{"entity": "journal", "iuid": "869f05f30b9845fba25dccab65f772cd", "timestamp": "2026-08-29T04:24:07.107Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Diabetes%20Metab%20Syndr%20Obes.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Diabetes%20Metab%20Syndr%20Obes"}}, "title": "Diabetes Metab Syndr Obes", "issn": "1178-7007", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "059298fda51f4bf8a5085c44eb095429", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/059298fda51f4bf8a5085c44eb095429.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/059298fda51f4bf8a5085c44eb095429"}}, "title": "Circulating Tissue Factor-Positive Procoagulant Microparticles in Patients with Type 1 Diabetes.", "authors": [{"family": "Zhang", "given": "Chenghui", "initials": "C"}, {"family": "Ou", "given": "Qing", "initials": "Q"}, {"family": "Gu", "given": "Yan", "initials": "Y"}, {"family": "Cheng", "given": "Gaiping", "initials": "G"}, {"family": "Du", "given": "Rong", "initials": "R"}, {"family": "Yuan", "given": "Li", "initials": "L"}, {"family": "Cordiner", "given": "Ruth Lm", "initials": "RL"}, {"family": "Kang", "given": "Deying", "initials": "D", "orcid": "0000-0003-1488-7047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33ee2f3d75e240d18315c940bff0de71.json"}}, {"family": "Zhang", "given": "Jiaying", "initials": "J"}, {"family": "Huang", "given": "Qiaorong", "initials": "Q"}, {"family": "Yu", "given": "Chuan", "initials": "C"}, {"family": "Kang", "given": "Li", "initials": "L"}, {"family": "Wang", "given": "Xuan", "initials": "X"}, {"family": "Sun", "given": "Xin", "initials": "X"}, {"family": "Mo", "given": "Xianming", "initials": "X"}, {"family": "Tian", "given": "Haoming", "initials": "H", "orcid": "0000-0002-1921-4733", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/165291dbf8a0444398664529be84c43e.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER"}, {"family": "Meng", "given": "Wentong", "initials": "W"}, {"family": "Li", "given": "Sheyu", "initials": "S", "orcid": "0000-0003-0060-0287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5dbca24cdca54d9299e3643ac2f75ae0.json"}}], "type": "journal article", "published": "2019-12-31", "journal": {"title": "Diabetes Metab Syndr Obes", "issn": "1178-7007", "volume": "12", "pages": "2819-2828", "issn-l": null}, "abstract": "To investigate the count of circulating tissue factor-positive (TF+) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM).\n\nThis case-control study included patients with T1DM and age and sex-matched healthy volunteers. The counts of phosphatidylserine-positive (PS+) MPs and TF+PS+MPs and the subgroups derived from different cell types were measured in the peripheral blood sample of the two groups using multicolor flow cytometric assay. We compared the counts of each MP between groups as well as the ratio of the TF+PS+MPs and PS+MPs (TF+PS+MPs/PS+MPs).\n\nWe recruited 36 patients with T1DM and 36 matched healthy controls. Compared with healthy volunteers, PS+MPs, TF+PS+MPs and TF+PS+MPs/PS+MPs were elevated in patients with T1DM (PS+MPs: 1078.5 \u00b1 158.08 vs 686.84 \u00b1 122.04/\u03bcL, P <0.001; TF+PS+MPs: 202.10 \u00b1 47.47 vs 108.33 \u00b1 29.42/\u03bcL, P <0.001; and TF+PS+MPs/PS+MPs: 0.16 \u00b1 0.04 vs 0.19 \u00b1 0.05, P = 0.004), mostly derived from platelet, lymphocytes and endothelial cells. In the subgroup analysis, the counts of total and platelet TF+PS+MPs were increased in patients with diabetic retinopathy (DR) and with higher HbA1c, respectively.\n\nCirculating TF+PS+MPs and those derived from platelet, lymphocytes and endothelial cells were elevated in patients with T1DM.", "doi": "10.2147/DMSO.S225761", "pmid": "32021345", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6978680"}, {"db": "pii", "key": "225761"}], "notes": [], "created": "2026-08-21T12:55:24.062Z", "modified": "2026-08-21T12:55:24.196Z"}], "created": "2026-08-21T12:55:24.161Z", "modified": "2026-08-21T12:55:24.161Z"}