{"entity": "journal", "iuid": "2244dab68cf14ad5b4a9088de41207ef", "timestamp": "2026-09-15T20:57:04.350Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Biol%20Psychiatry%20Glob%20Open%20Sci.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Biol%20Psychiatry%20Glob%20Open%20Sci"}}, "title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "issn-l": null, "publications_count": 4, "publications": [{"entity": "publication", "iuid": "bd5d44cffcf6442cb40b91d2dc805683", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bd5d44cffcf6442cb40b91d2dc805683.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bd5d44cffcf6442cb40b91d2dc805683"}}, "title": "Impairment of Executive Functions in Premenstrual Syndrome: State or Trait?", "authors": [{"family": "Gnaiger", "given": "Anna Madeleine", "initials": "AM", "orcid": "0009-0008-3794-9830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fae12746d3045519cb64739833b659d.json"}}, {"family": "Werlein", "given": "Patricia", "initials": "P"}, {"family": "Gruschwitz", "given": "Patricia", "initials": "P"}, {"family": "Siebers", "given": "Magdalena", "initials": "M"}, {"family": "Panzik", "given": "Alina", "initials": "A"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E"}, {"family": "Pletzer", "given": "Belinda", "initials": "B"}], "type": "journal-article", "published": "2026-07-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "6", "issue": "4", "pages": "100730", "issn-l": null}, "abstract": "The aim of this study was to explore whether cognitive impairments in women with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are phase-dependent or persist across the menstrual cycle. Furthermore, we investigated whether such deficits are limited to working memory (WM) or also extend to inhibitory control (IC).\n\nA total of 105 regularly cycling women between the ages of 19 and 35 years were tested across 3 menstrual cycle phases (mid-follicular, mid-luteal, and late luteal). Premenstrual symptoms were tracked across 2 cycles. Fifty-one women were allocated to the PMS/PMDD group, and 54 women served as control participants. WM and IC were assessed using the n-back and stop signal task, respectively. Hormone levels were determined using saliva samples.\n\nWM deficits in the PMS/PMDD group emerged under high cognitive load and did not vary by cycle phase. The PMS/PMDD group also had significantly longer stop signal reaction times across all cycle phases, with stop signal reaction times positively correlating with premenstrual symptom severity. There was no significant correlation between performance measures and gonadal hormone levels.\n\nCognitive impairments in PMS/PMDD appear to be trait-like and affect both WM and IC. Additionally, IC was significantly associated with premenstrual symptom severity. Executive deficits may underlie difficulties in emotion regulation and are not solely attributable to gonadal hormone levels.", "doi": "10.1016/j.bpsgos.2026.100730", "pmid": "42254277", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC13235494"}, {"db": "pii", "key": "S2667-1743(26)00043-1"}], "notes": [], "created": "2026-08-23T09:41:15.934Z", "modified": "2026-08-25T08:17:53.507Z"}, {"entity": "publication", "iuid": "9287b76dfbed4d9a9f28d0e08cdb6fc8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9287b76dfbed4d9a9f28d0e08cdb6fc8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9287b76dfbed4d9a9f28d0e08cdb6fc8"}}, "title": "White Matter Regional Volumes in Relation to Menstrual Cycle Phase and Premenstrual Dysphoric Disorder.", "authors": [{"family": "Stenhammar", "given": "Elin", "initials": "E"}, {"family": "Dubol", "given": "Manon", "initials": "M", "orcid": "0000-0001-8637-3390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/112ad612d243424886e9f4e8c8a8ebdb.json"}}, {"family": "Stiernman", "given": "Louise", "initials": "L", "orcid": "0000-0002-9662-981X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/968f45819dc647f4bf7773a498b6db8b.json"}}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Bixo", "given": "Marie", "initials": "M", "orcid": "0000-0002-4988-1967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4914c0fd58a40f2b9332be301cb2e3f.json"}}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-11-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "5", "issue": "6", "pages": "100573", "issn-l": null}, "abstract": "Premenstrual dysphoric disorder (PMDD) is an understudied, debilitating, and hormone-related mental disorder. Recent evidence suggests alterations in white matter structure during the symptomatic luteal phase in PMDD. In this study, white matter volumes (WMVs) in the brains of women with PMDD versus control women were compared across the menstrual cycle, to determine whether these differences reflect state- or trait-like characteristics.\n\nAnatomical magnetic resonance imaging was performed during the midfollicular phase and the late luteal phase of the menstrual cycle in 28 women with PMDD and 27 control women. WMVs were assessed using voxel-based morphometry, employing both region-of-interest (ROI) and exploratory whole-brain approaches.\n\nNo group-by-phase interaction effects on WMVs were found. Across menstrual cycle phases, women with PMDD exhibited greater WMVs than control women within ROIs (in the bilateral uncinate fasciculus, right inferior fronto-occipital fasciculus, and left crus and fimbria of the fornix) and across the whole brain (in inferior occipital areas and near the angular gyrus), indicating trait- rather than state-like structural markers of PMDD.\n\nThese findings suggest that women with PMDD exhibit larger WMVs than healthy control women, during both the symptomatic and asymptomatic phases of the menstrual cycle, in white matter tracts involved in emotion processing and regulation, memory, and connecting limbic and prefrontal regions of relevance to mood disorders.", "doi": "10.1016/j.bpsgos.2025.100573", "pmid": "41017818", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12466263"}, {"db": "pii", "key": "S2667-1743(25)00127-2"}], "notes": [], "created": "2025-10-02T18:22:37.524Z", "modified": "2025-10-21T07:34:54.521Z"}, {"entity": "publication", "iuid": "19e7ba728b4b48c1867a2ae45e808ac7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/19e7ba728b4b48c1867a2ae45e808ac7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/19e7ba728b4b48c1867a2ae45e808ac7"}}, "title": "Contextualizing Telomere Biology Through Biopsychological Plasticity: Insights From the Differential Susceptibility Hypothesis.", "authors": [{"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "5", "issue": "5", "pages": "100548", "issn-l": null}, "abstract": null, "doi": "10.1016/j.bpsgos.2025.100548", "pmid": "40687635", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pmc", "key": "PMC12272861"}, {"db": "pii", "key": "S2667-1743(25)00102-8"}], "notes": [], "created": "2025-07-24T19:46:56.616Z", "modified": "2025-09-09T09:28:53.228Z"}, {"entity": "publication", "iuid": "b6d11842314245849594ec1f1ab68adc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b6d11842314245849594ec1f1ab68adc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b6d11842314245849594ec1f1ab68adc"}}, "title": "Investigating the Microbiome in Relation to Mental Distress Across Two Points During Pregnancy: Data From U.S. and Swedish Cohorts.", "authors": [{"family": "Kimmel", "given": "Mary", "initials": "M"}, {"family": "Tong", "given": "Bangzhuo", "initials": "B"}, {"family": "Devall", "given": "Alfons Edbom", "initials": "AE"}, {"family": "Bj\u00f6rvang", "given": "Richelle D", "initials": "RD"}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Fransson", "given": "Emma", "initials": "E"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Hugerth", "given": "Luisa W", "initials": "LW"}], "type": "journal article", "published": "2025-05-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "5", "issue": "3", "pages": "100453", "issn-l": null}, "abstract": "In this study, we aimed to characterize the gut microbiome and its potential functioning in 2 populations at 2 time points during pregnancy in relation to mental distress.\n\nDuring the second and third trimester, individuals from the United States and Sweden completed the Edinburgh Postnatal Depression Scale and provided fecal samples for whole-genome metagenomics. A total of 832 and 161 samples were sequenced and analyzed from the Swedish cohort and the U.S. cohort, respectively. Multiple characterizations of the microbial community were analyzed in relation to distress measured using the Edinburgh Postnatal Depression Scale. Principal coordinate analysis and distance-based redundancy analysis assessed variation in functional gut-brain modules. For the U.S. cohort, the Trier Social Stress Test was administered 8 weeks postpartum while collecting salivary cortisol.\n\nPrincipal coordinate analysis identified 4 sample clusters based on the gut-brain modules distinguished by functions such as short-chain fatty acid synthesis and cortisol degradation. While with distance-based redundancy analysis, mental distress subtypes did not significantly contribute to variation in gut-brain modules (p = .085 for Sweden, p = .23 for the U.S.), a U.S. sample cluster distinguished by lower cortisol degradation from another cluster with higher gut microbial cortisol degradation abundance had significantly higher odds of being associated with depression (p = .024). The U.S. sample cluster with lower gut microbial cortisol degradation abundance also had significantly higher cortisol levels after a postpartum social stressor.\n\nFurther studies are warranted to investigate the potential for the gut microbiome to serve as biomarkers of gut-brain axis health during pregnancy across disparate populations.", "doi": "10.1016/j.bpsgos.2025.100453", "pmid": "40115744", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11925571"}, {"db": "pii", "key": "S2667-1743(25)00007-2"}], "notes": [], "created": "2026-08-20T06:49:27.372Z", "modified": "2026-08-20T06:49:27.385Z"}], "created": "2025-07-24T19:46:56.630Z", "modified": "2025-07-24T19:46:56.630Z"}