{"entity": "journal", "iuid": "63e73322f3014891a4c53c6515e20223", "timestamp": "2026-03-17T00:47:56.286Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Future%20Microbiol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Future%20Microbiol"}}, "title": "Future Microbiol", "issn": "1746-0921", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "4cbb920d4a474c3dbfb36029af14f141", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4cbb920d4a474c3dbfb36029af14f141.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4cbb920d4a474c3dbfb36029af14f141"}}, "title": "Regulation of c-di-GMP metabolism in biofilms.", "authors": [{"family": "Jonas", "given": "Kristina", "initials": "K"}, {"family": "Melefors", "given": "Ojar", "initials": "O"}, {"family": "R\u00f6mling", "given": "Ute", "initials": "U"}], "type": "journal article", "published": "2009-04-00", "journal": {"title": "Future Microbiol", "issn": "1746-0921", "volume": "4", "issue": "3", "pages": "341-358", "issn-l": null}, "abstract": "Cyclic (5 to 3 )-diguanosine monophosphate (c-di-GMP) is a small molecule that regulates the transition between the sessile and motile lifestyle, an integrative part of biofilm formation and other multicellular behavior, in many bacteria. The recognition of c-di-GMP as a novel secondary messenger soon raised the question about the specificity of the signaling system, as individual bacterial genomes frequently encode numerous c-di-GMP metabolizing proteins. Recent work has demonstrated that several global regulators concertedly modify the expression of selected panels of c-di-GMP metabolizing proteins, which act on targets with physiological functions. Within complex feed-forward arrangements, the global regulators commonly combine the control of c-di-GMP metabolism with the direct regulation of proteins with functions in motility or biofilm formation, leading to precise and fine-tuned output responses that determine bacterial behavior. c-di-GMP metabolizing proteins are also controlled at the post-translational level by mechanisms including phosphorylation, localization, protein-protein interactions or protein stability. A detailed understanding of such complex regulatory mechanisms will not only help to explain the specificity in c-di-GMP signaling systems, but will also be necessary to understand the high phenotypic diversity within bacterial biofilms at the single cell level.", "doi": "10.2217/fmb.09.7", "pmid": "19327118", "labels": {"Kristina Jonas": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-30T14:48:56.436Z", "modified": "2022-11-07T11:33:47.277Z"}], "created": "2020-11-30T14:48:56.452Z", "modified": "2020-11-30T14:48:56.452Z"}