{"entity": "journal", "iuid": "a9bb75f988664f3b89c1a6cc51318f12", "timestamp": "2026-08-22T06:57:01.584Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Eur%20J%20Cell%20Biol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Eur%20J%20Cell%20Biol"}}, "title": "Eur J Cell Biol", "issn": "1618-1298", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "4cf9c385bde04784aa4f412ca04fd0b3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4cf9c385bde04784aa4f412ca04fd0b3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4cf9c385bde04784aa4f412ca04fd0b3"}}, "title": "The nexus of nuclear envelope dynamics, circular economy and cancer cell pathophysiology.", "authors": [{"family": "Keuper", "given": "Kristina", "initials": "K"}, {"family": "Bartek", "given": "Jiri", "initials": "J"}, {"family": "Maya-Mendoza", "given": "Apolinar", "initials": "A"}], "type": "journal article", "published": "2024-06-00", "journal": {"title": "Eur J Cell Biol", "issn": "1618-1298", "volume": "103", "issue": "2", "pages": "151394", "issn-l": null}, "abstract": "The nuclear envelope (NE) is a critical component in maintaining the function and structure of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to enable an open mitosis. Nuclear architecture construction and deconstruction is a prime example of a circular economy, as it fulfills a highly efficient recycling program bound to continuous assessment of the quality and functionality of the building blocks. Alterations in the nuclear dynamics and lamina structure have emerged as important contributors to both oncogenic transformation and cancer progression. However, the knowledge of the NE breakdown and reassembly is still limited to a fraction of participating proteins and complexes. As cancer cells contain highly diverse nuclei in terms of DNA content, but also in terms of nuclear number, size, and shape, it is of great interest to understand the intricate relationship between these nuclear features in cancer cell pathophysiology. In this review, we provide insights into how those NE dynamics are regulated, and how lamina destabilization processes may alter the NE circular economy. Moreover, we expand the knowledge of the lamina-associated domain region by using strategic algorithms, including Artificial Intelligence, to infer protein associations, assess their function and location, and predict cancer-type specificity with implications for the future of cancer diagnosis, prognosis and treatment. Using this approach we identified NUP98 and MECP2 as potential proteins that exhibit upregulation in Acute Myeloid Leukemia (LAML) patients with implications for early diagnosis.", "doi": "10.1016/j.ejcb.2024.151394", "pmid": "38340500", "labels": [], "xrefs": [{"db": "pii", "key": "S0171-9335(24)00011-6"}], "notes": [], "created": "2026-08-20T07:54:31.158Z", "modified": "2026-08-20T07:54:31.203Z"}, {"entity": "publication", "iuid": "e08e4f80237045f1a35c73735bb2871f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e08e4f80237045f1a35c73735bb2871f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e08e4f80237045f1a35c73735bb2871f"}}, "title": "OxLDL sensitizes platelets for increased formation of extracellular vesicles capable of finetuning macrophage gene expression.", "authors": [{"family": "Maaninka", "given": "Katariina", "initials": "K"}, {"family": "Neuvonen", "given": "Maarit", "initials": "M"}, {"family": "Kerkel\u00e4", "given": "Erja", "initials": "E"}, {"family": "Hyv\u00e4rinen", "given": "Kati", "initials": "K"}, {"family": "Palviainen", "given": "Mari", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Federico", "given": "Antonio", "initials": "A"}, {"family": "Greco", "given": "Dario", "initials": "D"}, {"family": "Laitinen", "given": "Saara", "initials": "S"}, {"family": "\u00d6\u00f6rni", "given": "Katariina", "initials": "K"}, {"family": "Siljander", "given": "Pia Rm", "initials": "PR"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Eur J Cell Biol", "issn": "1618-1298", "volume": "102", "issue": "2", "pages": "151311", "issn-l": null}, "abstract": "Platelet extracellular vesicles (PEVs) generated upon platelet activation may play a role in inflammatory pathologies such as atherosclerosis. Oxidized low-density lipoprotein (oxLDL), a well-known contributor to atherogenesis, activates platelets and presensitizes them for activation by other agonists. We studied the effect of oxLDL on the secretion, composition, and inflammatory functions of PEVs using contemporary EV analytics. Platelets were activated by co-stimulation with thrombin (T) and collagen (C) \u00b1 oxLDL and characterized by high-resolution flow cytometry, nanoparticle tracking analysis, proximity extension assay, western blot, and electron microscopy. The effect of PEVs on macrophage differentiation and functionality was examined by analyzing macrophage surface markers, cytokine secretion, and transcriptome. OxLDL upregulated TC-induced formation of CD61+, P-selectin+ and phosphatidylserine+ PEVs. Blocking the scavenger receptor CD36 significantly suppressed the oxLDL+TC-induced PEV formation, and HDL caused a slight but detectable suppression. The inflammatory protein cargo differed between the PEVs from stimulated and unstimulated platelets. Both oxLDL+TC- and TC-induced PEVs enhanced macrophage HLA-DR and CD86 expression and decreased CD11c expression as well as secretion of several cytokines. Pathways related to cell cycle and regulation of gene expression, and immune system signaling were overrepresented in the differentially expressed genes between TC PEV -treated vs. control macrophages and oxLDL+TC PEV -treated vs. control macrophages, respectively. In conclusion, we speculate that oxLDL and activated platelets contribute to proatherogenic processes by increasing the number of PEVs that provide an adhesive and procoagulant surface, contain inflammatory mediators, and subtly finetune the macrophage gene expression.", "doi": "10.1016/j.ejcb.2023.151311", "pmid": "36963245", "labels": [], "xrefs": [{"db": "pii", "key": "S0171-9335(23)00026-2"}], "notes": [], "created": "2026-08-20T07:54:28.986Z", "modified": "2026-08-20T07:54:29.035Z"}, {"entity": "publication", "iuid": "896e55c3b77a4b62bdb8d54ebdf55ae7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/896e55c3b77a4b62bdb8d54ebdf55ae7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/896e55c3b77a4b62bdb8d54ebdf55ae7"}}, "title": "Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility.", "authors": [{"family": "Zambarda", "given": "Chiara", "initials": "C"}, {"family": "P\u00e9rez Gonz\u00e1lez", "given": "Carlos", "initials": "C"}, {"family": "Schoenit", "given": "Andreas", "initials": "A"}, {"family": "Veits", "given": "Nisha", "initials": "N"}, {"family": "Schimmer", "given": "Clara", "initials": "C"}, {"family": "Jung", "given": "Raimund", "initials": "R"}, {"family": "Ollech", "given": "Dirk", "initials": "D"}, {"family": "Christian", "given": "Joel", "initials": "J"}, {"family": "Roca-Cusachs", "given": "Pere", "initials": "P"}, {"family": "Trepat", "given": "Xavier", "initials": "X"}, {"family": "Cavalcanti-Adam", "given": "Elisabetta Ada", "initials": "EA"}], "type": "journal article", "published": "2022-09-17", "journal": {"title": "Eur J Cell Biol", "issn": "1618-1298", "volume": "101", "issue": "4", "pages": "151274", "issn-l": null}, "abstract": "Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myosin machinery. In this study we present the effects of EGF on the contractility of epithelial cancer cell colonies in confined geometry of different sizes. We show that the extent to which EGF triggers contractility scales with the cluster size and thus the number of cells. Moreover, the collective contractility results in a radial distribution of traction forces, which are dependent on integrin \u03b21 peripheral adhesions and transmitted to neighboring cells through adherens junctions. Taken together, EGF-induced contractility acts on the mechanical crosstalk and linkage between the cell-cell and cell-matrix compartments, regulating collective responses.", "doi": "10.1016/j.ejcb.2022.151274", "pmid": "36152392", "labels": [], "xrefs": [{"db": "pii", "key": "S0171-9335(22)00077-2"}], "notes": [], "created": "2026-08-21T11:18:30.803Z", "modified": "2026-08-21T11:18:30.836Z"}], "created": "2026-08-20T07:54:28.995Z", "modified": "2026-08-20T07:54:28.995Z"}