{"entity": "journal", "iuid": "e9d05455f9584df6948ff17bc2acb5e9", "timestamp": "2026-08-22T06:58:12.778Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Fungi%20%28Basel%29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Fungi%20%28Basel%29"}}, "title": "J Fungi (Basel)", "issn": "2309-608X", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "7997637aa1214217a898a9bab87b56ac", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7997637aa1214217a898a9bab87b56ac.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7997637aa1214217a898a9bab87b56ac"}}, "title": "The Fungal Endophyte Penicillium olsonii ML37 Reduces Fusarium Head Blight by Local Induced Resistance in Wheat Spikes.", "authors": [{"family": "Rojas", "given": "Edward C", "initials": "EC", "orcid": "0000-0002-0562-5902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50d8157beff642789409360a444bc39f.json"}}, {"family": "Jensen", "given": "Birgit", "initials": "B", "orcid": "0000-0003-2476-805X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6dbec502c95c45e690dc6d58a00ef5ef.json"}}, {"family": "J\u00f8rgensen", "given": "Hans J L", "initials": "HJL", "orcid": "0000-0002-5902-6550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1622d236d55b42c68537cfda33b7ba13.json"}}, {"family": "Latz", "given": "Meike A C", "initials": "MAC", "orcid": "0000-0002-6583-9291", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/336c3f1c68b5431abc7659faeb3353e9.json"}}, {"family": "Esteban", "given": "Pilar", "initials": "P", "orcid": "0000-0003-2252-7316", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e609d9396ab452ea70d7e4410b2e066.json"}}, {"family": "Collinge", "given": "David B", "initials": "DB", "orcid": "0000-0001-6869-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2354584493904dd3a6ada29ce5a58d59.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "J Fungi (Basel)", "issn": "2309-608X", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "The fungal endophyte Penicillium olsonii ML37 is a biocontrol agent of Fusarium head blight in wheat (caused by Fusarium graminearum), which has shown a limited direct inhibition of fungal growth in vitro. We used RNA-seq and LC-MS/MS analyses to elucidate metabolic interactions of the three-way system Penicillium-wheat-Fusarium in greenhouse experiments. We demonstrated that P. olsonii ML37 colonises wheat spikes and transiently activates plant defence mechanisms, as pretreated spikes show a faster and stronger expression of the defence metabolism during the first 24 h after pathogen inoculation. This effect was transient and the expression of the same genes was lower in the pathogen-infected spikes than in those infected by P. olsonii alone. This response to the endophyte includes the transcriptional activation of several WRKY transcription factors. This early activation is associated with a reduction in FHB symptoms and significantly lower levels of the F. graminearum metabolites 15-acetyl-DON and culmorin. An increase in the Penicillium-associated metabolite asperphanamate confirms colonisation by the endophyte. Our results suggest that the mode of action used by P. olsonii ML37 is via a local defence activation in wheat spikes, and that this fungus has potential as a novel biological alternative in wheat disease control.", "doi": "10.3390/jof8040345", "pmid": "35448576", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9025337"}, {"db": "pii", "key": "jof8040345"}], "notes": [], "created": "2026-08-21T13:03:59.907Z", "modified": "2026-08-21T13:04:00.185Z"}], "created": "2026-08-21T13:04:00.145Z", "modified": "2026-08-21T13:04:00.145Z"}