{"entity": "journal", "iuid": "ef435ec0bc95487bbaea57523bc91361", "timestamp": "2026-09-26T23:02:44.850Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/BMJ%20Open%20Respir%20Res.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/BMJ%20Open%20Respir%20Res"}}, "title": "BMJ Open Respir Res", "issn": "2052-4439", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "6f8991181de44b3a9f63c4a17e95cb35", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6f8991181de44b3a9f63c4a17e95cb35.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6f8991181de44b3a9f63c4a17e95cb35"}}, "title": "Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective.", "authors": [{"family": "T\u00e9nyi", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-4880-6594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f68442e88c114c2c9bcee1871e166fc1.json"}}, {"family": "Vela", "given": "Emili", "initials": "E"}, {"family": "Cano", "given": "Isaac", "initials": "I"}, {"family": "Cleries", "given": "Montserrat", "initials": "M"}, {"family": "Monterde", "given": "David", "initials": "D"}, {"family": "Gomez-Cabrero", "given": "David", "initials": "D"}, {"family": "Roca", "given": "Josep", "initials": "J"}], "type": "journal article", "published": "2018-06-13", "journal": {"title": "BMJ Open Respir Res", "issn": "2052-4439", "volume": "5", "issue": "1", "pages": "e000302", "issn-l": null}, "abstract": "Comorbidities in patients with chronic obstructive pulmonary disease (COPD) generate a major burden on healthcare. Identification of cost-effective strategies aiming at preventing and enhancing management of comorbid conditions in patients with COPD requires deeper knowledge on epidemiological patterns and on shared biological pathways explaining co-occurrence of diseases.\n\nThe study assesses the co-occurrence of several chronic conditions in patients with COPD using two different datasets: Catalan Healthcare Surveillance System (CHSS) (ES, 1.4 million registries) and Medicare (USA, 13 million registries). Temporal order of disease diagnosis was analysed in the CHSS dataset.\n\nThe results demonstrate higher prevalence of most of the diseases, as comorbid conditions, in elderly (>65) patients with COPD compared with non-COPD subjects, an effect observed in both CHSS and Medicare datasets. Analysis of temporal order of disease diagnosis showed that comorbid conditions in elderly patients with COPD tend to appear after the diagnosis of the obstructive disease, rather than before it.\n\nThe results provide a population health perspective of the comorbidity challenge in patients with COPD, indicating the increased risk of developing comorbid conditions in these patients. The research reinforces the need for novel approaches in the prevention and management of comorbidities in patients with COPD to effectively reduce the overall burden of the disease on these patients.", "doi": "10.1136/bmjresp-2018-000302", "pmid": "29955364", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6018856"}, {"db": "pii", "key": "bmjresp-2018-000302"}], "notes": [], "created": "2026-09-23T13:02:49.421Z", "modified": "2026-09-23T13:02:49.504Z"}, {"entity": "publication", "iuid": "4d1e5521d7ee401f87931d808e831c27", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4d1e5521d7ee401f87931d808e831c27.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4d1e5521d7ee401f87931d808e831c27"}}, "title": "ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.", "authors": [{"family": "Crosbie", "given": "Philip A J", "initials": "PA"}, {"family": "Crosbie", "given": "Emma J", "initials": "EJ"}, {"family": "Aspinall-O'Dea", "given": "Mark", "initials": "M"}, {"family": "Walker", "given": "Michael", "initials": "M"}, {"family": "Harrison", "given": "Rebecca", "initials": "R"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}, {"family": "Shah", "given": "Rajesh", "initials": "R"}, {"family": "Joseph", "given": "Leena", "initials": "L"}, {"family": "Booton", "given": "Richard", "initials": "R"}, {"family": "Pierce", "given": "Andrew", "initials": "A"}, {"family": "Whetton", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2016-02-17", "journal": {"title": "BMJ Open Respir Res", "issn": "2052-4439", "volume": "3", "issue": "1", "pages": "e000114", "issn-l": null}, "abstract": "Emphysema is an independent risk factor for the development of lung cancer in smokers. Activation of oncogenic signalling proteins AKT and ERK by phosphorylation has an established role in the development of lung cancer and has also been implicated in the pathogenesis of emphysema. The aim of this study was to compare the protein level and phosphorylation status of AKT and ERK in paired lung cancer and emphysema tissue using a highly sensitive phosphoprotein analysis approach.\n\nAn antibody-based, nanocapillary isoelectric focusing (cIEF) assay was used to determine the relative quantities and phosphorylation status of AKT and ERK in tumour and matched lung tissue from patients, with or without evidence of emphysema, undergoing curative resection for non-small cell lung cancer.\n\n20 patients with adenocarcinoma (n=9) or squamous cell carcinoma (n=11) of the lung were included (mean age 67.3 years (SD 7.5, range 47-80 years)), 12 were men and all were current (n=10) or former smokers (n=10). Paired macroscopically normal lung tissue was either histologically normal (n=7) or showed emphysema (n=13). Total and phosphorylated AKT levels were fourfold (p=0.0001) and fivefold (p=0.001) higher in tumour compared with matched lung, respectively. There was no correlation with tumour histology, stage or differentiation; however, total AKT signal in tumour was significantly correlated with fluorodeoxyglucose avidity on positron emission tomography-CT scan (r=0.53, p=0.035). Total ERK was not differentially expressed, but doubly phosphorylated (activated) ERK was threefold higher in emphysema (23.5%, SD 9.2) than either matched tumour (8.8%, SD 8.6) or normal lung tissue (8.3%, SD 9.0) and correlated with the histological severity of emphysema (p=0.005).\n\ncIEF offers opportunities for quantifying subtle shifts in the phosphorylation status of oncoproteins in nanogram amounts of lung tissue. ERK activation is a feature of emphysema.", "doi": "10.1136/bmjresp-2015-000114", "pmid": "26918193", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC4762086"}, {"db": "pii", "key": "bmjresp-2015-000114"}], "notes": [], "created": "2026-09-23T11:47:21.400Z", "modified": "2026-09-23T11:47:21.451Z"}], "created": "2026-09-23T11:47:21.407Z", "modified": "2026-09-23T11:47:21.407Z"}