", "pages": "136811", "issn-l": null}, "abstract": "Microbial biotransformation of trace organic chemicals (TOrCs) is an essential process in wastewater treatment to eliminate environmental pollution. Understanding TOrC biotransformation mechanisms, especially at their original concentrations, is important to optimize treatment performance, whereas our current knowledge is limited. Here, we investigated the biotransformation of seven TOrCs by 24 model communities. The genome-centric analyses unraveled potential biotransformation drivers concerning functional genes, enzymes, and responsible bacteria. We obtained efficient model communities for completely removing ibuprofen, caffeine, and atenolol, with transformation efficiencies between 0 % and 45 % for sulfamethoxazole, carbamazepine, trimethoprim, and gabapentin. Biotransformation performance was not fully reflected by the presence of known biotransformation genes and enzymes in the metagenomes of the communities. Functional similar homologs to existing biotransformation genes and enzymes (e.g., long-chain-fatty-acid-CoA ligase encoded by fadD and fadD13 gene) could play critical roles in TOrC metabolism. Finally, we identified previously undescribed degrading strains, e.g., Rhodococcus qingshengii for caffeine, carbamazepine, sulfamethoxazole, and ibuprofen biotransformation, and potential transformation enzymes, e.g., SDR family oxidoreductase targeting sulfamethoxazole and putative hypothetical proteins for caffeine, atenolol and gabapentin biotransformation. This study provides fundamental insights into naturally assembled low-complexity degrader communities that can help to identify and tackle the current research gaps on biotransformation.", "doi": "10.1016/j.jhazmat.2024.136811", "pmid": "39662353", "labels": [], "xrefs": [{"db": "pii", "key": "S0304-3894(24)03392-2"}], "notes": [], "created": "2026-08-21T11:22:08.991Z", "modified": "2026-08-21T11:22:09.004Z"}, {"entity": "publication", "iuid": "86716a94908f4ed695d40f5fe71d9b7c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/86716a94908f4ed695d40f5fe71d9b7c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/86716a94908f4ed695d40f5fe71d9b7c"}}, "title": "Shifts in mercury methylation across a peatland chronosequence: From sulfate reduction to methanogenesis and syntrophy.", "authors": [{"family": "Hu", "given": "Haiyan", "initials": "H"}, {"family": "Wang", "given": "Baolin", "initials": "B"}, {"family": "Bravo", "given": "Andrea G", "initials": "AG"}, {"family": "Bj\u00f6rn", "given": "Erik", "initials": "E"}, {"family": "Skyllberg", "given": "Ulf", "initials": "U"}, {"family": "Amouroux", "given": "David", "initials": "D"}, {"family": "Tessier", "given": "Emmanuel", "initials": "E"}, {"family": "Zopfi", "given": "Jakob", "initials": "J"}, {"family": "Feng", "given": "Xinbin", "initials": "X"}, {"family": "Bishop", "given": "Kevin", "initials": "K"}, {"family": "Nilsson", "given": "Mats B", "initials": "MB"}, {"family": "Bertilsson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-04-05", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "volume": "387", "pages": "121967", "issn-l": null}, "abstract": "Peatlands are globally important ecosystems where inorganic mercury is converted to bioaccumulating and highly toxic methylmercury, resulting in high risks of methylmercury exposure in adjacent aquatic ecosystems. Although biological mercury methylation has been known for decades, there is still a lack of knowledge about the organisms involved in mercury methylation and the drivers controlling their methylating capacity. In order to investigate the metabolisms responsible for mercury methylation and methylmercury degradation as well as the controls of both processes, we studied a chronosequence of boreal peatlands covering fundamentally different biogeochemical conditions. Potential mercury methylation rates decreased with peatland age, being up to 53 times higher in the youngest peatland compared to the oldest. Methylation in young mires was driven by sulfate reduction, while methanogenic and syntrophic metabolisms became more important in older systems. Demethylation rates were also highest in young wetlands, with a gradual shift from biotic to abiotic methylmercury degradation along the chronosequence. Our findings reveal how metabolic shifts drive mercury methylation and its ratio to demethylation as peatlands age.", "doi": "10.1016/j.jhazmat.2019.121967", "pmid": "31901845", "labels": [], "xrefs": [{"db": "pii", "key": "S0304-3894(19)31921-1"}], "notes": [], "created": "2026-08-20T07:59:00.759Z", "modified": "2026-08-20T07:59:00.831Z"}], "created": "2026-08-20T07:59:00.792Z", "modified": "2026-08-20T07:59:00.792Z"}