{"entity": "journal", "iuid": "40aaf626627645da9ee61d94e2e0de5a", "timestamp": "2026-08-22T06:56:12.666Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Transl%20Sci.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Transl%20Sci"}}, "title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "c743b2a3a4ad40899df9fadab69453ce", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c743b2a3a4ad40899df9fadab69453ce.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c743b2a3a4ad40899df9fadab69453ce"}}, "title": "Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity.", "authors": [{"family": "Kvitne", "given": "Kine Eide", "initials": "KE", "orcid": "0000-0001-8118-7660", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2cc96a6df2d34cf7a41eb1fd7ba2887e.json"}}, {"family": "\u00c5sberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-0628-1769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/153c90f914b4461b8fa381a2e24a7954.json"}}, {"family": "Johnson", "given": "Line K", "initials": "LK"}, {"family": "Wegler", "given": "Christine", "initials": "C"}, {"family": "Hertel", "given": "Jens K", "initials": "JK"}, {"family": "Artursson", "given": "Per", "initials": "P", "orcid": "0000-0002-3708-7395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9908209a413a4088b6bf44a924d27319.json"}}, {"family": "Karlsson", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-4299-8775", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e8e4f9bc85a4912bc72bf0430c1360b.json"}}, {"family": "Andersson", "given": "Shalini", "initials": "S"}, {"family": "Sandbu", "given": "Rune", "initials": "R"}, {"family": "Skovlund", "given": "Eva", "initials": "E"}, {"family": "Christensen", "given": "Hege", "initials": "H"}, {"family": "Jansson-L\u00f6fmark", "given": "Rasmus", "initials": "R"}, {"family": "Hjelmesaeth", "given": "J\u00f8ran", "initials": "J"}, {"family": "Robertsen", "given": "Ida", "initials": "I"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "volume": "15", "issue": "11", "pages": "2685-2696", "issn-l": null}, "abstract": "Previous studies have not accounted for the close link between type 2 diabetes mellitus (T2DM) and obesity when investigating the impact of T2DM on cytochrome P450 (CYP) activities. The aim was to investigate the effect of T2DM on in vivo activities and protein expressions of CYP2C19, CYP3A, CYP1A2, and CYP2C9 in patients with obesity. A total of 99 patients from the COCKTAIL study (NCT02386917) were included in this cross-sectional analysis; 29 with T2DM and obesity (T2DM-obesity), 53 with obesity without T2DM (obesity), and 17 controls without T2DM and obesity (controls). CYP activities were assessed after the administration of a cocktail of probe drugs including omeprazole (CYP2C19), midazolam (CYP3A), caffeine (CYP1A2), and losartan (CYP2C9). Jejunal and liver biopsies were also obtained to determine protein concentrations of the respective CYPs. CYP2C19 activity and jejunal CYP2C19 concentration were 63% (-0.39 [95% CI: -0.82, -0.09]) and 40% (-0.09 fmol/\u03bcg protein [95% CI: -0.18, -0.003]) lower in T2DM-obesity compared with the obesity group, respectively. By contrast, there were no differences in the in vivo activities and protein concentrations of CYP3A, CYP1A2, and CYP2C9. Multivariable regression analyses also indicated that T2DM was associated with interindividual variability in CYP2C19 activity, but not CYP3A, CYP1A2, and CYP2C9 activities. The findings indicate that T2DM has a significant downregulating impact on CYP2C19 activity, but not on CYP3A, CYP1A2, and CYP2C9 activities and protein concentrations in patients with obesity. Hence, the effect of T2DM seems to be isoform-specific.", "doi": "10.1111/cts.13394", "pmid": "36037309", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9652437"}, {"db": "ClinicalTrials.gov", "key": "NCT02386917"}], "notes": [], "created": "2026-08-21T12:18:17.769Z", "modified": "2026-08-21T12:18:17.855Z"}, {"entity": "publication", "iuid": "014efc2260df424a9a16ea0a615d699e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/014efc2260df424a9a16ea0a615d699e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/014efc2260df424a9a16ea0a615d699e"}}, "title": "Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity - a non-randomized three-armed controlled trial.", "authors": [{"family": "Kvitne", "given": "Kine Eide", "initials": "KE"}, {"family": "Robertsen", "given": "Ida", "initials": "I"}, {"family": "Skovlund", "given": "Eva", "initials": "E"}, {"family": "Christensen", "given": "Hege", "initials": "H"}, {"family": "Krogstad", "given": "Veronica", "initials": "V"}, {"family": "Wegler", "given": "Christine", "initials": "C"}, {"family": "Angeles", "given": "Philip Carlo", "initials": "PC"}, {"family": "Wollmann", "given": "Birgit Malene", "initials": "BM"}, {"family": "Hole", "given": "Kristine", "initials": "K"}, {"family": "Johnson", "given": "Line Kristin", "initials": "LK"}, {"family": "Sandbu", "given": "Rune", "initials": "R"}, {"family": "Artursson", "given": "Per", "initials": "P"}, {"family": "Karlsson", "given": "Cecilia", "initials": "C"}, {"family": "Andersson", "given": "Shalini", "initials": "S"}, {"family": "Andersson", "given": "Tommy B", "initials": "TB"}, {"family": "Hjelmesaeth", "given": "J\u00f8ran", "initials": "J"}, {"family": "Jansson-L\u00f6fmark", "given": "Rasmus", "initials": "R"}, {"family": "\u00c5sberg", "given": "Anders", "initials": "A"}], "type": "comparative study", "published": "2022-01-00", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "volume": "15", "issue": "1", "pages": "221-233", "issn-l": null}, "abstract": "It remains uncertain whether pharmacokinetic changes following Roux-en-Y gastric bypass (RYGB) can be attributed to surgery-induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to compare short- and long-term effects of RYGB and calorie restriction on CYP3A-activity, and cross-sectionally compare CYP3A-activity with normal weight to overweight controls using midazolam as probe drug. This three-armed controlled trial included patients with severe obesity preparing for RYGB (n = 41) or diet-induced (n = 41) weight-loss, and controls (n = 18). Both weight-loss groups underwent a 3-week low-energy-diet (<1200 kcal/day) followed by a 6-week very-low-energy-diet or RYGB (both <800 kcal/day). Patients were followed for 2 years, with four pharmacokinetic investigations using semisimultaneous oral and intravenous dosing to determine changes in midazolam absolute bioavailability and clearance, within and between groups. The RYGB and diet groups showed similar weight-loss at week 9 (13 \u00b1 2.4% vs. 11 \u00b1 3.6%), but differed substantially after 2 years (-30 \u00b1 7.0% vs. -3.1 \u00b1 6.3%). At baseline, mean absolute bioavailability and clearance of midazolam were similar in the RYGB and diet groups, but higher compared with controls. On average, absolute bioavailability was unaltered at week 9, but decreased by 40 \u00b1 7.5% in the RYGB group and 32 \u00b1 6.1% in the diet group at year 2 compared with baseline, with no between-group difference. No difference in clearance was observed over time, nor between groups. In conclusion, neither RYGB per se nor weight loss impacted absolute bioavailability or clearance of midazolam short term. Long term, absolute bioavailability was similarly decreased in both groups despite different weight loss, suggesting that the recovered CYP3A-activity is not only dependent on weight-loss through RYGB.", "doi": "10.1111/cts.13142", "pmid": "34435745", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8742654"}], "notes": [], "created": "2026-08-21T12:18:15.867Z", "modified": "2026-08-21T12:18:15.912Z"}], "created": "2026-08-21T12:18:15.876Z", "modified": "2026-08-21T12:18:15.876Z"}