{"entity": "journal", "iuid": "a455d85544fa408bbff542555356a10c", "timestamp": "2026-08-25T21:25:06.370Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/BJOG.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/BJOG"}}, "title": "BJOG", "issn": "1471-0528", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "889ff644a16940699cd137ac2266ff9a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/889ff644a16940699cd137ac2266ff9a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/889ff644a16940699cd137ac2266ff9a"}}, "title": "The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.", "authors": [{"family": "Norenhag", "given": "J", "initials": "J"}, {"family": "Du", "given": "J", "initials": "J", "orcid": "0000-0001-7649-9571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f67834a614ca4cd4aff026e5e9a1a1e4.json"}}, {"family": "Olovsson", "given": "M", "initials": "M", "orcid": "0000-0003-4472-840X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5466be16f4ef4a9f879a3b73f59cb54b.json"}}, {"family": "Verstraelen", "given": "H", "initials": "H", "orcid": "0000-0002-4070-1587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca4a2b3b0fea44ffbeebb799606c6b2a.json"}}, {"family": "Engstrand", "given": "L", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Brusselaers", "given": "N", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70d0a6a2f4eb4272be4865e7e369c0e9.json"}}], "type": "journal article", "published": "2020-01-00", "journal": {"title": "BJOG", "issn": "1471-0528", "volume": "127", "issue": "2", "pages": "171-180", "issn-l": null}, "abstract": "Persistent infection with high-risk human papillomavirus can lead to cervical dysplasia and cancer. Recent studies have suggested associations between the composition of the vaginal microbiota, infection with human papillomavirus (HPV) and progression to cervical dysplasia and cancer.\n\nTo assess how specific cervico-vaginal microbiota compositions are associated with HPV infection, cervical dysplasia and cancer, we conducted a systematic review and network meta-analysis (registered in PROSPERO: CRD42018112862).\n\nPubMed, Web of science, Embase and Cochrane database.\n\nAll original studies describing at least two community state types of bacteria (CST), based on molecular techniques enabling identification of bacteria, and reporting the association with HPV infection, cervical dysplasia and/or cervical cancer.\n\nFor the meta-analysis, a network map was constructed to provide an overview of the network relationships and to assess how many studies provided direct evidence for the different vaginal microbiota compositions and HPV, cervical dysplasia or cancer. Thereafter, the consistency of the model was assessed, and forest plots were constructed to pool and summarise the available evidence, presenting odds ratios and 95% confidence intervals.\n\nVaginal microbiota dominated by non-Lactobacilli species or Lactobacillus iners were associated with three to five times higher odds of any prevalent HPV and two to three times higher for high-risk HPV and dysplasia/cervical cancer compared with Lactobacillus crispatus.\n\nThese findings suggest an association between certain bacterial community types of the vaginal microbiota and HPV infection and HPV-related disease. This may be useful for guiding treatment options or serve as biomarkers for HPV-related disease.\n\nThis network meta-analysis suggests an association between different vaginal bacterial community types and the risk of HPV.", "doi": "10.1111/1471-0528.15854", "pmid": "31237400", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:16:23.585Z", "modified": "2026-08-21T12:16:23.718Z"}, {"entity": "publication", "iuid": "9ccbae7c807a4da48acf1299d6808026", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9ccbae7c807a4da48acf1299d6808026.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9ccbae7c807a4da48acf1299d6808026"}}, "title": "Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study.", "authors": [{"family": "Fonnes", "given": "T", "initials": "T"}, {"family": "Trovik", "given": "J", "initials": "J"}, {"family": "Edqvist", "given": "P-Hd", "initials": "PH"}, {"family": "Fasmer", "given": "K E", "initials": "KE"}, {"family": "Marcickiewicz", "given": "J", "initials": "J"}, {"family": "Tingulstad", "given": "S", "initials": "S"}, {"family": "Staff", "given": "A C", "initials": "AC"}, {"family": "Bj\u00f8rge", "given": "L", "initials": "L"}, {"family": "Amant", "given": "F", "initials": "F"}, {"family": "Haldorsen", "given": "I S", "initials": "IS"}, {"family": "Werner", "given": "Hmj", "initials": "H"}, {"family": "Akslen", "given": "L A", "initials": "LA"}, {"family": "Tangen", "given": "I L", "initials": "IL"}, {"family": "Krakstad", "given": "C", "initials": "C"}], "type": "journal article", "published": "2018-12-00", "journal": {"title": "BJOG", "issn": "1471-0528", "volume": "125", "issue": "13", "pages": "1695-1703", "issn-l": null}, "abstract": "Correct preoperative identification of high-risk patients is important to optimise surgical treatment and improve survival. We wanted to explore if asparaginase-like protein 1 (ASRGL1) expression in curettage could predict lymph node metastases and poor outcome, potentially improving preoperative risk stratification.\n\nMulticentre study.\n\nTen hospitals in Norway, Sweden and Belgium.\n\nWomen diagnosed with endometrial carcinoma.\n\nASRGL1 expression in curettage specimens from 1144 women was determined by immunohistochemistry.\n\nASRGL1 status related to disease-specific survival, lymph node status, preoperative imaging parameters and clinicopathological data.\n\nASRGL1 expression had independent prognostic value in multivariate survival analyses, both in the whole patient population (hazard ratio (HR) 1.63, 95% CI 1.11-2.37, P = 0.012) and in the low-risk curettage histology subgroup (HR 2.54, 95% CI 1.44-4.47, P = 0.001). Lymph node metastases were more frequent in women with low expression of ASRGL1 compared with women with high ASRGL1 levels (23% versus 10%, P < 0.001), and low ASRGL1 level was found to independently predict lymph node metastases (odds ratio 2.07, 95% CI 1.27-3.38, P = 0.003).\n\nLow expression of ASRGL1 in curettage independently predicts lymph node metastases and poor disease-specific survival.\n\nLow ASRGL1 expression in curettage predicts lymph node metastasis and poor survival in endometrial carcinoma.", "doi": "10.1111/1471-0528.15403", "pmid": "29989298", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:16:21.664Z", "modified": "2026-08-21T12:16:21.703Z"}], "created": "2026-08-21T12:16:21.672Z", "modified": "2026-08-21T12:16:21.672Z"}