{"entity": "journal", "iuid": "3df71013c27548238aac232f96333a32", "timestamp": "2026-08-22T06:51:05.986Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Immunity.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Immunity"}}, "title": "Immunity", "issn": "1097-4180", "issn-l": null, "publications_count": 4, "publications": [{"entity": "publication", "iuid": "8839ec7fa92a49c69f3e282ee4b54c7e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8839ec7fa92a49c69f3e282ee4b54c7e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8839ec7fa92a49c69f3e282ee4b54c7e"}}, "title": "NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression.", "authors": [{"family": "McManus", "given": "R\u00f3is\u00edn M", "initials": "RM"}, {"family": "Komes", "given": "Max P", "initials": "MP"}, {"family": "Griep", "given": "Angelika", "initials": "A"}, {"family": "Santarelli", "given": "Francesco", "initials": "F"}, {"family": "Schwartz", "given": "Stephanie", "initials": "S"}, {"family": "Ram\u00f3n Perea", "given": "Juan", "initials": "J"}, {"family": "Schlachetzki", "given": "Johannes C M", "initials": "JCM"}, {"family": "Bouvier", "given": "David S", "initials": "DS"}, {"family": "Khalil", "given": "Michelle-Amirah", "initials": "MA"}, {"family": "Lauterbach", "given": "Mario A", "initials": "MA"}, {"family": "Heinemann", "given": "Lea", "initials": "L"}, {"family": "Schl\u00fcter", "given": "Titus", "initials": "T"}, {"family": "Pour", "given": "Mehran Shaban", "initials": "MS"}, {"family": "Lovotti", "given": "Marta", "initials": "M"}, {"family": "Stahl", "given": "Rainer", "initials": "R"}, {"family": "Duthie", "given": "Fraser", "initials": "F"}, {"family": "Rodr\u00edguez-Alc\u00e1zar", "given": "Juan F", "initials": "JF"}, {"family": "Schmidt", "given": "Susanne V", "initials": "SV"}, {"family": "Spitzer", "given": "Jasper", "initials": "J"}, {"family": "Noori", "given": "Peri", "initials": "P"}, {"family": "Maillo", "given": "Alberto", "initials": "A"}, {"family": "Boettcher", "given": "Andreas", "initials": "A"}, {"family": "Herron", "given": "Brian", "initials": "B"}, {"family": "McConville", "given": "John", "initials": "J"}, {"family": "Gomez-Cabrero", "given": "David", "initials": "D"}, {"family": "Tegn\u00e9r", "given": "Jesper", "initials": "J"}, {"family": "Glass", "given": "Christopher K", "initials": "CK"}, {"family": "Hiller", "given": "Karsten", "initials": "K"}, {"family": "Latz", "given": "Eicke", "initials": "E"}, {"family": "Heneka", "given": "Michael T", "initials": "MT"}], "type": "journal article", "published": "2025-02-11", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "58", "issue": "2", "pages": "326-343.e11", "issn-l": null}, "abstract": "Activation of the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer's disease (AD) via the release of IL-1\u03b2 and ASC specks. However, whether NLRP3 is involved in pathways beyond this remained unknown. Here, we found that A\u03b2 deposition in vivo directly triggered NLRP3 activation in APP/PS1 mice, which model many features of AD. Loss of NLRP3 increased glutamine- and glutamate-related metabolism and increased expression of microglial Slc1a3, which was associated with enhanced mitochondrial and metabolic activity. The generation of \u03b1-ketoglutarate during this process impacted cellular function, including increased clearance of A\u03b2 peptides as well as epigenetic and gene transcription changes. This pathway was conserved between murine and human cells. Critically, we could mimic this effect pharmacologically using NLRP3-specific inhibitors, but only with chronic NLRP3 inhibition. Together, these data demonstrate an additional role for NLRP3, where it can modulate mitochondrial and metabolic function, with important downstream consequences for the progression of AD.", "doi": "10.1016/j.immuni.2025.01.007", "pmid": "39904338", "labels": [], "xrefs": [{"db": "pii", "key": "S1074-7613(25)00032-9"}, {"db": "GEO", "key": "GSE269886 , GSE271192 , GSE283243 , GSE283244"}], "notes": [], "created": "2026-08-21T11:21:00.387Z", "modified": "2026-08-21T11:21:00.403Z"}, {"entity": "publication", "iuid": "eba66f25fbbc4b00985e7cace9394686", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eba66f25fbbc4b00985e7cace9394686.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eba66f25fbbc4b00985e7cace9394686"}}, "title": "In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.", "authors": [{"family": "Nyberg", "given": "William A", "initials": "WA"}, {"family": "Wang", "given": "Charlotte H", "initials": "CH"}, {"family": "Ark", "given": "Jonathan", "initials": "J"}, {"family": "Liu", "given": "Chang", "initials": "C"}, {"family": "Clouden", "given": "Sylvanie", "initials": "S"}, {"family": "Qualls", "given": "Anita", "initials": "A"}, {"family": "Caryotakis", "given": "Sofia", "initials": "S"}, {"family": "Wells", "given": "Elina", "initials": "E"}, {"family": "Simon", "given": "Katherine", "initials": "K"}, {"family": "Garza", "given": "Celeste", "initials": "C"}, {"family": "Bernard", "given": "Pierre-Louis", "initials": "PL"}, {"family": "Lopez-Ichikawa", "given": "Maya", "initials": "M"}, {"family": "Li", "given": "Zhongmei", "initials": "Z"}, {"family": "Seo", "given": "Jin", "initials": "J"}, {"family": "Kimmerly", "given": "Gabriella R", "initials": "GR"}, {"family": "Muldoon", "given": "Joseph J", "initials": "JJ"}, {"family": "Chen", "given": "Peixin Amy", "initials": "PA"}, {"family": "Li", "given": "Mingcheng", "initials": "M"}, {"family": "Liang", "given": "Hong-Erh", "initials": "HE"}, {"family": "Kersten", "given": "Kelly", "initials": "K"}, {"family": "Rosales", "given": "Alan", "initials": "A"}, {"family": "Kuhn", "given": "Nicholas", "initials": "N"}, {"family": "Ye", "given": "Chun Jimmie", "initials": "CJ"}, {"family": "Gardner", "given": "James M", "initials": "JM"}, {"family": "Molofsky", "given": "Ari", "initials": "A"}, {"family": "Ricardo-Gonzalez", "given": "Roberto R", "initials": "RR"}, {"family": "Asokan", "given": "Aravind", "initials": "A"}, {"family": "Eyquem", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2025-02-11", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "58", "issue": "2", "pages": "499-512.e7", "issn-l": null}, "abstract": "Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a transient transgene expression cassette was feasible using Ark313, and this serotype outperformed natural serotypes. A single intravenous injection of a Cre recombinase-expressing Ark313 in the Ai9 fluorescent reporter mouse model achieved permanent genetic modifications of T cells. Ark313 facilitated in vivo gene editing in both tissue-resident and splenic T cells and validation of immunotherapy targets in solid tumor models. Ark313 delivered large DNA donor templates to T cells in vivo and integrated transgenes in primary CD4+ and CD8+ T cells, including naive T cells. Ark313-mediated transgene delivery presents an efficient approach to target mouse T cells in vivo and a resource for the interrogation of T cell biology and for immunotherapy applications.", "doi": "10.1016/j.immuni.2025.01.009", "pmid": "39909036", "labels": [], "xrefs": [{"db": "pii", "key": "S1074-7613(25)00034-2"}], "notes": [], "created": "2026-08-21T11:21:02.444Z", "modified": "2026-08-21T11:21:02.455Z"}, {"entity": "publication", "iuid": "241ddb6a6bc141c483880c2f931f97d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/241ddb6a6bc141c483880c2f931f97d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/241ddb6a6bc141c483880c2f931f97d4"}}, "title": "B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing.", "authors": [{"family": "Frede", "given": "Annika", "initials": "A"}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Monasterio", "given": "Gustavo", "initials": "G"}, {"family": "Tripathi", "given": "Kumar P", "initials": "KP"}, {"family": "Bejarano", "given": "David A", "initials": "DA"}, {"family": "Ramirez Flores", "given": "Ricardo O", "initials": "RO"}, {"family": "Sorini", "given": "Chiara", "initials": "C"}, {"family": "Larsson", "given": "Ludvig", "initials": "L"}, {"family": "Luo", "given": "Xinxin", "initials": "X"}, {"family": "Geerlings", "given": "Laura", "initials": "L"}, {"family": "Novella-Rausell", "given": "Claudio", "initials": "C"}, {"family": "Zagami", "given": "Chiara", "initials": "C"}, {"family": "Kuiper", "given": "Raoul", "initials": "R"}, {"family": "Morales", "given": "Rodrigo A", "initials": "RA"}, {"family": "Castillo", "given": "Francisca", "initials": "F"}, {"family": "Hunt", "given": "Matthew", "initials": "M"}, {"family": "Mariano", "given": "Livia Lacerda", "initials": "LL"}, {"family": "Hu", "given": "Yue O O", "initials": "YOO"}, {"family": "Engblom", "given": "Camilla", "initials": "C"}, {"family": "Lennon-Dum\u00e9nil", "given": "Ana-Maria", "initials": "AM"}, {"family": "Mittenzwei", "given": "Romy", "initials": "R"}, {"family": "Westendorf", "given": "Astrid M", "initials": "AM"}, {"family": "H\u00f6velmeyer", "given": "Nadine", "initials": "N"}, {"family": "Lundeberg", "given": "Joakim", "initials": "J"}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J"}, {"family": "Schlitzer", "given": "Andreas", "initials": "A"}, {"family": "Das", "given": "Srustidhar", "initials": "S"}, {"family": "Villablanca", "given": "Eduardo J", "initials": "EJ"}], "type": "journal article", "published": "2022-12-13", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "55", "issue": "12", "pages": "2336-2351.e12", "issn-l": null}, "abstract": "Therapeutic promotion of intestinal regeneration holds great promise, but defining the cellular mechanisms that influence tissue regeneration remains an unmet challenge. To gain insight into the process of mucosal healing, we longitudinally examined the immune cell composition during intestinal damage and regeneration. B cells were the dominant cell type in the healing colon, and single-cell RNA sequencing (scRNA-seq) revealed expansion of an IFN-induced B cell subset during experimental mucosal healing that predominantly located in damaged areas and associated with colitis severity. B cell depletion accelerated recovery upon injury, decreased epithelial ulceration, and enhanced gene expression programs associated with tissue remodeling. scRNA-seq from the epithelial and stromal compartments combined with spatial transcriptomics and multiplex immunostaining showed that B cells decreased interactions between stromal and epithelial cells during mucosal healing. Activated B cells disrupted the epithelial-stromal cross talk required for organoid survival. Thus, B cell expansion during injury impairs epithelial-stromal cell interactions required for mucosal healing, with implications for the treatment of IBD.", "doi": "10.1016/j.immuni.2022.11.002", "pmid": "36462502", "labels": [], "xrefs": [{"db": "pii", "key": "S1074-7613(22)00592-1"}], "notes": [], "created": "2026-08-20T07:57:12.687Z", "modified": "2026-08-20T07:57:12.758Z"}, {"entity": "publication", "iuid": "223346f3468b47dc946b6ab5c7885153", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/223346f3468b47dc946b6ab5c7885153.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/223346f3468b47dc946b6ab5c7885153"}}, "title": "Powerful Populations Respond to Viruses and Vaccines.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2015-12-15", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "43", "issue": "6", "pages": "1035-1037", "issn-l": null}, "abstract": "In this issue of Immunity, Andres-Terre et al. (2015) and Nakaya et al. (2015) perform multi-cohort meta-analyses of immune responses to viruses and vaccines. With increased statistical power and more diverse sampling populations, their findings promise to be more generally applicable and suggestive of novel mechanisms for regulating immunity.", "doi": "10.1016/j.immuni.2015.11.018", "pmid": "26682979", "labels": [], "xrefs": [{"db": "pii", "key": "S1074-7613(15)00496-3"}], "notes": [], "created": "2026-08-21T11:20:58.420Z", "modified": "2026-08-21T11:20:58.434Z"}], "created": "2026-08-20T07:57:12.720Z", "modified": "2026-08-20T07:57:12.721Z"}