{"entity": "journal", "iuid": "0af3568e86e648fc9935cdcfe272e441", "timestamp": "2026-10-13T19:05:12.299Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Cardiovasc%20Res.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Cardiovasc%20Res"}}, "title": "Cardiovasc Res", "issn": "1755-3245", "issn-l": null, "publications_count": 5, "publications": [{"entity": "publication", "iuid": "f71bbf0f28b74406bc2d44dd11089059", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f71bbf0f28b74406bc2d44dd11089059.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f71bbf0f28b74406bc2d44dd11089059"}}, "title": "Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study-differences and similarities.", "authors": [{"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O", "orcid": "0000-0002-3474-2438", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4777b51cdf8e4993bebcb6e56a50d291.json"}}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Brandberg", "given": "John", "initials": "J"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Chorell", "given": "Elin", "initials": "E", "orcid": "0000-0002-8057-1684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55301da9c3f948b9bfb5bc27ed3bf0dd.json"}}, {"family": "Engvall", "given": "Jan Edvin", "initials": "JE"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5756c7fca760434da1fc7e001232eee3.json"}}, {"family": "Hjelmgren", "given": "Ola", "initials": "O"}, {"family": "Hultdin", "given": "Johan", "initials": "J"}, {"family": "Jernberg", "given": "Tomas", "initials": "T", "orcid": "0000-0003-1695-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a82eb1ecd69941878e6486de4bf601da.json"}}, {"family": "Kihlberg", "given": "Johan", "initials": "J"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Fredrik Hans", "initials": "FH"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dba446415bd84f97a7c9bb74afc27ae2.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}], "type": "journal article", "published": "2025-09-29", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "121", "issue": "11", "pages": "1649-1652", "issn-l": null}, "abstract": null, "doi": "10.1093/cvr/cvaf076", "pmid": "40327543", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12477672"}, {"db": "pii", "key": "8125826"}], "notes": [], "created": "2026-09-23T12:30:45.869Z", "modified": "2026-09-23T12:30:46.063Z"}, {"entity": "publication", "iuid": "28398ceab09e4657b8a3f15940a833cf", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/28398ceab09e4657b8a3f15940a833cf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/28398ceab09e4657b8a3f15940a833cf"}}, "title": "Low-fibre diet is associated with high-risk coronary plaque features.", "authors": [{"family": "Larsson", "given": "Ingrid", "initials": "I"}, {"family": "Sun", "given": "Jiangming", "initials": "J"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Carlh\u00e4ll", "given": "Carl-Johan", "initials": "CJ", "orcid": "0000-0003-2198-9690", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/925ac167bb13458797d53d1bb1326db9.json"}}, {"family": "Cederlund", "given": "Kerstin", "initials": "K"}, {"family": "Drake", "given": "Isabel", "initials": "I"}, {"family": "Engvall", "given": "Jan E", "initials": "JE"}, {"family": "Eriksson", "given": "Mats", "initials": "M"}, {"family": "Hagstr\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Jernberg", "given": "Tomas", "initials": "T", "orcid": "0000-0003-1695-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a82eb1ecd69941878e6486de4bf601da.json"}}, {"family": "Kero", "given": "Tanja", "initials": "T"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Mannila", "given": "Maria", "initials": "M"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Rawshani", "given": "Araz", "initials": "A", "orcid": "0000-0003-2066-3533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/988e64c7923844018a9c5fe01d8c6917.json"}}, {"family": "Ris\u00e9rus", "given": "Ulf", "initials": "U"}, {"family": "Rosengren", "given": "Annika", "initials": "A", "orcid": "0000-0002-5409-6605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d710fa95d7684cc1ba0ba44e62bfffbe.json"}}, {"family": "Ryberg", "given": "Mats", "initials": "M"}, {"family": "Schmidt", "given": "Caroline", "initials": "C"}, {"family": "Sonestedt", "given": "Emily", "initials": "E", "orcid": "0000-0002-0747-4562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2bc16f046654d34a114b6561ef2eb52.json"}}, {"family": "Wennberg", "given": "Maria", "initials": "M", "orcid": "0000-0002-1673-8494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b29bff7661c42059c477182333448e0.json"}}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Goncalves", "given": "Isabel", "initials": "I", "orcid": "0000-0002-2935-0181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0336863be78948cc937bb5df3af614b8.json"}}], "type": "journal article", "published": "2025-07-31", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "121", "issue": "8", "pages": "1204-1214", "issn-l": null}, "abstract": "Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features.\n\nThe cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited in 2013 to 2018 who were free of clinical cardiovascular disease. The recruitment and comprehensive examinations were conducted at six locations in Sweden. A dietary index (DI) based on a previously published anti-inflammatory DI including high proportion of plant-based foods, and low in red or processed meat and sugar-sweetened beverages was constructed. The reference group was within lowest DI tertile. Coronary atherosclerosis assessed by coronary computed tomography angiography, including any-, significant-, and adverse or high-risk coronary plaque, which is non-calcified with a significant stenosis \u226550%. Lowest, compared to highest DI tertile was associated with younger age, more often men (62.2% vs. 32.9%), higher high-sensitive C-reactive protein, more cardiometabolic risk and smokers, higher alcohol-, and higher energy-intake. In the highest and lowest tertile, coronary plaques were present in 36.3% and 44.3%, respectively, stenosis \u2265 50% in 3.7% and 6.0%. Non-calcified coronary plaques with stenosis \u226550% were present in 0.9% and 1.5% in highest and lowest tertiles. In multivariable analyses, the lowest tertile of DI was associated with high-risk plaque features after adjusting for age, sex, smoking, with waist circumference, triglycerides (TGs), and hypertension as possible mediators.\n\nA low-fibre diet with high red meat content was associated with high-risk plaques features, increased coronary calcification and significant stenosis. Waist circumference, TGs, and hypertension emerged as potential mediators of these associations, underscoring the role of metabolic and hemodynamic factors in the dietary impact on coronary atherosclerosis. Our findings strengthen the importance of cardioprotective dietary recommendations.", "doi": "10.1093/cvr/cvaf088", "pmid": "40518615", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12310279"}, {"db": "pii", "key": "8162637"}], "notes": [], "created": "2026-08-21T12:08:01.616Z", "modified": "2026-09-23T11:34:05.242Z"}, {"entity": "publication", "iuid": "78f53a4876a74b038c44ec7e3a77e9bc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/78f53a4876a74b038c44ec7e3a77e9bc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/78f53a4876a74b038c44ec7e3a77e9bc"}}, "title": "Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function.", "authors": [{"family": "Celik", "given": "Selvi", "initials": "S"}, {"family": "Hyrefelt", "given": "Ludvig", "initials": "L"}, {"family": "Czuba", "given": "Tomasz", "initials": "T"}, {"family": "Li", "given": "Yuan", "initials": "Y"}, {"family": "Assis", "given": "Juliana", "initials": "J", "orcid": "0000-0001-5995-8684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec1fa0ff229d4314b0f45dcc411c46b5.json"}}, {"family": "Martinez", "given": "Julia", "initials": "J"}, {"family": "Johansson", "given": "Markus", "initials": "M"}, {"family": "Andr\u00e9", "given": "Oscar", "initials": "O"}, {"family": "Synnergren", "given": "Jane", "initials": "J"}, {"family": "Sandstedt", "given": "Joakim", "initials": "J", "orcid": "0000-0002-6458-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38eb6a0b7f224fd1adad6eab5e6752c6.json"}}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}, {"family": "Vukusic", "given": "Kristina", "initials": "K"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Gidl\u00f6f", "given": "Olof", "initials": "O", "orcid": "0000-0002-7402-3139", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/211e326c75464ee7826b3dc7eba27ecf.json"}}], "type": "journal article", "published": "2025-05-06", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "121", "issue": "4", "pages": "629-642", "issn-l": null}, "abstract": "Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative splicing of the sense gene. The TTN gene locus harbours >80 natural antisense transcripts (NATs) with unknown function in the human heart. The aim of this study was to determine if TTN antisense transcripts play a role in alternative splicing of TTN.\n\nRNA-sequencing and RNA in situ hybridization (ISH) of cardiac tissue from heart failure (HF) patients, unused donor hearts, and human iPS-derived cardiomyocytes (iPS-CMs) were used to determine the expression and localization of TTN NATs. Live cell imaging was used to analyse the effect of NATs on sarcomere properties. RNA ISH and immunofluorescence was performed in iPS-CMs to study the interaction between NATs, TTN mRNA, and splice factor protein RBM20. We found that TTN-AS1-276 was the predominant TTN NAT in the human heart and that it was up-regulated in HF. Knockdown of TTN-AS1-276 in human iPS-CMs resulted in decreased interaction between RBM20 and TTN pre-mRNA, decreased TTN I-band exon skipping, and markedly lower expression of the less compliant TTN isoform N2B. The effect on TTN exon usage was independent of sense-antisense exon overlap and polymerase II elongation rate. Furthermore, knockdown resulted in longer sarcomeres with preserved alignment, improved fractional shortening, and relaxation times.\n\nWe demonstrate a role for TTN-AS1-276 in facilitating alternative splicing of TTN and regulating sarcomere properties. This transcript could constitute a target for improving cardiac passive stiffness and diastolic function in conditions such as heart failure with preserved ejection fraction.", "doi": "10.1093/cvr/cvaf037", "pmid": "40042822", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12054628"}, {"db": "pii", "key": "8052712"}], "notes": [], "created": "2026-09-23T11:34:59.476Z", "modified": "2026-09-23T11:34:59.530Z"}, {"entity": "publication", "iuid": "1ec4aea248e54794acb926703e7b5385", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1ec4aea248e54794acb926703e7b5385.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1ec4aea248e54794acb926703e7b5385"}}, "title": "Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function.", "authors": [{"family": "Laudette", "given": "Marion", "initials": "M"}, {"family": "Lindbom", "given": "Malin", "initials": "M"}, {"family": "Arif", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-2261-0881", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8ffc9889ace44e3b992816601b817e2.json"}}, {"family": "Cinato", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-8490-4335", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b2d3790356a446e85061a007b50bb28.json"}}, {"family": "Ruiz", "given": "Mario", "initials": "M"}, {"family": "Doran", "given": "Stephen", "initials": "S", "orcid": "0000-0002-9236-5407", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/836142c593f64f98a4c5a5ea20663485.json"}}, {"family": "Miljanovic", "given": "Azra", "initials": "A"}, {"family": "Rutberg", "given": "Mikael", "initials": "M"}, {"family": "Andersson", "given": "Linda", "initials": "L"}, {"family": "Klevstig", "given": "Martina", "initials": "M"}, {"family": "Henricsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-4202-0339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0fbd663456e4767acbfbe87f79a930b.json"}}, {"family": "Bergh", "given": "Per-Olof", "initials": "PO"}, {"family": "Bollano", "given": "Entela", "initials": "E"}, {"family": "Aung", "given": "Nay", "initials": "N", "orcid": "0000-0001-5095-1611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/741c9417ac1d451c8f6fcd4adfa7b78a.json"}}, {"family": "Gustav Smith", "given": "J", "initials": "J"}, {"family": "Pilon", "given": "Marc", "initials": "M"}, {"family": "Hy\u00f6tyl\u00e4inen", "given": "Tuulia", "initials": "T", "orcid": "0000-0002-1389-8302", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc08a199297b42afa85e07adc381a8f4.json"}}, {"family": "Ore\u0161i\u010d", "given": "Matej", "initials": "M"}, {"family": "Perkins", "given": "Rosie", "initials": "R"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Levin", "given": "Malin C", "initials": "MC"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J", "orcid": "0000-0003-0786-8091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73a770eb9e614448a046b8e9199052e9.json"}}], "type": "journal article", "published": "2023-07-04", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "119", "issue": "7", "pages": "1537-1552", "issn-l": null}, "abstract": "Pro-protein convertase subtilisin-kexin type 9 (PCSK9), which is expressed mainly in the liver and at low levels in the heart, regulates cholesterol levels by directing low-density lipoprotein receptors to degradation. Studies to determine the role of PCSK9 in the heart are complicated by the close link between cardiac function and systemic lipid metabolism. Here, we sought to elucidate the function of PCSK9 specifically in the heart by generating and analysing mice with cardiomyocyte-specific Pcsk9 deficiency (CM-Pcsk9-/- mice) and by silencing Pcsk9 acutely in a cell culture model of adult cardiomyocyte-like cells.\n\nMice with cardiomyocyte-specific deletion of Pcsk9 had reduced contractile capacity, impaired cardiac function, and left ventricular dilatation at 28 weeks of age and died prematurely. Transcriptomic analyses revealed alterations of signalling pathways linked to cardiomyopathy and energy metabolism in hearts from CM-Pcsk9-/- mice vs. wild-type littermates. In agreement, levels of genes and proteins involved in mitochondrial metabolism were reduced in CM-Pcsk9-/- hearts. By using a Seahorse flux analyser, we showed that mitochondrial but not glycolytic function was impaired in cardiomyocytes from CM-Pcsk9-/- mice. We further showed that assembly and activity of electron transport chain (ETC) complexes were altered in isolated mitochondria from CM-Pcsk9-/- mice. Circulating lipid levels were unchanged in CM-Pcsk9-/- mice, but the lipid composition of mitochondrial membranes was altered. In addition, cardiomyocytes from CM-Pcsk9-/- mice had an increased number of mitochondria-endoplasmic reticulum contacts and alterations in the morphology of cristae, the physical location of the ETC complexes. We also showed that acute Pcsk9 silencing in adult cardiomyocyte-like cells reduced the activity of ETC complexes and impaired mitochondrial metabolism.\n\nPCSK9, despite its low expression in cardiomyocytes, contributes to cardiac metabolic function, and PCSK9 deficiency in cardiomyocytes is linked to cardiomyopathy, impaired heart function, and compromised energy production.", "doi": "10.1093/cvr/cvad041", "pmid": "36880401", "labels": {"Adil Mardinoglu": "", "SciLifeLab Fellow": "", "DDLS Fellow": "", "Muhammad Arif": ""}, "xrefs": [{"db": "pmc", "key": "PMC10318396"}, {"db": "pii", "key": "7070420"}], "notes": [], "created": "2023-12-04T14:52:58.422Z", "modified": "2026-09-23T11:06:27.783Z"}, {"entity": "publication", "iuid": "ecfe414277de43cb834382379d90e39b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ecfe414277de43cb834382379d90e39b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ecfe414277de43cb834382379d90e39b"}}, "title": "Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.", "authors": [{"family": "Paloschi", "given": "Valentina", "initials": "V", "orcid": "0000-0002-5778-8981", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66de19d73cc54d8592ce6fe0a6d6f3aa.json"}}, {"family": "Sabater-Lleal", "given": "Maria", "initials": "M", "orcid": "0000-0002-0128-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75767107e4c74735959e7b893b4687de.json"}}, {"family": "Middelkamp", "given": "Heleen", "initials": "H"}, {"family": "Vivas", "given": "Aisen", "initials": "A", "orcid": "0000-0003-1721-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d35883f8b84481290cdbd8801e4ed33.json"}}, {"family": "Johansson", "given": "Sofia", "initials": "S", "orcid": "0000-0003-3672-9883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d976bdc17d7248d6b60c4f7a47fc84c7.json"}}, {"family": "van der Meer", "given": "Andries", "initials": "A", "orcid": "0000-0002-8761-4077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4232e14ac59d40fea9c6f3ba0ddaa65c.json"}}, {"family": "Tenje", "given": "Maria", "initials": "M", "orcid": "0000-0002-1264-1337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd13273274574923b354ca9c605efc8f.json"}}, {"family": "Maegdefessel", "given": "Lars", "initials": "L", "orcid": "0000-0001-5228-2634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17d6648126d04eaab303a92744664c64.json"}}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "117", "issue": "14", "pages": "2742-2754", "issn-l": null}, "abstract": "The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. Several models of hearts-on-chips and vessels-on-chips have been demonstrated to recapitulate fundamental aspects of the human cardiovascular system in the recent past. These 2D and 3D systems include synchronized beating cardiomyocytes in hearts-on-chips and vessels-on-chips with layer-based structures and the inclusion of physiological and pathological shear stress conditions. The opportunities to discover novel targets and to perform drug testing with chip-based platforms have substantially enhanced, thanks to the utilization of patient-derived cells and precise control of their microenvironment. These organ models will provide an important asset for future approaches to personalized cardiovascular medicine and improved patient care. However, certain technical and biological challenges remain, making the global utilization of OoCs to tackle unanswered questions in cardiovascular science still rather challenging. This review article aims to introduce and summarize published work on hearts- and vessels-on chips but also to provide an outlook and perspective on how these advanced in vitro systems can be used to tailor disease models with patient-specific characteristics.", "doi": "10.1093/cvr/cvab088", "pmid": "33729461", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8683705"}, {"db": "pii", "key": "6174689"}], "notes": [], "created": "2026-08-20T09:40:37.026Z", "modified": "2026-09-23T07:40:55.178Z"}], "created": "2023-12-04T14:52:58.653Z", "modified": "2023-12-04T14:52:58.654Z"}