{"entity": "journal", "iuid": "360639088fef4290af1915cbc08d886c", "timestamp": "2026-06-07T20:16:28.465Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Evolution.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Evolution"}}, "title": "Evolution", "issn": "1558-5646", "issn-l": "0014-3820", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "fd8b51db3fff4e129a4cf2a2f67a92d5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fd8b51db3fff4e129a4cf2a2f67a92d5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fd8b51db3fff4e129a4cf2a2f67a92d5"}}, "title": "Is evolution predictable? Quantitative genetics under complex genotype-phenotype maps.", "authors": [{"family": "Milocco", "given": "Lisandro", "initials": "L", "orcid": "0000-0003-3953-0407", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74f9e4dfff0e4b008c46b75e3d319673.json"}}, {"family": "Salazar-Ciudad", "given": "Isaac", "initials": "I", "orcid": "0000-0003-1607-0962", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d1949fc8c294af6b5231b0c308460ee.json"}}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Evolution", "issn": "1558-5646", "volume": "74", "issue": "2", "pages": "230-244", "issn-l": "0014-3820"}, "abstract": "A fundamental aim of post-genomic 21st century biology is to understand the genotype-phenotype map (GPM) or how specific genetic variation relates to specific phenotypic variation. Quantitative genetics approximates such maps using linear models, and has developed methods to predict the response to selection in a population. The other major field of research concerned with the GPM, developmental evolutionary biology, or evo-devo, has found the GPM to be highly nonlinear and complex. Here, we quantify how the predictions of quantitative genetics are affected by a complex, nonlinear map based on the development of a multicellular organ. We compared the predicted change in mean phenotype for a single generation using the multivariate breeder's equation, with the change observed from the model of development. We found that there are frequent disagreements between predicted and observed responses to selection due to the nonlinear nature of the genotype-phenotype map. Our results are a step toward integrating the fields studying the GPM.", "doi": "10.1111/evo.13907", "pmid": "31883344", "labels": {"DDLS Fellow": null, "Lisandro Milocco": null}, "xrefs": [{"db": "Dryad", "key": "10.5061/dryad.9cnp5hqdr"}], "notes": [], "created": "2025-11-28T14:28:15.053Z", "modified": "2025-11-28T14:28:55.122Z"}, {"entity": "publication", "iuid": "4a25fbeeec7344d1b90a366e0c29ddcd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4a25fbeeec7344d1b90a366e0c29ddcd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4a25fbeeec7344d1b90a366e0c29ddcd"}}, "title": "GENE-dosage effects on fitness in recent adaptive duplications: ace-1 in the mosquito Culex pipiens.", "authors": [{"family": "Labb\u00e9", "given": "Pierrick", "initials": "P"}, {"family": "Milesi", "given": "Pascal", "initials": "P"}, {"family": "Y\u00e9bakima", "given": "Andr\u00e9", "initials": "A"}, {"family": "Pasteur", "given": "Nicole", "initials": "N"}, {"family": "Weill", "given": "Myl\u00e8ne", "initials": "M"}, {"family": "Lenormand", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2014-07-00", "journal": {"title": "Evolution", "issn": "1558-5646", "volume": "68", "issue": "7", "pages": "2092-2101", "issn-l": "0014-3820"}, "abstract": "Gene duplications have long been advocated to contribute to the evolution of new functions. The role of selection in their early spread is more controversial. Unless duplications are favored for a direct benefit of increased expression, they are likely detrimental. In this article, we investigated the case of duplications favored because they combine already functionally divergent alleles. Their gene-dosage/fitness relations are poorly known because selection may operate on both overall expression and duplicates relative dosage. Using the well-documented case of Culex pipiens resistance to insecticides, we compared strains with various ace-1 allele combinations, including two duplicated alleles carrying both susceptible and resistant copies. The overall protein activity was nearly additive, but, surprisingly, fitness correlated better with the relative proportion of susceptible and resistant copies rather than any absolute measure of activity. Gene dosage is thus crucial, duplications stabilizing a \"heterozygote\" phenotype. It corroborates the view that these were favored because they fix a permanent heterosis, thereby solving the irreducible trade-off between resistance and synaptic transmission. Moreover, we showed that the contrasted successes of the two duplicated alleles in natural populations depend on genetic changes unrelated to ace-1, confirming the probable implication of recessive sublethal mutations linked to structural rearrangements in some duplications.", "doi": "10.1111/evo.12372", "pmid": "24494966", "labels": {"Pascal Milesi": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-30T09:24:21.971Z", "modified": "2022-11-07T11:36:18.983Z"}, {"entity": "publication", "iuid": "06a2ead5ed6244f092f29f5a95979bc1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/06a2ead5ed6244f092f29f5a95979bc1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/06a2ead5ed6244f092f29f5a95979bc1"}}, "title": "Genetic architecture and adaptive significance of the selfing syndrome in Capsella.", "authors": [{"family": "Slotte", "given": "Tanja", "initials": "T"}, {"family": "Hazzouri", "given": "Khaled M", "initials": "KM"}, {"family": "Stern", "given": "David", "initials": "D"}, {"family": "Andolfatto", "given": "Peter", "initials": "P"}, {"family": "Wright", "given": "Stephen I", "initials": "SI"}], "type": "journal article", "published": "2012-05-00", "journal": {"title": "Evolution", "issn": "1558-5646", "volume": "66", "issue": "5", "pages": "1360-1374", "issn-l": "0014-3820"}, "abstract": "The transition from outcrossing to predominant self-fertilization is one of the most common evolutionary transitions in flowering plants. This shift is often accompanied by a suite of changes in floral and reproductive characters termed the selfing syndrome. Here, we characterize the genetic architecture and evolutionary forces underlying evolution of the selfing syndrome in Capsella rubella following its recent divergence from the outcrossing ancestor C. grandiflora. We conduct genotyping by multiplexed shotgun sequencing and map floral and reproductive traits in a large (N= 550) F2 population. Our results suggest that in contrast to previous studies of the selfing syndrome, changes at a few loci, some with major effects, have shaped the evolution of the selfing syndrome in Capsella. The directionality of QTL effects, as well as population genetic patterns of polymorphism and divergence at 318 loci, is consistent with a history of directional selection on the selfing syndrome. Our study is an important step toward characterizing the genetic basis and evolutionary forces underlying the evolution of the selfing syndrome in a genetically accessible model system.", "doi": "10.1111/j.1558-5646.2011.01540.x", "pmid": "22519777", "labels": {"Tanja Slotte": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5063048"}, {"db": "mid", "key": "NIHMS818038"}], "notes": [], "created": "2018-12-04T10:21:15.728Z", "modified": "2022-11-07T11:38:19.818Z"}], "created": "2018-12-04T10:21:15.742Z", "modified": "2020-11-27T13:12:55.742Z"}