{"entity": "journal", "iuid": "b551a310290041bda5663b20e666031e", "timestamp": "2026-09-03T05:14:40.218Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Environ%20Pollut.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Environ%20Pollut"}}, "title": "Environ Pollut", "issn": "1873-6424", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "a5477c45551748468dd6be833b0c1b68", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a5477c45551748468dd6be833b0c1b68.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a5477c45551748468dd6be833b0c1b68"}}, "title": "Inputs, amplification and sinks of perfluoroalkyl substances at coastal Antarctica.", "authors": [{"family": "Casas", "given": "Gemma", "initials": "G"}, {"family": "Iriarte", "given": "Jon", "initials": "J"}, {"family": "D'Agostino", "given": "Lisa A", "initials": "LA"}, {"family": "Roscales", "given": "Jose L", "initials": "JL"}, {"family": "Martinez-Varela", "given": "Alicia", "initials": "A"}, {"family": "Vila-Costa", "given": "Maria", "initials": "M"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW"}, {"family": "Jim\u00e9nez", "given": "Bego\u00f1a", "initials": "B"}, {"family": "Dachs", "given": "Jordi", "initials": "J"}], "type": "journal article", "published": "2023-12-01", "journal": {"title": "Environ Pollut", "issn": "1873-6424", "volume": "338", "pages": "122608", "issn-l": null}, "abstract": "The sources, biogeochemical controls and sinks of perfluoroalkyl substances, such as perfluoroalkyl acids (PFAAs), in polar coastal regions are largely unknown. These were evaluated by measuring a large multi-compartment dataset of PFAAs concentrations at coastal Livingston and Deception Islands (maritime Antarctica) during three austral summers. PFAAs were abundant in atmospheric-derived samples (aerosols, rain, snow), consistent with the importance of atmospheric deposition as an input of PFAAs to Antarctica. Such PFAAs deposition was unequivocally demonstrated by the occurrence of PFAAs in small Antarctic lakes. Several lines of evidence supported the relevant amplification of PFAAs concentrations in surface waters driven by snow scavenging of sea-spray aerosol-bound PFAAs followed by snow-melting. For example, vertical profiles showed higher PFAAs concentrations at lower-salinity surface seawaters, and PFAAs concentrations in snow were significantly higher than in seawater. The higher levels of PFAAs at Deception Island than at Livingston Island are consistent with the semi-enclosed nature of the bay. Concentrations of PFOS decreased from 2014 to 2018, consistent with observations in other oceans. The sink of PFAAs due to the biological pump, transfer to the food web, and losses due to sea-spray aerosols alone are unlikely to have driven the decrease in PFOS concentrations. An exploratory assessment of the potential sinks of PFAAs suggests that microbial degradation of perfluoroalkyl sulfonates should be a research priority for the evaluation of PFAAs persistence in the coming decade.", "doi": "10.1016/j.envpol.2023.122608", "pmid": "37742857", "labels": [], "xrefs": [{"db": "pii", "key": "S0269-7491(23)01610-X"}], "notes": [], "created": "2026-08-20T07:55:16.551Z", "modified": "2026-08-20T07:55:16.601Z"}, {"entity": "publication", "iuid": "532b42c661ad4f56b9a535dd0877a6cb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/532b42c661ad4f56b9a535dd0877a6cb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/532b42c661ad4f56b9a535dd0877a6cb"}}, "title": "Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice.", "authors": [{"family": "Li", "given": "Xueshu", "initials": "X"}, {"family": "Liu", "given": "Yanna", "initials": "Y"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW"}, {"family": "Cui", "given": "Julia Yue", "initials": "JY"}, {"family": "Lehmler", "given": "Hans-Joachim", "initials": "HJ"}], "type": "journal article", "published": "2021-01-01", "journal": {"title": "Environ Pollut", "issn": "1873-6424", "volume": "268", "issue": "Pt A", "pages": "115726", "issn-l": null}, "abstract": "Mammalian polychlorinated biphenyl (PCB) metabolism has not been systematically explored with nontarget high-resolution mass spectrometry (Nt-HRMS). Here we investigated the importance of the gut microbiome in PCB biotransformation by Nt-HRMS analysis of feces from conventional (CV) and germ-free (GF) adult female mice exposed to a single oral dose of an environmental PCB mixture (6 mg/kg or 30 mg/kg in corn oil). Feces were collected for 24 h after PCB administration, PCB metabolites were extracted from pooled samples, and the extracts were analyzed by Nt-HRMS. Twelve classes of PCB metabolites were detected in the feces from CV mice, including PCB sulfates, hydroxylated PCB sulfates (OH-PCB sulfates), PCB sulfonates, and hydroxylated methyl sulfone PCBs (OH-MeSO2-PCBs) reported previously. We also observed eight additional PCB metabolite classes that were tentatively identified as hydroxylated PCBs (OH-PCBs), dihydroxylated PCBs (DiOH-PCBs), monomethoxylated dihydroxylated PCBs (MeO-OH-PCBs), methoxylated PCB sulfates (MeO-PCB sulfates), mono-to tetra-hydroxylated PCB quinones ((OH)x-quinones, x = 1-4), and hydroxylated polychlorinated benzofurans (OH-PCDF). Most metabolite classes were also detected in the feces from GF mice, except for MeO-OH-PCBs, OH-MeSO2-PCBs, and OH-PCDFs. Semi-quantitative analyses demonstrate that relative PCB metabolite levels increased with increasing dose and were higher in CV than GF mice, except for PCB sulfates and MeO-PCB sulfates, which were higher in GF mice. These findings demonstrate that the gut microbiome plays a direct or indirect role in the absorption, distribution, metabolism, or excretion of PCB metabolites, which in turn may affect toxic outcomes following PCB exposure.", "doi": "10.1016/j.envpol.2020.115726", "pmid": "33032095", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1632913"}, {"db": "pmc", "key": "PMC7746632"}, {"db": "pii", "key": "S0269-7491(20)36415-0"}], "notes": [], "created": "2026-08-20T07:55:14.615Z", "modified": "2026-08-20T07:55:14.690Z"}], "created": "2026-08-20T07:55:14.644Z", "modified": "2026-08-20T07:55:14.644Z"}