{"entity": "journal", "iuid": "220af1a5c41a4589ae9ef81a31b4ddb8", "timestamp": "2026-08-23T09:24:45.479Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Nutr.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Nutr"}}, "title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "14a3005a3b8b44948fb8d882e363b7d0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/14a3005a3b8b44948fb8d882e363b7d0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/14a3005a3b8b44948fb8d882e363b7d0"}}, "title": "Ultra-processed food consumption, plasma metabolite profile, and risk of all-cause and cause-specific mortality in a population-based cohort.", "authors": [{"family": "Du", "given": "Yufeng", "initials": "Y"}, {"family": "Zhang", "given": "Shunming", "initials": "S"}, {"family": "Schj\u00f8lberg", "given": "Johanne Sl\u00f8rdal", "initials": "JS"}, {"family": "Hadden", "given": "Deja", "initials": "D"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Qi", "given": "Lu", "initials": "L"}, {"family": "Sonestedt", "given": "Emily", "initials": "E"}, {"family": "Born\u00e9", "given": "Yan", "initials": "Y"}], "type": "journal article", "published": "2024-12-00", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "volume": "43", "issue": "12", "pages": "184-193", "issn-l": null}, "abstract": "Epidemiological evidence on ultra-processed food (UPF) and cause-specific mortality remains limited and mixed. Molecular mechanisms underlying UPF intake and mortality remain unexplored. This study aimed to evaluate the associations between UPF consumption, metabolic signatures, and all-cause, premature, and cause-specific mortality.\n\nThis study included 27670 participants (mean age 58.1 years) from the Malm\u00f6 Diet and Cancer (MDC) cohort study. Consumption of UPF was assessed using a food frequency questionnaire and a 7-day food diary. In a subset of the MDC (n = 879), the associations of UPF with 991 plasma metabolites were investigated. An elastic net regression model was used to establish the metabolic signature of UPF. Cox proportional hazards regression model was used to determine the association between UPF intake, metabolic signature, and mortality risk.\n\nDuring a median follow-up of 23.3 years, a total of 11333 participants died. UPF intake showed a nonlinear positive association with all-cause mortality, with more pronounced associations found in females (Pinteraction = 0.044); in females, UPF was linked to a higher mortality risk in a linear manner, while the association was J-shaped in males. Each standard deviation (SD) increment in UPF intake was associated with an increased risk of premature mortality (HR, 1.06; 95 % CI, 1.03-1.09), cardiovascular disease (CVD) mortality (HR, 1.05; 95 % CI, 1.01-1.08) or respiratory disease mortality (HR, 1.08; 95 % CI, 1.01-1.15), but not cancer mortality. The metabolic signature for UPF consumption (with 93 metabolites) was positively associated with all-cause mortality risk (HR per 1 SD, 1.23; 95 % CI, 1.06-1.42).\n\nOur results suggest that higher UPF intake is associated with increased risk of all-cause, premature, CVD, and respiratory disease mortality, with the association varying across sex for all-cause mortality. The plasma metabolic signature of UPF showed a positive association with all-cause mortality.", "doi": "10.1016/j.clnu.2024.10.023", "pmid": "39471546", "labels": [], "xrefs": [{"db": "pii", "key": "S0261-5614(24)00380-7"}], "notes": [], "created": "2026-08-21T11:16:47.873Z", "modified": "2026-08-21T11:16:47.936Z"}, {"entity": "publication", "iuid": "61cf9ddcdb88426a9ef3eb84087e1868", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/61cf9ddcdb88426a9ef3eb84087e1868.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/61cf9ddcdb88426a9ef3eb84087e1868"}}, "title": "Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants.", "authors": [{"family": "Klevebro", "given": "Susanna", "initials": "S"}, {"family": "Kebede Merid", "given": "Simon", "initials": "S"}, {"family": "Sj\u00f6bom", "given": "Ulrika", "initials": "U"}, {"family": "Zhong", "given": "Wen", "initials": "W"}, {"family": "Danielsson", "given": "Hanna", "initials": "H"}, {"family": "Wackernagel", "given": "Dirk", "initials": "D"}, {"family": "Hansen-Pupp", "given": "Ingrid", "initials": "I"}, {"family": "Ley", "given": "David", "initials": "D"}, {"family": "S\u00e4vman", "given": "Karin", "initials": "K"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Smith", "given": "Lois E H", "initials": "LEH"}, {"family": "Hellstr\u00f6m", "given": "Ann", "initials": "A"}, {"family": "Nilsson", "given": "Anders K", "initials": "AK"}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "volume": "43", "issue": "5", "pages": "1162-1170", "issn-l": null}, "abstract": "Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and inflammation-related proteins during the neonatal period in extremely preterm infants.\n\nA retrospective exploratory study of infants (n = 183) born below 28 weeks gestation from the Mega Donna Mega trial, a randomized multicenter trial designed to study the effect of DHA and AA on retinopathy of prematurity. Serial serum samples were collected after birth until postnatal day 100 (median 7 samples per infant) and analyzed for phospholipid fatty acids and proteins using targeted proteomics covering 538 proteins. Associations over time between LCPUFAs and proteins were explored using mixed effect modeling with splines, including an interaction term for time, and adjusted for gestational age, sex, and center.\n\nOn postnatal day one, 55 proteins correlated with DHA levels and 10 proteins with AA levels. Five proteins were related to both fatty acids, all with a positive correlation. Over the first 100 days after birth, we identified 57 proteins to be associated with DHA and/or AA. Of these proteins, 41 (72%) related to inflammation. Thirty-eight proteins were associated with both fatty acids and the overall direction of association did not differ between DHA and AA, indicating that both LCPUFAs similarly contribute to up- and down-regulation of the preterm neonate inflammatory proteome. Primary examples of this were the inflammation-modulating cytokines IL-6 and CCL7, both being negatively related to levels of DHA and AA in the postnatal period.\n\nThis study supports postnatal non-antagonistic and potentially synergistic effects of DHA and AA on the inflammation proteome in preterm infants, indicating that supplementation with both fatty acids may contribute to limiting the disease burden in this vulnerable population.\n\nClinicalTrials.gov (NCT03201588).", "doi": "10.1016/j.clnu.2024.03.031", "pmid": "38603973", "labels": [], "xrefs": [{"db": "pii", "key": "S0261-5614(24)00105-5"}, {"db": "ClinicalTrials.gov", "key": "NCT03201588"}], "notes": [], "created": "2026-08-20T07:52:41.372Z", "modified": "2026-08-20T07:52:41.415Z"}], "created": "2026-08-20T07:52:41.381Z", "modified": "2026-08-20T07:52:41.381Z"}