{"entity": "journal", "iuid": "f71ed988caf74c5cb94d267acfeae5b6", "timestamp": "2026-08-23T09:24:47.534Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Cell%20Immunol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Cell%20Immunol"}}, "title": "Cell Immunol", "issn": "1090-2163", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "2db21953ea5147d6844d0ad4772bc8fb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2db21953ea5147d6844d0ad4772bc8fb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2db21953ea5147d6844d0ad4772bc8fb"}}, "title": "MALT1 inhibition suppresses antigen-specific T cell responses.", "authors": [{"family": "Kerzeli", "given": "Iliana K", "initials": "IK"}, {"family": "Nasi", "given": "Aikaterini", "initials": "A"}, {"family": "Fletcher", "given": "Erika", "initials": "E"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Kallin", "given": "Anders", "initials": "A"}, {"family": "Finnberg", "given": "Niklas", "initials": "N"}, {"family": "Ersmark", "given": "Karolina", "initials": "K"}, {"family": "Lampinen", "given": "Maria", "initials": "M"}, {"family": "Albertella", "given": "Mark", "initials": "M"}, {"family": "\u00d6berg", "given": "Fredrik", "initials": "F"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}], "type": "journal article", "published": "2024-02-24", "journal": {"title": "Cell Immunol", "issn": "1090-2163", "volume": "397-398", "pages": "104814", "issn-l": null}, "abstract": "The aim of this study was to assess the potential use of a selective small molecule MALT1 inhibitor in solid tumor treatment as an immunotherapy targeting regulatory T-cells (Tregs). In vitro, MALT1 inhibition suppressed the proteolytic cleavage of the MALT1-substrate HOIL1 and blocked IL-2 secretion in Jurkat cells. It selectively suppressed the proliferation of PBMC-derived Tregs, with no effect on conventional CD4+T-cells. In vivo, however, no evident anti-tumor effect was achieved by MALT1 inhibition monotherapy or in combination with anti-CTLA4 in the MB49 cancer model. Despite decreased Treg-frequencies in lymph nodes of tumor-bearing animals, intratumoral Treg depletion was not observed. We also showed that MALT1-inhibition caused a reduction of antigen-specific CD8+T-cells in an adoptive T-cell transfer model. Thus, selective targeting of Tregs would be required to improve the immunotherapeutic effect of MALT1-inhibition. Also, various dosing schedules and combination therapy strategies should be carefully designed and evaluated further.", "doi": "10.1016/j.cellimm.2024.104814", "pmid": "38422979", "labels": [], "xrefs": [{"db": "pii", "key": "S0008-8749(24)00017-0"}], "notes": [], "created": "2026-08-20T06:50:50.523Z", "modified": "2026-08-20T06:50:50.571Z"}, {"entity": "publication", "iuid": "edcebf31995e48529194baa0be4a8775", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/edcebf31995e48529194baa0be4a8775.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/edcebf31995e48529194baa0be4a8775"}}, "title": "Promoter anchored interaction landscape of THP-1 macrophages captures early immune response processes.", "authors": [{"family": "Pradhananga", "given": "Sailendra", "initials": "S"}, {"family": "Spalinskas", "given": "Rapolas", "initials": "R"}, {"family": "Poujade", "given": "Flore-Anne", "initials": "FA"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Sahl\u00e9n", "given": "Pelin", "initials": "P"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cell Immunol", "issn": "1090-2163", "volume": "355", "pages": "104148", "issn-l": null}, "abstract": "Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulated THP-1 macrophages (0 and 2 h) using capture Hi-C. Success of LPS stimulation was validated with transcriptome sequencing. Circa 2900 genes changed their interaction profile upon LPS stimulation and those gaining interactions were enriched for LPS response relevant processes, suggesting a substantial role for distal regulation. Immune and cardiovascular risk variants were enriched within the interacting regions, thereby providing insights into macrophage biology.", "doi": "10.1016/j.cellimm.2020.104148", "pmid": "32592980", "labels": [], "xrefs": [{"db": "pii", "key": "S0008-8749(20)30308-7"}], "notes": [], "created": "2026-08-20T06:50:48.220Z", "modified": "2026-08-20T06:50:48.287Z"}, {"entity": "publication", "iuid": "57976f960cde45db8921d29a7aec9383", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/57976f960cde45db8921d29a7aec9383.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/57976f960cde45db8921d29a7aec9383"}}, "title": "V\u03b39V\u03b42 T cells proliferate in response to phosphoantigens released from erythrocytes infected with asexual and gametocyte stage Plasmodium falciparum.", "authors": [{"family": "Liu", "given": "Chenxiao", "initials": "C"}, {"family": "Emami", "given": "S Noushin", "initials": "SN"}, {"family": "Pettersson", "given": "Jean", "initials": "J"}, {"family": "Ranford-Cartwright", "given": "Lisa", "initials": "L"}, {"family": "Faye", "given": "Ingrid", "initials": "I"}, {"family": "Parmryd", "given": "Ingela", "initials": "I"}], "type": "journal article", "published": "2018-12-00", "journal": {"title": "Cell Immunol", "issn": "1090-2163", "volume": "334", "pages": "11-19", "issn-l": null}, "abstract": "V\u03b39V\u03b42 T cells, the dominant \u03b3\u03b4 T cell subset in human peripheral blood, are stimulated by phosphoantigens, of which (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate, is produced in the apicoplast of malaria parasites. Cell-free media from synchronised Plasmodium falciparum asexual ring, trophozoite, and schizont stage-cultures of high purity as well as media from ruptured schizont cultures, all stimulated V\u03b39V\u03b42 T cell proliferation, as did media from pure gametocyte cultures, whereas media from uninfected erythrocytes cultures did not. The media from ruptured schizont cultures and all the asexual and gametocyte stage cultures contained only background iron levels, suggesting that all erythrocyte haemoglobin is consumed as the parasites develop and supporting that the phosphoantigens were released from intact parasitized erythrocytes. The V\u03b39V\u03b42 T cell-stimulating agent was not affected by freezing, thawing or heating but was sensitive to phosphatase treatment, confirming its phosphoantigen identity. In summary, phosphoantigens are released from parasitised erythrocytes at all developmental blood stages.", "doi": "10.1016/j.cellimm.2018.08.012", "pmid": "30177348", "labels": [], "xrefs": [{"db": "pii", "key": "S0008-8749(18)30384-8"}], "notes": [], "created": "2026-08-21T11:15:23.930Z", "modified": "2026-08-21T11:15:23.959Z"}], "created": "2026-08-20T06:50:48.251Z", "modified": "2026-08-20T06:50:48.251Z"}