{"entity": "journal", "iuid": "e57d20fa0f0a444eb5505f064a92eacb", "timestamp": "2026-10-10T11:29:46.425Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Br%20J%20Psychiatry.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Br%20J%20Psychiatry"}}, "title": "Br J Psychiatry", "issn": "1472-1465", "issn-l": null, "publications_count": 6, "publications": [{"entity": "publication", "iuid": "56efe6252f9443b7be9bdf59131abb8a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/56efe6252f9443b7be9bdf59131abb8a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/56efe6252f9443b7be9bdf59131abb8a"}}, "title": "Escitalopram and brain reactivity to aggressive stimuli in premenstrual dysphoric disorder.", "authors": [{"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Gr\u00f6ndal", "given": "Maria", "initials": "M"}, {"family": "Schmidt", "given": "Felix", "initials": "F"}, {"family": "Fisher", "given": "Patrick M", "initials": "PM"}, {"family": "Frokjaer", "given": "Vibe Gedsoe", "initials": "VG"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Eriksson", "given": "Elias", "initials": "E", "orcid": "0000-0002-4128-2046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c6705c68b474be9bc40f367cecbd066.json"}}, {"family": "Sundstr\u00f8m", "given": "Inger", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2026-07-28", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "pages": "1-9", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is a condition linked to the menstrual cycle and characterised by cyclic emotional distress, irritability and anger, which can disrupt social functioning. Intermittent selective serotonin reuptake inhibitor treatment is effective in alleviating symptoms, yet the neural underpinnings of its efficacy in PMDD remain unknown.\n\nThis randomised, placebo-controlled trial aimed to evaluate the impact of intermittent escitalopram treatment on PMDD symptoms and aggressiveness, and on neural responses to social provocation.\n\nWomen with PMDD were randomised to receive either intermittent escitalopram (20 mg/day) or placebo during the luteal phase. Outcomes of interest were changes in mood (assessed by the Daily Record of Severity of Problems), self-rated state aggression (measured by the Aggression Questionnaire) and neural responses to aggression-related stimuli, captured by functional magnetic resonance imaging during the Point Subtraction Aggression Paradigm.\n\nIntermittent escitalopram treatment significantly reduced PMDD symptoms compared with placebo, in particular irritability or anger (Cohen's d = -0.93, 95% CI [-1.48, -0.38]). Aggressiveness, which was positively associated with these symptoms (Pearson's r = 0.33, 95% CI [0.06, 0.55]), diminished following treatment (Cohen's d = -0.42, 95% CI [1.4 \u00d7 10-4, 0.84]), with the reduction in irritability or anger partly mediating this association (standardised indirect effect -0.32, 95% CI [-0.77, -0.03]). Escitalopram treatment was nominally associated with lower reactivity to provocation in the anterior insula (involved in salience and threat detection) (Cohen's d = -0.34, 95% CI [-0.66, -0.02]), the activation of which was positively related to irritability or anger (Spearman's \u03c1 = 0.39, 95% CI [0.07, 0.64]).\n\nThis randomised controlled trial provides timely confirmation of escitalopram as an effective treatment for PMDD within a contemporary clinical context and using prospective daily symptom ratings. Functional neuroimaging suggests that modulation of serotonergic function in PMDD is related to corticolimbic circuits involved in irritability or anger and interpersonal behaviour.", "doi": "10.1192/bjp.2026.10721", "pmid": "42515970", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0007125026107211"}], "notes": [], "created": "2026-08-23T09:41:02.729Z", "modified": "2026-08-24T07:18:48.810Z"}, {"entity": "publication", "iuid": "0f1d2865d828464694053000946e393a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0f1d2865d828464694053000946e393a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0f1d2865d828464694053000946e393a"}}, "title": "Women at the heart of mental science: commentary, Pinto da Costa et al.", "authors": [{"family": "Pinto da Costa", "given": "Mariana", "initials": "M", "orcid": "0000-0002-5966-5723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29c993dd36ac4ccfbcfc5deb4d827aff.json"}}, {"family": "de Cates", "given": "Angharad N", "initials": "AN", "orcid": "0000-0001-7848-1295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12cbd20164b34403b7f21fbe2c65046a.json"}}, {"family": "Dhamala", "given": "Elvisha", "initials": "E"}, {"family": "McAlonan", "given": "Grainne M", "initials": "GM"}, {"family": "Upthegrove", "given": "Rachel", "initials": "R"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2026-05-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "228", "issue": "5", "pages": "484-486", "issn-l": null}, "abstract": null, "doi": "10.1192/bjp.2025.10516", "pmid": "41668430", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0007125025105163"}], "notes": [], "created": "2026-08-23T09:42:33.866Z", "modified": "2026-09-20T18:13:51.624Z"}, {"entity": "publication", "iuid": "cc3996606a574425b86f22d0d0853c37", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cc3996606a574425b86f22d0d0853c37.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cc3996606a574425b86f22d0d0853c37"}}, "title": "The value of mental science: we publish what matters.", "authors": [{"family": "Malhi", "given": "Gin S", "initials": "GS", "orcid": "0000-0002-4524-9091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b2b12dad6c64344a2e1361399b76438.json"}}, {"family": "Adlington", "given": "Katherine", "initials": "K", "orcid": "0000-0002-9296-4952", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ec4834be2764086a62b42a6b67bdf82.json"}}, 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"given": "G Mustafa", "initials": "GM", "orcid": "0000-0002-0395-557X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdaae25485fc4e469e3bd5cf29c1f721.json"}}, {"family": "Srinivasan", "given": "Ramya", "initials": "R", "orcid": "0000-0003-1478-2018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddea8f5b34724853893fe19b2054eba2.json"}}, {"family": "Sumathipala", "given": "Athula", "initials": "A", "orcid": "0000-0002-8706-2698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abbfab9aa1b04f95a2a11cb89034b21c.json"}}, {"family": "Szymaniak", "given": "Kinga", "initials": "K", "orcid": "0000-0001-5887-9028", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7799c57f193948529f32169f7a93d16c.json"}}, {"family": "Tan", "given": "Eric", "initials": "E", "orcid": "0000-0003-4812-5630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f873452238074442ab0fb5e0da3903d8.json"}}, {"family": "Tarokh", "given": "Leila", "initials": "L", "orcid": "0000-0003-4014-428X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a2d609239304afdb075f65676ad0f61.json"}}, {"family": "Tracy", "given": "Derek", "initials": "D", "orcid": "0000-0002-3609-9407", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a88eecd69e9e48b18750ad184c375808.json"}}, {"family": "Watson", "given": "Stuart", "initials": "S", "orcid": "0000-0002-2558-3367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fffa3d060fef4b2698f820a4a3e66a43.json"}}, {"family": "Williams", "given": "Richard", "initials": "R", "orcid": "0000-0003-1230-0222", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b5df7b383e74e3eabcbce4df4d2c997.json"}}, {"family": "Wu", "given": "Jingwei", "initials": "J", "orcid": "0000-0003-1003-619X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02edef8d2f93440883a56e47718e2795.json"}}, {"family": "Young", "given": "Allan H", "initials": "AH", "orcid": "0000-0003-2291-6952", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66efc06be6af4abd9a354c328595a2eb.json"}}, {"family": "Zisman-Ilani", "given": "Yaara", "initials": "Y", "orcid": "0000-0001-6852-2583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21f287c537194a879b54ae429d0ddac6.json"}}, {"family": "Fernandez-Egea", "given": "Emilio", "initials": "E", "orcid": "0000-0003-4128-8955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/000844480b014d1d985970a6631a7425.json"}}], "type": "editorial", "published": "2025-07-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "227", "issue": "1", "pages": "429-433", "issn-l": null}, "abstract": "Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.", "doi": "10.1192/bjp.2025.118", "pmid": "40485480", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0007125025001187"}], "notes": [], "created": "2025-07-24T19:47:07.778Z", "modified": "2025-07-24T19:47:45.103Z"}, {"entity": "publication", "iuid": "012de59b9bfa4df6b23aa99608e18c84", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/012de59b9bfa4df6b23aa99608e18c84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/012de59b9bfa4df6b23aa99608e18c84"}}, "title": "Psychiatric symptoms on the ovarian hormone roller-coaster.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Kulkarni", "given": "Jayashri", "initials": "J", "orcid": "0000-0002-3875-5623", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c330461db87549bb929d1fa330628753.json"}}], "type": "editorial", "published": "2025-06-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "226", "issue": "6", "pages": "329-330", "issn-l": null}, "abstract": "This themed issue examines the impact of ovarian hormone fluctuations on women's mental health across the lifespan, including puberty, the menstrual cycle, pregnancy, postpartum and menopause. It highlights critical gaps and calls for sex-specific approaches in reproductive psychiatry and hormone-informed mental care.", "doi": "10.1192/bjp.2025.10298", "pmid": "40528482", "labels": {"SciLifeLab Fellow": "", "Erika Comasco": ""}, "xrefs": [{"db": "pii", "key": "S0007125025102985"}], "notes": [], "created": "2025-07-24T19:47:01.856Z", "modified": "2026-09-23T12:32:47.481Z"}, {"entity": "publication", "iuid": "44bf7617d6b5480ab8b48a5f35ffd675", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/44bf7617d6b5480ab8b48a5f35ffd675.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/44bf7617d6b5480ab8b48a5f35ffd675"}}, "title": "Subjective, behavioural and physiological correlates of stress in women using hormonal contraceptives.", "authors": [{"family": "B\u00fcrger", "given": "Zo\u00e9", "initials": "Z", "orcid": "0000-0003-4597-0425", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/907b16865ddc43cb93d67781f7864938.json"}}, {"family": "Kordowich", "given": "Charlotte", "initials": "C"}, {"family": "K\u00fcbbeler", "given": "Julia", "initials": "J"}, {"family": "M\u00fcllersch\u00f6n", "given": "Carolin", "initials": "C"}, {"family": "Kimmig", "given": "Ann-Christin S", "initials": "AS", "orcid": "0000-0002-8353-6593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3ee0f1b0d0b4ebd9c9e66b4850b6600.json"}}, {"family": "Su", "given": "Min", "initials": "M"}, {"family": "L\u00e4mmerhofer", "given": "Michael", "initials": "M"}, {"family": "Sacher", "given": "Julia", "initials": "J", "orcid": "0000-0003-0944-0558", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb8f8d3839014e83b43723c55ad8d1d2.json"}}, {"family": "Henes", "given": "Melanie", "initials": "M"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Derntl", "given": "Birgit", "initials": "B", "orcid": "0000-0003-0133-4486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5665196138234baaa2a6144a6098a3fa.json"}}, {"family": "Kogler", "given": "Lydia", "initials": "L", "orcid": "0000-0002-9493-2321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d502b7c4fd64f6294534374793fb03e.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "226", "issue": "6", "pages": "392-400", "issn-l": null}, "abstract": "Stress, a major risk factor for mental health problems, is influenced by hormonal fluctuations from the menstrual cycle and hormonal oral contraceptives (OC). Despite widespread use, the impact of hormonal intrauterine devices (IUDs) on stress is limited to one study.\n\nThis study examines psychoendocrine stress responses in women using IUDs, OCs and women with a natural, regular menstrual cycle (NC) to better understand how endogenous and exogenous hormones influence stress.\n\nUsing a repeated-measures design, we investigated stress responses in IUD and OC users and NC women. The Maastricht Acute Stress Task and its control task were applied twice within 4 months to assess subjective, endocrine and physiological stress correlates. Detailed endogenous and exogenous hormonal profiles were obtained, and women completed a 7-day diary (via ecological momentary assessment) after each appointment.\n\nBased on subjective, physiological and cortisol responses, stress induction was successful in all groups. IUD users reported higher subjective stress, negative affect and anxiety and lower positive affect compared to NC women. OC users exhibited a blunted cortisol response and higher heart rate but reported less acute stress and negative emotions than the other groups in the 7-day diary. Oestradiol and progesterone were suppressed in OC and IUD users compared with NC women. Progesterone, testosterone and oestradiol were differently associated with skin conductance, socio-emotional stress and negative affect.\n\nIUD and OC use distinctly affect stress response, possibly because of their diverging metabolic pathways and hormone levels. IUD users showed higher emotional reactivity to stress in both lab and daily life, while OCs influenced physiological correlates. These findings highlight that exogenous hormone administration, previously thought to have limited systemic effects, affects women's psychological well-being, underscoring the need for further research into stress-related disorders among women using hormonal contraceptives.", "doi": "10.1192/bjp.2025.7", "pmid": "40511505", "labels": {"SciLifeLab Fellow": "", "Erika Comasco": ""}, "xrefs": [{"db": "pmc", "key": "PMC12257283"}, {"db": "pii", "key": "S0007125025000078"}], "notes": [], "created": "2025-07-24T19:47:04.097Z", "modified": "2026-09-23T12:25:52.363Z"}, {"entity": "publication", "iuid": "935ae35dd7f14a4f9bf49e709c6682ba", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/935ae35dd7f14a4f9bf49e709c6682ba.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/935ae35dd7f14a4f9bf49e709c6682ba"}}, "title": "Trajectories and dimensional phenotypes of depressive symptoms throughout pregnancy and postpartum in relation to prior premenstrual symptoms.", "authors": [{"family": "Schleimann-Jensen", "given": "Ella", "initials": "E"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Meltzer-Brody", "given": "Samantha", "initials": "S"}, {"family": "Eisenlohr-Moul", "given": "Tory A", "initials": "TA"}, {"family": "Papadopoulos", "given": "Fotis C", "initials": "FC"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/882f68bd159a46e5999dedb151bd7ea4.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "226", "issue": "6", "pages": "401-409", "issn-l": null}, "abstract": "Sensitivity to ovarian hormone fluctuations can lead to mental distress during the luteal phase of the menstrual cycle, such as in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), and also during pregnancy and postpartum, as in perinatal depression (PND).\n\nIn two cohorts, we investigated the relationship between history of PMS/PMDD and PND symptoms. We also examined how premenstrual symptoms are associated with perinatal symptom trajectories and dimensional phenotypes of PND symptoms, which remains unidentified.\n\nFrom early pregnancy until 6 months postpartum, participants of two large longitudinal cohorts were followed using the Edinburgh Postnatal Depression Scale (EPDS). Premenstrual symptoms were self-reported retrospectively.\n\nBoth pre-pregnancy PMS and PMDD were associated with higher EPDS scores across pregnancy and postpartum, even after adjustment for confounders. The odds of developing PND were higher among those reporting PMS and PMDD, ranging up to 1.68 (95% CI 1.25-2.29) (6-13 weeks postpartum) and 3.05 (95% CI 2.26-4.10) (late pregnancy) respectively for PMS and PMDD, throughout the perinatal period. Premenstrual symptomatology was associated more with certain PND trajectories based on the time of occurrence and persistence of symptoms. However, PND symptom severity did not differ depending on premenstrual symptomatology in any trajectory. Prior PMS/PMDD was associated with underlying dimensions of symptom constructs of PND, including severe and moderate symptoms of depressed mood, anxiety and anhedonia.\n\nWomen with a history of PMS/PMDD require coordinated care by psychiatrists, other mental health clinicians, midwives and gynaecologists during pregnancy as well as postpartum.", "doi": "10.1192/bjp.2025.38", "pmid": "40538355", "labels": {"SciLifeLab Fellow": "", "Erika Comasco": ""}, "xrefs": [{"db": "pmc", "key": "PMC12257281"}, {"db": "pii", "key": "S0007125025000388"}], "notes": [], "created": "2025-07-24T19:46:59.658Z", "modified": "2026-09-23T09:11:46.730Z"}], "created": "2025-07-24T19:46:59.704Z", "modified": "2025-07-24T19:46:59.704Z"}