{"entity": "journal", "iuid": "6c5e6f1a7c1740b6b173a0484b1060ca", "timestamp": "2026-03-10T03:44:34.242Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Curr.%20Genet..json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Curr.%20Genet."}}, "title": "Curr. Genet.", "issn": "1432-0983", "issn-l": "0172-8083", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "ac546a11ebbc480cbb0c27f3cf3d2c0b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ac546a11ebbc480cbb0c27f3cf3d2c0b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ac546a11ebbc480cbb0c27f3cf3d2c0b"}}, "title": "Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.", "authors": [{"family": "Maksimov", "given": "Vladimir", "initials": "V"}, {"family": "W\u00e4neskog", "given": "Marcus", "initials": "M"}, {"family": "Rodriguez", "given": "Alejandro", "initials": "A"}, {"family": "Bjerling", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2017-05-00", "journal": {"title": "Curr. Genet.", "issn": "1432-0983", "volume": "63", "issue": "2", "pages": "343-357", "issn-l": "0172-8083"}, "abstract": "The development of new drugs against the pathogenic yeast Candida albicans is compelling and the evolution of relevant bioassays is important to achieve this goal. Promising drug targets are proteins that lack human counterparts which are true for the His-to-Asp phosphorelay signal transduction systems, important for stress sensing in bacteria, fungi, and plants. In the pathogenic yeast, Candida albicans, the CaChk1 histidine kinase is a trigger of the pathway that leads to a switch from yeast to hyphal growth necessary for invasion. Intriguingly, the model yeast Schizosaccharomyces pombe has a similar phosphorelay system, with three histidine kinases named Mak1, Mak2, and Mak3, which are important for the prevention of aberrant mating and sporulation on rich media. This study uncovered distinct functions for the three histidine kinases; Mak1 alone or Mak2 and Mak3 together were sufficient for the repression of the meiotic cycle when nutrients were available. Moreover, strains lacking histidine kinase genes were sensitive to various types of stress conditions in an auxotrophic strain background, while the stress sensitivity was lost in prototrophic strains. Finally, the stress sensitivity of a S. pombe strain that lacks endogenous histidine kinases could be complemented by the ectopic expression of the CaChk1 histidine kinase from C. albicans. This finding opens up for the possibility to perform a drug screen with a biological read-out in S. pombe to find inhibitors of CaChk1.", "doi": "10.1007/s00294-016-0644-9", "pmid": "27613427", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00294-016-0644-9"}, {"db": "pmc", "key": "PMC5383687"}], "notes": [], "created": "2018-12-05T13:00:29.387Z", "modified": "2018-12-05T13:00:29.406Z"}, {"entity": "publication", "iuid": "8b85ca2973124492970ffe843c00792b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8b85ca2973124492970ffe843c00792b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8b85ca2973124492970ffe843c00792b"}}, "title": "Advancing our understanding of functional genome organisation through studies in the fission yeast.", "authors": [{"family": "Olsson", "given": "Ida", "initials": "I"}, {"family": "Bjerling", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2011-02-00", "journal": {"title": "Curr. Genet.", "issn": "1432-0983", "volume": "57", "issue": "1", "pages": "1-12", "issn-l": "0172-8083"}, "abstract": "Significant progress has been made in understanding the functional organisation of the cell nucleus. Still many questions remain to be answered about the relationship between the spatial organisation of the nucleus and the regulation of the genome function. There are many conflicting data in the field making it very difficult to merge published results on mammalian cells into one model on subnuclear chromatin organisation. The fission yeast, Schizosaccharomyces pombe, over the last decades has emerged as a valuable model organism in understanding basic biological mechanisms, especially the cell cycle and chromosome biology. In this review we describe and compare the nuclear organisation in mammalian and fission yeast cells. We believe that fission yeast is a good tool to resolve at least some of the contradictions and unanswered questions concerning functional nuclear architecture, since S. pombe has chromosomes structurally similar to that of human. S. pombe also has the advantage over higher eukaryotes in that the genome can easily be manipulated via homologous recombination making it possible to integrate the tools needed for visualisation of chromosomes using live-cell microscopy. Classical genetic experiments can be used to elucidate what factors are involved in a certain mechanism. The knowledge we have gained during the last few years indicates similarities between the genome organisation in fission yeast and mammalian cells. We therefore propose the use of fission yeast for further advancement of our understanding of functional nuclear organisation.", "doi": "10.1007/s00294-010-0327-x", "pmid": "21113595", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pmc", "key": "PMC3023017"}], "notes": [], "created": "2018-12-05T09:56:55.719Z", "modified": "2018-12-05T09:56:55.752Z"}], "created": "2018-12-05T09:56:55.733Z", "modified": "2020-11-27T13:12:53.673Z"}