{"entity": "journal", "iuid": "97e1368de3714539b8112d0644a02928", "timestamp": "2026-08-23T09:24:49.560Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Front%20Toxicol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Front%20Toxicol"}}, "title": "Front Toxicol", "issn": "2673-3080", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "c5bad361d9e4443d977c46168aae66ff", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c5bad361d9e4443d977c46168aae66ff.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c5bad361d9e4443d977c46168aae66ff"}}, "title": "New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project.", "authors": [{"family": "Tal", "given": "Tamara", "initials": "T"}, {"family": "Myhre", "given": "Oddvar", "initials": "O"}, {"family": "Fritsche", "given": "Ellen", "initials": "E"}, {"family": "R\u00fcegg", "given": "Jo\u00eblle", "initials": "J"}, {"family": "Craenen", "given": "Kai", "initials": "K"}, {"family": "Aiello-Holden", "given": "Kiara", "initials": "K"}, {"family": "Agrillo", "given": "Caroline", "initials": "C"}, {"family": "Babin", "given": "Patrick J", "initials": "PJ"}, {"family": "Escher", "given": "Beate I", "initials": "BI"}, {"family": "Dirven", "given": "Hubert", "initials": "H"}, {"family": "Hellsten", "given": "Kati", "initials": "K"}, {"family": "Dolva", "given": "Kristine", "initials": "K"}, {"family": "Hessel", "given": "Ellen", "initials": "E"}, {"family": "Heusinkveld", "given": "Harm J", "initials": "HJ"}, {"family": "Hadzhiev", "given": "Yavor", "initials": "Y"}, {"family": "Hurem", "given": "Selma", "initials": "S"}, {"family": "Jagiello", "given": "Karolina", "initials": "K"}, {"family": "Judzinska", "given": "Beata", "initials": "B"}, {"family": "Kl\u00fcver", "given": "Nils", "initials": "N"}, {"family": "Knoll-Gellida", "given": "Anja", "initials": "A"}, {"family": "K\u00fchne", "given": "Britta A", "initials": "BA"}, {"family": "Leist", "given": "Marcel", "initials": "M"}, {"family": "Lislien", "given": "Malene", "initials": "M"}, {"family": "Lyche", "given": "Jan L", "initials": "JL"}, {"family": "M\u00fcller", "given": "Ferenc", "initials": "F"}, {"family": "Colbourne", "given": "John K", "initials": "JK"}, {"family": "Neuhaus", "given": "Winfried", "initials": "W"}, {"family": "Pallocca", "given": "Giorgia", "initials": "G"}, {"family": "Seeger", "given": "Bettina", "initials": "B"}, {"family": "Scharkin", "given": "Ilka", "initials": "I"}, {"family": "Scholz", "given": "Stefan", "initials": "S"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Torres-Ruiz", "given": "Monica", "initials": "M"}, {"family": "Bartmann", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2024-04-26", "journal": {"title": "Front Toxicol", "issn": "2673-3080", "volume": "6", "pages": "1359507", "issn-l": null}, "abstract": "In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public expects chemicals and products to be safe for the developing and mature nervous systems, considerable numbers of chemicals in commerce have not, or only to a limited extent, been assessed for their potential to cause neurotoxicity. As such, there is a societal push toward the replacement of animal models with in vitro or alternative methods. New approach methods (NAMs) can contribute to the regulatory knowledge base, increase chemical safety, and modernize chemical hazard and risk assessment. Provided they reach an acceptable level of regulatory relevance and reliability, NAMs may be considered as replacements for specific in vivo studies. The European Partnership for the Assessment of Risks from Chemicals (PARC) addresses challenges to the development and implementation of NAMs in chemical risk assessment. In collaboration with regulatory agencies, Project 5.2.1e (Neurotoxicity) aims to develop and evaluate NAMs for developmental neurotoxicity (DNT) and adult neurotoxicity (ANT) and to understand the applicability domain of specific NAMs for the detection of endocrine disruption and epigenetic perturbation. To speed up assay time and reduce costs, we identify early indicators of later-onset effects. Ultimately, we will assemble second-generation developmental neurotoxicity and first-generation adult neurotoxicity test batteries, both of which aim to provide regulatory hazard and risk assessors and industry stakeholders with robust, speedy, lower-cost, and informative next-generation hazard and risk assessment tools.", "doi": "10.3389/ftox.2024.1359507", "pmid": "38742231", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11089904"}, {"db": "pii", "key": "1359507"}], "notes": [], "created": "2026-08-20T13:38:18.080Z", "modified": "2026-08-20T13:38:18.092Z"}, {"entity": "publication", "iuid": "e8478b1068984148bad015ab6db60529", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e8478b1068984148bad015ab6db60529.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e8478b1068984148bad015ab6db60529"}}, "title": "Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project.", "authors": [{"family": "Braeuning", "given": "Albert", "initials": "A"}, {"family": "Balaguer", "given": "Patrick", "initials": "P"}, {"family": "Bourguet", "given": "William", "initials": "W"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J"}, {"family": "Feiertag", "given": "Katreece", "initials": "K"}, {"family": "Kamstra", "given": "Jorke H", "initials": "JH"}, {"family": "Knapen", "given": "Dries", "initials": "D"}, {"family": "Lichtenstein", "given": "Dajana", "initials": "D"}, {"family": "Marx-Stoelting", "given": "Philip", "initials": "P"}, {"family": "Rietdijk", "given": "Jonne", "initials": "J"}, {"family": "Schubert", "given": "Kristin", "initials": "K"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Stinckens", "given": "Evelyn", "initials": "E"}, {"family": "Thedieck", "given": "Kathrin", "initials": "K"}, {"family": "van den Boom", "given": "Rik", "initials": "R"}, {"family": "Vergauwen", "given": "Lucia", "initials": "L"}, {"family": "von Bergen", "given": "Martin", "initials": "M"}, {"family": "Wewer", "given": "Neele", "initials": "N"}, {"family": "Zalko", "given": "Daniel", "initials": "D"}], "type": "published erratum", "published": "2024-03-25", "journal": {"title": "Front Toxicol", "issn": "2673-3080", "volume": "6", "pages": "1394396", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.3389/ftox.2023.1212509.].", "doi": "10.3389/ftox.2024.1394396", "pmid": "38590784", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11000267"}, {"db": "pii", "key": "1394396"}], "notes": [], "created": "2026-08-20T13:38:19.989Z", "modified": "2026-08-20T13:38:20.037Z"}, {"entity": "publication", "iuid": "af9069c1f44b4900b9d77115732381ab", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/af9069c1f44b4900b9d77115732381ab.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/af9069c1f44b4900b9d77115732381ab"}}, "title": "Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project.", "authors": [{"family": "Braeuning", "given": "Albert", "initials": "A"}, {"family": "Balaguer", "given": "Patrick", "initials": "P"}, {"family": "Bourguet", "given": "William", "initials": "W"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J"}, {"family": "Feiertag", "given": "Katreece", "initials": "K"}, {"family": "Kamstra", "given": "Jorke H", "initials": "JH"}, {"family": "Knapen", "given": "Dries", "initials": "D"}, {"family": "Lichtenstein", "given": "Dajana", "initials": "D"}, {"family": "Marx-Stoelting", "given": "Philip", "initials": "P"}, {"family": "Rietdijk", "given": "Jonne", "initials": "J"}, {"family": "Schubert", "given": "Kristin", "initials": "K"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Stinckens", "given": "Evelyn", "initials": "E"}, {"family": "Thedieck", "given": "Kathrin", "initials": "K"}, {"family": "van den Boom", "given": "Rik", "initials": "R"}, {"family": "Vergauwen", "given": "Lucia", "initials": "L"}, {"family": "von Bergen", "given": "Martin", "initials": "M"}, {"family": "Wewer", "given": "Neele", "initials": "N"}, {"family": "Zalko", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2023-06-29", "journal": {"title": "Front Toxicol", "issn": "2673-3080", "volume": "5", "pages": "1212509", "issn-l": null}, "abstract": "In past times, the analysis of endocrine disrupting properties of chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well as on aspects of steroidogenesis and the modulation of thyroid signaling. More recently, disruption of energy metabolism and related signaling pathways by exogenous substances, so-called metabolism-disrupting chemicals (MDCs) have come into focus. While general effects such as body and organ weight changes are routinely monitored in animal studies, there is a clear lack of mechanistic test systems to determine and characterize the metabolism-disrupting potential of chemicals. In order to contribute to filling this gap, one of the project within EU-funded Partnership for the Assessment of Risks of Chemicals (PARC) aims at developing novel in vitro methods for the detection of endocrine metabolic disruptors. Efforts will comprise projects related to specific signaling pathways, for example, involving mTOR or xenobiotic-sensing nuclear receptors, studies on hepatocytes, adipocytes and pancreatic beta cells covering metabolic and morphological endpoints, as well as metabolism-related zebrafish-based tests as an alternative to classic rodent bioassays. This paper provides an overview of the approaches and methods of these PARC projects and how this will contribute to the improvement of the toxicological toolbox to identify substances with endocrine disrupting properties and to decipher their mechanisms of action.", "doi": "10.3389/ftox.2023.1212509", "pmid": "37456981", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10349382"}, {"db": "pii", "key": "1212509"}], "notes": [], "created": "2026-08-20T13:38:12.041Z", "modified": "2026-08-20T13:38:12.113Z"}], "created": "2026-08-20T13:38:12.075Z", "modified": "2026-08-20T13:38:12.075Z"}