{"entity": "journal", "iuid": "afabe2616b184fad803ddbc013e59f3e", "timestamp": "2026-06-08T11:17:17.202Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Immunol.%20Rev..json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Immunol.%20Rev."}}, "title": "Immunol. Rev.", "issn": "1600-065X", "issn-l": "0105-2896", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "a8ba4bd1408c4171a189568e3f61fdee", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a8ba4bd1408c4171a189568e3f61fdee.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a8ba4bd1408c4171a189568e3f61fdee"}}, "title": "Newtonian cell interactions shape natural killer cell education.", "authors": [{"family": "Goodridge", "given": "Jodie P", "initials": "JP"}, {"family": "\u00d6nfelt", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}], "type": "journal article", "published": "2015-09-00", "journal": {"title": "Immunol. Rev.", "issn": "1600-065X", "volume": "267", "issue": "1", "pages": "197-213", "issn-l": "0105-2896"}, "abstract": "Newton's third law of motion states that for every action on a physical object there is an equal and opposite reaction. The dynamic change in functional potential of natural killer (NK) cells during education bears many features of such classical mechanics. Cumulative physical interactions between cells, under a constant influence of homeostatic drivers of differentiation, lead to a reactive spectrum that ultimately shapes the functionality of each NK cell. Inhibitory signaling from an array of self-specific receptors appear not only to suppress self-reactivity but also aid in the persistence of effector functions over time, thereby allowing the cell to gradually build up a functional potential. Conversely, the frequent non-cytolytic interactions between normal cells in the absence of such inhibitory signaling result in continuous stimulation of the cells and attenuation of effector function. Although an innate cell, the degree to which the fate of the NK cell is predetermined versus its ability to adapt to its own environment can be revealed through a Newtonian view of NK cell education, one which is both chronological and dynamic. As such, the development of NK cell functional diversity is the product of qualitatively different physical interactions with host cells, rather than simply the sum of their signals or an imprint based on intrinsically different transcriptional programs. ", "doi": "10.1111/imr.12325", "pmid": "26284479", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pmc", "key": "PMC4832384"}], "notes": [], "created": "2018-12-05T09:41:10.669Z", "modified": "2018-12-05T09:41:10.700Z"}, {"entity": "publication", "iuid": "ee2a71cdee8940a897d64c03d4f2f2ff", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ee2a71cdee8940a897d64c03d4f2f2ff.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ee2a71cdee8940a897d64c03d4f2f2ff"}}, "title": "The structure, regulation, and function of ZAP-70.", "authors": [{"family": "Au-Yeung", "given": "Byron B", "initials": "BB"}, {"family": "Deindl", "given": "Sebastian", "initials": "S"}, {"family": "Hsu", "given": "Lih-Yun", "initials": "LY"}, {"family": "Palacios", "given": "Emil H", "initials": "EH"}, {"family": "Levin", "given": "Susan E", "initials": "SE"}, {"family": "Kuriyan", "given": "John", "initials": "J"}, {"family": "Weiss", "given": "Arthur", "initials": "A"}], "type": "journal article", "published": "2009-03-00", "journal": {"title": "Immunol. Rev.", "issn": "1600-065X", "volume": "228", "issue": "1", "pages": "41-57", "issn-l": "0105-2896"}, "abstract": "The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement. The importance of ZAP-70 is evidenced by the severe combined immunodeficiency that occurs in ZAP-70-deficient mice and humans. In this review, we describe recent analyses of the ZAP-70 crystal structure, revealing a complex regulatory mechanism of ZAP-70 activity, the differential requirements for ZAP-70 and spleen tyrosine kinase (SyK) in early T-cell development, as well as the role of ZAP-70 in chronic lymphocytic leukemia and autoimmunity. Thus, the critical importance of ZAP-70 in TCR signaling and its predominantly T-cell-restricted expression pattern make ZAP-70 an attractive drug target for the inhibition of pathological T-cell responses in disease.", "doi": "10.1111/j.1600-065X.2008.00753.x", "pmid": "19290920", "labels": {"Sebastian Deindl": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "IMR753"}], "notes": [], "created": "2020-10-09T09:53:53.719Z", "modified": "2022-11-07T11:37:50.953Z"}], "created": "2018-12-05T09:41:10.682Z", "modified": "2020-11-27T13:12:56.091Z"}