{"entity": "journal", "iuid": "220739a34bbf4ed9ad22e9a3aac66b24", "timestamp": "2026-08-20T20:25:23.621Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Immunotherapy.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Immunotherapy"}}, "title": "Immunotherapy", "issn": "1750-7448", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "78127039e4944fc48bbe578234be9179", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/78127039e4944fc48bbe578234be9179.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/78127039e4944fc48bbe578234be9179"}}, "title": "Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors.", "authors": [{"family": "Jin", "given": "Chuan", "initials": "C"}, {"family": "Yu", "given": "Di", "initials": "D"}, {"family": "Essand", "given": "Magnus", "initials": "M"}], "type": "editorial", "published": "2016-12-00", "journal": {"title": "Immunotherapy", "issn": "1750-7448", "volume": "8", "issue": "12", "pages": "1355-1361", "issn-l": null}, "abstract": "Adoptive transfer of patient-derived T-cells engineered with a chimeric antigen receptor (CAR) targeting the pan-B-cell marker CD19 has led to complete remission in patients with B-cell leukemias while response rates are more modest for B-cell lymphomas. This can be attributed to the fact that the semi-solid structure of lymphomas impedes T-cell infiltration and that the immune suppressive microenvironment within these tumors dampens the effect of CAR T-cells. These obstacles are even more pronounced for solid tumors where dense and often highly immunosuppressive structures are found. This article focuses on different aspects of how to improve CAR T-cells for solid tumors, primarily by decreasing their sensitivity to the harsh tumor microenvironment, by altering the immunosuppressive microenvironment inside tumors and by inducing bystander immunity.", "doi": "10.2217/imt-2016-0125", "pmid": "28000533", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:02:30.207Z", "modified": "2026-08-20T13:02:30.270Z"}], "created": "2026-08-20T13:02:30.235Z", "modified": "2026-08-20T13:02:30.235Z"}