{"entity": "journal", "iuid": "95d03825c596409b83da0085ca4c3f92", "timestamp": "2026-08-20T20:45:18.381Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Front%20Aging%20Neurosci.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Front%20Aging%20Neurosci"}}, "title": "Front Aging Neurosci", "issn": "1663-4365", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "f005dcf41be94886948499f6c48e7e41", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f005dcf41be94886948499f6c48e7e41.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f005dcf41be94886948499f6c48e7e41"}}, "title": "Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin.", "authors": [{"family": "Croteau", "given": "Deborah L", "initials": "DL"}, {"family": "Navarro", "given": "Jose Fernandez", "initials": "JF"}, {"family": "Comptdaer", "given": "Thomas", "initials": "T"}, {"family": "Andrusivova", "given": "Zaneta", "initials": "Z"}, {"family": "Jurek", "given": "Aleksandra", "initials": "A"}, {"family": "Bonnefoy", "given": "Eliette", "initials": "E"}, {"family": "Bu\u00e9e", "given": "Luc", "initials": "L"}, {"family": "Bohr", "given": "Vilhelm A", "initials": "VA"}, {"family": "Lundeberg", "given": "Joakim", "initials": "J"}, {"family": "Galas", "given": "Marie-Christine", "initials": "MC"}], "type": "journal article", "published": "2025-10-31", "journal": {"title": "Front Aging Neurosci", "issn": "1663-4365", "volume": "17", "pages": "1656850", "issn-l": null}, "abstract": "RNA expression is modulated by tau. We used two mouse models, THY-Tau22 mice, which express pro-aggregation tau, and TauKO mice, which are null for tau, to improve our understanding of tau-altered mRNA expression in brain.\n\nSpatial transcriptomics on Tau22 and TauKO mice were used to interrogate regional mRNA expression changes. We focused on mRNA expression changes in the hippocampus and ventricles; two regions altered early in Alzheimer's disease.\n\nWe identified the transthyretin mRNA, Ttr, as being dysregulated in a tau-dependent manner. Immunofluorescence (IF) revealed increased TTR protein expression in THY-Tau22 mice and lowered expression in TauKO mice in the choroid plexus epithelial cells.\n\nAs TTR is involved in the clearance of A\u03b2 and the prevention of A\u03b2 aggregation, we evaluated endogenous mouse A\u03b2 in TauKO mice and observed increased A\u03b2 deposits. Our study reveals a hitherto unknown regulatory role of tau on Ttr mRNA and protein expression, which may participate in a feedback loop contributing to A\u03b2 disease progression.", "doi": "10.3389/fnagi.2025.1656850", "pmid": "41245137", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12615506"}], "notes": [], "created": "2026-08-20T13:07:37.947Z", "modified": "2026-08-20T13:07:37.980Z"}, {"entity": "publication", "iuid": "bb57a73d5ea345038dff21034a80b02f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bb57a73d5ea345038dff21034a80b02f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bb57a73d5ea345038dff21034a80b02f"}}, "title": "Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37.", "authors": [{"family": "Zhang", "given": "Xiaoqun", "initials": "X"}, {"family": "Mantas", "given": "Ioannis", "initials": "I"}, {"family": "Fridjonsdottir", "given": "Elva", "initials": "E"}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE"}, {"family": "Chergui", "given": "Karima", "initials": "K"}, {"family": "Svenningsson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-03-27", "journal": {"title": "Front Aging Neurosci", "issn": "1663-4365", "volume": "12", "pages": "84", "issn-l": null}, "abstract": "Parkinson's disease (PD) etiology is attributed to aging and the progressive neurodegeneration of dopamine (DA) neurons of substantia nigra pars compacta (SNc). GPR37 is an orphan G-protein Coupled Receptor (GPCR) that is linked to the juvenile form of PD. In addition, misfolded GPR37 has been found in Lewy bodies. However, properly folded GPR37 found at the cell membrane appears to exert neuroprotection. In the present study we investigated the role of GPR37 in motor deficits due to aging or toxin-induced experimental parkinsonism. Elderly GPR37 knock out (KO) mice displayed hypolocomotion and worse fine movement performance compared to their WT counterparts. Striatal slice electrophysiology reveiled that GPR37 KO mice show profound decrease in long term potentiation (LTP) formation which is accompanied by an alteration in glutamate receptor subunit content. GPR37 KO animals exposed to intrastriatal 6-hydroxydopamine (6-OHDA) show poorer score in the behavioral cylinder test and more loss of the DA transporter (DAT) in striatum. The GPR37 KO striata exhibit a significant increase in GABA which is aggravated after DA depletion. Our data indicate that GPR37 KO mice have DA neuron deficit, enhanced striatal GABA levels and deficient corticostriatal LTP. They also respond stronger to 6-OHDA-induced neurotoxicity. Taken together, the data indicate that properly functional GPR37 may counteract aging processes and parkinsonism.", "doi": "10.3389/fnagi.2020.00084", "pmid": "32292338", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7120535"}], "notes": [], "created": "2026-08-20T13:07:35.988Z", "modified": "2026-08-20T13:07:36.072Z"}], "created": "2026-08-20T13:07:36.018Z", "modified": "2026-08-20T13:07:36.018Z"}