{"entity": "journal", "iuid": "975609b9ff834b54a86de00b672e33bc", "timestamp": "2026-08-15T13:07:58.945Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/American%20journal%20of%20transplantation%20%3A%20official%20journal%20of%20the%20American%20Society%20of%20Transplantation%20and%20the%20American%20Society%20of%20Transplant%20Surgeons.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/American%20journal%20of%20transplantation%20%3A%20official%20journal%20of%20the%20American%20Society%20of%20Transplantation%20and%20the%20American%20Society%20of%20Transplant%20Surgeons"}}, "title": "American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons", "issn": "1600-6143", "issn-l": "1600-6135", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "4b6510cc24ef4d02ac65a261b42cc860", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4b6510cc24ef4d02ac65a261b42cc860.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4b6510cc24ef4d02ac65a261b42cc860"}}, "title": "Transplantation of macroencapsulated human islets within the bioartificial pancreas \u03b2Air to patients with type 1 diabetes mellitus.", "authors": [{"family": "Carlsson", "given": "Per-Ola", "initials": "PO"}, {"family": "Espes", "given": "Daniel", "initials": "D"}, {"family": "Sedigh", "given": "Amir", "initials": "A", "orcid": "0000-0003-0238-0839", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92a08cec5b4844c4be9e085592d5cb98.json"}}, {"family": "Rotem", "given": "Avi", "initials": "A"}, {"family": "Zimerman", "given": "Baruch", "initials": "B"}, {"family": "Grinberg", "given": "Helena", "initials": "H"}, {"family": "Goldman", "given": "Tali", "initials": "T"}, {"family": "Barkai", "given": "Uriel", "initials": "U"}, {"family": "Avni", "given": "Yuval", "initials": "Y"}, {"family": "Westermark", "given": "Gunilla T", "initials": "GT"}, {"family": "Carlbom", "given": "Lina", "initials": "L"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Eriksson", "given": "Olof", "initials": "O", "orcid": "0000-0002-2515-8790", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85991bf00e4b4a26ab15599d25c58601.json"}}, {"family": "Olerud", "given": "Johan", "initials": "J"}, {"family": "Korsgren", "given": "Olle", "initials": "O"}], "type": "clinical trial, phase i", "published": "2018-07-00", "journal": {"title": "American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons", "issn": "1600-6143", "issn-l": "1600-6135", "volume": "18", "issue": "7", "pages": "1735-1744"}, "abstract": "Macroencapsulation devices provide the dual possibility of immunoprotecting transplanted cells while also being retrievable, the latter bearing importance for safety in future trials with stem cell-derived cells. However, macroencapsulation entails a problem with oxygen supply to the encapsulated cells. The \u03b2Air device solves this with an incorporated refillable oxygen tank. This phase 1 study evaluated the safety and efficacy of implanting the \u03b2Air device containing allogeneic human pancreatic islets into patients with type 1 diabetes. Four patients were transplanted with 1-2 \u03b2Air devices, each containing 155 000-180 000 islet equivalents (ie, 1800-4600 islet equivalents per kg body weight), and monitored for 3-6 months, followed by the recovery of devices. Implantation of the \u03b2Air device was safe and successfully prevented immunization and rejection of the transplanted tissue. However, although beta cells survived in the device, only minute levels of circulating C-peptide were observed with no impact on metabolic control. Fibrotic tissue with immune cells was formed in capsule surroundings. Recovered devices displayed a blunted glucose-stimulated insulin response, and amyloid formation in the endocrine tissue. We conclude that the \u03b2Air device is safe and can support survival of allogeneic islets for several months, although the function of the transplanted cells was limited (Clinicaltrials.gov: NCT02064309).", "doi": "10.1111/ajt.14642", "pmid": "29288549", "labels": {"Olof Eriksson": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC6055594"}, {"db": "pii", "key": "S1600-6135(22)09620-4"}, {"db": "ClinicalTrials.gov", "key": "NCT02064309"}], "notes": [], "created": "2020-10-06T13:41:20.719Z", "modified": "2023-05-14T14:56:36.556Z"}, {"entity": "publication", "iuid": "4fd1d59d505b4d1dac26615ff1686e4e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4fd1d59d505b4d1dac26615ff1686e4e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4fd1d59d505b4d1dac26615ff1686e4e"}}, "title": "Rapid Restoration of Vascularity and Oxygenation in Mouse and Human Islets Transplanted to Omentum May Contribute to Their Superior Function Compared to Intraportally Transplanted Islets.", "authors": [{"family": "Espes", "given": "D", "initials": "D"}, {"family": "Lau", "given": "J", "initials": "J"}, {"family": "Quach", "given": "M", "initials": "M"}, {"family": "Ullsten", "given": "S", "initials": "S"}, {"family": "Christoffersson", "given": "G", "initials": "G"}, {"family": "Carlsson", "given": "P O", "initials": "PO"}], "type": "journal article", "published": "2016-11-00", "journal": {"title": "American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons", "issn": "1600-6143", "volume": "16", "issue": "11", "pages": "3246-3254", "issn-l": "1600-6135"}, "abstract": "Transplantation of islets into the liver confers several site-specific challenges, including a delayed vascularization and prevailing hypoxia. The greater omentum has in several experimental studies been suggested as an alternative implantation site for clinical use, but there has been no direct functional comparison to the liver. In this experimental study in mice, we characterized the engraftment of mouse and human islets in the omentum and compared engraftment and functional outcome with those in the intraportal site. The vascularization and innervation of the islets transplanted into the omentum were restored within the first month by paralleled ingrowth of capillaries and nerves. The hypoxic conditions in the islets early posttransplantation were transient and restricted to the first days. Newly formed blood vessels were fully functional, and the blood perfusion and oxygenation of the islets became similar to that of endogenous islets. Furthermore, islet grafts in the omentum showed at 1 month posttransplantation functional superiority to intraportally transplanted grafts. We conclude that in contrast to the liver the omentum provides excellent engraftment conditions for transplanted islets. Future studies in humans will be of great interest to investigate the capability of this site to also harbor larger grafts without interfering with islet functionality.", "doi": "10.1111/ajt.13927", "pmid": "27321369", "labels": {"Gustaf Christoffersson": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2020-11-04T09:41:54.194Z", "modified": "2022-11-07T11:32:18.367Z"}, {"entity": "publication", "iuid": "fe5c29b9b23545d99acc2e7b769791d8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fe5c29b9b23545d99acc2e7b769791d8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fe5c29b9b23545d99acc2e7b769791d8"}}, "title": "Positron emission tomography in clinical islet transplantation.", "authors": [{"family": "Eriksson", "given": "O", "initials": "O"}, {"family": "Eich", "given": "T", "initials": "T"}, {"family": "Sundin", "given": "A", "initials": "A"}, {"family": "Tibell", "given": "A", "initials": "A"}, {"family": "Tufveson", "given": "G", "initials": "G"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Felldin", "given": "M", "initials": "M"}, {"family": "Foss", "given": "A", "initials": "A"}, {"family": "Kyll\u00f6nen", "given": "L", "initials": "L"}, {"family": "Langstrom", "given": "B", "initials": "B"}, {"family": "Nilsson", "given": "B", "initials": "B"}, {"family": "Korsgren", "given": "O", "initials": "O"}, {"family": "Lundgren", "given": "T", "initials": "T"}], "type": "clinical trial", "published": "2009-12-00", "journal": {"title": "American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons", "issn": "1600-6143", "volume": "9", "issue": "12", "pages": "2816-2824", "issn-l": "1600-6135"}, "abstract": "The fate of islets in clinical transplantation is unclear. To elude on this positron emission tomography combined with computed tomography (PET/CT) was performed for 60 min during islet transplantation in five patients receiving six transplants. A fraction of the islets (23%) were labeled with 18F-fluorodeoxyglucose ([(18)F]FDG) and carefully mixed with unlabeled islets just prior to intraportal transplantation. The peak radioactivity concentration in the liver was found at 19 min after start of islet infusion and corresponded to only 75% of what was expected, indicating that islets are lost during the transplantation procedure. No accumulation of radioactivity was found in the lungs. A nonphysiological peak of C-peptide was found in plasma during and immediately after transplantation in all subjects. Distribution in the liver was heterogeneous with wide variations in location and concentration. Islets found in areas with concentrations of >400 IEQ/cc liver tissue varied between 1% and 32% of the graft in different subjects. No side effects attributed to the PET/CT procedure were found. Clinical outcome in all patients was comparable to that previously observed indicating that the [(18)F]FDG labeling procedure did not harm the islets. The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation.", "doi": "10.1111/j.1600-6143.2009.02844.x", "pmid": "19845588", "labels": {"Olof Eriksson": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "AJT2844"}, {"db": "ClinicalTrials.gov", "key": "NCT00417131"}], "notes": [], "created": "2020-10-06T14:08:40.109Z", "modified": "2022-11-07T11:35:51.895Z"}], "created": "2020-10-06T13:41:20.731Z", "modified": "2020-11-27T13:12:56.121Z"}