{"entity": "journal", "iuid": "7bb28be8185d471c80ab59a498682edf", "timestamp": "2026-08-26T22:46:29.871Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Card%20Fail.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/J%20Card%20Fail"}}, "title": "J Card Fail", "issn": "1532-8414", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "cae59f1d81ac45a59c859dcca0444e7c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cae59f1d81ac45a59c859dcca0444e7c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cae59f1d81ac45a59c859dcca0444e7c"}}, "title": "Metabolomic Profile in HFpEF vs HFrEF Patients.", "authors": [{"family": "Hage", "given": "Camilla", "initials": "C"}, {"family": "L\u00f6fgren", "given": "Lars", "initials": "L"}, {"family": "Michopoulos", "given": "Filippos", "initials": "F"}, {"family": "Nilsson", "given": "Ralph", "initials": "R"}, {"family": "Davidsson", "given": "Pia", "initials": "P"}, {"family": "Kumar", "given": "Chanchal", "initials": "C"}, {"family": "Ekstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Eriksson", "given": "Maria J", "initials": "MJ"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Persson", "given": "Bengt", "initials": "B"}, {"family": "Wall\u00e9n", "given": "Hakan", "initials": "H"}, {"family": "Gan", "given": "Li Ming", "initials": "LM"}, {"family": "Persson", "given": "Hans", "initials": "H"}, {"family": "Linde", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Card Fail", "issn": "1532-8414", "volume": "26", "issue": "12", "pages": "1050-1059", "issn-l": null}, "abstract": "Heart failure with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) are associated with metabolic derangements, which may have different pathophysiological implications.\n\nIn new-onset HFpEF (EF of \u226550%, n = 46) and HFrEF (EF of <40%, n = 75) patients, 109 endogenous plasma metabolites including amino acids, phospholipids and acylcarnitines were assessed using targeted metabolomics. Differentially altered metabolites and associations with clinical characteristics were explored. Patients with HFpEF were older, more often female with hypertension, atrial fibrillation, and diabetes compared with patients with HFrEF. Patients with HFpEF displayed higher levels of hydroxyproline and symmetric dimethyl arginine, alanine, cystine, and kynurenine reflecting fibrosis, inflammation and oxidative stress. Serine, cGMP, cAMP, l-carnitine, lysophophatidylcholine (18:2), lactate, and arginine were lower compared with patients with HFrEF. In patients with HFpEF with diabetes, kynurenine was higher (P = .014) and arginine lower (P = .014) vs patients with no diabetes, but did not differ with diabetes status in HFrEF. Decreasing kynurenine was associated with higher eGFR only in HFpEF (Pinteraction = .020).\n\nPatients with new-onset HFpEF compared with patients with new-onset HFrEF display a different metabolic profile associated with comorbidities, such as diabetes and kidney dysfunction. HFpEF is associated with indices of increased inflammation and oxidative stress, impaired lipid metabolism, increased collagen synthesis, and downregulated nitric oxide signaling. Together, these findings suggest a more predominant systemic microvascular endothelial dysfunction and inflammation linked to increased fibrosis in HFpEF compared with HFrEF.\n\nClinicalTrials.gov NCT03671122 https://clinicaltrials.gov.", "doi": "10.1016/j.cardfail.2020.07.010", "pmid": "32750486", "labels": [], "xrefs": [{"db": "pii", "key": "S1071-9164(20)30892-7"}, {"db": "ClinicalTrials.gov", "key": "NCT03671122"}], "notes": [], "created": "2026-08-20T06:49:49.032Z", "modified": "2026-08-20T06:49:49.066Z"}, {"entity": "publication", "iuid": "294c1cf0eae34134af5382779d609c89", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/294c1cf0eae34134af5382779d609c89.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/294c1cf0eae34134af5382779d609c89"}}, "title": "Increased iron absorption in patients with chronic heart failure and iron deficiency.", "authors": [{"family": "Cabrera", "given": "Carin C", "initials": "CC"}, {"family": "Ekstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Linde", "given": "Cecilia", "initials": "C"}, {"family": "Persson", "given": "Hans", "initials": "H"}, {"family": "Hage", "given": "Camilla", "initials": "C"}, {"family": "Eriksson", "given": "Maria J", "initials": "MJ"}, {"family": "Wall\u00e9n", "given": "H\u00e5kan", "initials": "H"}, {"family": "Persson", "given": "Bengt", "initials": "B"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}], "type": "clinical trial", "published": "2020-05-00", "journal": {"title": "J Card Fail", "issn": "1532-8414", "volume": "26", "issue": "5", "pages": "440-443", "issn-l": null}, "abstract": "Iron deficiency (ID) is common in patients with chronic heart failure (CHF), but the underlying causes are not fully understood. We investigated whether ID is associated with decreased iron absorption in patients with CHF.\n\nWe performed an oral iron-absorption test in 30 patients and 12 controls. The patients had CHF with reduced (n = 15) or preserved (n = 15) ejection fraction and ID, defined as s-ferritin < 100 \u00b5g/L, or s-ferritin 100-299 \u00b5g/L and transferrin saturation < 20%. The controls had no HF or ID and were of similar age and gender. Blood samples were taken before and 2 hours after ingestion of 100 mg ferroglycin sulphate. The primary endpoint was the delta plasma iron at 2 hours. The delta plasma iron was higher in the group with HF than in the control group (median increase 83.8 [61.5;128.5] \u00b5g/dL in HF vs 47.5 [30.7;61.5] \u00b5g/dL in controls, P = 0.001), indicating increased iron absorption. There was no significant difference between the groups with preserved or reduced ejection fraction (P = 0.46).\n\nWe found increased iron absorption in patients with CHF and ID compared to controls without ID and HF, indicating that reduced iron absorption is not a primary cause of the high prevalence of ID in patients with CHF.\n\nEudraCT 2017-000158-21.", "doi": "10.1016/j.cardfail.2020.03.004", "pmid": "32165346", "labels": [], "xrefs": [{"db": "pii", "key": "S1071-9164(20)30164-0"}], "notes": [], "created": "2026-08-20T06:49:46.859Z", "modified": "2026-08-20T06:49:46.925Z"}, {"entity": "publication", "iuid": "6298948e52ba4008b66560af90d59c6e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6298948e52ba4008b66560af90d59c6e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6298948e52ba4008b66560af90d59c6e"}}, "title": "Effects of Oral Supplementation With Nitrate-Rich Beetroot Juice in Patients With Pulmonary Arterial Hypertension-Results From BEET-PAH, an Exploratory Randomized, Double-Blind, Placebo-Controlled, Crossover Study.", "authors": [{"family": "Henrohn", "given": "Dan", "initials": "D"}, {"family": "Bj\u00f6rkstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Lundberg", "given": "Jon O", "initials": "JO"}, {"family": "Granstam", "given": "Sven-Olof", "initials": "SO"}, {"family": "Baron", "given": "Tomasz", "initials": "T"}, {"family": "Ingimarsd\u00f3ttir", "given": "Inga J", "initials": "IJ"}, {"family": "Hedenstr\u00f6m", "given": "Hans", "initials": "H"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Wernroth", "given": "Mona-Lisa", "initials": "ML"}, {"family": "Jansson", "given": "Martin", "initials": "M"}, {"family": "Hedeland", "given": "Mikael", "initials": "M"}, {"family": "Wikstr\u00f6m", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2018-10-00", "journal": {"title": "J Card Fail", "issn": "1532-8414", "volume": "24", "issue": "10", "pages": "640-653", "issn-l": null}, "abstract": "The nitrate-nitrite-nitric oxide (NO) pathway may represent a potential therapeutic target in patients with pulmonary arterial hypertension (PAH). We explored the effects of dietary nitrate supplementation, with the use of nitrate-rich beetroot juice (BRJ), in patients with PAH.\n\nWe prospectively studied 15 patients with PAH in an exploratory randomized, double-blind, placebo-controlled, crossover trial. The patients received nitrate-rich beetroot juice (\u223c16 mmol nitrate per day) and placebo in 2 treatment periods of 7 days each. The assessments included; exhaled NO and NO flow-independent parameters (alveolar NO and bronchial NO flux), plasma and salivary nitrate and nitrite, biomarkers and metabolites of the NO-system, N-terminal pro-B-type natriuretic peptide, echocardiography, ergospirometry, diffusing capacity of the lung for carbon monoxide, and the 6-minute walk test. Compared with placebo ingestion of BRJ resulted in increases in; fractional exhaled NO at all flow-rates, alveolar NO concentrations and bronchial NO flux, and plasma and salivary levels of nitrate and nitrite. Plasma ornithine levels decreased and indices of relative arginine availability increased after BRJ compared to placebo. A decrease in breathing frequency was observed during ergospirometry after BRJ. A tendency for an improvement in right ventricular function was observed after ingestion of BRJ. In addition a tendency for an increase in the peak power output to peak oxygen consumption ratio (W peak/VO2 peak) was observed, which became significant in patients reaching an increase of plasma nitrite >30% (responders).\n\nBRJ administered for 1 week increases pulmonary NO production and the relative arginine bioavailability in patients with PAH, compared with placebo. An increase in the W peak/VO2 peak ratio was observed after BRJ ingestion in plasma nitrite responders. These findings indicate that supplementation with inorganic nitrate increase NO synthase-independent NO production from the nitrate-nitrite-NO pathway.", "doi": "10.1016/j.cardfail.2018.09.010", "pmid": "30244181", "labels": [], "xrefs": [{"db": "pii", "key": "S1071-9164(18)31003-0"}], "notes": [], "created": "2026-08-21T11:14:39.132Z", "modified": "2026-08-21T11:14:39.164Z"}], "created": "2026-08-20T06:49:46.894Z", "modified": "2026-08-20T06:49:46.894Z"}