{"entity": "journal", "iuid": "627b0a4cf2ba4b8eb3bf5fc97e73eebd", "timestamp": "2026-09-23T16:02:13.562Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Transl%20Immunology.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Transl%20Immunology"}}, "title": "Clin Transl Immunology", "issn": "2050-0068", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "5252c6a3cd20412cbe6fc913478566fc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5252c6a3cd20412cbe6fc913478566fc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5252c6a3cd20412cbe6fc913478566fc"}}, "title": "Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity.", "authors": [{"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Granja", "given": "Diana", "initials": "D"}, {"family": "Snik", "given": "Marijn E", "initials": "ME"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Barros", "given": "Guilherme Wf", "initials": "GW"}, {"family": "Charles", "given": "Afandi", "initials": "A"}, {"family": "Lepzien", "given": "Rico", "initials": "R"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Holmes", "given": "Tyson H", "initials": "TH"}, {"family": "Maecker", "given": "Holden", "initials": "H"}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2025-03-03", "journal": {"title": "Clin Transl Immunology", "issn": "2050-0068", "volume": "14", "issue": "3", "pages": "e70026", "issn-l": null}, "abstract": "Monocytes and dendritic cells (DCs) are essential players in the immune response to infections, involved in shaping innate and adaptive immunity. However, a complete understanding of their specific roles in respiratory infections, including SARS-CoV-2, remains elusive.\n\nTo investigate the dynamics of monocytes and DCs in blood as well as the upper and lower airways, we sampled 147 patients with varying degree of COVID-19 severity longitudinally during the spring of 2020.\n\nUsing flow cytometry, proteomics and in vitro TLR stimulation, we found differences in the distribution and function of monocytes and DCs in patients compared with controls, and importantly, reduced levels of DCs in both blood and airways. In fact, lower frequencies of cDC2s (Lin- HLA-DR+ CD1c+) early after symptom onset predicted subsequent severe disease, and depletion of DC subsets lasted longer in patients with more severe disease. In contrast, severe COVID-19 was associated with increased frequencies of activated monocytes in the lower, but not the upper, airways. Proteomic analysis showed that monocyte and DC-related cytokines in plasma and airways associated with disease severity. During convalescence, cell frequencies and responses to TLR ligands normalised in blood, except for persistently low plasmacytoid DCs.\n\nOur study reveals a distinct pattern of recruitment of monocytes but not DCs to the airways during severe COVID-19. Instead, decreased levels of DCs in both blood and airways were found, possibly contributing to more severe COVID-19. The connection between low blood DCs early in disease course and more severe outcomes provides insight into COVID-19 immunopathology, with possible therapeutic implications.", "doi": "10.1002/cti2.70026", "pmid": "40041475", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11873541"}, {"db": "pii", "key": "CTI270026"}], "notes": [], "created": "2026-09-23T12:32:18.094Z", "modified": "2026-09-23T12:32:18.127Z"}, {"entity": "publication", "iuid": "ad98c9e675ed454889c5113c7ea16838", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ad98c9e675ed454889c5113c7ea16838.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ad98c9e675ed454889c5113c7ea16838"}}, "title": "Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb7ddbd0be2d4dca9249f55081fb86b3.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a1bdfd8500c4dbea343132bc0d8e44c.json"}}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2022-04-18", "journal": {"title": "Clin Transl Immunology", "issn": "2050-0068", "volume": "11", "issue": "4", "pages": "e1388", "issn-l": null}, "abstract": "To determine the long-term impact of prior SARS-CoV-2 infection on immune responses after COVID-19 vaccination.\n\nUsing longitudinally collected blood samples from the COMMUNITY study, we determined binding (WHO BAU mL-1) and neutralising antibody titres against ten SARS-CoV-2 variants over 7 months following BNT162b2 in SARS-CoV-2-recovered (n = 118) and SARS-CoV-2-na\u00efve (n = 289) healthcare workers with confirmed prior SARS-CoV-2 infection. A smaller group with (n = 47) and without (n = 60) confirmed prior SARS-CoV-2 infection receiving ChAdOx1 nCoV-19 was followed for 3 months. SARS-CoV-2-specific memory T-cell responses were investigated in a subset of SARS-CoV-2-na\u00efve and SARS-CoV-2-recovered vaccinees.\n\nVaccination with both vaccine platforms resulted in substantially enhanced T-cell responses, anti-spike IgG responses and neutralising antibodies effective against ten SARS-CoV-2 variants in SARS-CoV-2-recovered participants as compared to SARS-CoV-2-na\u00efve participants. The enhanced immune responses sustained over 7 months following vaccination.\n\nThese findings imply that prior SARS-CoV-2 infection should be taken into consideration when planning booster doses and design of current and future COVID-19 vaccine programmes.", "doi": "10.1002/cti2.1388", "pmid": "35444806", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9015077"}, {"db": "pii", "key": "CTI21388"}], "notes": [], "created": "2026-09-23T10:12:30.912Z", "modified": "2026-09-23T10:50:53.860Z"}, {"entity": "publication", "iuid": "cfdb134add814f3dbc9b0b9222cf1337", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cfdb134add814f3dbc9b0b9222cf1337.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cfdb134add814f3dbc9b0b9222cf1337"}}, "title": "Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "authors": [{"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a1bdfd8500c4dbea343132bc0d8e44c.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3eae6b2da5f4460b86e96614adf47e76.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36e1c0cae02d4307be2b4bae725d122d.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R", "orcid": "0000-0003-1363-5796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d78ebc1fe5f140dd8a8011d8f7f4d05c.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c4a7070f339466690b40d63ad6ea769.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Kanje", "given": "Sara", "initials": "S"}, {"family": "Berling", "given": "Anna", "initials": "A"}, {"family": "Svensson", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Jensen", "given": "Gabriella", "initials": "G"}, {"family": "Enstedt", "given": "Henric", "initials": "H"}, {"family": "Afshari", "given": "Delaram", "initials": "D"}, {"family": "Xu", "given": "Lan Lan", "initials": "LL"}, {"family": "Zwahlen", "given": "Martin", "initials": "M"}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Lendel", "given": "Christofer", "initials": "C"}, {"family": "Roth", "given": "Robert G", "initials": "RG"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "Da Silva Rodrigues", "given": "Rui", "initials": "R"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb7ddbd0be2d4dca9249f55081fb86b3.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/584e7e091c0f41259bf2d98cdf713a91.json"}}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b9de19b82b4406d8904cb937a466e8b.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1533d567ad31481fae15627d3b316382.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M", "orcid": "0000-0003-0140-419X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e979c6ac95bb4dfe9319bcde53fd6cf7.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Clin Transl Immunology", "issn": "2050-0068", "volume": "10", "issue": "7", "pages": "e1312", "issn-l": null}, "abstract": "The COVID-19 pandemic poses an immense need for accurate, sensitive and high-throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present the development and validation of a high-throughput multiplex bead-based serological assay.\n\nMore than 100 representations of SARS-CoV-2 proteins were included for initial evaluation, including antigens produced in bacterial and mammalian hosts as well as synthetic peptides. The five best-performing antigens, three representing the spike glycoprotein and two representing the nucleocapsid protein, were further evaluated for detection of IgG antibodies in samples from 331 COVID-19 patients and convalescents, and in 2090 negative controls sampled before 2020.\n\nThree antigens were finally selected, represented by a soluble trimeric form and the S1-domain of the spike glycoprotein as well as by the C-terminal domain of the nucleocapsid. The sensitivity for these three antigens individually was found to be 99.7%, 99.1% and 99.7%, and the specificity was found to be 98.1%, 98.7% and 95.7%. The best assay performance was although achieved when utilising two antigens in combination, enabling a sensitivity of up to 99.7% combined with a specificity of 100%. Requiring any two of the three antigens resulted in a sensitivity of 99.7% and a specificity of 99.4%.\n\nThese observations demonstrate that a serological test based on a combination of several SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "doi": "10.1002/cti2.1312", "pmid": "34295471", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8288725"}, {"db": "pii", "key": "CTI21312"}], "notes": [], "created": "2026-09-23T09:50:56.457Z", "modified": "2026-09-23T10:24:57.937Z"}], "created": "2026-09-23T09:50:56.597Z", "modified": "2026-09-23T09:50:56.597Z"}