{"entity": "journal", "iuid": "b85fbc6331d541d59ac6744973e8e821", "timestamp": "2026-10-18T01:10:10.301Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Front%20Psychol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Front%20Psychol"}}, "title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "1b57e00b3f7147a4b4fad594623fa821", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1b57e00b3f7147a4b4fad594623fa821.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1b57e00b3f7147a4b4fad594623fa821"}}, "title": "Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age.", "authors": [{"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Bixo", "given": "Marie", "initials": "M"}, {"family": "Jensen", "given": "Peter", "initials": "P"}, {"family": "Frokjaer", "given": "Vibe G", "initials": "VG"}], "type": "journal article", "published": "2019-01-11", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "9", "issue": null, "pages": "2767"}, "abstract": "Allopregnanolone is a metabolite of the sex hormone progesterone, with suggested relevance for female mood disorders. While allopregnanolone and serotonin are known to influence psychological well-being, the molecular and psychological specifics of their relationship are to date poorly understood, especially in women of fertile age who experience regular fluctuations of progesterone across the menstrual cycle. Availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (SERT), which can be imaged in the living human brain by use of positron emission tomography (PET) and the radiotracer [11C]DASB. To evaluate sex-specific allopregnanolone-SERT interactions, the present study investigated the relationship between cerebral SERT availability, serum allopregnanolone levels and psychological well-being in women of fertile age. Brain imaging data, self-reported symptoms of mental distress and emotion regulation, and biobank material from ninety healthy women were available from the Center for Integrated Molecular Brain Imaging (CIMBI) database. Age, BMI, and daylight minutes were included as covariates in the analyses and SERT genotype (5-HTTLPR) was considered a potential confounder. Lower serum allopregnanolone levels were associated with higher SERT binding in the prefrontal cortex. Moreover, allopregnanolone levels were negatively associated with measures of alertness, although this finding was not mediated by prefrontal cortex SERT binding. These findings suggest a link between the typical psychological well-being experienced in the follicular phase when allopregnanolone levels are low and higher SERT in the prefrontal cortex, a region for higher cognitive functions and top-down regulation of emotions.", "doi": "10.3389/fpsyg.2018.02767", "pmid": "30687199", "labels": {"Erika Comasco": "", "SciLifeLab Fellow": ""}, "xrefs": [{"db": "pmc", "key": "PMC6336902"}], "notes": [], "created": "2020-09-28T11:49:17.346Z", "modified": "2026-09-23T11:49:23.928Z"}, {"entity": "publication", "iuid": "1e13c42a27e944eea32f177a8658501f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1e13c42a27e944eea32f177a8658501f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1e13c42a27e944eea32f177a8658501f"}}, "title": "Large-Scale Brain Simulation and Disorders of Consciousness. Mapping Technical and Conceptual Issues.", "authors": [{"family": "Farisco", "given": "Michele", "initials": "M"}, {"family": "Kotaleski", "given": "Jeanette H", "initials": "JH"}, {"family": "Evers", "given": "Kathinka", "initials": "K"}], "type": "journal article", "published": "2018-04-24", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "9", "issue": null, "pages": "585", "issn-l": "1664-1078"}, "abstract": "Modeling and simulations have gained a leading position in contemporary attempts to describe, explain, and quantitatively predict the human brain's operations. Computer models are highly sophisticated tools developed to achieve an integrated knowledge of the brain with the aim of overcoming the actual fragmentation resulting from different neuroscientific approaches. In this paper we investigate the plausibility of simulation technologies for emulation of consciousness and the potential clinical impact of large-scale brain simulation on the assessment and care of disorders of consciousness (DOCs), e.g., Coma, Vegetative State/Unresponsive Wakefulness Syndrome, Minimally Conscious State. Notwithstanding their technical limitations, we suggest that simulation technologies may offer new solutions to old practical problems, particularly in clinical contexts. We take DOCs as an illustrative case, arguing that the simulation of neural correlates of consciousness is potentially useful for improving treatments of patients with DOCs.", "doi": "10.3389/fpsyg.2018.00585", "pmid": "29740372", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5928391"}], "notes": [], "created": "2018-12-05T12:42:02.671Z", "modified": "2026-09-23T11:14:54.151Z"}], "created": "2018-12-05T12:42:02.684Z", "modified": "2020-11-27T13:12:56.434Z"}