{"entity": "journal", "iuid": "56f6dc8f283f49c199d8c4a23958aa4a", "timestamp": "2026-08-15T13:20:10.170Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Chemistry.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Chemistry"}}, "title": "Chemistry", "issn": "1521-3765", "issn-l": "0947-6539", "publications_count": 5, "publications": [{"entity": "publication", "iuid": "e8165ae547874c139610c5b67f09f6b2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e8165ae547874c139610c5b67f09f6b2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e8165ae547874c139610c5b67f09f6b2"}}, "title": "Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.", "authors": [{"family": "Nainyt\u0117", "given": "Milda", "initials": "M"}, {"family": "M\u00fcller", "given": "Felix", "initials": "F"}, {"family": "Ganazzoli", "given": "Giacomo", "initials": "G"}, {"family": "Chan", "given": "Chun-Yin", "initials": "CY"}, {"family": "Crisp", "given": "Antony", "initials": "A"}, {"family": "Globisch", "given": "Daniel", "initials": "D"}, {"family": "Carell", "given": "Thomas", "initials": "T", "orcid": "0000-0001-7898-2831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf14453af8b5496dbf332d290df0d50f.json"}}], "type": "journal article", "published": "2020-11-20", "journal": {"title": "Chemistry", "issn": "1521-3765", "issn-l": "0947-6539", "volume": "26", "issue": "65", "pages": "14856-14860"}, "abstract": "Fossils of extinct species allow us to reconstruct the process of Darwinian evolution that led to the species diversity we see on Earth today. The origin of the first functional molecules able to undergo molecular evolution and thus eventually able to create life, are largely unknown. The most prominent idea in the field posits that biology was preceded by an era of molecular evolution, in which RNA molecules encoded information and catalysed their own replication. This RNA world concept stands against other hypotheses, that argue for example that life may have begun with catalytic peptides and primitive metabolic cycles. The question whether RNA or peptides were first is addressed by the RNA-peptide world concept, which postulates a parallel existence of both molecular species. A plausible experimental model of how such an RNA-peptide world may have looked like, however, is absent. Here we report the synthesis and physicochemical evaluation of amino acid containing adenosine bases, which are closely related to molecules that are found today in the anticodon stem-loop of tRNAs from all three kingdoms of life. We show that these adenosines lose their base pairing properties, which allow them to equip RNA with amino acids independent of the sequence context. As such we may consider them to be living molecular fossils of an extinct molecular RNA-peptide world.", "doi": "10.1002/chem.202002929", "pmid": "32573861", "labels": {"Daniel Globisch": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC7756884"}], "notes": [], "created": "2020-12-09T09:34:46.948Z", "modified": "2022-11-04T11:32:14.078Z"}, {"entity": "publication", "iuid": "2d04d1ae294949dd9f566326803d033a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2d04d1ae294949dd9f566326803d033a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2d04d1ae294949dd9f566326803d033a"}}, "title": "Synthesis of Galactosylated Glycosylphosphatidylinositol Derivatives from Trypanosoma brucei.", "authors": [{"family": "Grube", "given": "Maurice", "initials": "M"}, {"family": "Lee", "given": "Bo-Young", "initials": "BY"}, {"family": "Garg", "given": "Monika", "initials": "M"}, {"family": "Michel", "given": "Dana", "initials": "D"}, {"family": "Vilotijevi\u0107", "given": "Ivan", "initials": "I"}, {"family": "Malik", "given": "Ankita", "initials": "A"}, {"family": "Seeberger", "given": "Peter H", "initials": "PH"}, {"family": "Var\u00f3n Silva", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2018-03-02", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "24", "issue": "13", "pages": "3271-3282", "issn-l": "0947-6539"}, "abstract": "Trypanosoma brucei uses variant surface glycoproteins (VSGs) to evade the host immune system and ensure parasitic longevity in animals and humans. VSGs are attached to the cell membrane by complex glycosylphosphatidylinositol anchors (GPI). Distinguishing structural feature of VSG GPIs are multiple \u03b1- and \u03b2-galactosides attached to the conserved GPI core structure. T. brucei GPIs have been associated with macrophage activation and alleviation of parasitemia during infection, acting as disease onset delaying antigens. Literature reports that link structural modifications in the GPIs to changes in biological activity are contradictory. We have established a synthetic route to prepare structurally overlapping GPI derivatives bearing different T. brucei characteristic structural modifications. The GPI collection will be used to assess the effect of galactosylation and phosphorylation on T. brucei GPI immunomodulatory activity, and to perform an epitope mapping of this complex glycolipid as potential diagnostic marker for Trypanosomiasis. A strategy for the synthesis of a complete \u03b1-tetragalactoside using the 2-naphthylmethyl protecting group and for subsequent attachment of GPI fragments to peptides is presented.", "doi": "10.1002/chem.201705511", "pmid": "29314341", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T12:47:10.658Z", "modified": "2018-12-05T12:47:10.676Z"}, {"entity": "publication", "iuid": "db9e01ef91b8422687d4dd1af97f2c2b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/db9e01ef91b8422687d4dd1af97f2c2b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/db9e01ef91b8422687d4dd1af97f2c2b"}}, "title": "Furan- and Thiophene-Based Auxochromes Red-shift Chlorin Absorptions and Enable Oxidative Chlorin Polymerizations.", "authors": [{"family": "Xiong", "given": "Ruisheng", "initials": "R"}, {"family": "Bornhof", "given": "Anna-Bea", "initials": "AB"}, {"family": "Arkhypchuk", "given": "Anna I", "initials": "AI"}, {"family": "Orthaber", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5403-9902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552c92ecc3354480857f4b2dea4e4c7f.json"}}, {"family": "Borbas", "given": "K Eszter", "initials": "KE", "orcid": "0000-0003-2449-102X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/333ff8a07b9849198a618b9be6e77449.json"}}], "type": "journal article", "published": "2017-03-23", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "23", "issue": "17", "pages": "4089-4095", "issn-l": "0947-6539"}, "abstract": "The de novo syntheses of chemically stable chlorins with five-membered heterocyclic (furane, thiophene, formylfurane and formylthiophene) substituents in selected meso- and \u03b2-positions are reported. Heterocycle incorporation in the 3- and 13-positions shifted the chlorin absorption and emission to the red (up to \u03bbem =680 nm), thus these readily incorporated substituents function analogously to auxochromes present in chlorophylls, for example, formyl and vinyl groups. Photophysical, theoretical and X-ray crystallographic experiments revealed small but significant differences between the behavior of the furan- and the thiophene-based auxochromes. Four regioisomeric bis-thienylchlorins (3,10; 3,13, 3,15 and 10,15) were oxidatively electropolymerized; the chlorin monomer geometry had a profound impact on the polymerization efficiency and the electrochemical properties of the resulting material. Chemical co-polymerization of 3,13-bis-thienylchlorin with 3-hexylthiophene yielded an organic-soluble red-emitting polymer.", "doi": "10.1002/chem.201604655", "pmid": "27859811", "labels": {"Ruisheng Xiong": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5396321"}], "notes": [], "created": "2025-11-27T17:36:43.796Z", "modified": "2025-11-27T17:36:43.821Z"}, {"entity": "publication", "iuid": "fba6ce21356d4808877d430d61ca775f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fba6ce21356d4808877d430d61ca775f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fba6ce21356d4808877d430d61ca775f"}}, "title": "Rapid and Efficient Conversion of (11) CO2 to (11) CO through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations.", "authors": [{"family": "Nordeman", "given": "Patrik", "initials": "P"}, {"family": "Friis", "given": "Stig D", "initials": "SD"}, {"family": "Andersen", "given": "Thomas L", "initials": "TL"}, {"family": "Audrain", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Larhed", "given": "Mats", "initials": "M"}, {"family": "Skrydstrup", "given": "Troels", "initials": "T"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2015-12-01", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "21", "issue": "49", "pages": "17601-17604", "issn-l": "0947-6539"}, "abstract": "Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (11) CO2 to (11) CO and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (11) CO. With this fast and near-quantitative conversion of (11) CO2 into (11) CO, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84\u2009%. ", "doi": "10.1002/chem.201503262", "pmid": "26492852", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T09:58:18.684Z", "modified": "2018-12-05T09:58:18.716Z"}, {"entity": "publication", "iuid": "0ef2e94591644d06bb5af86bfd7e346e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0ef2e94591644d06bb5af86bfd7e346e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0ef2e94591644d06bb5af86bfd7e346e"}}, "title": "Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.", "authors": [{"family": "Llona-Minguez", "given": "Sabin", "initials": "S"}, {"family": "Desroses", "given": "Matthieu", "initials": "M"}, {"family": "Ghassemian", "given": "Artin", "initials": "A"}, {"family": "Jacques", "given": "Sylvain A", "initials": "SA"}, {"family": "Eriksson", "given": "Lars", "initials": "L"}, {"family": "Isacksson", "given": "Rebecka", "initials": "R"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Scobie", "given": "Martin", "initials": "M"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2015-05-11", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "21", "issue": "20", "pages": "7394-7398", "issn-l": "0947-6539"}, "abstract": "A two-step synthesis of structurally diverse pyrrole-containing bicyclic systems is reported. ortho-Nitro-haloarenes coupled with vinylic N-methyliminodiacetic acid (MIDA) boronates generate ortho-vinyl-nitroarenes, which undergo a \"metal-free\" nitrene insertion, resulting in a new pyrrole ring. This novel synthetic approach has a wide substrate tolerance and it is applicable in the preparation of more complex \"drug-like\" molecules. Interestingly, an ortho-nitro-allylarene derivative furnished a cyclic \u03b2-aminophosphonate motif. ", "doi": "10.1002/chem.201406549", "pmid": "25809883", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T11:01:09.514Z", "modified": "2018-12-05T11:01:09.533Z"}], "created": "2018-12-05T09:58:18.697Z", "modified": "2020-11-27T13:12:54.788Z"}