{"entity": "journal", "iuid": "3a6c3dc559094b04bccfd7b67d56ad2d", "timestamp": "2026-08-26T22:46:29.623Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Neuropathol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Clin%20Neuropathol"}}, "title": "Clin Neuropathol", "issn": "0722-5091", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "98b8f6801a8c4d929760e4ecb5209eb3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/98b8f6801a8c4d929760e4ecb5209eb3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/98b8f6801a8c4d929760e4ecb5209eb3"}}, "title": "Expression of the stem cell marker CD133 in malignant meningioma.", "authors": [{"family": "Maier", "given": "Andrea D", "initials": "AD"}, {"family": "Mirian", "given": "Christian", "initials": "C"}, {"family": "Bartek", "given": "Jiri", "initials": "J"}, {"family": "Juhler", "given": "Marianne", "initials": "M"}, {"family": "Bartkova", "given": "Jirina", "initials": "J"}, {"family": "Broholm", "given": "Helle", "initials": "H"}, {"family": "Mathiesen", "given": "Tiit I", "initials": "TI"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Clin Neuropathol", "issn": "0722-5091", "volume": "40", "issue": "3", "pages": "151-159", "issn-l": null}, "abstract": "The stem cell marker CD133 has been sporadically investigated in meningioma, but because of the rarity of malignant meningioma (WHO grade III), only 7 malignant meningioma specimens have been included in previous studies. We investigated CD133 expression using the AC133 antibody clone in a consecutive cohort of 38 malignant meningiomas. Our results showed few, small CD133-positive hot spots with a pattern dominated by membranous staining and capping of the proteins without any nuclear CD133 staining in 30 of the 38 tumors. We could not corroborate spatial co-expression of hot spots with the proliferative marker, Ki-67, and CD133 hot spots in adjacent slides, nor did we find differences between Ki-67 expression in CD133-negative and -positive tumor specimens (Fisher's exact test: p = 0.69). CD13-positive niches represented only 0 - 1% of meningioma cells in most of the malignant meningioma, while CD133-positive cells were undetectable in 21% of the whole-section tumor samples. We found stem cell niches in 79% of malignant meningioma specimens in our cohort.", "doi": "10.5414/NP301327", "pmid": "33250074", "labels": [], "xrefs": [{"db": "pii", "key": "187477"}], "notes": [], "created": "2026-08-21T13:07:04.951Z", "modified": "2026-08-21T13:07:04.994Z"}], "created": "2026-08-21T13:07:04.959Z", "modified": "2026-08-21T13:07:04.959Z"}